Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms

Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Cell host & microbe Ročník 26; číslo 1; s. 15
Hlavní autori: Yan, Jing, Bassler, Bonnie L
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 10.07.2019
Predmet:
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Bacteria - growth & development
Biofilms - drug effects
Biofilms - growth & development
Drug Resistance, Bacterial
Drug Tolerance
Microbial Viability - drug effects
persistence
bacteria
antibiotic resistance
tolerance
biofilm
ISSN:1934-6069, 1934-6069
On-line prístup:Zistit podrobnosti o prístupe
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the mechanical features that drive biofilm resilience and the biofilm formation process at single-cell resolution. We discuss findings regarding mechanisms underlying bacterial tolerance and persistence in biofilms and how these phenotypes are linked to antibiotic resistance. New strategies for combatting tolerance and persistence in biofilms and possible methods for biofilm eradication are highlighted to inspire future development.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1934-6069
1934-6069
DOI:10.1016/j.chom.2019.06.002