Extracellular matrix in the trabecular meshwork: Intraocular pressure regulation and dysregulation in glaucoma
The trabecular meshwork (TM) is located in the anterior segment of the eye and is responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous outflow causes intraocular pressure to increase, which is the primary risk factor for glaucoma. TM cells reside on a series of fe...
Uloženo v:
| Vydáno v: | Experimental eye research Ročník 133; s. 112 - 125 |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
England
Elsevier Ltd
01.04.2015
|
| Témata: | |
| ISSN: | 0014-4835, 1096-0007, 1096-0007 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | The trabecular meshwork (TM) is located in the anterior segment of the eye and is responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous outflow causes intraocular pressure to increase, which is the primary risk factor for glaucoma. TM cells reside on a series of fenestrated beams and sheets through which the aqueous humor flows to exit the anterior chamber via Schlemm's canal. The outer trabecular cells are phagocytic and are thought to function as a pre-filter. However, most of the outflow resistance is thought to be from the extracellular matrix (ECM) of the juxtacanalicular region, the deepest portion of the TM, and from the inner wall basement membrane of Schlemm's canal. It is becoming increasingly evident that the extracellular milieu is important in maintaining the integrity of the TM. In glaucoma, not only have ultrastructural changes been observed in the ECM of the TM, and a significant number of mutations in ECM genes been noted, but the stiffness of glaucomatous TM appears to be greater than that of normal tissue. Additionally, TGFβ2 has been found to be elevated in the aqueous humor of glaucoma patients and is assumed to be involved in ECM changes deep with the juxtacanalicular region of the TM. This review summarizes the current literature on trabecular ECM as well as the development and function of the TM. Animal models and organ culture models targeting specific ECM molecules to investigate the mechanisms of glaucoma are described. Finally, the growing number of mutations that have been identified in ECM genes and genes that modulate ECM in humans with glaucoma are documented.
•Development and function of the trabecular meshwork are described in detail.•Involvement of TGFβ and the extracellular matrix in glaucoma are discussed.•Extracellular matrix changes with glaucoma, including compliance of the trabecular meshwork.•Mutations in extracellular matrix genes associated with glaucoma in humans are detailed here.•Organ culture and animal models used to study intraocular pressure and extracellular matrix are discussed. |
|---|---|
| AbstractList | The trabecular meshwork (TM) is located in the anterior segment of the eye and is responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous outflow causes intraocular pressure to increase, which is the primary risk factor for glaucoma. TM cells reside on a series of fenestrated beams and sheets through which the aqueous humor flows to exit the anterior chamber via Schlemm’s canal. The outer trabecular cells are phagocytic and are thought to function as a pre-filter. However, most of the outflow resistance is thought to be from the extracellular matrix (ECM) of the juxtacanalicular region, the deepest portion of the TM, and from the inner wall basement membrane of Schlemm’s canal. It is becoming increasingly evident that the extracellular milieu is important in maintaining the integrity of the TM. Not only have ultrastructural changes been observed in the ECM of the TM in glaucoma, and a significant number of mutations in ECM genes are known to be associated with glaucoma, but the stiffness of glaucomatous TM appears to be greater than that of normal tissue. Additionally, TGFβ2 has been found to be elevated in the aqueous humor of glaucoma patients and is assumed to be involved in ECM changes deep with the juxtacanalicular region of the TM. This review summarizes the current literature on trabecular ECM as well as the development and function of the TM. Animal models and organ culture models targeting specific ECM molecules to investigate the mechanisms of glaucoma are described. Finally, the growing number of mutations that have been identified in ECM genes and genes that modulate ECM in humans with glaucoma are documented. The trabecular meshwork (TM) is located in the anterior segment of the eye and is responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous outflow causes intraocular pressure to increase, which is the primary risk factor for glaucoma. TM cells reside on a series of fenestrated beams and sheets through which the aqueous humor flows to exit the anterior chamber via Schlemm's canal. The outer trabecular cells are phagocytic and are thought to function as a pre-filter. However, most of the outflow resistance is thought to be from the extracellular matrix (ECM) of the juxtacanalicular region, the deepest portion of the TM, and from the inner wall basement membrane of Schlemm's canal. It is becoming increasingly evident that the extracellular milieu is important in maintaining the integrity of the TM. In glaucoma, not only have ultrastructural changes been observed in the ECM of the TM, and a significant number of mutations in ECM genes been noted, but the stiffness of glaucomatous TM appears to be greater than that of normal tissue. Additionally, TGFβ2 has been found to be elevated in the aqueous humor of glaucoma patients and is assumed to be involved in ECM changes deep with the juxtacanalicular region of the TM. This review summarizes the current literature on trabecular ECM as well as the development and function of the TM. Animal models and organ culture models targeting specific ECM molecules to investigate the mechanisms of glaucoma are described. Finally, the growing number of mutations that have been identified in ECM genes and genes that modulate ECM in humans with glaucoma are documented.The trabecular meshwork (TM) is located in the anterior segment of the eye and is responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous outflow causes intraocular pressure to increase, which is the primary risk factor for glaucoma. TM cells reside on a series of fenestrated beams and sheets through which the aqueous humor flows to exit the anterior chamber via Schlemm's canal. The outer trabecular cells are phagocytic and are thought to function as a pre-filter. However, most of the outflow resistance is thought to be from the extracellular matrix (ECM) of the juxtacanalicular region, the deepest portion of the TM, and from the inner wall basement membrane of Schlemm's canal. It is becoming increasingly evident that the extracellular milieu is important in maintaining the integrity of the TM. In glaucoma, not only have ultrastructural changes been observed in the ECM of the TM, and a significant number of mutations in ECM genes been noted, but the stiffness of glaucomatous TM appears to be greater than that of normal tissue. Additionally, TGFβ2 has been found to be elevated in the aqueous humor of glaucoma patients and is assumed to be involved in ECM changes deep with the juxtacanalicular region of the TM. This review summarizes the current literature on trabecular ECM as well as the development and function of the TM. Animal models and organ culture models targeting specific ECM molecules to investigate the mechanisms of glaucoma are described. Finally, the growing number of mutations that have been identified in ECM genes and genes that modulate ECM in humans with glaucoma are documented. The trabecular meshwork (TM) is located in the anterior segment of the eye and is responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous outflow causes intraocular pressure to increase, which is the primary risk factor for glaucoma. TM cells reside on a series of fenestrated beams and sheets through which the aqueous humor flows to exit the anterior chamber via Schlemm's canal. The outer trabecular cells are phagocytic and are thought to function as a pre-filter. However, most of the outflow resistance is thought to be from the extracellular matrix (ECM) of the juxtacanalicular region, the deepest portion of the TM, and from the inner wall basement membrane of Schlemm's canal. It is becoming increasingly evident that the extracellular milieu is important in maintaining the integrity of the TM. In glaucoma, not only have ultrastructural changes been observed in the ECM of the TM, and a significant number of mutations in ECM genes been noted, but the stiffness of glaucomatous TM appears to be greater than that of normal tissue. Additionally, TGFβ2 has been found to be elevated in the aqueous humor of glaucoma patients and is assumed to be involved in ECM changes deep with the juxtacanalicular region of the TM. This review summarizes the current literature on trabecular ECM as well as the development and function of the TM. Animal models and organ culture models targeting specific ECM molecules to investigate the mechanisms of glaucoma are described. Finally, the growing number of mutations that have been identified in ECM genes and genes that modulate ECM in humans with glaucoma are documented. The trabecular meshwork (TM) is located in the anterior segment of the eye and is responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous outflow causes intraocular pressure to increase, which is the primary risk factor for glaucoma. TM cells reside on a series of fenestrated beams and sheets through which the aqueous humor flows to exit the anterior chamber via Schlemm's canal. The outer trabecular cells are phagocytic and are thought to function as a pre-filter. However, most of the outflow resistance is thought to be from the extracellular matrix (ECM) of the juxtacanalicular region, the deepest portion of the TM, and from the inner wall basement membrane of Schlemm's canal. It is becoming increasingly evident that the extracellular milieu is important in maintaining the integrity of the TM. In glaucoma, not only have ultrastructural changes been observed in the ECM of the TM, and a significant number of mutations in ECM genes been noted, but the stiffness of glaucomatous TM appears to be greater than that of normal tissue. Additionally, TGFβ2 has been found to be elevated in the aqueous humor of glaucoma patients and is assumed to be involved in ECM changes deep with the juxtacanalicular region of the TM. This review summarizes the current literature on trabecular ECM as well as the development and function of the TM. Animal models and organ culture models targeting specific ECM molecules to investigate the mechanisms of glaucoma are described. Finally, the growing number of mutations that have been identified in ECM genes and genes that modulate ECM in humans with glaucoma are documented. •Development and function of the trabecular meshwork are described in detail.•Involvement of TGFβ and the extracellular matrix in glaucoma are discussed.•Extracellular matrix changes with glaucoma, including compliance of the trabecular meshwork.•Mutations in extracellular matrix genes associated with glaucoma in humans are detailed here.•Organ culture and animal models used to study intraocular pressure and extracellular matrix are discussed. |
| Author | Kelley, Mary J. Acott, Ted S. Keller, Kate E. Vranka, Janice A. |
| Author_xml | – sequence: 1 givenname: Janice A. surname: Vranka fullname: Vranka, Janice A. – sequence: 2 givenname: Mary J. surname: Kelley fullname: Kelley, Mary J. – sequence: 3 givenname: Ted S. surname: Acott fullname: Acott, Ted S. – sequence: 4 givenname: Kate E. surname: Keller fullname: Keller, Kate E. email: gregorka@ohsu.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25819459$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9UUtv1DAQtlAR3Rb-AAeUI5cEv5MghFRVBSpV4gJny3HGu14Se7GTsv33OKRUhUNPI32vGX1zhk588IDQa4Irgol8t6_gCLGimPAK11Uez9CG4FaWGOP6BG1whkreMHGKzlLaZ5Txmr9Ap1Q0pOWi3SB_dZyiNjAM86BjMeopumPhfDHtoMhMB2YlIO1-hfjjfXHtMxxW9BAhpTlCEWGbgckFX2jfF_1deoTktO2gZxNG_RI9t3pI8Op-nqPvn66-XX4pb75-vr68uCmNoGQqjW2t7notmTE1Z8B70kkOoLuu5lLUUrddJ6m1QmAgQlrLDBNWCtFooVvGztHHNfcwdyP0BpajB3WIbtTxTgXt1L-Mdzu1DbeKs7rltM4Bb-8DYvg5Q5rU6NJSk_YQ5qSIbCjFeRPN0jePdz0s-VtyFtBVYGJIuRj7ICFYLZ9Ue7V8Ui2fVLhWeWRT85_JuOlPn_leNzxt_bBaITd86zKbjANvoHcRzKT64J6y_wb5tb5K |
| CitedBy_id | crossref_primary_10_1371_journal_pone_0192636 crossref_primary_10_1016_j_semcdb_2018_07_016 crossref_primary_10_1371_journal_pone_0159259 crossref_primary_10_1167_iovs_18_25477 crossref_primary_10_1038_s41598_025_85835_0 crossref_primary_10_1038_s41467_021_25181_7 crossref_primary_10_31083_j_fbl2903091 crossref_primary_10_2147_OPTH_S482883 crossref_primary_10_1038_s41598_017_14938_0 crossref_primary_10_1186_s43088_020_0034_8 crossref_primary_10_3390_ijms24119625 crossref_primary_10_1016_j_yexcr_2024_114220 crossref_primary_10_1016_j_trim_2022_101636 crossref_primary_10_3390_jcm9082336 crossref_primary_10_1002_adhm_201701328 crossref_primary_10_3389_fcell_2022_898772 crossref_primary_10_3389_fcell_2022_936115 crossref_primary_10_3390_nu15081948 crossref_primary_10_1080_02713683_2021_1945109 crossref_primary_10_1007_s00210_025_03817_5 crossref_primary_10_1016_j_ejphar_2018_08_035 crossref_primary_10_1016_j_preteyeres_2016_09_003 crossref_primary_10_1038_eye_2015_160 crossref_primary_10_1097_IJG_0000000000001036 crossref_primary_10_1007_s10384_023_00998_5 crossref_primary_10_1111_ceo_12938 crossref_primary_10_1016_j_preteyeres_2016_09_005 crossref_primary_10_1172_jci_insight_188710 crossref_primary_10_3389_fmolb_2021_728932 crossref_primary_10_1016_j_ophtha_2020_07_027 crossref_primary_10_3390_ijms23136883 crossref_primary_10_1242_dmm_042853 crossref_primary_10_1016_j_exer_2025_110459 crossref_primary_10_1016_j_yexcr_2025_114759 crossref_primary_10_3390_bioengineering9110672 crossref_primary_10_1016_j_cmpb_2023_107485 crossref_primary_10_1111_jcmm_13030 crossref_primary_10_1016_j_preteyeres_2022_101064 crossref_primary_10_1038_s41598_019_57022_5 crossref_primary_10_3390_ijms21165934 crossref_primary_10_1096_fj_201902326R crossref_primary_10_1167_iovs_61_10_41 crossref_primary_10_1038_s41433_025_03911_1 crossref_primary_10_3390_ijms242015377 crossref_primary_10_1016_j_jnma_2023_01_014 crossref_primary_10_1007_s13577_022_00738_w crossref_primary_10_1002_jcp_25582 crossref_primary_10_3390_genes12050624 crossref_primary_10_3390_genes13061055 crossref_primary_10_1016_j_clae_2021_101535 crossref_primary_10_26683_2786_4855_2024_4_50__16_22 crossref_primary_10_1038_s41598_021_93580_3 crossref_primary_10_1080_14789450_2017_1298448 crossref_primary_10_1093_hmg_ddz222 crossref_primary_10_1038_s41467_020_19352_1 crossref_primary_10_1016_j_matt_2025_102094 crossref_primary_10_3390_stresses3030044 crossref_primary_10_1136_bmjophth_2023_001535 crossref_primary_10_1155_2019_7869130 crossref_primary_10_2147_OPTH_S254504 crossref_primary_10_1038_s41598_017_00845_x crossref_primary_10_3390_ijms24076363 crossref_primary_10_1016_j_bbadis_2024_167530 crossref_primary_10_1016_j_yexcr_2024_114137 crossref_primary_10_1371_journal_pone_0218471 crossref_primary_10_1080_14728222_2017_1386174 crossref_primary_10_3389_fcell_2022_886754 crossref_primary_10_3390_cells10082131 crossref_primary_10_26508_lsa_202201721 crossref_primary_10_1016_j_exer_2022_109280 crossref_primary_10_1111_jcmm_16361 crossref_primary_10_1371_journal_pone_0280331 crossref_primary_10_1039_D5PM00097A crossref_primary_10_1002_smll_201803239 crossref_primary_10_1080_02713683_2023_2235892 crossref_primary_10_3390_life13071581 crossref_primary_10_1371_journal_pone_0241006 crossref_primary_10_1016_j_ejphar_2016_03_003 crossref_primary_10_1016_j_cmpb_2022_106922 crossref_primary_10_1016_j_cmpb_2022_106921 crossref_primary_10_1371_journal_pone_0165326 crossref_primary_10_1111_jcmm_17229 crossref_primary_10_3390_genes12010055 crossref_primary_10_3390_genes12111802 crossref_primary_10_1038_s41598_020_66756_6 crossref_primary_10_1155_2022_7435754 crossref_primary_10_1167_iovs_17_23434 crossref_primary_10_1016_j_exer_2025_110272 crossref_primary_10_1016_j_exer_2021_108917 crossref_primary_10_1016_j_survophthal_2019_10_002 crossref_primary_10_3341_kjo_2021_0169 crossref_primary_10_1242_bio_059982 crossref_primary_10_1016_j_ajpath_2024_03_002 crossref_primary_10_1080_02713683_2022_2039204 crossref_primary_10_3390_ijms23137372 crossref_primary_10_1016_j_jtemb_2020_126652 crossref_primary_10_1167_iovs_65_10_3 crossref_primary_10_1002_jcb_29578 crossref_primary_10_1016_j_preteyeres_2017_04_004 crossref_primary_10_1097_APO_0000000000000171 crossref_primary_10_1007_s10792_018_1035_7 crossref_primary_10_1007_s10792_025_03593_4 crossref_primary_10_1016_j_exer_2025_110386 crossref_primary_10_1016_j_exer_2020_108046 crossref_primary_10_1002_jcp_27044 crossref_primary_10_1016_j_jconrel_2025_114027 crossref_primary_10_3390_biom12101368 crossref_primary_10_3390_jcm9113584 crossref_primary_10_1016_j_exer_2022_109055 crossref_primary_10_1111_jcmm_14975 crossref_primary_10_3390_genes9110527 crossref_primary_10_1038_s41598_020_80736_w crossref_primary_10_3390_molecules24203805 crossref_primary_10_1371_journal_pone_0251249 crossref_primary_10_1167_iovs_17_23579 crossref_primary_10_3390_ijms23020854 crossref_primary_10_1007_s11427_018_9430_2 crossref_primary_10_1038_eye_2016_221 crossref_primary_10_1080_08820538_2023_2211149 crossref_primary_10_12998_wjcc_v13_i28_107263 crossref_primary_10_1155_2020_6286105 crossref_primary_10_1111_aos_15027 crossref_primary_10_1097_IJG_0000000000000603 crossref_primary_10_1002_ca_23263 crossref_primary_10_1007_s10792_024_02917_0 crossref_primary_10_1167_iovs_61_13_16 crossref_primary_10_3389_fgene_2023_1130106 crossref_primary_10_1111_ceo_12777 crossref_primary_10_1016_j_biopha_2018_03_094 crossref_primary_10_1111_jcmm_18111 crossref_primary_10_3390_jcm10061180 crossref_primary_10_3390_jfb6030963 crossref_primary_10_1016_j_exer_2016_08_014 crossref_primary_10_3390_antiox12020405 crossref_primary_10_1167_iovs_65_14_38 crossref_primary_10_3390_cells10112864 crossref_primary_10_1155_2022_3584192 crossref_primary_10_1167_iovs_61_13_29 crossref_primary_10_3389_fcell_2022_886706 crossref_primary_10_1016_j_actbio_2023_04_008 crossref_primary_10_1167_iovs_18_26055 crossref_primary_10_3390_ijms20102526 crossref_primary_10_1002_ajmg_c_31833 crossref_primary_10_1159_000531247 crossref_primary_10_2147_TACG_S274884 crossref_primary_10_1016_j_exer_2022_109351 crossref_primary_10_1016_j_preteyeres_2020_100916 crossref_primary_10_1016_j_preteyeres_2020_100917 crossref_primary_10_3389_fcell_2022_886702 crossref_primary_10_1073_pnas_1911837116 crossref_primary_10_1097_ICU_0000000000000645 crossref_primary_10_1089_jop_2019_0076 crossref_primary_10_1016_j_exer_2022_109350 crossref_primary_10_1007_s00417_021_05279_w crossref_primary_10_1016_j_visres_2024_108505 crossref_primary_10_1167_iovs_66_3_25 crossref_primary_10_1534_g3_118_200190 crossref_primary_10_3390_biomedicines13010233 crossref_primary_10_1111_vop_13143 crossref_primary_10_1007_s00438_022_01958_3 crossref_primary_10_3390_cimb47070514 crossref_primary_10_1002_bit_28849 crossref_primary_10_1016_j_labinv_2024_102025 crossref_primary_10_1096_fj_202000702RR crossref_primary_10_1002_jcp_30769 crossref_primary_10_1007_s11095_018_2557_4 crossref_primary_10_1016_j_exer_2019_107860 crossref_primary_10_3390_genes14020495 crossref_primary_10_1167_iovs_62_6_3 crossref_primary_10_1016_j_preteyeres_2016_12_004 crossref_primary_10_1080_02713683_2021_1901939 crossref_primary_10_1177_11206721211051235 crossref_primary_10_1038_s41598_018_33257_6 crossref_primary_10_1038_s41598_021_86591_7 crossref_primary_10_1016_j_survophthal_2025_07_001 crossref_primary_10_1016_j_yexcr_2017_05_009 crossref_primary_10_3390_cells10030687 crossref_primary_10_1096_fj_202301185R crossref_primary_10_1007_s11307_023_01828_3 crossref_primary_10_1515_jbcpp_2019_0373 crossref_primary_10_1089_ten_tea_2024_0343 crossref_primary_10_1016_j_biomaterials_2021_121074 crossref_primary_10_3390_bioengineering8110147 crossref_primary_10_1155_2022_5038847 crossref_primary_10_1016_j_exer_2025_110296 crossref_primary_10_1167_iovs_19_28084 crossref_primary_10_1016_j_exer_2016_08_001 crossref_primary_10_3389_fnana_2023_1148956 crossref_primary_10_3892_etm_2019_7584 crossref_primary_10_1038_s41434_023_00407_z crossref_primary_10_1167_iovs_19_26585 crossref_primary_10_2147_EB_S472920 crossref_primary_10_1038_s42003_022_04346_0 crossref_primary_10_1111_jcmm_16408 crossref_primary_10_3390_antiox10010107 crossref_primary_10_3390_cells12242839 crossref_primary_10_1096_fba_2025_00080 crossref_primary_10_1016_S0140_6736_23_01289_8 crossref_primary_10_1155_2020_7246785 crossref_primary_10_1097_IJG_0000000000002058 crossref_primary_10_2147_OPTH_S242932 crossref_primary_10_3390_ijms23041928 crossref_primary_10_1155_2017_7598140 crossref_primary_10_1136_bjophthalmol_2019_314320 crossref_primary_10_1016_j_oftale_2020_03_003 crossref_primary_10_3390_ijms26073129 crossref_primary_10_1016_j_gene_2018_06_038 crossref_primary_10_3390_jcm9113524 crossref_primary_10_1016_j_jid_2021_05_006 crossref_primary_10_1038_s41598_018_24165_w crossref_primary_10_3390_ijms221810095 crossref_primary_10_1002_cti2_1101 crossref_primary_10_1038_s41598_020_72779_w crossref_primary_10_3389_fimmu_2023_1202704 crossref_primary_10_1002_adbi_202300530 crossref_primary_10_1167_iovs_63_2_12 crossref_primary_10_1080_17434440_2023_2259788 crossref_primary_10_1016_j_cmpb_2023_107909 crossref_primary_10_1080_02713683_2023_2253378 crossref_primary_10_1111_wrr_12929 crossref_primary_10_1016_j_pdpdt_2024_104334 crossref_primary_10_1016_j_oftal_2020_03_018 crossref_primary_10_1167_iovs_18_25698 crossref_primary_10_1016_j_preteyeres_2017_02_001 crossref_primary_10_7554_eLife_63677 crossref_primary_10_1038_gt_2016_14 crossref_primary_10_1016_j_exer_2021_108729 crossref_primary_10_3390_mi11060612 crossref_primary_10_2147_OPTH_S293702 crossref_primary_10_1080_07853890_2020_1758341 crossref_primary_10_3390_ph17060748 crossref_primary_10_1038_srep30505 crossref_primary_10_1016_j_exer_2024_109939 crossref_primary_10_3390_antiox11050886 crossref_primary_10_3390_cells11172738 crossref_primary_10_1016_j_lfs_2021_119564 crossref_primary_10_1016_j_matbio_2021_02_002 crossref_primary_10_3389_fmed_2024_1288854 crossref_primary_10_3390_biomedicines9081013 crossref_primary_10_1155_2016_4083735 crossref_primary_10_3390_cells12050737 crossref_primary_10_1038_s41598_020_63284_1 crossref_primary_10_1007_s11427_017_9140_8 |
| Cites_doi | 10.1016/S0925-4439(00)00068-5 10.1089/jop.2014.0013 10.1007/s00441-009-0822-x 10.1167/iovs.09-3380 10.1016/j.exer.2005.02.008 10.1006/exer.2002.1144 10.1371/journal.pone.0034792 10.1167/iovs.13-11620 10.1167/iovs.06-1089 10.1016/S0014-4835(02)92010-5 10.1167/iovs.07-1449 10.1167/iovs.06-0296 10.1074/jbc.M504803200 10.1016/j.exer.2009.01.005 10.1016/j.ceb.2009.05.005 10.1002/ajmg.a.35838 10.1016/0014-4835(89)90027-4 10.1167/iovs.14-14519 10.1021/pr900294g 10.1111/j.1748-1716.1954.tb01092.x 10.1167/iovs.10-6342 10.1167/iovs.09-3550 10.1167/iovs.08-3215 10.1371/journal.pone.0020110 10.1167/iovs.02-0759 10.1167/iovs.13-11651 10.1167/iovs.10-6069 10.1074/jbc.M110.188615 10.1093/hmg/11.10.1185 10.1007/s00417-008-0800-0 10.1016/j.exer.2008.11.033 10.1074/jbc.M111.231571 10.1089/jop.2013.0176 10.1167/iovs.05-0691 10.1016/j.exer.2008.11.023 10.1128/MCB.24.20.9019-9025.2004 10.1167/iovs.06-0226 10.2353/ajpath.2008.080535 10.1371/journal.pone.0048523 10.1159/000310781 10.1016/0014-4835(91)90024-9 10.1167/iovs.11-7409 10.1167/iovs.13-12801 10.1101/cshperspect.a004978 10.1167/iovs.12-9483o 10.1167/iovs.03-1008 10.1007/s00417-003-0638-4 10.1167/iovs.08-2339 10.1089/jop.2013.0185 10.1167/iovs.12-11362 10.1016/S0014-4835(88)80040-X 10.1167/iovs.04-0800 10.1167/iovs.07-0903 10.1007/s00441-011-1274-7 10.1097/01.ico.0000263121.45898.d2 10.1007/BF00406980 10.1016/j.exer.2011.05.012 10.1167/iovs.05-0164 10.1093/hmg/ddr038 10.1167/iovs.10-6618 10.1167/iovs.12-9500 10.1038/ng.661 10.1016/j.exer.2005.10.011 10.1167/iovs.10-5428 10.1016/j.exer.2007.10.018 10.1097/ICU.0b013e32834ff23e 10.1083/jcb.200112031 10.1093/hmg/ddm001 10.3109/02713688908997400 10.1167/iovs.10-5660 10.1167/iovs.10-5620 10.1167/iovs.11-7287 10.1074/jbc.M411233200 10.1016/j.ophtha.2013.09.012 10.1167/iovs.07-1339 10.1002/jcp.21147 10.1371/journal.pone.0082301 10.1167/iovs.05-0057 10.1006/exer.1997.0319 10.1016/0014-4835(75)90219-5 10.1167/iovs.09-4567 10.1167/iovs.05-0075 10.1093/hmg/dds346 10.1038/sj.eye.6702852 10.1016/j.jtos.2012.07.002 10.1002/j.1460-2075.1994.tb06649.x 10.1167/iovs.10-5209 10.1002/(SICI)1097-0029(19960301)33:4<336::AID-JEMT4>3.0.CO;2-N 10.1167/iovs.08-2489 10.1093/jb/mvs089 10.1167/iovs.11-9013 10.1089/jop.2013.0220 10.1111/ceo.12152 10.1074/jbc.M707820200 10.1167/iovs.11-8526 10.1016/S1350-9462(03)00018-1 10.1002/jcp.20030 10.1167/iovs.03-0796 10.1016/S0002-9440(10)65020-1 10.1089/jop.2013.0184 10.1167/iovs.05-0334 10.3109/13816810.2012.718029 10.1016/j.ajhg.2011.08.005 10.1076/ceyr.19.5.395.5297 10.1074/jbc.M504270200 10.1371/journal.pone.0072447 10.1167/iovs.07-0956 10.1089/jop.2013.0189 10.1167/iovs.11-7587 10.1016/j.exer.2004.02.010 10.1167/iovs.05-0292 10.1128/MCB.21.22.7707-7713.2001 10.1016/j.exer.2008.11.025 10.1002/jcp.24524 10.1076/ceyr.22.5.394.5500 10.1016/0002-9394(73)91145-8 10.1097/00061198-199300220-00002 10.1111/j.1755-3768.1972.tb05954.x 10.1136/jmg.40.1.34 10.1167/iovs.05-1060 10.1076/ceyr.25.5.299.13495 10.1167/iovs.02-1083 10.1016/S0925-4773(02)00260-5 10.1152/ajpcell.00481.2007 10.1371/journal.pone.0068668 10.1002/ajmg.a.20289 10.1167/iovs.09-4920 10.1016/0014-4835(90)90142-H 10.1152/ajpgi.00132.2011 10.1007/s00439-011-0968-y 10.1016/0014-4835(86)90004-7 10.1016/j.exer.2011.12.017 10.1167/iovs.07-1192 10.1001/archopht.1989.01070010586035 10.1016/j.ajhg.2009.09.011 10.1016/S0955-0674(02)00375-7 10.1016/S1350-9462(98)00011-1 10.1167/iovs.13-12494 10.1016/j.mvr.2011.08.001 10.1152/ajpcell.00317.2009 10.1167/iovs.09-4918 10.3109/13816810.2010.505225 10.1016/j.exer.2009.02.007 10.1167/iovs.06-0141 10.1093/hmg/ddp338 10.1074/mcp.M112.019745 10.1016/j.exer.2005.11.027 10.1167/iovs.06-0875 10.1038/ng0493-299 10.1186/1471-2156-2-18 10.1016/j.ajhg.2009.03.017 10.1089/jop.2013.0218 10.1242/jcs.073437 10.1126/science.1146554 10.1167/iovs.12-11107 10.1167/iovs.09-3673 10.1007/BF00177651 10.1006/exer.1994.1158 10.1038/eye.2011.201 10.1016/S0039-6257(96)80066-X 10.1038/ejhg.2010.11 10.1038/ng.2390 10.1167/iovs.13-13033 10.1016/j.exer.2008.08.019 10.1007/BF00410696 10.1371/journal.pgen.1001306 10.1167/iovs.05-0626 10.1002/bies.20009 10.1016/j.exer.2008.01.013 10.1016/S1350-9462(98)00035-4 10.1016/j.exer.2008.08.011 10.1167/iovs.08-2375 10.1016/j.ejmg.2012.10.007 10.1167/iovs.08-1707 10.1093/hmg/ddm024 10.1167/iovs.13-13091 10.1016/0002-9394(89)90253-5 10.1167/iovs.10-6948 10.1371/journal.pone.0034309 10.1001/archopht.1992.01080130112037 10.1167/iovs.10-6640 10.1111/cge.12176 10.1167/iovs.10-6019 10.2460/ajvr.1992.53.05.767 10.1091/mbc.E04-08-0672 10.1016/j.ophtha.2012.03.015 10.1016/j.exer.2013.06.012 10.1167/iovs.12-10950 10.1167/iovs.12-11007 10.1167/iovs.11-7839 |
| ContentType | Journal Article |
| Copyright | 2014 Elsevier Ltd Copyright © 2014 Elsevier Ltd. All rights reserved. 2014 Elsevier Ltd. All rights reserved. 2014 |
| Copyright_xml | – notice: 2014 Elsevier Ltd – notice: Copyright © 2014 Elsevier Ltd. All rights reserved. – notice: 2014 Elsevier Ltd. All rights reserved. 2014 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1016/j.exer.2014.07.014 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1096-0007 |
| EndPage | 125 |
| ExternalDocumentID | PMC4379427 25819459 10_1016_j_exer_2014_07_014 S0014483514001961 |
| Genre | Review Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NEI NIH HHS grantid: EY003279 – fundername: NEI NIH HHS grantid: P30 EY010572 – fundername: NEI NIH HHS grantid: R01 EY003279 – fundername: NEI NIH HHS grantid: EY008247 – fundername: NEI NIH HHS grantid: R01 EY025721 – fundername: NEI NIH HHS grantid: R01 EY019643 – fundername: NEI NIH HHS grantid: EY021800 – fundername: NEI NIH HHS grantid: R01 EY021800 – fundername: NEI NIH HHS grantid: EY019643 – fundername: NEI NIH HHS grantid: EY010572 |
| GroupedDBID | --- --K --M .55 .GJ .~1 0R~ 1B1 1RT 1~. 1~5 29G 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AAAJQ AACTN AADPK AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AAXLA AAXUO ABBQC ABCQJ ABFNM ABJNI ABLJU ABLVK ABMAC ABMZM ABXDB ABYKQ ACDAQ ACGFS ACNCT ACRLP ADBBV ADEZE ADFGL ADMUD AEBSH AEKER AENEX AFFNX AFKWA AFTJW AFXIZ AGEKW AGHFR AGUBO AGWIK AGYEJ AHHHB AHPSJ AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV C45 CAG CJTIS COF CS3 DM4 DU5 EBS EFBJH EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEA HMK HMO HMQ HVGLF HZ~ IHE J1W KOM L7B LCYCR LG5 LUGTX LZ2 M29 M2U M41 MO0 MOBAO MVM N9A O-L O9- OAUVE OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SDP SES SEW SNS SPCBC SSH SSI SSN SSZ T5K TEORI WUQ X7M XPP ZA5 ZGI ZMT ZU3 ~G- 9DU AATTM AAXKI AAYWO AAYXX ABWVN ACIEU ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD CGR CUY CVF ECM EIF NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c521t-cf9fabda63cc743e4d1b64eeabb746576a9bb62ff550e156ff3c35f6558a5a933 |
| ISICitedReferencesCount | 298 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000352824600011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0014-4835 1096-0007 |
| IngestDate | Tue Sep 30 16:54:32 EDT 2025 Thu Oct 02 07:16:20 EDT 2025 Thu Apr 03 07:04:48 EDT 2025 Sat Nov 29 05:31:29 EST 2025 Tue Nov 18 22:35:05 EST 2025 Fri Feb 23 02:29:42 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | animal models intraocular pressure perfusion culture glaucoma gene mutations extracellular matrix trabecular meshwork |
| Language | English |
| License | Copyright © 2014 Elsevier Ltd. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c521t-cf9fabda63cc743e4d1b64eeabb746576a9bb62ff550e156ff3c35f6558a5a933 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/4379427 |
| PMID | 25819459 |
| PQID | 1682209332 |
| PQPubID | 23479 |
| PageCount | 14 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4379427 proquest_miscellaneous_1682209332 pubmed_primary_25819459 crossref_primary_10_1016_j_exer_2014_07_014 crossref_citationtrail_10_1016_j_exer_2014_07_014 elsevier_sciencedirect_doi_10_1016_j_exer_2014_07_014 |
| PublicationCentury | 2000 |
| PublicationDate | April 2015 2015-04-00 2015-Apr 20150401 |
| PublicationDateYYYYMMDD | 2015-04-01 |
| PublicationDate_xml | – month: 04 year: 2015 text: April 2015 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Experimental eye research |
| PublicationTitleAlternate | Exp Eye Res |
| PublicationYear | 2015 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Bradley, Vranka, Colvis, Conger, Alexander, Fisk, Samples, Acott (bib22) 1998; 39 Parshley, Bradley, Fisk, Hadaegh, Samples, Van Buskirk, Acott (bib153) 1996; 37 Wordinger, Clark (bib221) 1999; 18 Micheal, Khan, Akhtar, Weiss, Islam, Ali, Qamar, Maugeri, den Hollander (bib142) 2012; 18 Resch, Fautsch (bib167) 2009; 88 Ethier, Coloma, Sit, Johnson (bib44) 1998; 39 Kao, Liu, Zhang (bib105) 2013; 11 Lutjen-Drecoll, Rittig, Rauterberg, Jander, Mollenhauer (bib135) 1989; 48 Borras (bib17) 2014; 30 Lutjen-Drecoll, Shimizu, Rohrbach, Rohen (bib137) 1986; 42 Johnson, Shapiro, Ethier, Kamm (bib100) 1992; 33 Tamm (bib198) 2009; 88 Haddadin, Oh, Kang, Villarreal, Kang, Jin, Gong, Rhee (bib79) 2012; 53 Quadri (bib162) 2012; 83 Tran-Viet, Soler, Quiette, Powell, Yanovitch, Metlapally, Luo, Katsanis, Nading, Young (bib207) 2013; 19 Ittner, Wurdak, Schwerdtfeger, Kunz, Ille, Leveen, Hjalt, Suter, Karlsson, Hafezi, Born, Sommer (bib92) 2005; 4 Sethi, Jain, Zode, Wordinger, Clark (bib184) 2011; 52 Keller, Vranka, Haddadin, Kang, Oh, Rhee, Yang, Sun, Kelley, Acott (bib114) 2013; 54 Fautsch, Bahler, Vrabel, Howell, Loewen, Teo, Poeschla, Johnson (bib48) 2006; 47 Gould, Miceli-Libby, Savinova, Torrado, Tomarev, Smith, John (bib72) 2004; 24 Tawara, Tou, Kubota, Harada, Yokota (bib200) 2008; 246 Faralli, Schwinn, Gonzalez, Filla, Peters (bib47) 2009; 88 Chowdhury, Jea, Oh, Rhee, Fautsch (bib33) 2011; 52 Morgan, Murphy, Russell (bib146) 2013; 115 Robertson, Siwakoti, West-Mays (bib170) 2013; 19 Aga, Bradley, Wanchu, Yang, Acott, Keller (bib240) Jul, 2014 Zhou, Maruyama, Li, Cheng, Yue (bib229) 1999; 19 Sakai, Shen, Koga, Park, Noskina, Tibudan, Yue (bib173) 2007; 213 Schlotzer-Schrehardt, Pasutto, Sommer, Hornstra, Kruse, Naumann, Reis, Zenkel (bib179) 2008; 173 Bradley, Kelley, Zhu, Anderssohn, Alexander, Acott (bib21) 2001; 42 Baulmann, Ohlmann, Flügel-Koch, Goswami, Cvekl, Tamm (bib241) 2002 Oct; 118 Snead, McNinch, Poulson, Bearcroft, Silverman, Gomersall, Parfect, Richards (bib189) 2011; 25 Desir, Sznajer, Depasse, Roulez, Schrooyen, Meire, Abramowicz (bib39) 2010; 18 Narooie-Nejad, Paylakhi, Shojaee, Fazlali, Rezaei Kanavi, Nilforushan, Yazdani, Babrzadeh, Suri, Ronaghi, Elahi, Paisan-Ruiz (bib148) 2009; 18 Keller, Bradley, Vranka, Acott (bib110) 2011; 52 Acharya, Huang, Fleisch, Allison, Walter (bib1) 2011; 20 Gould, Marchant, Savinova, Smith, John (bib71) 2007; 16 VanderWyst, Perkumas, Read, Overby, Stamer (bib211) 2011; 17 Buller, Johnson, Tschumper (bib28) 1990; 31 Schneemann, Leusink-Muis, van den Berg, Hoyng, Kamphuis (bib181) 2003; 241 Barany, Scotchbrook (bib9) 1954; 30 Caballero, Rowlette, Borras (bib29) 2000; 1502 Massam-Wu, Chiu, Choudhury, Chaudhry, Baldwin, McGovern, Baldock, Shuttleworth, Kielty (bib139) 2010; 123 Bhattacharya, Rockwood, Smith, Bonilha, Crabb, Kuchtey, Robertson, Peachey, Morton, Crabb (bib13) 2005; 280 Zhao, Jin, Liu, Chen, Hu (bib228) 2012; 34 Borras (bib15) 2003; 22 Filla, Woods, Kaufman, Peters (bib52) 2006; 47 Ito, Walter (bib91) 2014; 42 Matsuo, Osumi-Yamashita, Noji, Ohuchi, Koyama, Myokai, Matsuo, Taniguchi, Doi, Iseki (bib140) 1993; 3 Clark, Nosie, Walker, Faralli, Filla, Barrett-Wilt, Peters (bib35) 2013; 12 Brubaker (bib25) 1975; 14 Sengle, Charbonneau, Ono, Sasaki, Alvarez, Keene, Bachinger, Sakai (bib182) 2008; 283 Sengle, Ono, Sasaki, Sakai (bib183) 2011; 286 Lutjen-Drecoll (bib133) 2005; 81 Thorleifsson, Walters, Hewitt, Masson, Helgason, DeWan, Sigurdsson, Jonasdottir, Gudjonsson, Magnusson, Stefansson, Lam, Tam, Gudmundsdottir, Southgate, Burdon, Gottfredsdottir, Aldred, Mitchell, St Clair, Collier, Tang, Sveinsson, Macgregor, Martin, Cree, Gibson, Macleod, Jacob, Ennis, Young, Chan, Karwatowski, Hammond, Thordarson, Zhang, Wadelius, Lotery, Trembath, Pang, Hoh, Craig, Kong, Mackey, Jonasson, Thorsteinsdottir, Stefansson (bib205) 2010; 42 Tripathi, Tripathi (bib208) 1989; 107 Fuchshofer, Tamm (bib56) 2012; 347 Johnson, Johnson, Kamm, DeKater, Epstein (bib99) 1990; 50 Ricard-Blum (bib168) 2011; 3 Miyamoto, Inoue, Sakamoto, Kudo, Naito, Mikawa, Mikawa, Isashiki, Osabe, Shinohara, Shiota, Itakura (bib144) 2005; 46 Shepard, Millar, Pang, Jacobson, Wang, Clark (bib187) 2010; 51 Aihara, Lindsey, Weinreb (bib4) 2003; 44 O'Brien, Wang, Ying, Yue (bib150) 2014; 30 Clark, Wilson, McCartney, Miggans, Kunkle, Howe (bib34) 1994; 35 Ali, McKibbin, Booth, Parry, Jain, Riazuddin, Hejtmancik, Khan, Firasat, Shires, Gilmour, Towns, Murphy, Azmanov, Tournev, Cherninkova, Jafri, Raashid, Toomes, Craig, Mackey, Kalaydjieva, Riazuddin, Inglehearn (bib6) 2009; 84 Robertson, Golesic, Gauldie, West-Mays (bib169) 2010; 51 Pattabiraman, Maddala, Rao (bib155) 2014; 229 Gottanka, Chan, Eichhorn, Lutjen-Drecoll, Ethier (bib69) 2004; 45 de Kater, Melamed, Epstein (bib38) 1989; 107 Alexander, Elrod (bib5) 2002; 200 Izzotti, Longobardi, Cartiglia, Rathschuler, Sacca (bib94) 2011; 6 Lutjen-Drecoll (bib132) 1999; 18 Spiga, Borras (bib192) 2010; 51 Santas, Bahler, Peterson, Filla, Kaufman, Tamm, Johnson, Peters (bib175) 2003; 44 McKay, Congrove, Johnson, Dismuke, Bowen, Stamer (bib141) 2013; 8 Gum, Samuelson, Gelatt (bib77) 1992; 53 Fuchshofer, Tamm (bib55) 2009; 88 Hocking, Kowalski (bib87) 2002; 158 Kuo, Labelle-Dumais, Gould (bib125) 2012; 21 Tektas, Lutjen-Drecoll (bib201) 2009; 88 Iwao, Inatani, Matsumoto, Ogata-Iwao, Takihara, Irie, Yamaguchi, Okinami, Tanihara (bib93) 2009; 119 Bradley, Anderssohn, Colvis, Parshley, Zhu, Ruddat, Samples, Acott (bib20) 2000; 41 Schlotzer-Schrehardt, Hammer, Krysta, Hofmann-Rummelt, Pasutto, Sasaki, Kruse, Zenkel (bib178) 2012; 119 Acott, Kelley, Keller, Vranka, Abu-Hassan, Li, Aga, Bradley (bib3) 2014 Kuchtey, Kunkel, McCallister, Scichilone, Kuchtey (bib242) 2014; 55 Faivre, Gorlin, Wirtz, Godfrey, Dagoneau, Samples, Le Merrer, Collod-Beroud, Boileau, Munnich, Cormier-Daire (bib46) 2003; 40 Ueda, Wentz-Hunter, Yue (bib210) 2002; 43 Wordinger, Fleenor, Hellberg, Pang, Tovar, Zode, Fuller, Clark (bib222) 2007; 48 Knepper, Farbman, Telser (bib118) 1984; 25 Grierson, Lee (bib74) 1974; 192 Fuchshofer, Yu, Welge-Lussen, Tamm (bib58) 2007; 48 Ethier, Chan (bib43) 2001; 42 Ethier (bib42) 2002; 74 Johnson (bib97) 2006; 82 Sherwood, Richardson (bib188) 1988; 46 Takenouchi, Nishina, Kosaki, Torii, Furukawa, Takahashi, Kosaki (bib197) 2013; 56 Brubaker (bib24) 1970; 9 Wight, Potter-Perigo (bib220) 2011; 301 Nelson, Fessler, Takagi, Blumberg, Keene, Olson, Parker, Fessler (bib149) 1994; 13 Sethi, Mao, Wordinger, Clark (bib185) 2011; 52 Tian, Geiger, Epstein, Kaufman (bib206) 2000; 41 Tanihara, Inatani, Koga, Yano, Kimura (bib199) 2002; 21 Johnson, Tschumper (bib96) 1987; 28 Stamer, Acott (bib193) 2012; 23 Chang, Smith, Peters, Savinova, Hawes, Zabaleta, Nusinowitz, Martin, Davisson, Cepko, Hogan, John (bib31) 2001; 2 Keller, Kelley, Acott (bib111) 2007; 48 Yue (bib225) 1996; 40 Raghunathan, Morgan, Dreier, Reilly, Thomasy, Wood, Ly, Tuyen, Hughbanks, Murphy, Russell (bib163) 2013; 54 Ramirez, Rifkin (bib164) 2009; 21 Millar, Clark, Pang (bib143) 2011; 52 Davis, Bayless, Davis, Meininger (bib37) 2000; 156 Mukhopadhyay, Nikopoulos, Maugeri, de Brouwer, van Nouhuys, Boon, Perveen, Zegers, Wittebol-Post, van den Biesen, van der Velde-Visser, Brunner, Black, Hoyng, Cremers (bib147) 2006; 47 Swaminathan, Oh, Kang, Ren, Jin, Gong, Rhee (bib196) 2013; 54 Hann, Fautsch (bib82) 2009; 50 Giovingo, Nolan, McCarty, Pang, Clark, Beverley, Schwartz, Stamer, Walker, Grybauskas, Skuran, Kuprys, Yue, Knepper (bib64) 2013; 19 Wallace, Clark, Lipson, Andrews, Crean, O'Brien (bib215) 2013; 54 Wight (bib219) 2002; 14 Hernandez, Gong (bib86) 1996 Camras, Stamer, Epstein, Gonzalez, Yuan (bib30) 2014; 55 Furuyoshi, Furuyoshi, Futa, Gottanka, Lutjen-Drecoll (bib59) 1997; 211 Porter, Epstein, Liton (bib160) 2012; 7 Kaarniranta, Ihanamaki, Sahlman, Pulkkinen, Uusitalo, Arita, Tammi, Lammi, Helminen (bib103) 2006; 83 Overby, Stamer, Johnson (bib152) 2009; 88 Borras, Rowlette, Tamm, Gottanka, Epstein (bib18) 2002; 43 Goel, Sienkiewicz, Picciani, Wang, Lee, Bhattacharya (bib65) 2012; 7 Gong, Ruberti, Overby, Johnson, Freddo (bib66) 2002; 75 Grierson, Lee (bib75) 1975; 20 Keller, Acott (bib106) 2013; 1 Kuchtey, Chang, Panagis, Kuchtey (bib121) 2013; 161A Filla, David, Weinreb, Kaufman, Peters (bib49) 2004; 79 Schlunck, Han, Wecker, Kampik, Meyer-ter-Vehn, Grehn (bib180) 2008; 49 Thomasy, Wood, Kass, Murphy, Russell (bib203) 2012; 53 Mabuchi, Lindsey, Aihara, Mackey, Weinreb (bib138) 2004; 45 Gong, Trinkaus-Randall, Freddo (bib68) 1989; 8 Kang, Oh, Rhee (bib104) 2011; 52 Floyd, Cleveland, Worthen (bib54) 1985; 26 Rohen, Futa, Lutjen-Drecoll (bib171) 1981; 21 Johnstone (bib101) 1979; 18 Sottile, Chandler (bib190) 2005; 16 Desronvil, Logan-Wyatt, Abdrabou, Triana, Jones, Taheri, Del Bono, Pasquale, Olivier, Haines, Fan, Wiggs (bib40) 2010; 16 Kloeckener-Gruissem, Bartholdi, Abdou, Zimmermann, Berger (bib117) 2006; 12 Russell, Gasiorowski, Nealy, Murphy (bib172) 2008; 49 Wang, McNatt, Pang, Millar, Hellberg, Hellberg, Steely, Rubin, Fingert, Sheffield, Stone, Clark (bib216) 2008; 118 WuDunn (bib224) 2001; 22 Perkumas, Stamer (bib158) 2012; 96 Sanka, Maddala, Epstein, Rao (bib174) 2007; 48 Gregory, Ono, Charbonneau, Kuo, Keene, Bachinger, Sakai (bib73) 2005; 280 Zhang, Rao (bib227) 2005; 46 Chatterjee, Villarreal, Rhee (bib32) 2014; 30 Lütjen-Drecoll, Futa, Rohen (bib134) 1981; 21 Sawaguchi, Yue, Yeh, Tso (bib177) 1992; 110 Tripathi, Li, Chan, Tripathi (bib209) 1994; 59 Filla, Schwinn, Sheibani, Kaufman, Peters (bib51) 2009; 50 Browne, Ho, Kane, Oliver, Clark, O'Brien, Crean (bib23) 2011; 52 Filla, Schwinn, Nosie, Clark, Peters (bib50) 2011; 52 Alvarado, Yeh, Franse-Carman, Marcellino, Brownstein (bib7) 2005; 103 Fleenor, Shepard, Hellberg, Jacobson, Pang, Clark (bib53) 2006; 47 Grierson, Lee, Abraham, Howes (bib76) 1978; 208 Kuchtey, Kuchtey (bib122) 2014; 30 Barry, Ny, Zackai, Grunwald, Forbes (bib10) 2010; 31 Hann, Bahler, Johnson (bib81) 2005; 46 Gage, Rhoades, Prucka, Hjalt (bib60) 2005; 46 Jelodari-Mamaghani, Haji-Seyed-Javadi, Suri, Nilforushan, Yazdani, Kamyab, Elahi (bib95) 2013; 19 Lei, Overby, Boussommier-Calleja, Stamer, Ethier (bib128) 2011; 52 Horiguchi, Ota, Rifkin (bi Porter (10.1016/j.exer.2014.07.014_bib159) 2013; 8 Sethi (10.1016/j.exer.2014.07.014_bib185) 2011; 52 Filla (10.1016/j.exer.2014.07.014_bib52) 2006; 47 Kao (10.1016/j.exer.2014.07.014_bib105) 2013; 11 Chowdhury (10.1016/j.exer.2014.07.014_bib33) 2011; 52 Filla (10.1016/j.exer.2014.07.014_bib50) 2011; 52 Wallace (10.1016/j.exer.2014.07.014_bib215) 2013; 54 Fuchshofer (10.1016/j.exer.2014.07.014_bib56) 2012; 347 Jelodari-Mamaghani (10.1016/j.exer.2014.07.014_bib95) 2013; 19 Sengle (10.1016/j.exer.2014.07.014_bib183) 2011; 286 Miyamoto (10.1016/j.exer.2014.07.014_bib144) 2005; 46 Porter (10.1016/j.exer.2014.07.014_bib160) 2012; 7 Schlotzer-Schrehardt (10.1016/j.exer.2014.07.014_bib179) 2008; 173 Ramirez (10.1016/j.exer.2014.07.014_bib165) 2010; 339 Snead (10.1016/j.exer.2014.07.014_bib189) 2011; 25 Sawaguchi (10.1016/j.exer.2014.07.014_bib176) 1993; 2 Johnson (10.1016/j.exer.2014.07.014_bib96) 1987; 28 Wight (10.1016/j.exer.2014.07.014_bib220) 2011; 301 Desronvil (10.1016/j.exer.2014.07.014_bib40) 2010; 16 Johnson (10.1016/j.exer.2014.07.014_bib100) 1992; 33 Belforte (10.1016/j.exer.2014.07.014_bib12) 2010; 51 Thorleifsson (10.1016/j.exer.2014.07.014_bib204) 2007; 317 Quadri (10.1016/j.exer.2014.07.014_bib162) 2012; 83 Wang (10.1016/j.exer.2014.07.014_bib216) 2008; 118 Fleenor (10.1016/j.exer.2014.07.014_bib53) 2006; 47 Heimark (10.1016/j.exer.2014.07.014_bib85) 2002; 25 Robertson (10.1016/j.exer.2014.07.014_bib170) 2013; 19 Bradley (10.1016/j.exer.2014.07.014_bib21) 2001; 42 Wight (10.1016/j.exer.2014.07.014_bib219) 2002; 14 Haddadin (10.1016/j.exer.2014.07.014_bib78) 2009; 50 Chatterjee (10.1016/j.exer.2014.07.014_bib32) 2014; 30 Clark (10.1016/j.exer.2014.07.014_bib34) 1994; 35 Gould (10.1016/j.exer.2014.07.014_bib71) 2007; 16 Parshley (10.1016/j.exer.2014.07.014_bib153) 1996; 37 Gong (10.1016/j.exer.2014.07.014_bib66) 2002; 75 de Kater (10.1016/j.exer.2014.07.014_bib38) 1989; 107 Floyd (10.1016/j.exer.2014.07.014_bib54) 1985; 26 Gould (10.1016/j.exer.2014.07.014_bib72) 2004; 24 Hocking (10.1016/j.exer.2014.07.014_bib87) 2002; 158 Browne (10.1016/j.exer.2014.07.014_bib23) 2011; 52 Barany (10.1016/j.exer.2014.07.014_bib9) 1954; 30 Pattabiraman (10.1016/j.exer.2014.07.014_bib156) 2007; 54 Gong (10.1016/j.exer.2014.07.014_bib68) 1989; 8 Amelinckx (10.1016/j.exer.2014.07.014_bib8) 2009; 8 Kim (10.1016/j.exer.2014.07.014_bib116) 2001; 21 Ito (10.1016/j.exer.2014.07.014_bib91) 2014; 42 Cvekl (10.1016/j.exer.2014.07.014_bib36) 2004; 26 Aihara (10.1016/j.exer.2014.07.014_bib4) 2003; 44 Gong (10.1016/j.exer.2014.07.014_bib67) 1996; 33 Tian (10.1016/j.exer.2014.07.014_bib206) 2000; 41 Ittner (10.1016/j.exer.2014.07.014_bib92) 2005; 4 Millar (10.1016/j.exer.2014.07.014_bib143) 2011; 52 Santas (10.1016/j.exer.2014.07.014_bib175) 2003; 44 Acharya (10.1016/j.exer.2014.07.014_bib1) 2011; 20 Nelson (10.1016/j.exer.2014.07.014_bib149) 1994; 13 Thorleifsson (10.1016/j.exer.2014.07.014_bib205) 2010; 42 VanderWyst (10.1016/j.exer.2014.07.014_bib211) 2011; 17 Narooie-Nejad (10.1016/j.exer.2014.07.014_bib148) 2009; 18 Kutz (10.1016/j.exer.2014.07.014_bib126) 2011; 286 Fuchshofer (10.1016/j.exer.2014.07.014_bib58) 2007; 48 Brubaker (10.1016/j.exer.2014.07.014_bib25) 1975; 14 Izzotti (10.1016/j.exer.2014.07.014_bib94) 2011; 6 Bradley (10.1016/j.exer.2014.07.014_bib22) 1998; 39 Vittal (10.1016/j.exer.2014.07.014_bib213) 2005; 46 Grierson (10.1016/j.exer.2014.07.014_bib76) 1978; 208 Perkumas (10.1016/j.exer.2014.07.014_bib158) 2012; 96 Vittitow (10.1016/j.exer.2014.07.014_bib214) 2004; 201 Hann (10.1016/j.exer.2014.07.014_bib83) 2011; 52 Ricard-Blum (10.1016/j.exer.2014.07.014_bib168) 2011; 3 Keller (10.1016/j.exer.2014.07.014_bib106) 2013; 1 Faivre (10.1016/j.exer.2014.07.014_bib45) 2003; 123A Hann (10.1016/j.exer.2014.07.014_bib82) 2009; 50 Johnstone (10.1016/j.exer.2014.07.014_bib102) 1973; 75 Hann (10.1016/j.exer.2014.07.014_bib81) 2005; 46 Wordinger (10.1016/j.exer.2014.07.014_bib223) 2014; 30 Clark (10.1016/j.exer.2014.07.014_bib35) 2013; 12 Filla (10.1016/j.exer.2014.07.014_bib51) 2009; 50 Alexander (10.1016/j.exer.2014.07.014_bib5) 2002; 200 Giovingo (10.1016/j.exer.2014.07.014_bib64) 2013; 19 Yue (10.1016/j.exer.2014.07.014_bib225) 1996; 40 Pattabiraman (10.1016/j.exer.2014.07.014_bib157) 2010; 298 Gum (10.1016/j.exer.2014.07.014_bib77) 1992; 53 Mabuchi (10.1016/j.exer.2014.07.014_bib138) 2004; 45 Thomasy (10.1016/j.exer.2014.07.014_bib203) 2012; 53 Kloeckener-Gruissem (10.1016/j.exer.2014.07.014_bib117) 2006; 12 Baulmann (10.1016/j.exer.2014.07.014_bib241) 2002; 118 Buie (10.1016/j.exer.2014.07.014_bib27) 2013; 54 Sawaguchi (10.1016/j.exer.2014.07.014_bib177) 1992; 110 Keller (10.1016/j.exer.2014.07.014_bib112) 2012; 7 Mukhopadhyay (10.1016/j.exer.2014.07.014_bib147) 2006; 47 Hogan (10.1016/j.exer.2014.07.014_bib88) 1971 Tripathi (10.1016/j.exer.2014.07.014_bib209) 1994; 59 Ueda (10.1016/j.exer.2014.07.014_bib210) 2002; 43 Tervo (10.1016/j.exer.2014.07.014_bib202) 1995; 233 Grierson (10.1016/j.exer.2014.07.014_bib74) 1974; 192 Zhang (10.1016/j.exer.2014.07.014_bib227) 2005; 46 Loomis (10.1016/j.exer.2014.07.014_bib129) 2014; 121 Iwao (10.1016/j.exer.2014.07.014_bib93) 2009; 119 Wiggs (10.1016/j.exer.2014.07.014_bib217) 2013; 84 Schlotzer-Schrehardt (10.1016/j.exer.2014.07.014_bib178) 2012; 119 Lu (10.1016/j.exer.2014.07.014_bib130) 2008; 86 Hubbard (10.1016/j.exer.2014.07.014_bib90) 1997; 65 Gregory (10.1016/j.exer.2014.07.014_bib73) 2005; 280 Lutjen-Drecoll (10.1016/j.exer.2014.07.014_bib137) 1986; 42 Johnson (10.1016/j.exer.2014.07.014_bib99) 1990; 50 Keller (10.1016/j.exer.2014.07.014_bib114) 2013; 54 Tektas (10.1016/j.exer.2014.07.014_bib201) 2009; 88 Pasutto (10.1016/j.exer.2014.07.014_bib154) 2008; 49 Caballero (10.1016/j.exer.2014.07.014_bib29) 2000; 1502 Pattabiraman (10.1016/j.exer.2014.07.014_bib155) 2014; 229 Morales (10.1016/j.exer.2014.07.014_bib145) 2009; 85 Stamer (10.1016/j.exer.2014.07.014_bib194) 2011; 52 Ali (10.1016/j.exer.2014.07.014_bib6) 2009; 84 Knepper (10.1016/j.exer.2014.07.014_bib118) 1984; 25 Hardy (10.1016/j.exer.2014.07.014_bib84) 2005; 280 Lütjen-Drecoll (10.1016/j.exer.2014.07.014_bib134) 1981; 21 Swaminathan (10.1016/j.exer.2014.07.014_bib196) 2013; 54 Buller (10.1016/j.exer.2014.07.014_bib28) 1990; 31 Schneemann (10.1016/j.exer.2014.07.014_bib181) 2003; 241 Kuchtey (10.1016/j.exer.2014.07.014_bib242) 2014; 55 Davis (10.1016/j.exer.2014.07.014_bib37) 2000; 156 Kumar (10.1016/j.exer.2014.07.014_bib124) 2013; 8 Bouhenni (10.1016/j.exer.2014.07.014_bib19) 2012; 2012 Sanka (10.1016/j.exer.2014.07.014_bib174) 2007; 48 Chang (10.1016/j.exer.2014.07.014_bib31) 2001; 2 Knepper (10.1016/j.exer.2014.07.014_bib119) 1996; 37 Acott (10.1016/j.exer.2014.07.014_bib2) 2008; 86 Filla (10.1016/j.exer.2014.07.014_bib49) 2004; 79 Sakai (10.1016/j.exer.2014.07.014_bib173) 2007; 213 Aga (10.1016/j.exer.2014.07.014_bib240) 2014 Russell (10.1016/j.exer.2014.07.014_bib172) 2008; 49 Resch (10.1016/j.exer.2014.07.014_bib167) 2009; 88 Gerometta (10.1016/j.exer.2014.07.014_bib62) 2013; 54 Borras (10.1016/j.exer.2014.07.014_bib16) 2012; 53 Lei (10.1016/j.exer.2014.07.014_bib128) 2011; 52 Gould (10.1016/j.exer.2014.07.014_bib70) 2002; 11 Tripathi (10.1016/j.exer.2014.07.014_bib208) 1989; 107 Gagen (10.1016/j.exer.2014.07.014_bib61) 2014; 30 Keller (10.1016/j.exer.2014.07.014_bib109) 2008; 49 Haddadin (10.1016/j.exer.2014.07.014_bib79) 2012; 53 Robertson (10.1016/j.exer.2014.07.014_bib169) 2010; 51 Brubaker (10.1016/j.exer.2014.07.014_bib24) 1970; 9 Ethier (10.1016/j.exer.2014.07.014_bib44) 1998; 39 Grierson (10.1016/j.exer.2014.07.014_bib75) 1975; 20 Reis (10.1016/j.exer.2014.07.014_bib166) 2011; 130 Overby (10.1016/j.exer.2014.07.014_bib152) 2009; 88 Tawara (10.1016/j.exer.2014.07.014_bib200) 2008; 246 Zhou (10.1016/j.exer.2014.07.014_bib229) 1999; 19 Tamm (10.1016/j.exer.2014.07.014_bib198) 2009; 88 Acott (10.1016/j.exer.2014.07.014_bib3) 2014 Spiga (10.1016/j.exer.2014.07.014_bib192) 2010; 51 Last (10.1016/j.exer.2014.07.014_bib127) 2011; 52 Han (10.1016/j.exer.2014.07.014_bib80) 2011; 52 Tanihara (10.1016/j.exer.2014.07.014_bib199) 2002; 21 Lutjen-Drecoll (10.1016/j.exer.2014.07.014_bib132) 1999; 18 Keller (10.1016/j.exer.2014.07.014_bib107) 2009; 88 Camras (10.1016/j.exer.2014.07.014_bib30) 2014; 55 Bhattacharya (10.1016/j.exer.2014.07.014_bib13) 2005; 280 Desir (10.1016/j.exer.2014.07.014_bib39) 2010; 18 Johnson (10.1016/j.exer.2014.07.014_bib98) 2000 Rohen (10.1016/j.exer.2014.07.014_bib171) 1981; 21 Keller (10.1016/j.exer.2014.07.014_bib110) 2011; 52 Borras (10.1016/j.exer.2014.07.014_bib15) 2003; 22 Horiguchi (10.1016/j.exer.2014.07.014_bib89) 2012; 152 Johnson (10.1016/j.exer.2014.07.014_bib97) 2006; 82 Borras (10.1016/j.exer.2014.07.014_bib18) 2002; 43 Sowden (10.1016/j.exer.2014.07.014_bib191) 2007; 21 Fuchshofer (10.1016/j.exer.2014.07.014_bib57) 2006; 47 Wordinger (10.1016/j.exer.2014.07.014_bib221) 1999; 18 Bill (10.1016/j.exer.2014.07.014_bib14) 1972; 50 Shepard (10.1016/j.exer.2014.07.014_bib186) 2007; 16 Sengle (10.1016/j.exer.2014.07.014_bib182) 2008; 283 Oh (10.1016/j.exer.2014.07.014_bib151) 2013; 54 Johnstone (10.1016/j.exer.2014.07.014_bib101) 1979; 18 Zhou (10.1016/j.exer.2014.07.014_bib230) 2008; 49 Ethier (10.1016/j.exer.2014.07.014_bib43) 2001; 42 Kaarniranta (10.1016/j.exer.2014.07.014_bib103) 2006; 83 McKay (10.1016/j.exer.2014.07.014_bib141) 2013; 8 Faralli (10.1016/j.exer.2014.07.014_bib47) 2009; 88 Lutjen-Drecoll (10.1016/j.exer.2014.07.014_bib135) 1989; 48 Ramirez (10.1016/j.exer.2014.07.014_bib164) 2009; 21 Massam-Wu (10.1016/j.exer.2014.07.014_bib139) 2010; 123 Matsuo (10.1016/j.exer.2014.07.014_bib140) 1993; 3 Fuchshofer (10.1016/j.exer.2014.07.014_bib55) 2009; 88 Erickson-Lamy (10.1016/j.exer.2014.07.014_bib41) 1991; 52 Kuo (10.1016/j.exer.2014.07.014_bib125) 2012; 21 Ethier (10.1016/j.exer.2014.07.014_bib42) 2002; 74 Wordinger (10.1016/j.exer.2014.07.014_bib222) 2007; 48 Hernandez (10.1016/j.exer.2014.07.014_bib86) 1996 Wiggs (10.1016/j.exer.2014.07.014_bib218) 2014; 55 Raghunathan (10.1016/j.exer.2014.07.014_bib163) 2013; 54 Goel (10.1016/j.exer.2014.07.014_bib65) 2012; 7 Borras (10.1016/j.exer.2014.07.014_bib17) 2014; 30 Fautsch (10.1016/j.exer.2014.07.014_bib48) 2006; 47 24401029 - J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):94-101 17317786 - Hum Mol Genet. 2007 Apr 1;16(7):798-807 23559862 - Mol Vis. 2013;19:684-95 14578401 - Invest Ophthalmol Vis Sci. 2003 Nov;44(11):4796-804 15579465 - J Biol Chem. 2005 Feb 18;280(7):6080-4 24521159 - J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):170-80 18155193 - Exp Eye Res. 2008 Feb;86(2):271-81 22262082 - Curr Opin Ophthalmol. 2012 Mar;23(2):135-43 12231358 - Curr Opin Cell Biol. 2002 Oct;14(5):617-23 16249490 - Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4130-8 11600941 - Curr Eye Res. 2001 May;22(5):394-7 21921955 - Eye (Lond). 2011 Nov;25(11):1389-400 17325160 - Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1164-72 24901502 - J Ocul Pharmacol Ther. 2014 Aug;30(6):447-63 24364042 - J Ocul Biol. 2013 Jun;1(1):3 21421911 - Cold Spring Harb Perspect Biol. 2011 Jan;3(1):a004978 18274669 - J Clin Invest. 2008 Mar;118(3):1056-64 21273548 - Invest Ophthalmol Vis Sci. 2011 May;52(6):2952-9 21135108 - J Biol Chem. 2011 Feb 18;286(7):5087-99 19513754 - Cell Tissue Res. 2010 Jan;339(1):71-82 16384965 - Invest Ophthalmol Vis Sci. 2006 Jan;47(1):213-21 8062820 - EMBO J. 1994 Aug 1;13(15):3438-47 24517218 - J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):154-62 7622078 - Graefes Arch Clin Exp Ophthalmol. 1995 May;233(5):291-5 8779084 - Surv Ophthalmol. 1996 Mar-Apr;40(5):379-90 14598350 - Am J Med Genet A. 2003 Dec 1;123A(2):204-7 21264055 - Mol Vis. 2011;17:199-209 23444230 - Am J Med Genet A. 2013 Apr;161A(4):880-3 15944158 - J Biol Chem. 2005 Aug 12;280(32):28917-26 21340693 - Hum Genet. 2011 Oct;130(4):495-504 7981749 - Nat Genet. 1993 Apr;3(4):299-304 20720231 - Invest Ophthalmol Vis Sci. 2011 Jan;52(1):45-50 16386733 - Exp Eye Res. 2006 Apr;82(4):545-57 10520215 - Curr Eye Res. 1999 Nov;19(5):395-402 21282571 - Invest Ophthalmol Vis Sci. 2011 May;52(6):2889-96 21139683 - Mol Vis. 2010;16:2185-91 20835238 - Nat Genet. 2010 Oct;42(10):906-9 15281095 - J Cell Physiol. 2004 Oct;201(1):126-37 17057799 - Trans Am Ophthalmol Soc. 2005;103:148-62; discussion 162-3 2338123 - Exp Eye Res. 1990 Apr;50(4):407-18 17251470 - Invest Ophthalmol Vis Sci. 2007 Feb;48(2):715-26 19509472 - J Clin Invest. 2009 Jul;119(7):1997-2008 21220554 - Invest Ophthalmol Vis Sci. 2011 Apr;52(5):2187-93 11068187 - Biochim Biophys Acta. 2000 Nov 15;1502(3):447-60 23385799 - Invest Ophthalmol Vis Sci. 2013 Mar;54(3):1636-49 19920491 - J Glaucoma. 1993 Summer;2(2):80-6 24204045 - Invest Ophthalmol Vis Sci. 2013 Dec;54(13):7836-48 24408980 - Invest Ophthalmol Vis Sci. 2014 Feb;55(2):814-23 19060275 - Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1692-7 20861483 - Invest Ophthalmol Vis Sci. 2011 Feb;52(2):685-94 22496787 - PLoS One. 2012;7(4):e34309 19643963 - Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5723-31 24367514 - PLoS One. 2013;8(12):e82301 12015278 - Hum Mol Genet. 2002 May 15;11(10):1185-93 18235008 - Invest Ophthalmol Vis Sci. 2008 Feb;49(2):629-35 19103197 - Exp Eye Res. 2009 Apr;88(4):656-70 11381054 - Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1505-13 23977299 - PLoS One. 2013;8(8):e72447 21282189 - Hum Mol Genet. 2011 Apr 15;20(8):1610-24 23621901 - Clin Genet. 2013 Aug;84(2):167-74 103860 - Invest Ophthalmol Vis Sci. 1979 Jan;18(1):44-51 2612196 - Curr Eye Res. 1989 Oct;8(10):1071-82 16639003 - Invest Ophthalmol Vis Sci. 2006 May;47(5):1956-67 24318513 - J Cell Physiol. 2014 Jul;229(7):927-42 21642622 - Invest Ophthalmol Vis Sci. 2011 Jul;52(8):5251-9 21669200 - Exp Eye Res. 2011 Oct;93(4):397-404 12525539 - J Med Genet. 2003 Jan;40(1):34-6 168092 - Exp Eye Res. 1975 Jun;20(6):523-30 18804106 - Exp Eye Res. 2009 Apr;88(4):704-12 1748546 - Invest Ophthalmol Vis Sci. 1991 Dec;32(13):3145-66 19578028 - Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5653-61 15929982 - J Biol Chem. 2005 Jul 29;280(30):27970-80 9856774 - Invest Ophthalmol Vis Sci. 1998 Dec;39(13):2649-58 21546528 - Invest Ophthalmol Vis Sci. 2011 Jul;52(8):5240-50 18436825 - Invest Ophthalmol Vis Sci. 2008 May;49(5):1932-9 23792172 - Exp Eye Res. 2013 Oct;115:1-12 23105009 - Mol Cell Proteomics. 2013 Jan;12(1):194-206 1731702 - Arch Ophthalmol. 1992 Jan;110(1):110-7 22665989 - J Biomed Biotechnol. 2012;2012:692609 16384967 - Invest Ophthalmol Vis Sci. 2006 Jan;47(1):226-34 20574017 - Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5768-75 20699357 - J Cell Sci. 2010 Sep 1;123(Pt 17):3006-18 12105189 - J Cell Biol. 2002 Jul 8;158(1):175-84 1524304 - Am J Vet Res. 1992 May;53(5):767-70 24176900 - Invest Ophthalmol Vis Sci. 2013 Dec;54(13):7903-9 21596823 - Invest Ophthalmol Vis Sci. 2011 Jul;52(8):5049-57 4678226 - Acta Ophthalmol (Copenh). 1972;50(3):295-320 4633234 - Am J Ophthalmol. 1973 Mar;75(3):365-83 12658549 - Curr Eye Res. 2002 Nov;25(5):299-308 11950226 - Exp Eye Res. 2002 Feb;74(2):161-72 8603864 - Invest Ophthalmol Vis Sci. 1996 Apr;37(5):795-804 19239914 - Exp Eye Res. 2009 Apr;88(4):648-55 17460268 - Invest Ophthalmol Vis Sci. 2007 May;48(5):2105-14 12484701 - Cornea. 2002 Oct;21(7 Suppl):S62-9 1123284 - Invest Ophthalmol. 1975 Apr;14(4):286-92 22914737 - Hum Mol Genet. 2012 Oct 15;21(R1):R97-110 8933758 - Invest Ophthalmol Vis Sci. 1996 Nov;37(12):2414-25 9176894 - Ophthalmologica. 1997;211(3):140-6 22529935 - PLoS One. 2012;7(4):e34792 23599341 - Invest Ophthalmol Vis Sci. 2013 May;54(5):3309-19 24572674 - Ophthalmology. 2014 Feb;121(2):508-16 18172101 - Invest Ophthalmol Vis Sci. 2008 Jan;49(1):262-9 21402694 - J Biol Chem. 2011 May 13;286(19):17156-67 21864544 - Microvasc Res. 2012 Jan;83(1):3-11 22923731 - J Biochem. 2012 Oct;152(4):321-9 11923248 - Invest Ophthalmol Vis Sci. 2002 Apr;43(4):1068-76 10793060 - Am J Pathol. 2000 May;156(5):1489-98 18313051 - Exp Eye Res. 2008 Apr;86(4):543-61 19696167 - Invest Ophthalmol Vis Sci. 2010 Jan;51(1):308-18 20089869 - Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3042-8 22247475 - Invest Ophthalmol Vis Sci. 2012 Feb;53(2):952-8 16249499 - Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4200-8 11722794 - BMC Genet. 2001;2:18 21169533 - Invest Ophthalmol Vis Sci. 2011 Mar;52(3):1865-71 21330667 - Invest Ophthalmol Vis Sci. 2011 May;52(6):3660-6 10711672 - Invest Ophthalmol Vis Sci. 2000 Mar;41(3):619-23 20809772 - Ophthalmic Genet. 2010 Dec;31(4):193-5 15978248 - Exp Eye Res. 2005 Jul;81(1):1-4 12162724 - J Anat. 2002 Jun;200(6):561-74 9920500 - Prog Retin Eye Res. 1999 Jan;18(1):91-119 23821199 - Invest Ophthalmol Vis Sci. 2013 Aug;54(8):5441-55 16043844 - Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2726-35 22950452 - Ophthalmic Genet. 2013 Mar-Jun;34(1-2):21-6 22930728 - Invest Ophthalmol Vis Sci. 2012;53(10):6708-17 7287346 - Invest Ophthalmol Vis Sci. 1981 Oct;21(4):563-73 23882691 - Invest Ophthalmol Vis Sci. 2013;54(8):5613-23 16043860 - Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2857-68 19385040 - Exp Eye Res. 2009 Apr;88(4):683-8 15623746 - Invest Ophthalmol Vis Sci. 2005 Jan;46(1):1-7 17914434 - Eye (Lond). 2007 Oct;21(10):1310-8 18835267 - Exp Eye Res. 2009 Apr;88(4):689-93 18974306 - Am J Pathol. 2008 Dec;173(6):1724-35 15161848 - Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1841-5 14691167 - Invest Ophthalmol Vis Sci. 2004 Jan;45(1):153-8 23592912 - Mol Vis. 2013;19:759-66 19656777 - Hum Mol Genet. 2009 Oct 15;18(20):3969-77 4983461 - Invest Ophthalmol. 1970 Jan;9(1):42-52 11431444 - Invest Ophthalmol Vis Sci. 2001 Jul;42(8):1795-802 17325163 - Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1191-200 19182256 - Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2796-801 8652890 - Microsc Res Tech. 1996 Mar 1;33(4):336-67 103456 - Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978 Nov 8;208(1-3):33-47 19525102 - Curr Opin Cell Biol. 2009 Oct;21(5):616-22 22876116 - Mol Vis. 2012;18:1918-26 24611521 - J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):291-9 24433355 - Clin Experiment Ophthalmol. 2014 Jan-Feb;42(1):13-24 20179738 - Eur J Hum Genet. 2010 Jul;18(7):761-7 15057935 - Bioessays. 2004 Apr;26(4):374-86 12742391 - Prog Retin Eye Res. 2003 Jul;22(4):435-63 1559767 - Invest Ophthalmol Vis Sci. 1992 Apr;33(5):1670-5 19168904 - Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3771-7 12384097 - Exp Eye Res. 2002 Sep;75(3):347-58 8300356 - Invest Ophthalmol Vis Sci. 1994 Jan;35(1):281-94 21743018 - Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6443-51 15183101 - Exp Eye Res. 2004 Jul;79(1):61-74 1855546 - Exp Eye Res. 1991 Jun;52(6):723-31 22695958 - Invest Ophthalmol Vis Sci. 2012;53(8):4616-25 18515587 - Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2495-505 16636652 - Mol Vis. 2006;12:350-5 11604506 - Mol Cell Biol. 2001 Nov;21(22):7707-13 19940066 - Am J Physiol Cell Physiol. 2010 Mar;298(3):C749-63 2211012 - Invest Ophthalmol Vis Sci. 1990 Oct;31(10):2156-63 18386038 - Graefes Arch Clin Exp Ophthalmol. 2008 Jul;246(7):1021-8 21220561 - Invest Ophthalmol Vis Sci. 2011 Apr;52(5):2147-52 22210126 - Exp Eye Res. 2012 Mar;96(1):82-7 22562852 - Invest Ophthalmol Vis Sci. 2012 May;53(5):2506-10 22701298 - Mol Vis. 2012;18:1093-106 12719994 - Graefes Arch Clin Exp Ophthalmol. 2003 Apr;241(4):321-6 17317787 - Hum Mol Genet. 2007 Mar 15;16(6):609-17 23139787 - PLoS One. 2012;7(11):e48523 17690259 - Science. 2007 Sep 7;317(5843):1397-400 20089870 - Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3029-41 23844232 - PLoS One. 2013;8(7):e68668 13158098 - Acta Physiol Scand. 1954;30(2-3):240-8 16546167 - Exp Eye Res. 2006 Aug;83(2):297-303 3720863 - Exp Eye Res. 1986 May;42(5):443-55 21379321 - PLoS Genet. 2011 Feb;7(2):e1001306 19087875 - Exp Eye Res. 2009 Apr;88(4):676-82 15456875 - Mol Cell Biol. 2004 Oct;24(20):9019-25 16877430 - Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3565-72 7287347 - Invest Ophthalmol Vis Sci. 1981 Oct;21(4):574-85 3583633 - Invest Ophthalmol Vis Sci. 1987 Jun;28(6):945-53 10670472 - Invest Ophthalmol Vis Sci. 2000 Feb;41(2):422-30 19361779 - Am J Hum Genet. 2009 May;84(5):664-71 2729407 - Am J Ophthalmol. 1989 Jun 15;107(6):583-90 4140699 - Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1974;192(2):89-104 19836009 - Am J Hum Genet. 2009 Nov;85(5):558-68 17516541 - J Cell Physiol. 2007 Dec;213(3):775-84 16505009 - Invest Ophthalmol Vis Sci. 2006 Mar;47(3):794-801 2920781 - Exp Eye Res. 1989 Jan;48(1):139-47 10438153 - Prog Retin Eye Res. 1999 Sep;18(5):629-67 18515571 - Invest Ophthalmo |
| References_xml | – volume: 229 start-page: 927 year: 2014 end-page: 942 ident: bib155 article-title: Regulation of plasticity and fibrogenic activity of trabecular meshwork cells by Rho GTPase signaling publication-title: J. Cell. Physiol. – volume: 54 start-page: 378 year: 2013 end-page: 386 ident: bib163 article-title: Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ publication-title: Invest Ophthalmol. Vis. Sci. – volume: 47 start-page: 3565 year: 2006 end-page: 3572 ident: bib147 article-title: Erosive vitreoretinopathy and wagner disease are caused by intronic mutations in CSPG2/Versican that result in an imbalance of splice variants publication-title: Invest Ophthalmol. Vis. Sci. – volume: 42 start-page: 13 year: 2014 end-page: 24 ident: bib91 article-title: Genomics and anterior segment dysgenesis: a review publication-title: Clin. Exp. Ophthalmol. – volume: 49 start-page: 1459 year: 2008 end-page: 1463 ident: bib154 article-title: Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma publication-title: Invest Ophthalmol. Vis. Sci. – volume: 88 start-page: 656 year: 2009 end-page: 670 ident: bib152 article-title: The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium publication-title: Exp. Eye Res. – volume: 25 start-page: 1389 year: 2011 end-page: 1400 ident: bib189 article-title: Stickler syndrome, ocular-only variants and a key diagnostic role for the ophthalmologist publication-title: Eye (Lond) – volume: 8 start-page: e68668 year: 2013 ident: bib159 article-title: Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge publication-title: PLoS One – volume: 16 start-page: 2185 year: 2010 end-page: 2191 ident: bib40 article-title: Distribution of COL8A2 and COL8A1 gene variants in Caucasian primary open angle glaucoma patients with thin central corneal thickness publication-title: Mol. Vis. – volume: 42 start-page: 443 year: 1986 end-page: 455 ident: bib137 article-title: Quantitative analysis of 'plaque material' in the inner- and outer wall of Schlemm's canal in normal- and glaucomatous eyes publication-title: Exp. Eye Res. – volume: 83 start-page: 3 year: 2012 end-page: 11 ident: bib162 article-title: Cross talk between focal adhesion kinase and cadherins: role in regulating endothelial barrier function publication-title: Microvasc. Res. – volume: 17 start-page: 199 year: 2011 end-page: 209 ident: bib211 article-title: Structural basement membrane components and corresponding integrins in Schlemm's canal endothelia publication-title: Mol. Vis. – volume: 30 start-page: 240 year: 1954 end-page: 248 ident: bib9 article-title: Influence of testicular hyaluronidase on the resistance to flow through the angle of the anterior chamber publication-title: Acta Physiol. Scand. – volume: 53 start-page: 6708 year: 2012 end-page: 6717 ident: bib79 article-title: Thrombospondin-1 (TSP1)-Null and TSP2-null mice exhibit lower intraocular pressures publication-title: Invest Ophthalmol. Vis. Sci. – volume: 88 start-page: 676 year: 2009 end-page: 682 ident: bib107 article-title: Extracellular matrix turnover and outflow resistance publication-title: Exp. Eye Res. – volume: 84 start-page: 167 year: 2013 end-page: 174 ident: bib217 article-title: Variations in COL15A1 and COL18A1 influence age of onset of primary open angle glaucoma publication-title: Clin. Genet. – volume: 11 start-page: 19 year: 2013 end-page: 24 ident: bib105 article-title: Wakayama symposium: challenges of future research in ocular surface cell biology publication-title: Ocul. Surf. – volume: 48 start-page: 2105 year: 2007 end-page: 2114 ident: bib174 article-title: Influence of actin cytoskeletal integrity on matrix metalloproteinase-2 activation in cultured human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. – volume: 21 start-page: R97 year: 2012 end-page: R110 ident: bib125 article-title: COL4A1 and COL4A2 mutations and disease: insights into pathogenic mechanisms and potential therapeutic targets publication-title: Hum. Mol. Genet. – volume: 45 start-page: 1841 year: 2004 end-page: 1845 ident: bib138 article-title: Optic nerve damage in mice with a targeted type I collagen mutation publication-title: Invest Ophthalmol. Vis. Sci. – volume: 88 start-page: 769 year: 2009 end-page: 775 ident: bib201 article-title: Structural changes of the trabecular meshwork in different kinds of glaucoma publication-title: Exp. Eye Res. – volume: 86 start-page: 543 year: 2008 end-page: 561 ident: bib2 article-title: Extracellular matrix in the trabecular meshwork publication-title: Exp. Eye Res. – volume: 2 start-page: 80 year: 1993 end-page: 86 ident: bib176 article-title: Effects of glycosaminoglycan-degrading enzymes on bovine trabecular meshwork in organ culture publication-title: J. Glaucoma – volume: 8 start-page: 1071 year: 1989 end-page: 1082 ident: bib68 article-title: Ultrastructural immunocytochemical localization of elastin in normal human trabecular meshwork publication-title: Curr. Eye Res. – volume: 50 start-page: 2796 year: 2009 end-page: 2801 ident: bib120 article-title: Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma publication-title: Invest Ophthalmol. Vis. Sci. – volume: 53 start-page: 2506 year: 2012 end-page: 2510 ident: bib16 article-title: Advances in glaucoma treatment and management: gene therapy publication-title: Invest Ophthalmol. Vis. Sci. – volume: 33 start-page: 336 year: 1996 end-page: 367 ident: bib67 article-title: Morphology of the aqueous outflow pathway publication-title: Microsc. Res. Tech. – volume: 48 start-page: 139 year: 1989 end-page: 147 ident: bib135 article-title: Immunomicroscopical study of type VI collagen in the trabecular meshwork of normal and glaucomatous eyes publication-title: Exp. Eye Res. – volume: 26 start-page: 374 year: 2004 end-page: 386 ident: bib36 article-title: Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseases publication-title: Bioessays – volume: 81 start-page: 1 year: 2005 end-page: 4 ident: bib133 article-title: Morphological changes in glaucomatous eyes and the role of TGFbeta2 for the pathogenesis of the disease publication-title: Exp. Eye Res. – volume: 52 start-page: 2952 year: 2011 end-page: 2959 ident: bib50 article-title: Dexamethasone-associated cross-linked actin network formation in human trabecular meshwork cells involves beta3 integrin signaling publication-title: Invest Ophthalmol. Vis. Sci. – volume: 85 start-page: 558 year: 2009 end-page: 568 ident: bib145 article-title: Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature publication-title: Am. J. Hum. Genet. – volume: 31 start-page: 193 year: 2010 end-page: 195 ident: bib10 article-title: A case report of a patient with Pfeiffer syndrome, an FGRF 2 mutation (Trp290Cys) and unique ocular anterior segment findings publication-title: Ophthalmic Genet. – year: Jul, 2014 ident: bib240 article-title: Differential effects of CAV1 and CAV2 knockdown on aqueous outflow and altered extracellular matrix turnover in CAV-silenced trabecular meshwork cells publication-title: Investig. Ophthalmol. Vis. Sci. – volume: 75 start-page: 347 year: 2002 end-page: 358 ident: bib66 article-title: A new view of the human trabecular meshwork using quick-freeze, deep-etch electron microscopy publication-title: Exp. Eye Res. – volume: 52 start-page: 5240 year: 2011 end-page: 5250 ident: bib185 article-title: Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. – volume: 37 start-page: 2414 year: 1996 end-page: 2425 ident: bib119 article-title: Glycosaminoglycan stratification of the juxtacanalicular tissue in normal and primary open-angle glaucoma publication-title: Invest Ophthalmol. Vis. Sci. – volume: 86 start-page: 271 year: 2008 end-page: 281 ident: bib130 article-title: The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes publication-title: Exp. Eye Res. – volume: 59 start-page: 723 year: 1994 end-page: 727 ident: bib209 article-title: Aqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2 publication-title: Exp. Eye Res. – volume: 39 start-page: 2649 year: 1998 end-page: 2658 ident: bib22 article-title: Effect of matrix metalloproteinases activity on outflow in perfused human organ culture publication-title: Invest Ophthalmol. Vis. Sci. – volume: 246 start-page: 1021 year: 2008 end-page: 1028 ident: bib200 article-title: Immunohistochemical evaluation of the extracellular matrix in trabecular meshwork in steroid-induced glaucoma publication-title: Graefes Arch. Clin. Exp. Ophthalmol. – volume: 52 start-page: 6443 year: 2011 end-page: 6451 ident: bib33 article-title: Expression profile of the matricellular protein osteopontin in primary open-angle glaucoma and the normal human eye publication-title: Invest Ophthalmol. Vis. Sci. – volume: 54 start-page: 1636 year: 2007 end-page: 1649 ident: bib156 article-title: MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure publication-title: Invest Ophthalmol. Vis. Sci. – volume: 31 start-page: 2156 year: 1990 end-page: 2163 ident: bib28 article-title: Human trabecular meshwork phagocytosis. Observations in an organ culture system publication-title: Invest Ophthalmol. Vis. Sci. – volume: 45 start-page: 153 year: 2004 end-page: 158 ident: bib69 article-title: Effects of TGF-beta2 in perfused human eyes publication-title: Invest Ophthalmol. Vis. Sci. – volume: 8 start-page: e72447 year: 2013 ident: bib124 article-title: Tissue plasminogen activator in trabecular meshwork attenuates steroid induced outflow resistance in mice publication-title: PLoS One – volume: 241 start-page: 321 year: 2003 end-page: 326 ident: bib181 article-title: Elevation of nitric oxide production in human trabecular meshwork by increased pressure publication-title: Graefes Arch. Clin. Exp. Ophthalmol. – volume: 93 start-page: 397 year: 2011 end-page: 404 ident: bib131 article-title: Similar hydrodynamic and morphological changes in the aqueous humor outflow pathway after washout and Y27632 treatment in monkey eyes publication-title: Exp. Eye Res. – volume: 14 start-page: 617 year: 2002 end-page: 623 ident: bib219 article-title: Versican: a versatile extracellular matrix proteoglycan in cell biology publication-title: Curr. Opin. Cell. Biol. – volume: 1 start-page: 10 year: 2013 ident: bib106 article-title: The juxtacanalicular region of ocular trabecular meshwork: a tissue with a unique extracellular matrix and specialized function publication-title: J. Ocul. Biol. – volume: 22 start-page: 394 year: 2001 end-page: 397 ident: bib224 article-title: The effect of mechanical strain on matrix metalloproteinase production by bovine trabecular meshwork cells publication-title: Curr. Eye Res. – volume: 123A start-page: 204 year: 2003 end-page: 207 ident: bib45 article-title: Clinical homogeneity and genetic heterogeneity in Weill-Marchesani syndrome publication-title: Am. J. Med. Genet. A – volume: 30 start-page: 202 year: 2014 end-page: 212 ident: bib17 article-title: The effects of myocilin expression on functionally relevant trabecular meshwork genes: a mini-review publication-title: J. Ocul. Pharmacol. Ther. – volume: 19 start-page: 684 year: 2013 end-page: 695 ident: bib170 article-title: Altered expression of transforming growth factor beta 1 and matrix metalloproteinase-9 results in elevated intraocular pressure in mice publication-title: Mol. Vis. – volume: 41 start-page: 422 year: 2000 end-page: 430 ident: bib20 article-title: Mediation of laser trabeculoplasty-induced matrix metalloproteinase expression by IL-1beta and TNFalpha publication-title: Invest Ophthalmol. Vis. Sci. – volume: 39 start-page: 2041 year: 1998 end-page: 2048 ident: bib44 article-title: Two pore types in the inner-wall endothelium of Schlemm's canal publication-title: Invest Ophthalmol. Vis. Sci. – volume: 35 start-page: 281 year: 1994 end-page: 294 ident: bib34 article-title: Glucocorticoid-induced formation of cross-linked actin networks in cultured human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. – volume: 55 start-page: 856 year: 2014 end-page: 864 ident: bib218 article-title: Disruption of the blood-aqueous barrier and lens abnormalities in mice lacking lysyl oxidase-like 1 (LOXL1) publication-title: Invest Ophthalmol. Vis. Sci. – volume: 49 start-page: 5346 year: 2008 end-page: 5352 ident: bib11 article-title: Reduction of the available area for aqueous humor outflow and increase in meshwork herniations into collector channels following acute IOP elevation in bovine eyes publication-title: Invest Ophthalmol. Vis. Sci. – volume: 156 start-page: 1489 year: 2000 end-page: 1498 ident: bib37 article-title: Regulation of tissue injury responses by the exposure of matricryptic sites within extracellular matrix molecules publication-title: Am. J. Pathol. – volume: 23 start-page: 135 year: 2012 end-page: 143 ident: bib193 article-title: Current understanding of conventional outflow dysfunction in glaucoma publication-title: Curr. Opin. Ophthalmol. – volume: 21 start-page: 574 year: 1981 end-page: 585 ident: bib171 article-title: The fine structure of the cribriform meshwork in normal and glaucomatous eyes as seen in tangential sections publication-title: Invest Ophthalmol. Vis. Sci. – volume: 34 start-page: 21 year: 2012 end-page: 26 ident: bib228 article-title: Ophthalmic findings in a family with early-onset isolated ectopia lentis and the p.Arg62Cys mutation of the fibrillin-1 gene (FBN1) publication-title: Ophthalmic Genet. – volume: 7 start-page: e34792 year: 2012 ident: bib160 article-title: Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells publication-title: PLoS One – volume: 19 start-page: 759 year: 2013 end-page: 766 ident: bib207 article-title: Mutation in collagen II alpha 1 isoforms delineates Stickler and Wagner syndrome phenotypes publication-title: Mol. Vis. – volume: 52 start-page: 685 year: 2011 end-page: 694 ident: bib143 article-title: Assessment of aqueous humor dynamics in the mouse by a novel method of constant-flow infusion publication-title: Invest Ophthalmol. Vis. Sci. – volume: 280 start-page: 27970 year: 2005 end-page: 27980 ident: bib73 article-title: The prodomain of BMP-7 targets the BMP-7 complex to the extracellular matrix publication-title: J. Biol. Chem. – volume: 119 start-page: 1832 year: 2012 end-page: 1843 ident: bib178 article-title: LOXL1 deficiency in the lamina cribrosa as candidate susceptibility factor for a pseudoexfoliation-specific risk of glaucoma publication-title: Ophthalmology – volume: 16 start-page: 757 year: 2005 end-page: 768 ident: bib190 article-title: Fibronectin matrix turnover occurs through a caveolin-1-dependent process publication-title: Mol. Biol. Cell. – volume: 51 start-page: 5768 year: 2010 end-page: 5775 ident: bib12 article-title: Effect of chondroitin sulfate on intraocular pressure in rats publication-title: Invest Ophthalmol. Vis. Sci. – volume: 41 start-page: 619 year: 2000 end-page: 623 ident: bib206 article-title: Cytoskeletal involvement in the regulation of aqueous humor outflow publication-title: Invest Ophthalmol. Vis. Sci. – volume: 8 start-page: e82301 year: 2013 ident: bib141 article-title: A role for myocilin in receptor-mediated endocytosis publication-title: PLoS One – volume: 26 start-page: 797 year: 1985 end-page: 804 ident: bib54 article-title: Fibronectin in human trabecular drainage channels publication-title: Invest Ophthalmol. Vis. Sci. – volume: 21 start-page: S62 year: 2002 end-page: S69 ident: bib199 article-title: Proteoglycans in the eye publication-title: Cornea – volume: 50 start-page: 5653 year: 2009 end-page: 5661 ident: bib161 article-title: Reduced corneal thickness and enlarged anterior chamber in a novel ColVIIIa2G257D mutant mouse publication-title: Invest Ophthalmol. Vis. Sci. – volume: 52 start-page: 2187 year: 2011 end-page: 2193 ident: bib104 article-title: Effect of hevin deletion in mice and characterization in trabecular meshwork publication-title: Invest Ophthalmol. Vis. Sci. – volume: 30 start-page: 291 year: 2014 end-page: 299 ident: bib150 article-title: Differential expression of genes in cells cultured from juxtacanalicular trabecular meshwork and Schlemm's canal publication-title: J. Ocul. Pharmacol. Ther. – volume: 46 start-page: 2857 year: 2005 end-page: 2868 ident: bib213 article-title: Changes in gene expression by trabecular meshwork cells in response to mechanical stretching publication-title: Invest Ophthalmol. Vis. Sci. – volume: 96 start-page: 82 year: 2012 end-page: 87 ident: bib158 article-title: Protein markers and differentiation in culture for Schlemm's canal endothelial cells publication-title: Exp. Eye Res. – volume: 74 start-page: 161 year: 2002 end-page: 172 ident: bib42 article-title: The inner wall of Schlemm's canal publication-title: Exp. Eye Res. – volume: 161A start-page: 880 year: 2013 end-page: 883 ident: bib121 article-title: Marfan syndrome caused by a novel FBN1 mutation with associated pigmentary glaucoma publication-title: Am. J. Med. Genet. A – volume: 19 start-page: 333 year: 2013 end-page: 347 ident: bib95 article-title: Contribution of the latent transforming growth factor-beta binding protein 2 gene to etiology of primary open angle glaucoma and pseudoexfoliation syndrome publication-title: Mol. Vis. – volume: 1502 start-page: 447 year: 2000 end-page: 460 ident: bib29 article-title: Altered secretion of a TIGR/MYOC mutant lacking the olfactomedin domain publication-title: Biochim. Biophys. Acta – volume: 19 start-page: 395 year: 1999 end-page: 402 ident: bib229 article-title: Expression of integrin receptors in the human trabecular meshwork publication-title: Curr. Eye Res. – volume: 211 start-page: 140 year: 1997 end-page: 146 ident: bib59 article-title: Ultrastructural changes in the trabecular meshwork of juvenile glaucoma publication-title: Ophthalmologica – volume: 52 start-page: 1865 year: 2011 end-page: 1871 ident: bib128 article-title: Outflow physiology of the mouse eye: pressure dependence and washout publication-title: Invest Ophthalmol. Vis. Sci. – volume: 280 start-page: 28917 year: 2005 end-page: 28926 ident: bib84 article-title: Extracellular trafficking of myocilin in human trabecular meshwork cells publication-title: J. Biol. Chem. – volume: 49 start-page: 1932 year: 2008 end-page: 1939 ident: bib230 article-title: Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma publication-title: Invest Ophthalmol. Vis. Sci. – volume: 48 start-page: 1164 year: 2007 end-page: 1172 ident: bib111 article-title: Extracellular matrix gene alternative splicing by trabecular meshwork cells in response to mechanical stretching publication-title: Invest Ophthalmol. Vis. Sci. – volume: 283 start-page: 13874 year: 2008 end-page: 13888 ident: bib182 article-title: Targeting of bone morphogenetic protein growth factor complexes to fibrillin publication-title: J. Biol. Chem. – volume: 173 start-page: 1724 year: 2008 end-page: 1735 ident: bib179 article-title: Genotype-correlated expression of lysyl oxidase-like 1 in ocular tissues of patients with pseudoexfoliation syndrome/glaucoma and normal patients publication-title: Am. J. Pathol. – volume: 192 start-page: 89 year: 1974 end-page: 104 ident: bib74 article-title: Junctions between the cells of the trabecular meshwork publication-title: Albrecht. Von. Graefes Arch. Klin. Exp. Ophthalmol. – volume: 40 start-page: 379 year: 1996 end-page: 390 ident: bib225 article-title: The extracellular matrix and its modulation in the trabecular meshwork publication-title: Surv. Ophthalmol. – volume: 21 start-page: 7707 year: 2001 end-page: 7713 ident: bib116 article-title: Targeted Disruption of the myocilin gene (Myoc) suggests that human glaucoma-causing mutations are gain of function publication-title: Mol. Cell. Biol. – volume: 54 start-page: 2035 year: 2013 end-page: 2047 ident: bib196 article-title: Secreted protein acidic and rich in cysteine (SPARC)-null mice exhibit more uniform outflow publication-title: Invest Ophthalmol. Vis. Sci. – volume: 89 start-page: 464 year: 2011 end-page: 473 ident: bib115 article-title: Homozygous mutations in PXDN cause congenital cataract, corneal opacity, and developmental glaucoma publication-title: Am. J. Hum. Genet. – volume: 46 start-page: 4130 year: 2005 end-page: 4138 ident: bib227 article-title: Blebbistatin, a novel inhibitor of myosin II ATPase activity, increases aqueous humor outflow facility in perfused enucleated porcine eyes publication-title: Invest Ophthalmol. Vis. Sci. – volume: 50 start-page: 1692 year: 2009 end-page: 1697 ident: bib82 article-title: Preferential fluid flow in the human trabecular meshwork near collector channels publication-title: Invest Ophthalmol. Vis. Sci. – volume: 301 start-page: G950 year: 2011 end-page: G955 ident: bib220 article-title: The extracellular matrix: an active or passive player in fibrosis? publication-title: Am. J. Physiol. Gastrointest. Liver Physiol. – volume: 12 start-page: 350 year: 2006 end-page: 355 ident: bib117 article-title: Identification of the genetic defect in the original Wagner syndrome family publication-title: Mol. Vis. – volume: 50 start-page: 5723 year: 2009 end-page: 5731 ident: bib51 article-title: Regulation of cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells by convergence of distinct beta1 and beta3 integrin pathways publication-title: Invest Ophthalmol. Vis. Sci. – volume: 21 start-page: 1310 year: 2007 end-page: 1318 ident: bib191 article-title: Molecular and developmental mechanisms of anterior segment dysgenesis publication-title: Eye (Lond) – volume: 3 start-page: 299 year: 1993 end-page: 304 ident: bib140 article-title: A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells publication-title: Nat. Genet. – volume: 49 start-page: 262 year: 2008 end-page: 269 ident: bib180 article-title: Substrate rigidity modulates cell matrix interactions and protein expression in human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. – volume: 107 start-page: 583 year: 1989 end-page: 590 ident: bib208 article-title: Neural crest origin of human trabecular meshwork and its implications for the pathogenesis of glaucoma publication-title: Am. J. Ophthalmol. – volume: 18 start-page: 761 year: 2010 end-page: 767 ident: bib39 article-title: LTBP2 null mutations in an autosomal recessive ocular syndrome with megalocornea, spherophakia, and secondary glaucoma publication-title: Eur. J. Hum. Genet. – volume: 286 start-page: 5087 year: 2011 end-page: 5099 ident: bib183 article-title: Prodomains of transforming growth factor beta (TGFbeta) superfamily members specify different functions: extracellular matrix interactions and growth factor bioavailability publication-title: J. Biol. Chem. – volume: 52 start-page: 5251 year: 2011 end-page: 5259 ident: bib184 article-title: Role of TGFbeta/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteins publication-title: Invest Ophthalmol. Vis. Sci. – volume: 42 start-page: 906 year: 2010 end-page: 909 ident: bib205 article-title: Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma publication-title: Nat. Genet. – volume: 54 start-page: 3309 year: 2013 end-page: 3319 ident: bib151 article-title: Overexpression of SPARC in human trabecular meshwork increases intraocular pressure and alters extracellular matrix publication-title: Invest Ophthalmol. Vis. Sci. – volume: 7 start-page: e48523 year: 2012 ident: bib112 article-title: Inhibition of hyaluronan synthesis reduces versican and fibronectin levels in trabecular meshwork cells publication-title: PLoS One – volume: 121 start-page: 508 year: 2014 end-page: 516 ident: bib129 article-title: Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss publication-title: Ophthalmology – volume: 6 start-page: e20110 year: 2011 ident: bib94 article-title: Trabecular meshwork gene expression after selective laser trabeculoplasty publication-title: PLoS One – volume: 11 start-page: 1185 year: 2002 end-page: 1193 ident: bib70 article-title: Anterior segment dysgenesis and the developmental glaucomas are complex traits publication-title: Hum. Mol. Genet. – volume: 30 start-page: 154 year: 2014 end-page: 162 ident: bib223 article-title: The role of TGF-beta2 and bone morphogenetic proteins in the trabecular meshwork and glaucoma publication-title: J. Ocul. Pharmacol. Ther. – volume: 18 start-page: 3969 year: 2009 end-page: 3977 ident: bib148 article-title: Loss of function mutations in the gene encoding latent transforming growth factor beta binding protein 2, LTBP2, cause primary congenital glaucoma publication-title: Hum. Mol. Genet. – volume: 22 start-page: 435 year: 2003 end-page: 463 ident: bib15 article-title: Gene expression in the trabecular meshwork and the influence of intraocular pressure publication-title: Prog. Retin Eye Res. – volume: 88 start-page: 704 year: 2009 end-page: 712 ident: bib167 article-title: Glaucoma-associated myocilin: a better understanding but much more to learn publication-title: Exp. Eye Res. – volume: 50 start-page: 5769 year: 2009 end-page: 5777 ident: bib108 article-title: Differential effects of ADAMTS-1, -4, and -5 in the trabecular meshwork publication-title: Invest Ophthalmol. Vis. Sci. – volume: 52 start-page: 9438 year: 2011 end-page: 9444 ident: bib194 article-title: eNOS, a pressure-dependent regulator of intraocular pressure publication-title: Invest Ophthalmol. Vis. Sci. – volume: 52 start-page: 45 year: 2011 end-page: 50 ident: bib83 article-title: The elastin fiber system between and adjacent to collector channels in the human juxtacanalicular tissue publication-title: Invest Ophthalmol. Vis. Sci. – volume: 21 start-page: 616 year: 2009 end-page: 622 ident: bib164 article-title: Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling publication-title: Curr. Opin. Cell. Biol. – volume: 55 start-page: 814 year: 2014 end-page: 823 ident: bib30 article-title: Circumferential tensile stiffness of glaucomatous trabecular meshwork publication-title: Invest Ophthalmol. Vis. Sci. – volume: 48 start-page: 1191 year: 2007 end-page: 1200 ident: bib222 article-title: Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma publication-title: Invest Ophthalmol. Vis. Sci. – volume: 51 start-page: 3029 year: 2010 end-page: 3041 ident: bib192 article-title: Development of a gene therapy virus with a glucocorticoid-inducible MMP1 for the treatment of steroid glaucoma publication-title: Invest Ophthalmol. Vis. Sci. – volume: 54 start-page: 5613 year: 2013 end-page: 5623 ident: bib114 article-title: The effects of Tenascin C knockdown on trabecular meshwork outflow resistance publication-title: Invest Ophthalmol. Vis. Sci. – volume: 317 start-page: 1397 year: 2007 end-page: 1400 ident: bib204 article-title: Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma publication-title: Science – volume: 25 start-page: 299 year: 2002 end-page: 308 ident: bib85 article-title: Human Schlemm's canal cells express the endothelial adherens proteins, VE-cadherin and PECAM-1 publication-title: Curr. Eye Res. – volume: 43 start-page: 1068 year: 2002 end-page: 1076 ident: bib210 article-title: Distribution of myocilin and extracellular matrix components in the juxtacanalicular tissue of human eyes publication-title: Invest Ophthalmol. Vis. Sci. – volume: 79 start-page: 61 year: 2004 end-page: 74 ident: bib49 article-title: Distribution of syndecans 1-4 within the anterior segment of the human eye: expression of a variant syndecan-3 and matrix-associated syndecan-2 publication-title: Exp. Eye Res. – volume: 51 start-page: 308 year: 2010 end-page: 318 ident: bib169 article-title: Ocular gene transfer of active TGF-beta induces changes in anterior segment morphology and elevated IOP in rats publication-title: Invest Ophthalmol. Vis. Sci. – volume: 12 start-page: 194 year: 2013 end-page: 206 ident: bib35 article-title: Comparative genomic and proteomic analysis of cytoskeletal changes in dexamethasone-treated trabecular meshwork cells publication-title: Mol. Cell. Proteomics – volume: 82 start-page: 545 year: 2006 end-page: 557 ident: bib97 article-title: 'What controls aqueous humour outflow resistance?' publication-title: Exp. Eye Res. – volume: 88 start-page: 648 year: 2009 end-page: 655 ident: bib198 article-title: The trabecular meshwork outflow pathways: structural and functional aspects publication-title: Exp. Eye Res. – volume: 19 start-page: 2151 year: 2013 end-page: 2164 ident: bib64 article-title: sCD44 overexpression increases intraocular pressure and aqueous outflow resistance publication-title: Mol. Vis. – volume: 110 start-page: 110 year: 1992 end-page: 117 ident: bib177 article-title: Effects of intracameral injection of chondroitinase ABC in vivo publication-title: Arch. Ophthalmol. – volume: 7 start-page: e34309 year: 2012 ident: bib65 article-title: Cochlin, intraocular pressure regulation and mechanosensing publication-title: PLoS One – volume: 18 start-page: 91 year: 1999 end-page: 119 ident: bib132 article-title: Functional morphology of the trabecular meshwork in primate eyes publication-title: Prog. Retin Eye Res. – volume: 213 start-page: 775 year: 2007 end-page: 784 ident: bib173 article-title: Mitochondrial association of myocilin, product of a glaucoma gene, in human trabecular meshwork cells publication-title: J. Cell. Physiol. – volume: 40 start-page: 34 year: 2003 end-page: 36 ident: bib46 article-title: In frame fibrillin-1 gene deletion in autosomal dominant Weill-Marchesani syndrome publication-title: J. Med. Genet. – volume: 30 start-page: 110 year: 2014 end-page: 120 ident: bib61 article-title: The role of integrins in the trabecular meshwork publication-title: J. Ocul. Pharmacol. Ther. – volume: 2 start-page: 18 year: 2001 ident: bib31 article-title: Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure publication-title: BMC Genet. – volume: 51 start-page: 3042 year: 2010 end-page: 3048 ident: bib63 article-title: Treatment of sheep steroid-induced ocular hypertension with a glucocorticoid-inducible MMP1 gene therapy virus publication-title: Invest Ophthalmol. Vis. Sci. – volume: 54 start-page: 7903 year: 2013 end-page: 7909 ident: bib62 article-title: Reduction of steroid-induced intraocular pressure elevation in sheep by tissue plasminogen activator publication-title: Invest Ophthalmol. Vis. Sci. – volume: 18 start-page: 629 year: 1999 end-page: 667 ident: bib221 article-title: Effects of glucocorticoids on the trabecular meshwork: towards a better understanding of glaucoma publication-title: Prog. Retin Eye Res. – volume: 46 start-page: 1 year: 2005 end-page: 7 ident: bib81 article-title: Cationic ferritin and segmental flow through the trabecular meshwork publication-title: Invest Ophthalmol. Vis. Sci. – volume: 54 start-page: 5441 year: 2013 end-page: 5455 ident: bib27 article-title: Development of a model of elevated intraocular pressure in rats by gene transfer of bone morphogenetic protein 2 publication-title: Invest Ophthalmol. Vis. Sci. – volume: 48 start-page: 715 year: 2007 end-page: 726 ident: bib58 article-title: Bone morphogenetic protein-7 is an antagonist of transforming growth factor-beta2 in human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. – volume: 7 start-page: e1001306 year: 2011 ident: bib123 article-title: Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma publication-title: PLoS Genet. – volume: 20 start-page: 1610 year: 2011 end-page: 1624 ident: bib1 article-title: A complex regulatory network of transcription factors critical for ocular development and disease publication-title: Hum. Mol. Genet. – volume: 24 start-page: 9019 year: 2004 end-page: 9025 ident: bib72 article-title: Genetically increasing Myoc expression supports a necessary pathologic role of abnormal proteins in glaucoma publication-title: Mol. Cell. Biol. – volume: 2012 start-page: 692609 year: 2012 ident: bib19 article-title: Animal models of glaucoma publication-title: J. Biomed. Biotechnol. – volume: 30 start-page: 170 year: 2014 end-page: 180 ident: bib122 article-title: The microfibril hypothesis of glaucoma: implications for treatment of elevated intraocular pressure publication-title: J. Ocul. Pharmacol. Ther. – volume: 49 start-page: 2495 year: 2008 end-page: 2505 ident: bib109 article-title: Effects of modifiers of glycosaminoglycan biosynthesis on outflow facility in perfusion culture publication-title: Invest Ophthalmol. Vis. Sci. – volume: 53 start-page: 767 year: 1992 end-page: 770 ident: bib77 article-title: Effect of hyaluronidase on aqueous outflow resistance in normotensive and glaucomatous eyes of dogs publication-title: Am. J. Vet. Res. – start-page: 213 year: 1996 end-page: 250 ident: bib86 article-title: Extracellular matrix of the trabecular meshwork and optic nerve head publication-title: The Glaucomas – volume: 130 start-page: 495 year: 2011 end-page: 504 ident: bib166 article-title: BMP4 loss-of-function mutations in developmental eye disorders including SHORT syndrome publication-title: Hum. Genet. – start-page: 94 year: 2014 end-page: 101 ident: bib3 article-title: Intraocular pressure homeostasis: maintaining balance in a high-pressure environment publication-title: J. Ocul. Pharmacol. Ther. – volume: 16 start-page: 609 year: 2007 end-page: 617 ident: bib186 article-title: Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure publication-title: Hum. Mol. Genet. – volume: 107 start-page: 572 year: 1989 end-page: 576 ident: bib38 article-title: Patterns of aqueous humor outflow in glaucomatous and nonglaucomatous human eyes. A tracer study using cationized ferritin publication-title: Arch. Ophthalmol. – volume: 53 start-page: 952 year: 2012 end-page: 958 ident: bib203 article-title: Substratum stiffness and latrunculin B regulate matrix gene and protein expression in human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. – volume: 33 start-page: 1670 year: 1992 end-page: 1675 ident: bib100 article-title: Modulation of outflow resistance by the pores of the inner wall endothelium publication-title: Invest Ophthalmol. Vis. Sci. – volume: 52 start-page: 2889 year: 2011 end-page: 2896 ident: bib80 article-title: Elasticity-dependent modulation of TGF-beta responses in human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. – volume: 4 start-page: 11 year: 2005 ident: bib92 article-title: Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells publication-title: J. Biol. – volume: 118 start-page: 3 year: 2002 Oct end-page: 17 ident: bib241 article-title: Pax6 heterozygous eyes show defects in chamber angle differentiation that are associated with a wide spectrum of other anterior eye segment abnormalities publication-title: Mech. Dev. – volume: 44 start-page: 4796 year: 2003 end-page: 4804 ident: bib175 article-title: Effect of heparin II domain of fibronectin on aqueous outflow in cultured anterior segments of human eyes publication-title: Invest Ophthalmol. Vis. Sci. – volume: 233 start-page: 291 year: 1995 end-page: 295 ident: bib202 article-title: Integrins in human anterior chamber angle publication-title: Graefes Arch. Clin. Exp. Ophthalmol. – volume: 52 start-page: 723 year: 1991 end-page: 731 ident: bib41 article-title: Outflow facility studies in the perfused human ocular anterior segment publication-title: Exp. Eye Res. – volume: 298 start-page: C749 year: 2010 end-page: C763 ident: bib157 article-title: Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells publication-title: Am. J. Physiol. Cell. Physiol. – start-page: 89 year: 1996 end-page: 123 ident: bib136 article-title: Morphology of aqueous outflow pathways in Normal and glaucomatous eyes publication-title: The Glaucomas – volume: 103 start-page: 148 year: 2005 end-page: 162 ident: bib7 article-title: Interactions between endothelia of the trabecular meshwork and of Schlemm's canal: a new insight into the regulation of aqueous outflow in the eye publication-title: Trans. Am. Ophthalmol. Soc. – year: 1971 ident: bib88 article-title: Histology of the Human Eye: an Atlas and Textbook – volume: 43 start-page: 33 year: 2002 end-page: 40 ident: bib18 article-title: Effects of elevated intraocular pressure on outflow facility and TIGR/MYOC expression in perfused human anterior segments publication-title: Invest Ophthalmol. Vis. Sci. – volume: 9 start-page: 42 year: 1970 end-page: 52 ident: bib24 article-title: The measurement of pseudofacility and true facility by constant pressure perfusion in the normal rhesus monkey eye publication-title: Invest Ophthalmol. – volume: 46 start-page: 2726 year: 2005 end-page: 2735 ident: bib144 article-title: Identification of a novel splice site mutation of the CSPG2 gene in a Japanese family with Wagner syndrome publication-title: Invest Ophthalmol. Vis. Sci. – volume: 50 start-page: 3771 year: 2009 end-page: 3777 ident: bib78 article-title: SPARC-null mice exhibit lower intraocular pressures publication-title: Invest Ophthalmol. Vis. Sci. – start-page: 2577 year: 2000 end-page: 2595 ident: bib98 article-title: Mechanisms and routes of aqueous humor drainage publication-title: Principles and Practice of Ophthalmology – volume: 47 start-page: 226 year: 2006 end-page: 234 ident: bib53 article-title: TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressure publication-title: Invest Ophthalmol. Vis. Sci. – volume: 52 start-page: 2147 year: 2011 end-page: 2152 ident: bib127 article-title: Elastic modulus determination of normal and glaucomatous human trabecular meshwork publication-title: Invest Ophthalmol. Vis. Sci. – volume: 56 start-page: 50 year: 2013 end-page: 53 ident: bib197 article-title: Concurrent deletion of BMP4 and OTX2 genes, two master genes in ophthalmogenesis publication-title: Eur. J. Med. Genet. – volume: 18 start-page: 1918 year: 2012 end-page: 1926 ident: bib142 article-title: Identification of a novel FBN1 gene mutation in a large Pakistani family with Marfan syndrome publication-title: Mol. Vis. – volume: 46 start-page: 4200 year: 2005 end-page: 4208 ident: bib60 article-title: Fate maps of neural crest and mesoderm in the mammalian eye publication-title: Invest Ophthalmol. Vis. Sci. – volume: 65 start-page: 177 year: 1997 end-page: 190 ident: bib90 article-title: Intraocular pressure and outflow facility are unchanged following acute and chronic intracameral chondroitinase ABC and hyaluronidase in monkeys publication-title: Exp. Eye Res. – volume: 88 start-page: 689 year: 2009 end-page: 693 ident: bib47 article-title: Functional properties of fibronectin in the trabecular meshwork publication-title: Exp. Eye Res. – volume: 119 start-page: 1997 year: 2009 end-page: 2008 ident: bib93 article-title: Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-beta2 signaling publication-title: J. Clin. Invest – volume: 286 start-page: 17156 year: 2011 end-page: 17167 ident: bib126 article-title: ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts publication-title: J. Biol. Chem. – volume: 42 start-page: 1505 year: 2001 end-page: 1513 ident: bib21 article-title: Effects of mechanical stretching on trabecular matrix metalloproteinases publication-title: Invest Ophthalmol. Vis. Sci. – volume: 30 start-page: 447 year: 2014 end-page: 463 ident: bib32 article-title: Matricellular proteins in the trabecular meshwork: review and update publication-title: J. Ocul. Pharmacol. Ther. – volume: 18 start-page: 44 year: 1979 end-page: 51 ident: bib101 article-title: Pressure-dependent changes in nuclei and the process origins of the endothelial cells lining Schlemm's canal publication-title: Invest Ophthalmol. Vis. Sci. – volume: 16 start-page: 798 year: 2007 end-page: 807 ident: bib71 article-title: Col4a1 mutation causes endoplasmic reticulum stress and genetically modifiable ocular dysgenesis publication-title: Hum. Mol. Genet. – volume: 158 start-page: 175 year: 2002 end-page: 184 ident: bib87 article-title: A cryptic fragment from fibronectin's III1 module localizes to lipid rafts and stimulates cell growth and contractility publication-title: J. Cell. Biol. – volume: 47 start-page: 794 year: 2006 end-page: 801 ident: bib57 article-title: Biochemical and morphological analysis of basement membrane component expression in corneoscleral and cribriform human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. – volume: 50 start-page: 295 year: 1972 end-page: 320 ident: bib14 article-title: Scanning electron microscopic studies of the trabecular meshwork and the canal of Schlemm–an attempt to localize the main resistance to outflow of aqueous humor in man publication-title: Acta Ophthalmol. (Copenh) – volume: 83 start-page: 297 year: 2006 end-page: 303 ident: bib103 article-title: A mouse model for Stickler's syndrome: ocular phenotype of mice carrying a targeted heterozygous inactivation of type II (pro)collagen gene (Col2a1) publication-title: Exp. Eye Res. – volume: 84 start-page: 664 year: 2009 end-page: 671 ident: bib6 article-title: Null mutations in LTBP2 cause primary congenital glaucoma publication-title: Am. J. Hum. Genet. – volume: 28 start-page: 945 year: 1987 end-page: 953 ident: bib96 article-title: Human trabecular meshwork organ culture. A new method publication-title: Invest Ophthalmol. Vis. Sci. – volume: 201 start-page: 126 year: 2004 end-page: 137 ident: bib214 article-title: Genes expressed in the human trabecular meshwork during pressure-induced homeostatic response publication-title: J. Cell. Physiol. – volume: 208 start-page: 33 year: 1978 end-page: 47 ident: bib76 article-title: Associations between the cells of the walls of Schlemm's canal publication-title: Albr. Von. Graefes Arch. Klin. Exp. Ophthalmol. – volume: 50 start-page: 407 year: 1990 end-page: 418 ident: bib99 article-title: The filtration characteristics of the aqueous outflow system publication-title: Exp. Eye Res. – volume: 14 start-page: 286 year: 1975 end-page: 292 ident: bib25 article-title: The effect of intraocular pressure on conventional outflow resistance in the enucleated human eye publication-title: Invest Ophthalmol. – volume: 44 start-page: 1142 year: 2012 end-page: 1146 ident: bib212 article-title: Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma publication-title: Nat. Genet. – volume: 18 start-page: 1093 year: 2012 end-page: 1106 ident: bib195 article-title: Mice with an induced mutation in collagen 8A2 develop larger eyes and are resistant to retinal ganglion cell damage in an experimental glaucoma model publication-title: Mol. Vis. – volume: 37 start-page: 795 year: 1996 end-page: 804 ident: bib153 article-title: Laser trabeculoplasty induces stromelysin expression by trabecular juxtacanalicular cells publication-title: Invest Ophthalmol. Vis. Sci. – volume: 25 start-page: 286 year: 1984 end-page: 293 ident: bib118 article-title: Exogenous hyaluronidases and degradation of hyaluronic acid in the rabbit eye publication-title: Invest Ophthalmol. Vis. Sci. – volume: 47 start-page: 1956 year: 2006 end-page: 1967 ident: bib52 article-title: Beta1 and beta3 integrins cooperate to induce syndecan-4-containing cross-linked actin networks in human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. – volume: 32 start-page: 3145 year: 1991 end-page: 3166 ident: bib26 article-title: Flow of aqueous humor in humans [The Friedenwald Lecture] publication-title: Invest Ophthalmol. Vis. Sci. – volume: 49 start-page: 629 year: 2008 end-page: 635 ident: bib172 article-title: Response of human trabecular meshwork cells to topographic cues on the nanoscale level publication-title: Invest Ophthalmol. Vis. Sci. – volume: 55 start-page: 3804 year: 2014 ident: bib242 article-title: Low tension glaucoma in microfibril deficient mice publication-title: IOVS ARVO E-abstract – volume: 152 start-page: 321 year: 2012 end-page: 329 ident: bib89 article-title: Matrix control of transforming growth factor-beta function publication-title: J. Biochem – volume: 46 start-page: 881 year: 1988 end-page: 895 ident: bib188 article-title: Phagocytosis by trabecular meshwork cells: sequence of events in cats and monkeys publication-title: Exp. Eye Res. – volume: 88 start-page: 683 year: 2009 end-page: 688 ident: bib55 article-title: Modulation of extracellular matrix turnover in the trabecular meshwork publication-title: Exp. Eye Res. – volume: 3 start-page: a004978 year: 2011 ident: bib168 article-title: The collagen family publication-title: Cold Spring Harb. Perspect. Biol. – volume: 53 start-page: 4616 year: 2012 end-page: 4625 ident: bib113 article-title: Perturbation of hyaluronan synthesis in the trabecular meshwork and the effects on outflow facility publication-title: Invest Ophthalmol. Vis. Sci. – volume: 13 start-page: 3438 year: 1994 end-page: 3447 ident: bib149 article-title: Peroxidasin: a novel enzyme-matrix protein of Drosophila development publication-title: Embo J. – volume: 20 start-page: 523 year: 1975 end-page: 530 ident: bib75 article-title: The fine structure of the trabecular meshwork at graded levels of intraocular pressure. (2) Pressures outside the physiological range (0 and 50 mmHg) publication-title: Exp. Eye Res. – volume: 54 start-page: 7836 year: 2013 end-page: 7848 ident: bib215 article-title: Anti-connective tissue growth factor antibody treatment reduces extracellular matrix production in trabecular meshwork and lamina cribrosa cells publication-title: Invest Ophthalmol. Vis. Sci. – volume: 118 start-page: 1056 year: 2008 end-page: 1064 ident: bib216 article-title: Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure publication-title: J. Clin. Invest – volume: 280 start-page: 6080 year: 2005 end-page: 6084 ident: bib13 article-title: Proteomics reveal Cochlin deposits associated with glaucomatous trabecular meshwork publication-title: J. Biol. Chem. – volume: 52 start-page: 3660 year: 2011 end-page: 3666 ident: bib23 article-title: Connective tissue growth factor is increased in pseudoexfoliation glaucoma publication-title: Invest Ophthalmol. Vis. Sci. – volume: 347 start-page: 279 year: 2012 end-page: 290 ident: bib56 article-title: The role of TGF-beta in the pathogenesis of primary open-angle glaucoma publication-title: Cell. Tissue Res. – volume: 339 start-page: 71 year: 2010 end-page: 82 ident: bib165 article-title: Biogenesis and function of fibrillin assemblies publication-title: Cell. Tissue Res. – volume: 295 start-page: C1057 year: 2008 end-page: C1070 ident: bib226 article-title: Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork publication-title: Am. J. Physiol. Cell. Physiol. – volume: 200 start-page: 561 year: 2002 end-page: 574 ident: bib5 article-title: Extracellular matrix, junctional integrity and matrix metalloproteinase interactions in endothelial permeability regulation publication-title: J. Anat. – volume: 21 start-page: 563 year: 1981 end-page: 573 ident: bib134 article-title: Ultrahistochemical studies on tangential sections of the trabecular meshwork in normal and glaucomatous eyes publication-title: Invest. Ophthalmol. Vis. Sci. – volume: 47 start-page: 213 year: 2006 end-page: 221 ident: bib48 article-title: Perfusion of his-tagged eukaryotic myocilin increases outflow resistance in human anterior segments in the presence of aqueous humor publication-title: Invest Ophthalmol. Vis. Sci. – volume: 52 start-page: 5049 year: 2011 end-page: 5057 ident: bib110 article-title: Segmental versican expression in the trabecular meshwork and involvement in outflow facility publication-title: Invest Ophthalmol. Vis. Sci. – volume: 51 start-page: 2067 year: 2010 end-page: 2076 ident: bib187 article-title: Adenoviral gene transfer of active human transforming growth factor-{beta}2 elevates intraocular pressure and reduces outflow facility in rodent eyes publication-title: Invest Ophthalmol. Vis. Sci. – volume: 123 start-page: 3006 year: 2010 end-page: 3018 ident: bib139 article-title: Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta publication-title: J. Cell. Sci. – volume: 115 start-page: 1 year: 2013 end-page: 12 ident: bib146 article-title: What do mechanotransduction, Hippo, Wnt, and TGFbeta have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease publication-title: Exp. Eye Res. – volume: 8 start-page: 3727 year: 2009 end-page: 3736 ident: bib8 article-title: Laser trabeculoplasty induces changes in the trabecular meshwork glycoproteome: a pilot study publication-title: J. Proteome Res. – volume: 44 start-page: 1581 year: 2003 end-page: 1585 ident: bib4 article-title: Ocular hypertension in mice with a targeted type I collagen mutation publication-title: Invest Ophthalmol. Vis. Sci. – volume: 42 start-page: 1795 year: 2001 end-page: 1802 ident: bib43 article-title: Cationic ferritin changes outflow facility in human eyes whereas anionic ferritin does not publication-title: Invest Ophthalmol. Vis. Sci. – volume: 75 start-page: 365 year: 1973 end-page: 383 ident: bib102 article-title: Pressure-dependent changes in structures of the aqueous outflow system of human and monkey eyes publication-title: Am. J. Ophthalmol. – volume: 1502 start-page: 447 year: 2000 ident: 10.1016/j.exer.2014.07.014_bib29 article-title: Altered secretion of a TIGR/MYOC mutant lacking the olfactomedin domain publication-title: Biochim. Biophys. Acta doi: 10.1016/S0925-4439(00)00068-5 – volume: 28 start-page: 945 year: 1987 ident: 10.1016/j.exer.2014.07.014_bib96 article-title: Human trabecular meshwork organ culture. A new method publication-title: Invest Ophthalmol. Vis. Sci. – volume: 30 start-page: 447 year: 2014 ident: 10.1016/j.exer.2014.07.014_bib32 article-title: Matricellular proteins in the trabecular meshwork: review and update publication-title: J. Ocul. Pharmacol. Ther. doi: 10.1089/jop.2014.0013 – volume: 339 start-page: 71 year: 2010 ident: 10.1016/j.exer.2014.07.014_bib165 article-title: Biogenesis and function of fibrillin assemblies publication-title: Cell. Tissue Res. doi: 10.1007/s00441-009-0822-x – volume: 51 start-page: 308 year: 2010 ident: 10.1016/j.exer.2014.07.014_bib169 article-title: Ocular gene transfer of active TGF-beta induces changes in anterior segment morphology and elevated IOP in rats publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.09-3380 – volume: 4 start-page: 11 year: 2005 ident: 10.1016/j.exer.2014.07.014_bib92 article-title: Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells publication-title: J. Biol. – volume: 81 start-page: 1 year: 2005 ident: 10.1016/j.exer.2014.07.014_bib133 article-title: Morphological changes in glaucomatous eyes and the role of TGFbeta2 for the pathogenesis of the disease publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2005.02.008 – volume: 74 start-page: 161 year: 2002 ident: 10.1016/j.exer.2014.07.014_bib42 article-title: The inner wall of Schlemm's canal publication-title: Exp. Eye Res. doi: 10.1006/exer.2002.1144 – volume: 7 start-page: e34792 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib160 article-title: Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells publication-title: PLoS One doi: 10.1371/journal.pone.0034792 – volume: 54 start-page: 5613 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib114 article-title: The effects of Tenascin C knockdown on trabecular meshwork outflow resistance publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.13-11620 – volume: 48 start-page: 2105 year: 2007 ident: 10.1016/j.exer.2014.07.014_bib174 article-title: Influence of actin cytoskeletal integrity on matrix metalloproteinase-2 activation in cultured human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.06-1089 – volume: 75 start-page: 347 year: 2002 ident: 10.1016/j.exer.2014.07.014_bib66 article-title: A new view of the human trabecular meshwork using quick-freeze, deep-etch electron microscopy publication-title: Exp. Eye Res. doi: 10.1016/S0014-4835(02)92010-5 – volume: 49 start-page: 1459 year: 2008 ident: 10.1016/j.exer.2014.07.014_bib154 article-title: Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.07-1449 – volume: 48 start-page: 1191 year: 2007 ident: 10.1016/j.exer.2014.07.014_bib222 article-title: Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.06-0296 – volume: 280 start-page: 28917 year: 2005 ident: 10.1016/j.exer.2014.07.014_bib84 article-title: Extracellular trafficking of myocilin in human trabecular meshwork cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M504803200 – volume: 88 start-page: 683 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib55 article-title: Modulation of extracellular matrix turnover in the trabecular meshwork publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2009.01.005 – volume: 21 start-page: 616 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib164 article-title: Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling publication-title: Curr. Opin. Cell. Biol. doi: 10.1016/j.ceb.2009.05.005 – volume: 161A start-page: 880 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib121 article-title: Marfan syndrome caused by a novel FBN1 mutation with associated pigmentary glaucoma publication-title: Am. J. Med. Genet. A doi: 10.1002/ajmg.a.35838 – volume: 48 start-page: 139 year: 1989 ident: 10.1016/j.exer.2014.07.014_bib135 article-title: Immunomicroscopical study of type VI collagen in the trabecular meshwork of normal and glaucomatous eyes publication-title: Exp. Eye Res. doi: 10.1016/0014-4835(89)90027-4 – year: 2014 ident: 10.1016/j.exer.2014.07.014_bib240 article-title: Differential effects of CAV1 and CAV2 knockdown on aqueous outflow and altered extracellular matrix turnover in CAV-silenced trabecular meshwork cells publication-title: Investig. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.14-14519 – volume: 8 start-page: 3727 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib8 article-title: Laser trabeculoplasty induces changes in the trabecular meshwork glycoproteome: a pilot study publication-title: J. Proteome Res. doi: 10.1021/pr900294g – volume: 30 start-page: 240 year: 1954 ident: 10.1016/j.exer.2014.07.014_bib9 article-title: Influence of testicular hyaluronidase on the resistance to flow through the angle of the anterior chamber publication-title: Acta Physiol. Scand. doi: 10.1111/j.1748-1716.1954.tb01092.x – volume: 52 start-page: 2147 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib127 article-title: Elastic modulus determination of normal and glaucomatous human trabecular meshwork publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.10-6342 – volume: 50 start-page: 5653 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib161 article-title: Reduced corneal thickness and enlarged anterior chamber in a novel ColVIIIa2G257D mutant mouse publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.09-3550 – volume: 50 start-page: 5723 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib51 article-title: Regulation of cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells by convergence of distinct beta1 and beta3 integrin pathways publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.08-3215 – volume: 6 start-page: e20110 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib94 article-title: Trabecular meshwork gene expression after selective laser trabeculoplasty publication-title: PLoS One doi: 10.1371/journal.pone.0020110 – volume: 44 start-page: 1581 year: 2003 ident: 10.1016/j.exer.2014.07.014_bib4 article-title: Ocular hypertension in mice with a targeted type I collagen mutation publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.02-0759 – volume: 54 start-page: 5441 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib27 article-title: Development of a model of elevated intraocular pressure in rats by gene transfer of bone morphogenetic protein 2 publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.13-11651 – volume: 52 start-page: 685 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib143 article-title: Assessment of aqueous humor dynamics in the mouse by a novel method of constant-flow infusion publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.10-6069 – volume: 286 start-page: 5087 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib183 article-title: Prodomains of transforming growth factor beta (TGFbeta) superfamily members specify different functions: extracellular matrix interactions and growth factor bioavailability publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110.188615 – volume: 11 start-page: 1185 year: 2002 ident: 10.1016/j.exer.2014.07.014_bib70 article-title: Anterior segment dysgenesis and the developmental glaucomas are complex traits publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/11.10.1185 – volume: 246 start-page: 1021 year: 2008 ident: 10.1016/j.exer.2014.07.014_bib200 article-title: Immunohistochemical evaluation of the extracellular matrix in trabecular meshwork in steroid-induced glaucoma publication-title: Graefes Arch. Clin. Exp. Ophthalmol. doi: 10.1007/s00417-008-0800-0 – volume: 88 start-page: 656 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib152 article-title: The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2008.11.033 – volume: 286 start-page: 17156 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib126 article-title: ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.231571 – volume: 19 start-page: 2151 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib64 article-title: sCD44 overexpression increases intraocular pressure and aqueous outflow resistance publication-title: Mol. Vis. – volume: 30 start-page: 110 year: 2014 ident: 10.1016/j.exer.2014.07.014_bib61 article-title: The role of integrins in the trabecular meshwork publication-title: J. Ocul. Pharmacol. Ther. doi: 10.1089/jop.2013.0176 – volume: 46 start-page: 4200 year: 2005 ident: 10.1016/j.exer.2014.07.014_bib60 article-title: Fate maps of neural crest and mesoderm in the mammalian eye publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.05-0691 – volume: 88 start-page: 676 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib107 article-title: Extracellular matrix turnover and outflow resistance publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2008.11.023 – volume: 24 start-page: 9019 year: 2004 ident: 10.1016/j.exer.2014.07.014_bib72 article-title: Genetically increasing Myoc expression supports a necessary pathologic role of abnormal proteins in glaucoma publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.20.9019-9025.2004 – volume: 48 start-page: 715 year: 2007 ident: 10.1016/j.exer.2014.07.014_bib58 article-title: Bone morphogenetic protein-7 is an antagonist of transforming growth factor-beta2 in human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.06-0226 – volume: 173 start-page: 1724 year: 2008 ident: 10.1016/j.exer.2014.07.014_bib179 article-title: Genotype-correlated expression of lysyl oxidase-like 1 in ocular tissues of patients with pseudoexfoliation syndrome/glaucoma and normal patients publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2008.080535 – volume: 7 start-page: e48523 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib112 article-title: Inhibition of hyaluronan synthesis reduces versican and fibronectin levels in trabecular meshwork cells publication-title: PLoS One doi: 10.1371/journal.pone.0048523 – volume: 211 start-page: 140 year: 1997 ident: 10.1016/j.exer.2014.07.014_bib59 article-title: Ultrastructural changes in the trabecular meshwork of juvenile glaucoma publication-title: Ophthalmologica doi: 10.1159/000310781 – volume: 52 start-page: 723 year: 1991 ident: 10.1016/j.exer.2014.07.014_bib41 article-title: Outflow facility studies in the perfused human ocular anterior segment publication-title: Exp. Eye Res. doi: 10.1016/0014-4835(91)90024-9 – volume: 52 start-page: 6443 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib33 article-title: Expression profile of the matricellular protein osteopontin in primary open-angle glaucoma and the normal human eye publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.11-7409 – volume: 54 start-page: 7903 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib62 article-title: Reduction of steroid-induced intraocular pressure elevation in sheep by tissue plasminogen activator publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.13-12801 – volume: 3 start-page: a004978 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib168 article-title: The collagen family publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a004978 – volume: 53 start-page: 2506 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib16 article-title: Advances in glaucoma treatment and management: gene therapy publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.12-9483o – volume: 45 start-page: 1841 year: 2004 ident: 10.1016/j.exer.2014.07.014_bib138 article-title: Optic nerve damage in mice with a targeted type I collagen mutation publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.03-1008 – volume: 241 start-page: 321 year: 2003 ident: 10.1016/j.exer.2014.07.014_bib181 article-title: Elevation of nitric oxide production in human trabecular meshwork by increased pressure publication-title: Graefes Arch. Clin. Exp. Ophthalmol. doi: 10.1007/s00417-003-0638-4 – volume: 50 start-page: 2796 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib120 article-title: Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.08-2339 – start-page: 94 year: 2014 ident: 10.1016/j.exer.2014.07.014_bib3 article-title: Intraocular pressure homeostasis: maintaining balance in a high-pressure environment publication-title: J. Ocul. Pharmacol. Ther. doi: 10.1089/jop.2013.0185 – volume: 9 start-page: 42 year: 1970 ident: 10.1016/j.exer.2014.07.014_bib24 article-title: The measurement of pseudofacility and true facility by constant pressure perfusion in the normal rhesus monkey eye publication-title: Invest Ophthalmol. – volume: 54 start-page: 3309 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib151 article-title: Overexpression of SPARC in human trabecular meshwork increases intraocular pressure and alters extracellular matrix publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.12-11362 – volume: 46 start-page: 881 year: 1988 ident: 10.1016/j.exer.2014.07.014_bib188 article-title: Phagocytosis by trabecular meshwork cells: sequence of events in cats and monkeys publication-title: Exp. Eye Res. doi: 10.1016/S0014-4835(88)80040-X – volume: 46 start-page: 1 year: 2005 ident: 10.1016/j.exer.2014.07.014_bib81 article-title: Cationic ferritin and segmental flow through the trabecular meshwork publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.04-0800 – volume: 49 start-page: 2495 year: 2008 ident: 10.1016/j.exer.2014.07.014_bib109 article-title: Effects of modifiers of glycosaminoglycan biosynthesis on outflow facility in perfusion culture publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.07-0903 – volume: 347 start-page: 279 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib56 article-title: The role of TGF-beta in the pathogenesis of primary open-angle glaucoma publication-title: Cell. Tissue Res. doi: 10.1007/s00441-011-1274-7 – volume: 21 start-page: S62 year: 2002 ident: 10.1016/j.exer.2014.07.014_bib199 article-title: Proteoglycans in the eye publication-title: Cornea doi: 10.1097/01.ico.0000263121.45898.d2 – volume: 208 start-page: 33 year: 1978 ident: 10.1016/j.exer.2014.07.014_bib76 article-title: Associations between the cells of the walls of Schlemm's canal publication-title: Albr. Von. Graefes Arch. Klin. Exp. Ophthalmol. doi: 10.1007/BF00406980 – volume: 93 start-page: 397 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib131 article-title: Similar hydrodynamic and morphological changes in the aqueous humor outflow pathway after washout and Y27632 treatment in monkey eyes publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2011.05.012 – volume: 46 start-page: 4130 year: 2005 ident: 10.1016/j.exer.2014.07.014_bib227 article-title: Blebbistatin, a novel inhibitor of myosin II ATPase activity, increases aqueous humor outflow facility in perfused enucleated porcine eyes publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.05-0164 – volume: 12 start-page: 350 year: 2006 ident: 10.1016/j.exer.2014.07.014_bib117 article-title: Identification of the genetic defect in the original Wagner syndrome family publication-title: Mol. Vis. – volume: 20 start-page: 1610 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib1 article-title: A complex regulatory network of transcription factors critical for ocular development and disease publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddr038 – volume: 52 start-page: 2952 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib50 article-title: Dexamethasone-associated cross-linked actin network formation in human trabecular meshwork cells involves beta3 integrin signaling publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.10-6618 – volume: 53 start-page: 4616 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib113 article-title: Perturbation of hyaluronan synthesis in the trabecular meshwork and the effects on outflow facility publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.12-9500 – volume: 18 start-page: 1093 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib195 article-title: Mice with an induced mutation in collagen 8A2 develop larger eyes and are resistant to retinal ganglion cell damage in an experimental glaucoma model publication-title: Mol. Vis. – volume: 42 start-page: 906 year: 2010 ident: 10.1016/j.exer.2014.07.014_bib205 article-title: Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma publication-title: Nat. Genet. doi: 10.1038/ng.661 – volume: 82 start-page: 545 year: 2006 ident: 10.1016/j.exer.2014.07.014_bib97 article-title: 'What controls aqueous humour outflow resistance?' publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2005.10.011 – volume: 52 start-page: 2187 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib104 article-title: Effect of hevin deletion in mice and characterization in trabecular meshwork publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.10-5428 – volume: 86 start-page: 271 year: 2008 ident: 10.1016/j.exer.2014.07.014_bib130 article-title: The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2007.10.018 – volume: 23 start-page: 135 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib193 article-title: Current understanding of conventional outflow dysfunction in glaucoma publication-title: Curr. Opin. Ophthalmol. doi: 10.1097/ICU.0b013e32834ff23e – volume: 158 start-page: 175 year: 2002 ident: 10.1016/j.exer.2014.07.014_bib87 article-title: A cryptic fragment from fibronectin's III1 module localizes to lipid rafts and stimulates cell growth and contractility publication-title: J. Cell. Biol. doi: 10.1083/jcb.200112031 – volume: 16 start-page: 609 year: 2007 ident: 10.1016/j.exer.2014.07.014_bib186 article-title: Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddm001 – volume: 8 start-page: 1071 year: 1989 ident: 10.1016/j.exer.2014.07.014_bib68 article-title: Ultrastructural immunocytochemical localization of elastin in normal human trabecular meshwork publication-title: Curr. Eye Res. doi: 10.3109/02713688908997400 – volume: 51 start-page: 5768 year: 2010 ident: 10.1016/j.exer.2014.07.014_bib12 article-title: Effect of chondroitin sulfate on intraocular pressure in rats publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.10-5660 – volume: 32 start-page: 3145 year: 1991 ident: 10.1016/j.exer.2014.07.014_bib26 article-title: Flow of aqueous humor in humans [The Friedenwald Lecture] publication-title: Invest Ophthalmol. Vis. Sci. – volume: 52 start-page: 45 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib83 article-title: The elastin fiber system between and adjacent to collector channels in the human juxtacanalicular tissue publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.10-5620 – volume: 52 start-page: 5240 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib185 article-title: Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.11-7287 – volume: 31 start-page: 2156 year: 1990 ident: 10.1016/j.exer.2014.07.014_bib28 article-title: Human trabecular meshwork phagocytosis. Observations in an organ culture system publication-title: Invest Ophthalmol. Vis. Sci. – volume: 280 start-page: 6080 year: 2005 ident: 10.1016/j.exer.2014.07.014_bib13 article-title: Proteomics reveal Cochlin deposits associated with glaucomatous trabecular meshwork publication-title: J. Biol. Chem. doi: 10.1074/jbc.M411233200 – volume: 121 start-page: 508 year: 2014 ident: 10.1016/j.exer.2014.07.014_bib129 article-title: Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss publication-title: Ophthalmology doi: 10.1016/j.ophtha.2013.09.012 – volume: 49 start-page: 1932 year: 2008 ident: 10.1016/j.exer.2014.07.014_bib230 article-title: Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.07-1339 – volume: 213 start-page: 775 year: 2007 ident: 10.1016/j.exer.2014.07.014_bib173 article-title: Mitochondrial association of myocilin, product of a glaucoma gene, in human trabecular meshwork cells publication-title: J. Cell. Physiol. doi: 10.1002/jcp.21147 – start-page: 2577 year: 2000 ident: 10.1016/j.exer.2014.07.014_bib98 article-title: Mechanisms and routes of aqueous humor drainage – volume: 8 start-page: e82301 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib141 article-title: A role for myocilin in receptor-mediated endocytosis publication-title: PLoS One doi: 10.1371/journal.pone.0082301 – volume: 46 start-page: 2726 year: 2005 ident: 10.1016/j.exer.2014.07.014_bib144 article-title: Identification of a novel splice site mutation of the CSPG2 gene in a Japanese family with Wagner syndrome publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.05-0057 – volume: 65 start-page: 177 year: 1997 ident: 10.1016/j.exer.2014.07.014_bib90 article-title: Intraocular pressure and outflow facility are unchanged following acute and chronic intracameral chondroitinase ABC and hyaluronidase in monkeys publication-title: Exp. Eye Res. doi: 10.1006/exer.1997.0319 – volume: 19 start-page: 333 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib95 article-title: Contribution of the latent transforming growth factor-beta binding protein 2 gene to etiology of primary open angle glaucoma and pseudoexfoliation syndrome publication-title: Mol. Vis. – volume: 20 start-page: 523 year: 1975 ident: 10.1016/j.exer.2014.07.014_bib75 article-title: The fine structure of the trabecular meshwork at graded levels of intraocular pressure. (2) Pressures outside the physiological range (0 and 50 mmHg) publication-title: Exp. Eye Res. doi: 10.1016/0014-4835(75)90219-5 – volume: 51 start-page: 2067 year: 2010 ident: 10.1016/j.exer.2014.07.014_bib187 article-title: Adenoviral gene transfer of active human transforming growth factor-{beta}2 elevates intraocular pressure and reduces outflow facility in rodent eyes publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.09-4567 – volume: 46 start-page: 2857 year: 2005 ident: 10.1016/j.exer.2014.07.014_bib213 article-title: Changes in gene expression by trabecular meshwork cells in response to mechanical stretching publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.05-0075 – volume: 16 start-page: 2185 year: 2010 ident: 10.1016/j.exer.2014.07.014_bib40 article-title: Distribution of COL8A2 and COL8A1 gene variants in Caucasian primary open angle glaucoma patients with thin central corneal thickness publication-title: Mol. Vis. – volume: 21 start-page: R97 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib125 article-title: COL4A1 and COL4A2 mutations and disease: insights into pathogenic mechanisms and potential therapeutic targets publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/dds346 – volume: 21 start-page: 1310 year: 2007 ident: 10.1016/j.exer.2014.07.014_bib191 article-title: Molecular and developmental mechanisms of anterior segment dysgenesis publication-title: Eye (Lond) doi: 10.1038/sj.eye.6702852 – volume: 11 start-page: 19 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib105 article-title: Wakayama symposium: challenges of future research in ocular surface cell biology publication-title: Ocul. Surf. doi: 10.1016/j.jtos.2012.07.002 – volume: 13 start-page: 3438 year: 1994 ident: 10.1016/j.exer.2014.07.014_bib149 article-title: Peroxidasin: a novel enzyme-matrix protein of Drosophila development publication-title: Embo J. doi: 10.1002/j.1460-2075.1994.tb06649.x – volume: 18 start-page: 1918 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib142 article-title: Identification of a novel FBN1 gene mutation in a large Pakistani family with Marfan syndrome publication-title: Mol. Vis. – volume: 26 start-page: 797 year: 1985 ident: 10.1016/j.exer.2014.07.014_bib54 article-title: Fibronectin in human trabecular drainage channels publication-title: Invest Ophthalmol. Vis. Sci. – volume: 52 start-page: 3660 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib23 article-title: Connective tissue growth factor is increased in pseudoexfoliation glaucoma publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.10-5209 – volume: 14 start-page: 286 year: 1975 ident: 10.1016/j.exer.2014.07.014_bib25 article-title: The effect of intraocular pressure on conventional outflow resistance in the enucleated human eye publication-title: Invest Ophthalmol. – volume: 43 start-page: 33 year: 2002 ident: 10.1016/j.exer.2014.07.014_bib18 article-title: Effects of elevated intraocular pressure on outflow facility and TIGR/MYOC expression in perfused human anterior segments publication-title: Invest Ophthalmol. Vis. Sci. – volume: 33 start-page: 336 year: 1996 ident: 10.1016/j.exer.2014.07.014_bib67 article-title: Morphology of the aqueous outflow pathway publication-title: Microsc. Res. Tech. doi: 10.1002/(SICI)1097-0029(19960301)33:4<336::AID-JEMT4>3.0.CO;2-N – volume: 50 start-page: 3771 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib78 article-title: SPARC-null mice exhibit lower intraocular pressures publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.08-2489 – volume: 152 start-page: 321 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib89 article-title: Matrix control of transforming growth factor-beta function publication-title: J. Biochem doi: 10.1093/jb/mvs089 – volume: 53 start-page: 6708 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib79 article-title: Thrombospondin-1 (TSP1)-Null and TSP2-null mice exhibit lower intraocular pressures publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.11-9013 – volume: 30 start-page: 154 year: 2014 ident: 10.1016/j.exer.2014.07.014_bib223 article-title: The role of TGF-beta2 and bone morphogenetic proteins in the trabecular meshwork and glaucoma publication-title: J. Ocul. Pharmacol. Ther. doi: 10.1089/jop.2013.0220 – volume: 42 start-page: 13 year: 2014 ident: 10.1016/j.exer.2014.07.014_bib91 article-title: Genomics and anterior segment dysgenesis: a review publication-title: Clin. Exp. Ophthalmol. doi: 10.1111/ceo.12152 – volume: 283 start-page: 13874 year: 2008 ident: 10.1016/j.exer.2014.07.014_bib182 article-title: Targeting of bone morphogenetic protein growth factor complexes to fibrillin publication-title: J. Biol. Chem. doi: 10.1074/jbc.M707820200 – volume: 53 start-page: 952 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib203 article-title: Substratum stiffness and latrunculin B regulate matrix gene and protein expression in human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.11-8526 – volume: 22 start-page: 435 year: 2003 ident: 10.1016/j.exer.2014.07.014_bib15 article-title: Gene expression in the trabecular meshwork and the influence of intraocular pressure publication-title: Prog. Retin Eye Res. doi: 10.1016/S1350-9462(03)00018-1 – volume: 201 start-page: 126 year: 2004 ident: 10.1016/j.exer.2014.07.014_bib214 article-title: Genes expressed in the human trabecular meshwork during pressure-induced homeostatic response publication-title: J. Cell. Physiol. doi: 10.1002/jcp.20030 – volume: 45 start-page: 153 year: 2004 ident: 10.1016/j.exer.2014.07.014_bib69 article-title: Effects of TGF-beta2 in perfused human eyes publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.03-0796 – volume: 156 start-page: 1489 year: 2000 ident: 10.1016/j.exer.2014.07.014_bib37 article-title: Regulation of tissue injury responses by the exposure of matricryptic sites within extracellular matrix molecules publication-title: Am. J. Pathol. doi: 10.1016/S0002-9440(10)65020-1 – volume: 30 start-page: 170 year: 2014 ident: 10.1016/j.exer.2014.07.014_bib122 article-title: The microfibril hypothesis of glaucoma: implications for treatment of elevated intraocular pressure publication-title: J. Ocul. Pharmacol. Ther. doi: 10.1089/jop.2013.0184 – volume: 47 start-page: 213 year: 2006 ident: 10.1016/j.exer.2014.07.014_bib48 article-title: Perfusion of his-tagged eukaryotic myocilin increases outflow resistance in human anterior segments in the presence of aqueous humor publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.05-0334 – year: 1971 ident: 10.1016/j.exer.2014.07.014_bib88 – volume: 34 start-page: 21 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib228 article-title: Ophthalmic findings in a family with early-onset isolated ectopia lentis and the p.Arg62Cys mutation of the fibrillin-1 gene (FBN1) publication-title: Ophthalmic Genet. doi: 10.3109/13816810.2012.718029 – volume: 89 start-page: 464 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib115 article-title: Homozygous mutations in PXDN cause congenital cataract, corneal opacity, and developmental glaucoma publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2011.08.005 – volume: 21 start-page: 574 year: 1981 ident: 10.1016/j.exer.2014.07.014_bib171 article-title: The fine structure of the cribriform meshwork in normal and glaucomatous eyes as seen in tangential sections publication-title: Invest Ophthalmol. Vis. Sci. – volume: 19 start-page: 395 year: 1999 ident: 10.1016/j.exer.2014.07.014_bib229 article-title: Expression of integrin receptors in the human trabecular meshwork publication-title: Curr. Eye Res. doi: 10.1076/ceyr.19.5.395.5297 – volume: 280 start-page: 27970 year: 2005 ident: 10.1016/j.exer.2014.07.014_bib73 article-title: The prodomain of BMP-7 targets the BMP-7 complex to the extracellular matrix publication-title: J. Biol. Chem. doi: 10.1074/jbc.M504270200 – volume: 8 start-page: e72447 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib124 article-title: Tissue plasminogen activator in trabecular meshwork attenuates steroid induced outflow resistance in mice publication-title: PLoS One doi: 10.1371/journal.pone.0072447 – volume: 49 start-page: 262 year: 2008 ident: 10.1016/j.exer.2014.07.014_bib180 article-title: Substrate rigidity modulates cell matrix interactions and protein expression in human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.07-0956 – volume: 119 start-page: 1997 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib93 article-title: Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-beta2 signaling publication-title: J. Clin. Invest – volume: 1 start-page: 10 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib106 article-title: The juxtacanalicular region of ocular trabecular meshwork: a tissue with a unique extracellular matrix and specialized function publication-title: J. Ocul. Biol. – volume: 30 start-page: 291 year: 2014 ident: 10.1016/j.exer.2014.07.014_bib150 article-title: Differential expression of genes in cells cultured from juxtacanalicular trabecular meshwork and Schlemm's canal publication-title: J. Ocul. Pharmacol. Ther. doi: 10.1089/jop.2013.0189 – volume: 52 start-page: 5251 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib184 article-title: Role of TGFbeta/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteins publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.11-7587 – volume: 200 start-page: 561 year: 2002 ident: 10.1016/j.exer.2014.07.014_bib5 article-title: Extracellular matrix, junctional integrity and matrix metalloproteinase interactions in endothelial permeability regulation publication-title: J. Anat. – volume: 79 start-page: 61 year: 2004 ident: 10.1016/j.exer.2014.07.014_bib49 article-title: Distribution of syndecans 1-4 within the anterior segment of the human eye: expression of a variant syndecan-3 and matrix-associated syndecan-2 publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2004.02.010 – volume: 47 start-page: 794 year: 2006 ident: 10.1016/j.exer.2014.07.014_bib57 article-title: Biochemical and morphological analysis of basement membrane component expression in corneoscleral and cribriform human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.05-0292 – volume: 21 start-page: 7707 year: 2001 ident: 10.1016/j.exer.2014.07.014_bib116 article-title: Targeted Disruption of the myocilin gene (Myoc) suggests that human glaucoma-causing mutations are gain of function publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.21.22.7707-7713.2001 – volume: 88 start-page: 769 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib201 article-title: Structural changes of the trabecular meshwork in different kinds of glaucoma publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2008.11.025 – volume: 229 start-page: 927 year: 2014 ident: 10.1016/j.exer.2014.07.014_bib155 article-title: Regulation of plasticity and fibrogenic activity of trabecular meshwork cells by Rho GTPase signaling publication-title: J. Cell. Physiol. doi: 10.1002/jcp.24524 – volume: 22 start-page: 394 year: 2001 ident: 10.1016/j.exer.2014.07.014_bib224 article-title: The effect of mechanical strain on matrix metalloproteinase production by bovine trabecular meshwork cells publication-title: Curr. Eye Res. doi: 10.1076/ceyr.22.5.394.5500 – volume: 75 start-page: 365 year: 1973 ident: 10.1016/j.exer.2014.07.014_bib102 article-title: Pressure-dependent changes in structures of the aqueous outflow system of human and monkey eyes publication-title: Am. J. Ophthalmol. doi: 10.1016/0002-9394(73)91145-8 – volume: 2 start-page: 80 year: 1993 ident: 10.1016/j.exer.2014.07.014_bib176 article-title: Effects of glycosaminoglycan-degrading enzymes on bovine trabecular meshwork in organ culture publication-title: J. Glaucoma doi: 10.1097/00061198-199300220-00002 – volume: 50 start-page: 295 year: 1972 ident: 10.1016/j.exer.2014.07.014_bib14 article-title: Scanning electron microscopic studies of the trabecular meshwork and the canal of Schlemm–an attempt to localize the main resistance to outflow of aqueous humor in man publication-title: Acta Ophthalmol. (Copenh) doi: 10.1111/j.1755-3768.1972.tb05954.x – volume: 40 start-page: 34 year: 2003 ident: 10.1016/j.exer.2014.07.014_bib46 article-title: In frame fibrillin-1 gene deletion in autosomal dominant Weill-Marchesani syndrome publication-title: J. Med. Genet. doi: 10.1136/jmg.40.1.34 – volume: 47 start-page: 226 year: 2006 ident: 10.1016/j.exer.2014.07.014_bib53 article-title: TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressure publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.05-1060 – volume: 25 start-page: 299 year: 2002 ident: 10.1016/j.exer.2014.07.014_bib85 article-title: Human Schlemm's canal cells express the endothelial adherens proteins, VE-cadherin and PECAM-1 publication-title: Curr. Eye Res. doi: 10.1076/ceyr.25.5.299.13495 – volume: 44 start-page: 4796 year: 2003 ident: 10.1016/j.exer.2014.07.014_bib175 article-title: Effect of heparin II domain of fibronectin on aqueous outflow in cultured anterior segments of human eyes publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.02-1083 – volume: 118 start-page: 3 issue: 1–2 year: 2002 ident: 10.1016/j.exer.2014.07.014_bib241 article-title: Pax6 heterozygous eyes show defects in chamber angle differentiation that are associated with a wide spectrum of other anterior eye segment abnormalities publication-title: Mech. Dev. doi: 10.1016/S0925-4773(02)00260-5 – volume: 295 start-page: C1057 year: 2008 ident: 10.1016/j.exer.2014.07.014_bib226 article-title: Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork publication-title: Am. J. Physiol. Cell. Physiol. doi: 10.1152/ajpcell.00481.2007 – volume: 8 start-page: e68668 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib159 article-title: Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge publication-title: PLoS One doi: 10.1371/journal.pone.0068668 – volume: 123A start-page: 204 year: 2003 ident: 10.1016/j.exer.2014.07.014_bib45 article-title: Clinical homogeneity and genetic heterogeneity in Weill-Marchesani syndrome publication-title: Am. J. Med. Genet. A doi: 10.1002/ajmg.a.20289 – volume: 51 start-page: 3042 year: 2010 ident: 10.1016/j.exer.2014.07.014_bib63 article-title: Treatment of sheep steroid-induced ocular hypertension with a glucocorticoid-inducible MMP1 gene therapy virus publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.09-4920 – volume: 50 start-page: 407 year: 1990 ident: 10.1016/j.exer.2014.07.014_bib99 article-title: The filtration characteristics of the aqueous outflow system publication-title: Exp. Eye Res. doi: 10.1016/0014-4835(90)90142-H – volume: 17 start-page: 199 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib211 article-title: Structural basement membrane components and corresponding integrins in Schlemm's canal endothelia publication-title: Mol. Vis. – volume: 301 start-page: G950 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib220 article-title: The extracellular matrix: an active or passive player in fibrosis? publication-title: Am. J. Physiol. Gastrointest. Liver Physiol. doi: 10.1152/ajpgi.00132.2011 – volume: 130 start-page: 495 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib166 article-title: BMP4 loss-of-function mutations in developmental eye disorders including SHORT syndrome publication-title: Hum. Genet. doi: 10.1007/s00439-011-0968-y – volume: 42 start-page: 443 year: 1986 ident: 10.1016/j.exer.2014.07.014_bib137 article-title: Quantitative analysis of 'plaque material' in the inner- and outer wall of Schlemm's canal in normal- and glaucomatous eyes publication-title: Exp. Eye Res. doi: 10.1016/0014-4835(86)90004-7 – volume: 96 start-page: 82 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib158 article-title: Protein markers and differentiation in culture for Schlemm's canal endothelial cells publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2011.12.017 – volume: 49 start-page: 629 year: 2008 ident: 10.1016/j.exer.2014.07.014_bib172 article-title: Response of human trabecular meshwork cells to topographic cues on the nanoscale level publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.07-1192 – volume: 107 start-page: 572 year: 1989 ident: 10.1016/j.exer.2014.07.014_bib38 article-title: Patterns of aqueous humor outflow in glaucomatous and nonglaucomatous human eyes. A tracer study using cationized ferritin publication-title: Arch. Ophthalmol. doi: 10.1001/archopht.1989.01070010586035 – volume: 85 start-page: 558 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib145 article-title: Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2009.09.011 – volume: 118 start-page: 1056 year: 2008 ident: 10.1016/j.exer.2014.07.014_bib216 article-title: Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure publication-title: J. Clin. Invest – volume: 14 start-page: 617 year: 2002 ident: 10.1016/j.exer.2014.07.014_bib219 article-title: Versican: a versatile extracellular matrix proteoglycan in cell biology publication-title: Curr. Opin. Cell. Biol. doi: 10.1016/S0955-0674(02)00375-7 – volume: 18 start-page: 91 year: 1999 ident: 10.1016/j.exer.2014.07.014_bib132 article-title: Functional morphology of the trabecular meshwork in primate eyes publication-title: Prog. Retin Eye Res. doi: 10.1016/S1350-9462(98)00011-1 – volume: 103 start-page: 148 year: 2005 ident: 10.1016/j.exer.2014.07.014_bib7 article-title: Interactions between endothelia of the trabecular meshwork and of Schlemm's canal: a new insight into the regulation of aqueous outflow in the eye publication-title: Trans. Am. Ophthalmol. Soc. – volume: 42 start-page: 1795 year: 2001 ident: 10.1016/j.exer.2014.07.014_bib43 article-title: Cationic ferritin changes outflow facility in human eyes whereas anionic ferritin does not publication-title: Invest Ophthalmol. Vis. Sci. – volume: 54 start-page: 7836 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib215 article-title: Anti-connective tissue growth factor antibody treatment reduces extracellular matrix production in trabecular meshwork and lamina cribrosa cells publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.13-12494 – volume: 83 start-page: 3 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib162 article-title: Cross talk between focal adhesion kinase and cadherins: role in regulating endothelial barrier function publication-title: Microvasc. Res. doi: 10.1016/j.mvr.2011.08.001 – volume: 42 start-page: 1505 year: 2001 ident: 10.1016/j.exer.2014.07.014_bib21 article-title: Effects of mechanical stretching on trabecular matrix metalloproteinases publication-title: Invest Ophthalmol. Vis. Sci. – volume: 298 start-page: C749 year: 2010 ident: 10.1016/j.exer.2014.07.014_bib157 article-title: Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells publication-title: Am. J. Physiol. Cell. Physiol. doi: 10.1152/ajpcell.00317.2009 – volume: 19 start-page: 759 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib207 article-title: Mutation in collagen II alpha 1 isoforms delineates Stickler and Wagner syndrome phenotypes publication-title: Mol. Vis. – volume: 51 start-page: 3029 year: 2010 ident: 10.1016/j.exer.2014.07.014_bib192 article-title: Development of a gene therapy virus with a glucocorticoid-inducible MMP1 for the treatment of steroid glaucoma publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.09-4918 – volume: 31 start-page: 193 year: 2010 ident: 10.1016/j.exer.2014.07.014_bib10 article-title: A case report of a patient with Pfeiffer syndrome, an FGRF 2 mutation (Trp290Cys) and unique ocular anterior segment findings publication-title: Ophthalmic Genet. doi: 10.3109/13816810.2010.505225 – volume: 88 start-page: 648 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib198 article-title: The trabecular meshwork outflow pathways: structural and functional aspects publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2009.02.007 – volume: 47 start-page: 3565 year: 2006 ident: 10.1016/j.exer.2014.07.014_bib147 article-title: Erosive vitreoretinopathy and wagner disease are caused by intronic mutations in CSPG2/Versican that result in an imbalance of splice variants publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.06-0141 – volume: 18 start-page: 3969 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib148 article-title: Loss of function mutations in the gene encoding latent transforming growth factor beta binding protein 2, LTBP2, cause primary congenital glaucoma publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddp338 – volume: 12 start-page: 194 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib35 article-title: Comparative genomic and proteomic analysis of cytoskeletal changes in dexamethasone-treated trabecular meshwork cells publication-title: Mol. Cell. Proteomics doi: 10.1074/mcp.M112.019745 – volume: 83 start-page: 297 year: 2006 ident: 10.1016/j.exer.2014.07.014_bib103 article-title: A mouse model for Stickler's syndrome: ocular phenotype of mice carrying a targeted heterozygous inactivation of type II (pro)collagen gene (Col2a1) publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2005.11.027 – volume: 18 start-page: 44 year: 1979 ident: 10.1016/j.exer.2014.07.014_bib101 article-title: Pressure-dependent changes in nuclei and the process origins of the endothelial cells lining Schlemm's canal publication-title: Invest Ophthalmol. Vis. Sci. – volume: 48 start-page: 1164 year: 2007 ident: 10.1016/j.exer.2014.07.014_bib111 article-title: Extracellular matrix gene alternative splicing by trabecular meshwork cells in response to mechanical stretching publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.06-0875 – volume: 3 start-page: 299 year: 1993 ident: 10.1016/j.exer.2014.07.014_bib140 article-title: A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells publication-title: Nat. Genet. doi: 10.1038/ng0493-299 – volume: 2 start-page: 18 year: 2001 ident: 10.1016/j.exer.2014.07.014_bib31 article-title: Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure publication-title: BMC Genet. doi: 10.1186/1471-2156-2-18 – volume: 84 start-page: 664 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib6 article-title: Null mutations in LTBP2 cause primary congenital glaucoma publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2009.03.017 – volume: 39 start-page: 2041 year: 1998 ident: 10.1016/j.exer.2014.07.014_bib44 article-title: Two pore types in the inner-wall endothelium of Schlemm's canal publication-title: Invest Ophthalmol. Vis. Sci. – volume: 43 start-page: 1068 year: 2002 ident: 10.1016/j.exer.2014.07.014_bib210 article-title: Distribution of myocilin and extracellular matrix components in the juxtacanalicular tissue of human eyes publication-title: Invest Ophthalmol. Vis. Sci. – volume: 30 start-page: 202 year: 2014 ident: 10.1016/j.exer.2014.07.014_bib17 article-title: The effects of myocilin expression on functionally relevant trabecular meshwork genes: a mini-review publication-title: J. Ocul. Pharmacol. Ther. doi: 10.1089/jop.2013.0218 – volume: 123 start-page: 3006 year: 2010 ident: 10.1016/j.exer.2014.07.014_bib139 article-title: Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta publication-title: J. Cell. Sci. doi: 10.1242/jcs.073437 – volume: 317 start-page: 1397 year: 2007 ident: 10.1016/j.exer.2014.07.014_bib204 article-title: Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma publication-title: Science doi: 10.1126/science.1146554 – volume: 54 start-page: 1636 year: 2007 ident: 10.1016/j.exer.2014.07.014_bib156 article-title: MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.12-11107 – volume: 50 start-page: 5769 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib108 article-title: Differential effects of ADAMTS-1, -4, and -5 in the trabecular meshwork publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.09-3673 – volume: 233 start-page: 291 year: 1995 ident: 10.1016/j.exer.2014.07.014_bib202 article-title: Integrins in human anterior chamber angle publication-title: Graefes Arch. Clin. Exp. Ophthalmol. doi: 10.1007/BF00177651 – volume: 59 start-page: 723 year: 1994 ident: 10.1016/j.exer.2014.07.014_bib209 article-title: Aqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2 publication-title: Exp. Eye Res. doi: 10.1006/exer.1994.1158 – volume: 25 start-page: 1389 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib189 article-title: Stickler syndrome, ocular-only variants and a key diagnostic role for the ophthalmologist publication-title: Eye (Lond) doi: 10.1038/eye.2011.201 – volume: 40 start-page: 379 year: 1996 ident: 10.1016/j.exer.2014.07.014_bib225 article-title: The extracellular matrix and its modulation in the trabecular meshwork publication-title: Surv. Ophthalmol. doi: 10.1016/S0039-6257(96)80066-X – volume: 55 start-page: 3804 year: 2014 ident: 10.1016/j.exer.2014.07.014_bib242 article-title: Low tension glaucoma in microfibril deficient mice publication-title: IOVS ARVO E-abstract – volume: 18 start-page: 761 year: 2010 ident: 10.1016/j.exer.2014.07.014_bib39 article-title: LTBP2 null mutations in an autosomal recessive ocular syndrome with megalocornea, spherophakia, and secondary glaucoma publication-title: Eur. J. Hum. Genet. doi: 10.1038/ejhg.2010.11 – volume: 44 start-page: 1142 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib212 article-title: Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma publication-title: Nat. Genet. doi: 10.1038/ng.2390 – volume: 55 start-page: 856 year: 2014 ident: 10.1016/j.exer.2014.07.014_bib218 article-title: Disruption of the blood-aqueous barrier and lens abnormalities in mice lacking lysyl oxidase-like 1 (LOXL1) publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.13-13033 – volume: 88 start-page: 689 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib47 article-title: Functional properties of fibronectin in the trabecular meshwork publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2008.08.019 – volume: 37 start-page: 795 year: 1996 ident: 10.1016/j.exer.2014.07.014_bib153 article-title: Laser trabeculoplasty induces stromelysin expression by trabecular juxtacanalicular cells publication-title: Invest Ophthalmol. Vis. Sci. – volume: 41 start-page: 619 year: 2000 ident: 10.1016/j.exer.2014.07.014_bib206 article-title: Cytoskeletal involvement in the regulation of aqueous humor outflow publication-title: Invest Ophthalmol. Vis. Sci. – volume: 192 start-page: 89 year: 1974 ident: 10.1016/j.exer.2014.07.014_bib74 article-title: Junctions between the cells of the trabecular meshwork publication-title: Albrecht. Von. Graefes Arch. Klin. Exp. Ophthalmol. doi: 10.1007/BF00410696 – volume: 7 start-page: e1001306 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib123 article-title: Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1001306 – volume: 47 start-page: 1956 year: 2006 ident: 10.1016/j.exer.2014.07.014_bib52 article-title: Beta1 and beta3 integrins cooperate to induce syndecan-4-containing cross-linked actin networks in human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.05-0626 – volume: 26 start-page: 374 year: 2004 ident: 10.1016/j.exer.2014.07.014_bib36 article-title: Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseases publication-title: Bioessays doi: 10.1002/bies.20009 – volume: 86 start-page: 543 year: 2008 ident: 10.1016/j.exer.2014.07.014_bib2 article-title: Extracellular matrix in the trabecular meshwork publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2008.01.013 – volume: 37 start-page: 2414 year: 1996 ident: 10.1016/j.exer.2014.07.014_bib119 article-title: Glycosaminoglycan stratification of the juxtacanalicular tissue in normal and primary open-angle glaucoma publication-title: Invest Ophthalmol. Vis. Sci. – volume: 18 start-page: 629 year: 1999 ident: 10.1016/j.exer.2014.07.014_bib221 article-title: Effects of glucocorticoids on the trabecular meshwork: towards a better understanding of glaucoma publication-title: Prog. Retin Eye Res. doi: 10.1016/S1350-9462(98)00035-4 – volume: 88 start-page: 704 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib167 article-title: Glaucoma-associated myocilin: a better understanding but much more to learn publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2008.08.011 – volume: 50 start-page: 1692 year: 2009 ident: 10.1016/j.exer.2014.07.014_bib82 article-title: Preferential fluid flow in the human trabecular meshwork near collector channels publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.08-2375 – start-page: 89 year: 1996 ident: 10.1016/j.exer.2014.07.014_bib136 article-title: Morphology of aqueous outflow pathways in Normal and glaucomatous eyes – volume: 56 start-page: 50 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib197 article-title: Concurrent deletion of BMP4 and OTX2 genes, two master genes in ophthalmogenesis publication-title: Eur. J. Med. Genet. doi: 10.1016/j.ejmg.2012.10.007 – volume: 49 start-page: 5346 year: 2008 ident: 10.1016/j.exer.2014.07.014_bib11 article-title: Reduction of the available area for aqueous humor outflow and increase in meshwork herniations into collector channels following acute IOP elevation in bovine eyes publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.08-1707 – volume: 39 start-page: 2649 year: 1998 ident: 10.1016/j.exer.2014.07.014_bib22 article-title: Effect of matrix metalloproteinases activity on outflow in perfused human organ culture publication-title: Invest Ophthalmol. Vis. Sci. – volume: 16 start-page: 798 year: 2007 ident: 10.1016/j.exer.2014.07.014_bib71 article-title: Col4a1 mutation causes endoplasmic reticulum stress and genetically modifiable ocular dysgenesis publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddm024 – volume: 35 start-page: 281 year: 1994 ident: 10.1016/j.exer.2014.07.014_bib34 article-title: Glucocorticoid-induced formation of cross-linked actin networks in cultured human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. – start-page: 213 year: 1996 ident: 10.1016/j.exer.2014.07.014_bib86 article-title: Extracellular matrix of the trabecular meshwork and optic nerve head – volume: 55 start-page: 814 year: 2014 ident: 10.1016/j.exer.2014.07.014_bib30 article-title: Circumferential tensile stiffness of glaucomatous trabecular meshwork publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.13-13091 – volume: 107 start-page: 583 year: 1989 ident: 10.1016/j.exer.2014.07.014_bib208 article-title: Neural crest origin of human trabecular meshwork and its implications for the pathogenesis of glaucoma publication-title: Am. J. Ophthalmol. doi: 10.1016/0002-9394(89)90253-5 – volume: 52 start-page: 5049 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib110 article-title: Segmental versican expression in the trabecular meshwork and involvement in outflow facility publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.10-6948 – volume: 19 start-page: 684 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib170 article-title: Altered expression of transforming growth factor beta 1 and matrix metalloproteinase-9 results in elevated intraocular pressure in mice publication-title: Mol. Vis. – volume: 7 start-page: e34309 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib65 article-title: Cochlin, intraocular pressure regulation and mechanosensing publication-title: PLoS One doi: 10.1371/journal.pone.0034309 – volume: 33 start-page: 1670 year: 1992 ident: 10.1016/j.exer.2014.07.014_bib100 article-title: Modulation of outflow resistance by the pores of the inner wall endothelium publication-title: Invest Ophthalmol. Vis. Sci. – volume: 110 start-page: 110 year: 1992 ident: 10.1016/j.exer.2014.07.014_bib177 article-title: Effects of intracameral injection of chondroitinase ABC in vivo publication-title: Arch. Ophthalmol. doi: 10.1001/archopht.1992.01080130112037 – volume: 52 start-page: 2889 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib80 article-title: Elasticity-dependent modulation of TGF-beta responses in human trabecular meshwork cells publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.10-6640 – volume: 2012 start-page: 692609 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib19 article-title: Animal models of glaucoma publication-title: J. Biomed. Biotechnol. – volume: 84 start-page: 167 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib217 article-title: Variations in COL15A1 and COL18A1 influence age of onset of primary open angle glaucoma publication-title: Clin. Genet. doi: 10.1111/cge.12176 – volume: 52 start-page: 1865 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib128 article-title: Outflow physiology of the mouse eye: pressure dependence and washout publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.10-6019 – volume: 53 start-page: 767 year: 1992 ident: 10.1016/j.exer.2014.07.014_bib77 article-title: Effect of hyaluronidase on aqueous outflow resistance in normotensive and glaucomatous eyes of dogs publication-title: Am. J. Vet. Res. doi: 10.2460/ajvr.1992.53.05.767 – volume: 16 start-page: 757 year: 2005 ident: 10.1016/j.exer.2014.07.014_bib190 article-title: Fibronectin matrix turnover occurs through a caveolin-1-dependent process publication-title: Mol. Biol. Cell. doi: 10.1091/mbc.E04-08-0672 – volume: 25 start-page: 286 year: 1984 ident: 10.1016/j.exer.2014.07.014_bib118 article-title: Exogenous hyaluronidases and degradation of hyaluronic acid in the rabbit eye publication-title: Invest Ophthalmol. Vis. Sci. – volume: 119 start-page: 1832 year: 2012 ident: 10.1016/j.exer.2014.07.014_bib178 article-title: LOXL1 deficiency in the lamina cribrosa as candidate susceptibility factor for a pseudoexfoliation-specific risk of glaucoma publication-title: Ophthalmology doi: 10.1016/j.ophtha.2012.03.015 – volume: 41 start-page: 422 year: 2000 ident: 10.1016/j.exer.2014.07.014_bib20 article-title: Mediation of laser trabeculoplasty-induced matrix metalloproteinase expression by IL-1beta and TNFalpha publication-title: Invest Ophthalmol. Vis. Sci. – volume: 115 start-page: 1 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib146 article-title: What do mechanotransduction, Hippo, Wnt, and TGFbeta have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2013.06.012 – volume: 54 start-page: 2035 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib196 article-title: Secreted protein acidic and rich in cysteine (SPARC)-null mice exhibit more uniform outflow publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.12-10950 – volume: 54 start-page: 378 year: 2013 ident: 10.1016/j.exer.2014.07.014_bib163 article-title: Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.12-11007 – volume: 52 start-page: 9438 year: 2011 ident: 10.1016/j.exer.2014.07.014_bib194 article-title: eNOS, a pressure-dependent regulator of intraocular pressure publication-title: Invest Ophthalmol. Vis. Sci. doi: 10.1167/iovs.11-7839 – volume: 21 start-page: 563 year: 1981 ident: 10.1016/j.exer.2014.07.014_bib134 article-title: Ultrahistochemical studies on tangential sections of the trabecular meshwork in normal and glaucomatous eyes publication-title: Invest. Ophthalmol. Vis. Sci. – reference: 20835238 - Nat Genet. 2010 Oct;42(10):906-9 – reference: 19553617 - Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5769-77 – reference: 21642622 - Invest Ophthalmol Vis Sci. 2011 Jul;52(8):5251-9 – reference: 22496787 - PLoS One. 2012;7(4):e34309 – reference: 18172101 - Invest Ophthalmol Vis Sci. 2008 Jan;49(1):262-9 – reference: 24194636 - Mol Vis. 2013;19:2151-64 – reference: 16403239 - J Biol. 2005;4(3):11 – reference: 22695958 - Invest Ophthalmol Vis Sci. 2012;53(8):4616-25 – reference: 3197758 - Exp Eye Res. 1988 Jun;46(6):881-95 – reference: 19940066 - Am J Physiol Cell Physiol. 2010 Mar;298(3):C749-63 – reference: 18436825 - Invest Ophthalmol Vis Sci. 2008 May;49(5):1932-9 – reference: 15579465 - J Biol Chem. 2005 Feb 18;280(7):6080-4 – reference: 12719994 - Graefes Arch Clin Exp Ophthalmol. 2003 Apr;241(4):321-6 – reference: 12231358 - Curr Opin Cell Biol. 2002 Oct;14(5):617-23 – reference: 21264055 - Mol Vis. 2011;17:199-209 – reference: 21546528 - Invest Ophthalmol Vis Sci. 2011 Jul;52(8):5240-50 – reference: 2612196 - Curr Eye Res. 1989 Oct;8(10):1071-82 – reference: 20089869 - Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3042-8 – reference: 22529935 - PLoS One. 2012;7(4):e34792 – reference: 15623746 - Invest Ophthalmol Vis Sci. 2005 Jan;46(1):1-7 – reference: 18515587 - Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2495-505 – reference: 19959644 - Invest Ophthalmol Vis Sci. 2010 Apr;51(4):2067-76 – reference: 18313051 - Exp Eye Res. 2008 Apr;86(4):543-61 – reference: 20809772 - Ophthalmic Genet. 2010 Dec;31(4):193-5 – reference: 17251470 - Invest Ophthalmol Vis Sci. 2007 Feb;48(2):715-26 – reference: 1524304 - Am J Vet Res. 1992 May;53(5):767-70 – reference: 11722794 - BMC Genet. 2001;2:18 – reference: 18515571 - Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5346-52 – reference: 15944158 - J Biol Chem. 2005 Aug 12;280(32):28917-26 – reference: 15281095 - J Cell Physiol. 2004 Oct;201(1):126-37 – reference: 21921955 - Eye (Lond). 2011 Nov;25(11):1389-400 – reference: 15563605 - Mol Biol Cell. 2005 Feb;16(2):757-68 – reference: 2705927 - Arch Ophthalmol. 1989 Apr;107(4):572-6 – reference: 18799648 - Am J Physiol Cell Physiol. 2008 Nov;295(5):C1057-70 – reference: 24367514 - PLoS One. 2013;8(12):e82301 – reference: 21907015 - Am J Hum Genet. 2011 Sep 9;89(3):464-73 – reference: 16877430 - Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3565-72 – reference: 17057799 - Trans Am Ophthalmol Soc. 2005;103:148-62; discussion 162-3 – reference: 19239914 - Exp Eye Res. 2009 Apr;88(4):648-55 – reference: 15978248 - Exp Eye Res. 2005 Jul;81(1):1-4 – reference: 22923731 - J Biochem. 2012 Oct;152(4):321-9 – reference: 18274669 - J Clin Invest. 2008 Mar;118(3):1056-64 – reference: 17914434 - Eye (Lond). 2007 Oct;21(10):1310-8 – reference: 22633114 - Ophthalmology. 2012 Sep;119(9):1832-43 – reference: 10438153 - Prog Retin Eye Res. 1999 Sep;18(5):629-67 – reference: 19103197 - Exp Eye Res. 2009 Apr;88(4):656-70 – reference: 2729407 - Am J Ophthalmol. 1989 Jun 15;107(6):583-90 – reference: 10670472 - Invest Ophthalmol Vis Sci. 2000 Feb;41(2):422-30 – reference: 15057935 - Bioessays. 2004 Apr;26(4):374-86 – reference: 24901502 - J Ocul Pharmacol Ther. 2014 Aug;30(6):447-63 – reference: 16384965 - Invest Ophthalmol Vis Sci. 2006 Jan;47(1):213-21 – reference: 17690259 - Science. 2007 Sep 7;317(5843):1397-400 – reference: 4140699 - Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1974;192(2):89-104 – reference: 12658549 - Curr Eye Res. 2002 Nov;25(5):299-308 – reference: 12162724 - J Anat. 2002 Jun;200(6):561-74 – reference: 20179738 - Eur J Hum Genet. 2010 Jul;18(7):761-7 – reference: 18235008 - Invest Ophthalmol Vis Sci. 2008 Feb;49(2):629-35 – reference: 22562852 - Invest Ophthalmol Vis Sci. 2012 May;53(5):2506-10 – reference: 8652890 - Microsc Res Tech. 1996 Mar 1;33(4):336-67 – reference: 23844232 - PLoS One. 2013;8(7):e68668 – reference: 24517218 - J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):154-62 – reference: 24204045 - Invest Ophthalmol Vis Sci. 2013 Dec;54(13):7836-48 – reference: 17460268 - Invest Ophthalmol Vis Sci. 2007 May;48(5):2105-14 – reference: 17317786 - Hum Mol Genet. 2007 Apr 1;16(7):798-807 – reference: 18804106 - Exp Eye Res. 2009 Apr;88(4):704-12 – reference: 16505009 - Invest Ophthalmol Vis Sci. 2006 Mar;47(3):794-801 – reference: 7287347 - Invest Ophthalmol Vis Sci. 1981 Oct;21(4):574-85 – reference: 12484701 - Cornea. 2002 Oct;21(7 Suppl):S62-9 – reference: 24266581 - J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):110-20 – reference: 21864544 - Microvasc Res. 2012 Jan;83(1):3-11 – reference: 3583633 - Invest Ophthalmol Vis Sci. 1987 Jun;28(6):945-53 – reference: 16639003 - Invest Ophthalmol Vis Sci. 2006 May;47(5):1956-67 – reference: 9856774 - Invest Ophthalmol Vis Sci. 1998 Dec;39(13):2649-58 – reference: 19656777 - Hum Mol Genet. 2009 Oct 15;18(20):3969-77 – reference: 19060275 - Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1692-7 – reference: 24364042 - J Ocul Biol. 2013 Jun;1(1):3 – reference: 15456875 - Mol Cell Biol. 2004 Oct;24(20):9019-25 – reference: 23258147 - Invest Ophthalmol Vis Sci. 2013 Jan;54(1):378-86 – reference: 22247475 - Invest Ophthalmol Vis Sci. 2012 Feb;53(2):952-8 – reference: 12742391 - Prog Retin Eye Res. 2003 Jul;22(4):435-63 – reference: 1855546 - Exp Eye Res. 1991 Jun;52(6):723-31 – reference: 1748546 - Invest Ophthalmol Vis Sci. 1991 Dec;32(13):3145-66 – reference: 16386733 - Exp Eye Res. 2006 Apr;82(4):545-57 – reference: 18385063 - Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1459-63 – reference: 4633234 - Am J Ophthalmol. 1973 Mar;75(3):365-83 – reference: 19087875 - Exp Eye Res. 2009 Apr;88(4):676-82 – reference: 11600941 - Curr Eye Res. 2001 May;22(5):394-7 – reference: 16249499 - Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4200-8 – reference: 6698747 - Invest Ophthalmol Vis Sci. 1984 Mar;25(3):286-93 – reference: 19920491 - J Glaucoma. 1993 Summer;2(2):80-6 – reference: 19114037 - Exp Eye Res. 2009 Apr;88(4):769-75 – reference: 21743018 - Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6443-51 – reference: 2211012 - Invest Ophthalmol Vis Sci. 1990 Oct;31(10):2156-63 – reference: 22922875 - Nat Genet. 2012 Oct;44(10):1142-6 – reference: 12015278 - Hum Mol Genet. 2002 May 15;11(10):1185-93 – reference: 8062820 - EMBO J. 1994 Aug 1;13(15):3438-47 – reference: 18339631 - J Biol Chem. 2008 May 16;283(20):13874-88 – reference: 9268586 - Exp Eye Res. 1997 Aug;65(2):177-90 – reference: 19182256 - Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2796-801 – reference: 18835267 - Exp Eye Res. 2009 Apr;88(4):689-93 – reference: 7698265 - Exp Eye Res. 1994 Dec;59(6):723-7 – reference: 19385040 - Exp Eye Res. 2009 Apr;88(4):683-8 – reference: 22262082 - Curr Opin Ophthalmol. 2012 Mar;23(2):135-43 – reference: 12105189 - J Cell Biol. 2002 Jul 8;158(1):175-84 – reference: 7622078 - Graefes Arch Clin Exp Ophthalmol. 1995 May;233(5):291-5 – reference: 21669200 - Exp Eye Res. 2011 Oct;93(4):397-404 – reference: 2920781 - Exp Eye Res. 1989 Jan;48(1):139-47 – reference: 4983461 - Invest Ophthalmol. 1970 Jan;9(1):42-52 – reference: 24521159 - J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):170-80 – reference: 10793060 - Am J Pathol. 2000 May;156(5):1489-98 – reference: 11604506 - Mol Cell Biol. 2001 Nov;21(22):7707-13 – reference: 23792172 - Exp Eye Res. 2013 Oct;115:1-12 – reference: 15183101 - Exp Eye Res. 2004 Jul;79(1):61-74 – reference: 11950226 - Exp Eye Res. 2002 Feb;74(2):161-72 – reference: 20574017 - Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5768-75 – reference: 22914737 - Hum Mol Genet. 2012 Oct 15;21(R1):R97-110 – reference: 21139683 - Mol Vis. 2010;16:2185-91 – reference: 17516541 - J Cell Physiol. 2007 Dec;213(3):775-84 – reference: 11381054 - Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1505-13 – reference: 24611521 - J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):291-9 – reference: 23559862 - Mol Vis. 2013;19:684-95 – reference: 22210126 - Exp Eye Res. 2012 Mar;96(1):82-7 – reference: 18155193 - Exp Eye Res. 2008 Feb;86(2):271-81 – reference: 21402694 - J Biol Chem. 2011 May 13;286(19):17156-67 – reference: 22701298 - Mol Vis. 2012;18:1093-106 – reference: 24401029 - J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):94-101 – reference: 14691167 - Invest Ophthalmol Vis Sci. 2004 Jan;45(1):153-8 – reference: 18386038 - Graefes Arch Clin Exp Ophthalmol. 2008 Jul;246(7):1021-8 – reference: 22101332 - Cell Tissue Res. 2012 Jan;347(1):279-90 – reference: 24318513 - J Cell Physiol. 2014 Jul;229(7):927-42 – reference: 9920500 - Prog Retin Eye Res. 1999 Jan;18(1):91-119 – reference: 10520215 - Curr Eye Res. 1999 Nov;19(5):395-402 – reference: 21421911 - Cold Spring Harb Perspect Biol. 2011 Jan;3(1):a004978 – reference: 19432485 - J Proteome Res. 2009 Jul;8(7):3727-36 – reference: 19361779 - Am J Hum Genet. 2009 May;84(5):664-71 – reference: 23401661 - Mol Vis. 2013;19:333-47 – reference: 21220554 - Invest Ophthalmol Vis Sci. 2011 Apr;52(5):2187-93 – reference: 2338123 - Exp Eye Res. 1990 Apr;50(4):407-18 – reference: 23103883 - Eur J Med Genet. 2013 Jan;56(1):50-3 – reference: 24425853 - Invest Ophthalmol Vis Sci. 2014 Feb;55(2):856-64 – reference: 24176900 - Invest Ophthalmol Vis Sci. 2013 Dec;54(13):7903-9 – reference: 19836009 - Am J Hum Genet. 2009 Nov;85(5):558-68 – reference: 15161848 - Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1841-5 – reference: 8300356 - Invest Ophthalmol Vis Sci. 1994 Jan;35(1):281-94 – reference: 168092 - Exp Eye Res. 1975 Jun;20(6):523-30 – reference: 16636652 - Mol Vis. 2006;12:350-5 – reference: 19525102 - Curr Opin Cell Biol. 2009 Oct;21(5):616-22 – reference: 21169533 - Invest Ophthalmol Vis Sci. 2011 Mar;52(3):1865-71 – reference: 21282571 - Invest Ophthalmol Vis Sci. 2011 May;52(6):2889-96 – reference: 12657595 - Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1581-5 – reference: 22930728 - Invest Ophthalmol Vis Sci. 2012;53(10):6708-17 – reference: 24564495 - J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):202-12 – reference: 17325160 - Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1164-72 – reference: 23105009 - Mol Cell Proteomics. 2013 Jan;12(1):194-206 – reference: 14578401 - Invest Ophthalmol Vis Sci. 2003 Nov;44(11):4796-804 – reference: 1731702 - Arch Ophthalmol. 1992 Jan;110(1):110-7 – reference: 11773009 - Invest Ophthalmol Vis Sci. 2002 Jan;43(1):33-40 – reference: 19168904 - Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3771-7 – reference: 21282189 - Hum Mol Genet. 2011 Apr 15;20(8):1610-24 – reference: 23592912 - Mol Vis. 2013;19:759-66 – reference: 1559767 - Invest Ophthalmol Vis Sci. 1992 Apr;33(5):1670-5 – reference: 8933758 - Invest Ophthalmol Vis Sci. 1996 Nov;37(12):2414-25 – reference: 15929982 - J Biol Chem. 2005 Jul 29;280(30):27970-80 – reference: 3891665 - Invest Ophthalmol Vis Sci. 1985 Jun;26(6):797-804 – reference: 23599341 - Invest Ophthalmol Vis Sci. 2013 May;54(5):3309-19 – reference: 20720231 - Invest Ophthalmol Vis Sci. 2011 Jan;52(1):45-50 – reference: 10711672 - Invest Ophthalmol Vis Sci. 2000 Mar;41(3):619-23 – reference: 16043844 - Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2726-35 – reference: 23321356 - Ocul Surf. 2013 Jan;11(1):19-24 – reference: 24572674 - Ophthalmology. 2014 Feb;121(2):508-16 – reference: 24408980 - Invest Ophthalmol Vis Sci. 2014 Feb;55(2):814-23 – reference: 21220561 - Invest Ophthalmol Vis Sci. 2011 Apr;52(5):2147-52 – reference: 19696167 - Invest Ophthalmol Vis Sci. 2010 Jan;51(1):308-18 – reference: 13158098 - Acta Physiol Scand. 1954;30(2-3):240-8 – reference: 23621901 - Clin Genet. 2013 Aug;84(2):167-74 – reference: 12525539 - J Med Genet. 2003 Jan;40(1):34-6 – reference: 21273548 - Invest Ophthalmol Vis Sci. 2011 May;52(6):2952-9 – reference: 19513754 - Cell Tissue Res. 2010 Jan;339(1):71-82 – reference: 11431444 - Invest Ophthalmol Vis Sci. 2001 Jul;42(8):1795-802 – reference: 4678226 - Acta Ophthalmol (Copenh). 1972;50(3):295-320 – reference: 21330667 - Invest Ophthalmol Vis Sci. 2011 May;52(6):3660-6 – reference: 14598350 - Am J Med Genet A. 2003 Dec 1;123A(2):204-7 – reference: 9761282 - Invest Ophthalmol Vis Sci. 1998 Oct;39(11):2041-8 – reference: 7287346 - Invest Ophthalmol Vis Sci. 1981 Oct;21(4):563-73 – reference: 1123284 - Invest Ophthalmol. 1975 Apr;14(4):286-92 – reference: 17317787 - Hum Mol Genet. 2007 Mar 15;16(6):609-17 – reference: 16546167 - Exp Eye Res. 2006 Aug;83(2):297-303 – reference: 3720863 - Exp Eye Res. 1986 May;42(5):443-55 – reference: 23977299 - PLoS One. 2013;8(8):e72447 – reference: 19578028 - Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5653-61 – reference: 23139787 - PLoS One. 2012;7(11):e48523 – reference: 23422826 - Invest Ophthalmol Vis Sci. 2013 Mar;54(3):2035-47 – reference: 22665989 - J Biomed Biotechnol. 2012;2012:692609 – reference: 16384967 - Invest Ophthalmol Vis Sci. 2006 Jan;47(1):226-34 – reference: 11068187 - Biochim Biophys Acta. 2000 Nov 15;1502(3):447-60 – reference: 21512158 - Am J Physiol Gastrointest Liver Physiol. 2011 Dec;301(6):G950-5 – reference: 20089870 - Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3029-41 – reference: 23882691 - Invest Ophthalmol Vis Sci. 2013;54(8):5613-23 – reference: 20861483 - Invest Ophthalmol Vis Sci. 2011 Feb;52(2):685-94 – reference: 23385799 - Invest Ophthalmol Vis Sci. 2013 Mar;54(3):1636-49 – reference: 21747927 - PLoS One. 2011;6(7):e20110 – reference: 103860 - Invest Ophthalmol Vis Sci. 1979 Jan;18(1):44-51 – reference: 19643963 - Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5723-31 – reference: 23821199 - Invest Ophthalmol Vis Sci. 2013 Aug;54(8):5441-55 – reference: 16043860 - Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2857-68 – reference: 20699357 - J Cell Sci. 2010 Sep 1;123(Pt 17):3006-18 – reference: 23444230 - Am J Med Genet A. 2013 Apr;161A(4):880-3 – reference: 7981749 - Nat Genet. 1993 Apr;3(4):299-304 – reference: 22039240 - Invest Ophthalmol Vis Sci. 2011;52(13):9438-44 – reference: 21135108 - J Biol Chem. 2011 Feb 18;286(7):5087-99 – reference: 11923248 - Invest Ophthalmol Vis Sci. 2002 Apr;43(4):1068-76 – reference: 22950452 - Ophthalmic Genet. 2013 Mar-Jun;34(1-2):21-6 – reference: 24433355 - Clin Experiment Ophthalmol. 2014 Jan-Feb;42(1):13-24 – reference: 16249490 - Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4130-8 – reference: 21340693 - Hum Genet. 2011 Oct;130(4):495-504 – reference: 9176894 - Ophthalmologica. 1997;211(3):140-6 – reference: 8603864 - Invest Ophthalmol Vis Sci. 1996 Apr;37(5):795-804 – reference: 103456 - Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978 Nov 8;208(1-3):33-47 – reference: 8779084 - Surv Ophthalmol. 1996 Mar-Apr;40(5):379-90 – reference: 18974306 - Am J Pathol. 2008 Dec;173(6):1724-35 – reference: 19509472 - J Clin Invest. 2009 Jul;119(7):1997-2008 – reference: 22876116 - Mol Vis. 2012;18:1918-26 – reference: 21379321 - PLoS Genet. 2011 Feb;7(2):e1001306 – reference: 12384097 - Exp Eye Res. 2002 Sep;75(3):347-58 – reference: 21596823 - Invest Ophthalmol Vis Sci. 2011 Jul;52(8):5049-57 – reference: 17325163 - Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1191-200 |
| SSID | ssj0003474 |
| Score | 2.5825744 |
| SecondaryResourceType | review_article |
| Snippet | The trabecular meshwork (TM) is located in the anterior segment of the eye and is responsible for regulating the outflow of aqueous humor. Increased resistance... |
| SourceID | pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 112 |
| SubjectTerms | animal models Animals Aqueous Humor - physiology extracellular matrix Extracellular Matrix - physiology gene mutations glaucoma Glaucoma - metabolism Glaucoma - physiopathology Humans intraocular pressure Intraocular Pressure - physiology perfusion culture trabecular meshwork Trabecular Meshwork - physiology |
| Title | Extracellular matrix in the trabecular meshwork: Intraocular pressure regulation and dysregulation in glaucoma |
| URI | https://dx.doi.org/10.1016/j.exer.2014.07.014 https://www.ncbi.nlm.nih.gov/pubmed/25819459 https://www.proquest.com/docview/1682209332 https://pubmed.ncbi.nlm.nih.gov/PMC4379427 |
| Volume | 133 |
| WOSCitedRecordID | wos000352824600011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1096-0007 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0003474 issn: 0014-4835 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1db9MwFLW6DiFeEGwwysdkJLSXKVMTx0nNW4U6AeoKDx3qm5U4jtapTUs_pvZX8Je5N3bSZINpPPCSVk7iWL0nt9fXx_cQ8iHxAsXipO3EXAjHZ1HqCB4yJ9CCQZOf8jyn-6MfDgad0Uh8bzR-FXthbiZhlnU2GzH_r6aGNjA2bp39B3OXnUIDfAejwxHMDscHGb63WS0izMfnBNMpluDfFGxGOBMbNdzTqV5eISkLUwJjzPDOTHtOjMVVhYVRqS_oysl2WWmB_iDuXsP4o1puv6oXoLfYSSVbhrpeqBFv6bkZ-KjTisef2PT5RU7kK5GoLKVkiKFx7eqCDqLtdgqbvHB5hfNi_G0bOdBtI3x7pv_QVjhpxipu1jXU6zvu32Qirs9Qrgppe35emNXsUq3X2h58k-eX_b4c9kbDk_lPB2XIcLnearLskX0vBPQ2yX73S2_0tfxzZ35e2Lsco92HZSiDtx_7t1jn7lzmNiW3EuMMn5GndnJCuwZUz0lDZwfksJtFq9l0S09oThfO12EOyOMLy8o4JFkNctRAjo4zCpCjO8jRAnIfaQVwtAAc3cGLAuBoDXDYWwG4F-TyvDf89NmxOh6OQrkMR6UijeIkCphSELBqP3HjwNc6iuPQD2DCG4k4Drw0hdmydnmQpkwxngacdyIeCcZekmY2y_QrQqNOqMJ2nEAUjoWOlBCJ4oHgnlK-6KikRdziF5fKFrlHrZWJLNiM1xKtJNFKsh1K-GiR0_KeuSnxcu_VvDCktEGqCT4lgPDe-94XVpfgwdEmUaZn66V0AwjSMbHotciRQUE5Do9DxO5z0SJhDR_lBVgdvn4mG1_lVeKx0Kjvha8f8Nw35Mnu5XxLmqvFWr8jj9TNarxcHJO9cNQ5ti_Cb1mE4Sk |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Extracellular+matrix+in+the+trabecular+meshwork%3A+intraocular+pressure+regulation+and+dysregulation+in+glaucoma&rft.jtitle=Experimental+eye+research&rft.au=Vranka%2C+Janice+A&rft.au=Kelley%2C+Mary+J&rft.au=Acott%2C+Ted+S&rft.au=Keller%2C+Kate+E&rft.date=2015-04-01&rft.issn=1096-0007&rft.eissn=1096-0007&rft.volume=133&rft.spage=112&rft_id=info:doi/10.1016%2Fj.exer.2014.07.014&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0014-4835&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0014-4835&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0014-4835&client=summon |