Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development

Hematopoietic stem cells (HSCs) first emerge in the embryonic aorta-gonad-mesonephros (AGM) region. Studies of model organisms defined intersecting signaling pathways that converge to promote HSC emergence predominantly in the ventral domain of the dorsal aorta. Much less is known about mechanisms d...

Full description

Bibliographic Details

Published in:	Cell stem cell Vol. 27; no. 5; p. 822
Main Authors:	Crosse, Edie I, Gordon-Keylock, Sabrina, Rybtsov, Stanislav, Binagui-Casas, Anahi, Felchle, Hannah, Nnadi, Nneka C, Kirschner, Kristina, Chandra, Tamir, Tamagno, Sara, Webb, David J, Rossi, Fiona, Anderson, Richard A, Medvinsky, Alexander
Format:	Journal Article
Language:	English
Published:	United States 05.11.2020
Subjects:	Endothelial Cells Gonads Hematopoiesis Hematopoietic Stem Cells Humans Mesonephros Transcriptome - genetics single cell transcriptome endothelin hematopoiesis AGM region HSC embryo spatial transcriptome
ISSN:	1875-9777, 1875-9777
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!