Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development

Hematopoietic stem cells (HSCs) first emerge in the embryonic aorta-gonad-mesonephros (AGM) region. Studies of model organisms defined intersecting signaling pathways that converge to promote HSC emergence predominantly in the ventral domain of the dorsal aorta. Much less is known about mechanisms d...

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Veröffentlicht in:	Cell stem cell Jg. 27; H. 5; S. 822
Hauptverfasser:	Crosse, Edie I, Gordon-Keylock, Sabrina, Rybtsov, Stanislav, Binagui-Casas, Anahi, Felchle, Hannah, Nnadi, Nneka C, Kirschner, Kristina, Chandra, Tamir, Tamagno, Sara, Webb, David J, Rossi, Fiona, Anderson, Richard A, Medvinsky, Alexander
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 05.11.2020
Schlagworte:	Endothelial Cells Gonads Hematopoiesis Hematopoietic Stem Cells Humans Mesonephros Transcriptome - genetics single cell transcriptome endothelin hematopoiesis AGM region HSC embryo spatial transcriptome
ISSN:	1875-9777, 1875-9777
Online-Zugang:	Weitere Angaben
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