An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells

Erasure of DNA methylation and repressive chromatin marks in the mammalian germline leads to risk of transcriptional activation of transposable elements (TEs). Here, we used mouse embryonic stem cells (ESCs) to identify an endosiRNA-based mechanism involved in suppression of TE transcription. In ESC...

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Vydané v:	Cell stem cell Ročník 21; číslo 5; s. 694
Hlavní autori:	Berrens, Rebecca V, Andrews, Simon, Spensberger, Dominik, Santos, Fátima, Dean, Wendy, Gould, Poppy, Sharif, Jafar, Olova, Nelly, Chandra, Tamir, Koseki, Haruhiko, von Meyenn, Ferdinand, Reik, Wolf
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 02.11.2017
Predmet:	germ line repeats DNMT1 RNAi IAP elements endogenous retroviruses transposable element primordial germ cell small RNAs
ISSN:	1875-9777, 1875-9777
On-line prístup:	Zistit podrobnosti o prístupe
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