Modeling Pharmacokinetics in Individual Patients Using Therapeutic Drug Monitoring and Artificial Population Quasi-Models: A Study with Piperacillin

Population pharmacokinetic (pop-PK) models constructed for model-informed precision dosing often have limited utility due to the low number of patients recruited. To augment such models, an approach is presented for generating fully artificial quasi-models which can be employed to make individual es...

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Bibliographic Details
Published in:	Pharmaceutics Vol. 16; no. 3; p. 358
Main Authors:	Karvaly, Gellért Balázs, Vincze, István, Neely, Michael Noel, Zátroch, István, Nagy, Zsuzsanna, Kocsis, Ibolya, Kopitkó, Csaba
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01.03.2024 MDPI
Subjects:	Algorithms Analysis Anesthesiology Antibiotics Bayesian models Drug stores Estimates Ethylenediaminetetraacetic acid Health aspects Human subjects Intensive care Laboratories Medical research Medicine, Experimental nonparametric adaptive grid Patient monitoring equipment Patients Pharmacokinetics piperacillin Pneumonia Reagents Tazobactam Teaching hospitals therapeutic drug monitoring Hungary Bayesian models intensive care model-informed precision dosing tazobactam pharmacokinetics piperacillin nonparametric adaptive grid therapeutic drug monitoring
ISSN:	1999-4923, 1999-4923
Online Access:	Get full text
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