The coagulation system and its function in early immune defense

Blood coagulation has a Janus-faced role in infectious diseases. When systemically activated, it can cause serious complications associated with high morbidity and mortality. However, coagulation is also part of the innate immune system and its local activation has been found to play an important ro...

Full description

Saved in:
Bibliographic Details
Published in:Thrombosis and haemostasis Vol. 112; no. 4; p. 640
Main Authors: van der Poll, Tom, Herwald, Heiko
Format: Journal Article
Language:English
Published: Germany 2014
Subjects:
Anti-Infective Agents - chemistry
Blood Coagulation - physiology
Blood Vessels - pathology
Carboxypeptidase B2 - metabolism
Communicable Diseases - immunology
Disease Progression
Fibrinolysis
Hemostasis
Humans
Immune System - physiology
Inflammation
Neutrophils - cytology
Neutrophils - metabolism
Phylogeny
Sepsis - immunology
Thrombosis - immunology
Bacterial infection
immunity
disseminated intravascular coagulation (DIC)
coagulation factors
infectious diseases
ISSN:0340-6245, 2567-689X, 2567-689X
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Blood coagulation has a Janus-faced role in infectious diseases. When systemically activated, it can cause serious complications associated with high morbidity and mortality. However, coagulation is also part of the innate immune system and its local activation has been found to play an important role in the early host response to infection. Though the latter aspect has been less investigated, phylogenetic studies have shown that many factors involved in coagulation have ancestral origins which are often combined with anti-microbial features. This review gives a general overview about the most recent advances in this area of research also referred to as immunothrombosis.
AbstractList Blood coagulation has a Janus-faced role in infectious diseases. When systemically activated, it can cause serious complications associated with high morbidity and mortality. However, coagulation is also part of the innate immune system and its local activation has been found to play an important role in the early host response to infection. Though the latter aspect has been less investigated, phylogenetic studies have shown that many factors involved in coagulation have ancestral origins which are often combined with anti-microbial features. This review gives a general overview about the most recent advances in this area of research also referred to as immunothrombosis.Blood coagulation has a Janus-faced role in infectious diseases. When systemically activated, it can cause serious complications associated with high morbidity and mortality. However, coagulation is also part of the innate immune system and its local activation has been found to play an important role in the early host response to infection. Though the latter aspect has been less investigated, phylogenetic studies have shown that many factors involved in coagulation have ancestral origins which are often combined with anti-microbial features. This review gives a general overview about the most recent advances in this area of research also referred to as immunothrombosis.
Blood coagulation has a Janus-faced role in infectious diseases. When systemically activated, it can cause serious complications associated with high morbidity and mortality. However, coagulation is also part of the innate immune system and its local activation has been found to play an important role in the early host response to infection. Though the latter aspect has been less investigated, phylogenetic studies have shown that many factors involved in coagulation have ancestral origins which are often combined with anti-microbial features. This review gives a general overview about the most recent advances in this area of research also referred to as immunothrombosis.
Author van der Poll, Tom
Herwald, Heiko
Author_xml – sequence: 1
  givenname: Tom
  surname: van der Poll
  fullname: van der Poll, Tom
– sequence: 2
  givenname: Heiko
  surname: Herwald
  fullname: Herwald, Heiko
  email: heiko.herwald@med.lu.se
  organization: Heiko Herwald, Department of Clinical Sciences, Lund, Division of Infection Medicine, BMC B14, Lund University, Tornavägen 10, SE-221 84 Lund, Sweden, Tel.: +46 46 2224182, Fax: +46 46 157756, E-mail heiko.herwald@med.lu.se
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24696161$$D View this record in MEDLINE/PubMed
BookMark eNo1j01LxDAURYOMOB-6cy1ZuonmJXmZdiUyqCMMuKngrqTJq1badGzaxfx7RcfVgcvhwlmyWewjMXYJ8gbAyttiC0ZIEFKiPmELhXYtbJa_zdhCaiOFVQbnbJnSp5RgTY5nbK6MzS1YWLC74oO479371Lqx6SNPhzRSx10MvBkTr6fof_cmcnJDe-BN102ReKCaYqJzdlq7NtHFkSv2-vhQbLZi9_L0vLnfCY8KRpHpeu3qgEFlXqLzSlcYPGonVbAaMdcOwbqwziqsrZFkwObGOyCswFVBrdj13-9-6L8mSmPZNclT27pI_ZRKQGszJRXAj3p1VKeqo1Duh6Zzw6H8j1bfThdZuQ
CitedBy_id crossref_primary_10_1186_s13613_017_0339_5
crossref_primary_10_1080_1744666X_2020_1803064
crossref_primary_10_1177_0310057X1604400110
crossref_primary_10_1016_j_jtha_2025_05_036
crossref_primary_10_1016_j_jcrc_2017_03_027
crossref_primary_10_1084_jem_20250049
crossref_primary_10_3389_fimmu_2025_1599639
crossref_primary_10_1007_s00134_023_06980_6
crossref_primary_10_1016_j_immuni_2019_11_005
crossref_primary_10_1016_j_aquaculture_2023_739662
crossref_primary_10_1016_j_ccc_2016_08_004
crossref_primary_10_1097_CCM_0000000000005033
crossref_primary_10_1161_CIRCRESAHA_124_324764
crossref_primary_10_1186_s12916_015_0327_2
crossref_primary_10_1055_s_0041_1732467
crossref_primary_10_3389_fimmu_2021_690477
crossref_primary_10_3390_v7020559
crossref_primary_10_1016_j_thromres_2021_06_003
crossref_primary_10_1093_bja_aew195
crossref_primary_10_1016_j_medine_2022_03_010
crossref_primary_10_3390_cells8030258
crossref_primary_10_1186_s12883_019_1248_z
crossref_primary_10_1186_s12879_022_07474_4
crossref_primary_10_3390_ijms231810393
crossref_primary_10_1016_j_thromres_2020_08_013
crossref_primary_10_1055_a_2043_2750
crossref_primary_10_1007_s00134_024_07586_2
crossref_primary_10_1016_j_ijbiomac_2021_10_015
crossref_primary_10_1016_j_dci_2018_06_001
crossref_primary_10_1097_MD_0000000000037519
crossref_primary_10_1165_rcmb_2020_0328OC
crossref_primary_10_1016_j_medin_2022_03_017
crossref_primary_10_1016_j_biomaterials_2021_121205
crossref_primary_10_1016_j_clinbiochem_2019_11_005
crossref_primary_10_1016_j_cca_2023_117458
crossref_primary_10_1186_s12864_018_4719_5
crossref_primary_10_1186_s13054_016_1415_1
crossref_primary_10_1007_s00134_016_4607_x
crossref_primary_10_1007_s12185_015_1904_z
crossref_primary_10_3390_pathogens9060493
crossref_primary_10_1160_TH14_09_0721
crossref_primary_10_1002_14651858_CD008562_pub3
crossref_primary_10_3389_fevo_2022_850817
crossref_primary_10_1038_s41390_023_02958_8
crossref_primary_10_3389_fimmu_2024_1495260
crossref_primary_10_1080_17476348_2021_1899815
crossref_primary_10_2147_JIR_S383053
crossref_primary_10_3233_CH_221519
crossref_primary_10_1080_21541248_2016_1215283
crossref_primary_10_3389_fimmu_2018_00312
crossref_primary_10_1182_blood_2015_11_683110
crossref_primary_10_1371_journal_pone_0117642
crossref_primary_10_1016_j_biocel_2018_05_008
crossref_primary_10_1016_j_apjtm_2017_06_007
crossref_primary_10_1186_s12964_020_00687_7
crossref_primary_10_1016_j_imlet_2014_10_010
crossref_primary_10_1186_s40249_017_0307_1
crossref_primary_10_1073_pnas_1613405114
crossref_primary_10_3390_jcm8050728
crossref_primary_10_1182_blood_2018_08_867267
crossref_primary_10_1097_CCM_0000000000001836
crossref_primary_10_1186_s40560_016_0160_5
crossref_primary_10_1002_path_5354
crossref_primary_10_1186_2197_425X_3_S1_A297
crossref_primary_10_1097_MPG_0000000000001215
crossref_primary_10_1177_1358863X20932640
crossref_primary_10_1111_jth_14371
crossref_primary_10_1016_j_amjms_2024_04_012
crossref_primary_10_1016_j_fsi_2019_11_008
crossref_primary_10_1016_j_immuni_2021_10_012
crossref_primary_10_3389_fmicb_2017_02602
crossref_primary_10_1055_s_0042_1756300
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1160/TH14-01-0053
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod no_fulltext_linktorsrc
Discipline Medicine
EISSN 2567-689X
ExternalDocumentID 24696161
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID ---
.55
.GJ
0R~
0VX
123
1KJ
4.4
53G
5RE
AAQQT
ABJNI
ABOCM
ACGFO
ACGFS
AENEX
AFFNX
AHRSK
ALMA_UNASSIGNED_HOLDINGS
BR6
C45
CGR
CS3
CUY
CVF
DU5
EBS
ECM
EIF
EJD
F5P
H13
J5H
NPM
OVD
P2P
RTC
RTE
SJN
TEORI
X7M
ZGI
ZXP
7X8
ID FETCH-LOGICAL-c521t-83f7afd5d28c05ac23b5dc53a02d635593a516ad78b5f640e41694ca1e5b1abd2
IEDL.DBID 7X8
ISICitedReferencesCount 86
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000342655100005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0340-6245
2567-689X
IngestDate Fri Jul 11 02:25:39 EDT 2025
Thu Jan 02 22:14:48 EST 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords Bacterial infection
immunity
disseminated intravascular coagulation (DIC)
coagulation factors
infectious diseases
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c521t-83f7afd5d28c05ac23b5dc53a02d635593a516ad78b5f640e41694ca1e5b1abd2
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
OpenAccessLink https://lup.lub.lu.se/record/4431156
PMID 24696161
PQID 1566820211
PQPubID 23479
ParticipantIDs proquest_miscellaneous_1566820211
pubmed_primary_24696161
PublicationCentury 2000
PublicationDate 20140000
PublicationDateYYYYMMDD 2014-01-01
PublicationDate_xml – year: 2014
  text: 20140000
PublicationDecade 2010
PublicationPlace Germany
PublicationPlace_xml – name: Germany
PublicationTitle Thrombosis and haemostasis
PublicationTitleAlternate Thromb Haemost
PublicationYear 2014
SSID ssj0016495
Score 2.4422092
SecondaryResourceType review_article
Snippet Blood coagulation has a Janus-faced role in infectious diseases. When systemically activated, it can cause serious complications associated with high morbidity...
SourceID proquest
pubmed
SourceType Aggregation Database
Index Database
StartPage 640
SubjectTerms Anti-Infective Agents - chemistry
Blood Coagulation - physiology
Blood Vessels - pathology
Carboxypeptidase B2 - metabolism
Communicable Diseases - immunology
Disease Progression
Fibrinolysis
Hemostasis
Humans
Immune System - physiology
Inflammation
Neutrophils - cytology
Neutrophils - metabolism
Phylogeny
Sepsis - immunology
Thrombosis - immunology
Title The coagulation system and its function in early immune defense
URI https://www.ncbi.nlm.nih.gov/pubmed/24696161
https://www.proquest.com/docview/1566820211
Volume 112
WOSCitedRecordID wos000342655100005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEA7qevDiA1_riwhey7ZNk7anRcRlD1r2sEpvJY-J9NKudvX3O0m7eBIELz0UAmUeme9LpvMRcpcwZRnmUACZQYKCgDyQSujAhCLnNgaQvuX_9Sktiqws88Vw4NYNbZWbPdFv1KbV7ox84ngGVivkK9PVe-BUo9zt6iChsU1GDKGMi-q09CJ0HPNfZHm56XUX4WQ5jxJPnkOnhPwbnvR1ZXbw3y86JPsDoqT3fQgckS1ojskU3U91K98GdS7aT2ymsjG0XnfUlTP_vm4ouBnHtHY_igA1YJHYwgl5mT0uH-bBoJUQaCdJEGTMptIabuJMh1zqmCluNGcyjI3DFDmTPBLSpJniViQhoFvyRMsIuIqkMvEp2WnaBs4JBe5V-5hVqUK6l7qB-BISJhONS4wak9uNPSqMRXfBIBtoP7vqxyJjctYbtVr1QzOqGHm4QHh58YfVl2QPcUnvrOiKjCxmIlyTXf21rruPG-9kfBaL528CQbJX
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+coagulation+system+and+its+function+in+early+immune+defense&rft.jtitle=Thrombosis+and+haemostasis&rft.au=van+der+Poll%2C+Tom&rft.au=Herwald%2C+Heiko&rft.date=2014-01-01&rft.issn=0340-6245&rft.volume=112&rft.issue=4&rft.spage=640&rft_id=info:doi/10.1160%2FTH14-01-0053&rft_id=info%3Apmid%2F24696161&rft_id=info%3Apmid%2F24696161&rft.externalDocID=24696161
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0340-6245&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0340-6245&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0340-6245&client=summon