Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, we investigate the effect of alpha-ketoglutarate (delivered in the form of a calcium salt, CaAKG) on healthspan an...

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Veröffentlicht in:	Cell metabolism Jg. 32; H. 3; S. 447
Hauptverfasser:	Asadi Shahmirzadi, Azar, Edgar, Daniel, Liao, Chen-Yu, Hsu, Yueh-Mei, Lucanic, Mark, Asadi Shahmirzadi, Arash, Wiley, Christopher D, Gan, Garbo, Kim, Dong Eun, Kasler, Herbert G, Kuehnemann, Chisaka, Kaplowitz, Brian, Bhaumik, Dipa, Riley, Rebeccah R, Kennedy, Brian K, Lithgow, Gordon J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.09.2020
Schlagworte:	frailty inflammation alpha-ketoglutarate lifespan longevity healthspan SASP IL-10
ISSN:	1932-7420, 1932-7420
Online-Zugang:	Weitere Angaben
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