Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups

Because polygenic risk scores (PRSs) for coronary heart disease (CHD) are derived from mainly European ancestry (EA) cohorts, their validity in African ancestry (AA) and Hispanic ethnicity (HE) individuals is unclear. We investigated associations of "restricted" and genome-wide PRSs with C...

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Veröffentlicht in:	American journal of human genetics Jg. 106; H. 5; S. 707
Hauptverfasser:	Dikilitas, Ozan, Schaid, Daniel J, Kosel, Matthew L, Carroll, Robert J, Chute, Christopher G, Denny, Joshua A, Fedotov, Alex, Feng, QiPing, Hakonarson, Hakon, Jarvik, Gail P, Lee, Ming Ta Michael, Pacheco, Jennifer A, Rowley, Robb, Sleiman, Patrick M, Stein, C Michael, Sturm, Amy C, Wei, Wei-Qi, Wiesner, Georgia L, Williams, Marc S, Zhang, Yanfei, Manolio, Teri A, Kullo, Iftikhar J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 07.05.2020
Schlagworte:	coronary artery disease risk prediction hispanic ischemic heart disease coronary heart disease multiethnic genome-wide polygenic score African American polygenic risk scores
ISSN:	1537-6605, 1537-6605
Online-Zugang:	Weitere Angaben
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