Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms

Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at...

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Bibliographic Details
Published in:	Cell host & microbe Vol. 26; no. 1; p. 15
Main Authors:	Yan, Jing, Bassler, Bonnie L
Format:	Journal Article
Language:	English
Published:	United States 10.07.2019
Subjects:	Anti-Bacterial Agents - pharmacology Bacteria - drug effects Bacteria - growth & development Biofilms - drug effects Biofilms - growth & development Drug Resistance, Bacterial Drug Tolerance Microbial Viability - drug effects persistence bacteria antibiotic resistance tolerance biofilm
ISSN:	1934-6069, 1934-6069
Online Access:	Get more information
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Abstract	Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the mechanical features that drive biofilm resilience and the biofilm formation process at single-cell resolution. We discuss findings regarding mechanisms underlying bacterial tolerance and persistence in biofilms and how these phenotypes are linked to antibiotic resistance. New strategies for combatting tolerance and persistence in biofilms and possible methods for biofilm eradication are highlighted to inspire future development.
AbstractList	Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the mechanical features that drive biofilm resilience and the biofilm formation process at single-cell resolution. We discuss findings regarding mechanisms underlying bacterial tolerance and persistence in biofilms and how these phenotypes are linked to antibiotic resistance. New strategies for combatting tolerance and persistence in biofilms and possible methods for biofilm eradication are highlighted to inspire future development.Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the mechanical features that drive biofilm resilience and the biofilm formation process at single-cell resolution. We discuss findings regarding mechanisms underlying bacterial tolerance and persistence in biofilms and how these phenotypes are linked to antibiotic resistance. New strategies for combatting tolerance and persistence in biofilms and possible methods for biofilm eradication are highlighted to inspire future development. Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the mechanical features that drive biofilm resilience and the biofilm formation process at single-cell resolution. We discuss findings regarding mechanisms underlying bacterial tolerance and persistence in biofilms and how these phenotypes are linked to antibiotic resistance. New strategies for combatting tolerance and persistence in biofilms and possible methods for biofilm eradication are highlighted to inspire future development.
Author	Bassler, Bonnie L Yan, Jing
Author_xml	– sequence: 1 givenname: Jing surname: Yan fullname: Yan, Jing organization: Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA – sequence: 2 givenname: Bonnie L surname: Bassler fullname: Bassler, Bonnie L email: bbassler@princeton.edu organization: Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address: bbassler@princeton.edu
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31295420$$D View this record in MEDLINE/PubMed
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SubjectTerms	Anti-Bacterial Agents - pharmacology Bacteria - drug effects Bacteria - growth & development Biofilms - drug effects Biofilms - growth & development Drug Resistance, Bacterial Drug Tolerance Microbial Viability - drug effects
Title	Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms
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