The coagulation system and its function in early immune defense

Blood coagulation has a Janus-faced role in infectious diseases. When systemically activated, it can cause serious complications associated with high morbidity and mortality. However, coagulation is also part of the innate immune system and its local activation has been found to play an important ro...

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Bibliographic Details
Published in:Thrombosis and haemostasis Vol. 112; no. 4; p. 640
Main Authors: van der Poll, Tom, Herwald, Heiko
Format: Journal Article
Language:English
Published: Germany 2014
Subjects:
Anti-Infective Agents - chemistry
Blood Coagulation - physiology
Blood Vessels - pathology
Carboxypeptidase B2 - metabolism
Communicable Diseases - immunology
Disease Progression
Fibrinolysis
Hemostasis
Humans
Immune System - physiology
Inflammation
Neutrophils - cytology
Neutrophils - metabolism
Phylogeny
Sepsis - immunology
Thrombosis - immunology
Bacterial infection
immunity
disseminated intravascular coagulation (DIC)
coagulation factors
infectious diseases
ISSN:0340-6245, 2567-689X, 2567-689X
Online Access:Get more information
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Summary:Blood coagulation has a Janus-faced role in infectious diseases. When systemically activated, it can cause serious complications associated with high morbidity and mortality. However, coagulation is also part of the innate immune system and its local activation has been found to play an important role in the early host response to infection. Though the latter aspect has been less investigated, phylogenetic studies have shown that many factors involved in coagulation have ancestral origins which are often combined with anti-microbial features. This review gives a general overview about the most recent advances in this area of research also referred to as immunothrombosis.
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ISSN:0340-6245
2567-689X
2567-689X
DOI:10.1160/TH14-01-0053