Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups

Because polygenic risk scores (PRSs) for coronary heart disease (CHD) are derived from mainly European ancestry (EA) cohorts, their validity in African ancestry (AA) and Hispanic ethnicity (HE) individuals is unclear. We investigated associations of "restricted" and genome-wide PRSs with C...

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Vydáno v:	American journal of human genetics Ročník 106; číslo 5; s. 707
Hlavní autoři:	Dikilitas, Ozan, Schaid, Daniel J, Kosel, Matthew L, Carroll, Robert J, Chute, Christopher G, Denny, Joshua A, Fedotov, Alex, Feng, QiPing, Hakonarson, Hakon, Jarvik, Gail P, Lee, Ming Ta Michael, Pacheco, Jennifer A, Rowley, Robb, Sleiman, Patrick M, Stein, C Michael, Sturm, Amy C, Wei, Wei-Qi, Wiesner, Georgia L, Williams, Marc S, Zhang, Yanfei, Manolio, Teri A, Kullo, Iftikhar J
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 07.05.2020
Témata:	coronary artery disease risk prediction hispanic ischemic heart disease coronary heart disease multiethnic genome-wide polygenic score African American polygenic risk scores
ISSN:	1537-6605, 1537-6605
On-line přístup:	Zjistit podrobnosti o přístupu
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