Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups

Because polygenic risk scores (PRSs) for coronary heart disease (CHD) are derived from mainly European ancestry (EA) cohorts, their validity in African ancestry (AA) and Hispanic ethnicity (HE) individuals is unclear. We investigated associations of "restricted" and genome-wide PRSs with C...

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Bibliographic Details

Published in:	American journal of human genetics Vol. 106; no. 5; p. 707
Main Authors:	Dikilitas, Ozan, Schaid, Daniel J, Kosel, Matthew L, Carroll, Robert J, Chute, Christopher G, Denny, Joshua A, Fedotov, Alex, Feng, QiPing, Hakonarson, Hakon, Jarvik, Gail P, Lee, Ming Ta Michael, Pacheco, Jennifer A, Rowley, Robb, Sleiman, Patrick M, Stein, C Michael, Sturm, Amy C, Wei, Wei-Qi, Wiesner, Georgia L, Williams, Marc S, Zhang, Yanfei, Manolio, Teri A, Kullo, Iftikhar J
Format:	Journal Article
Language:	English
Published:	United States 07.05.2020
Subjects:	coronary artery disease risk prediction hispanic ischemic heart disease coronary heart disease multiethnic genome-wide polygenic score African American polygenic risk scores
ISSN:	1537-6605, 1537-6605
Online Access:	Get more information
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