Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites

Dopamine controls essential brain functions through volume transmission. Different from fast synaptic transmission, where neurotransmitter release and receptor activation are tightly coupled by an active zone, dopamine transmission is widespread and may not necessitate these organized release sites....

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Bibliographic Details
Published in:	Cell Vol. 172; no. 4; p. 706
Main Authors:	Liu, Changliang, Kershberg, Lauren, Wang, Jiexin, Schneeberger, Shirin, Kaeser, Pascal S
Format:	Journal Article
Language:	English
Published:	United States 08.02.2018
Subjects:	Animals ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Axons - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Corpus Striatum - cytology Corpus Striatum - metabolism Dopamine - genetics Dopamine - metabolism Gene Knockdown Techniques Mice Mice, Transgenic Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism rab GTP-Binding Proteins Synaptic Transmission - physiology striatum RIM active zone superresolution varicosity volume transmission exocytosis bassoon dopamine ELKS
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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