Early Stage Diagnosis of Oral Cancer Using 1H NMR–Based Metabolomics

Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is better than 90% at 5 years, whereas late stage disease survival is only 30%. Therefore, there is an obvious clinical utility for novel metab...

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Published in:Neoplasia (New York, N.Y.) Vol. 11; no. 3; pp. 269,IN7 - 276,IN10
Main Authors: Tiziani, Stefano, Lopes, Victor, Günther, Ulrich L.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.03.2009
Neoplasia Press Inc
Elsevier
Subjects:
Aged
Biomarkers, Tumor - blood
Early Detection of Cancer
Female
Humans
Magnetic Resonance Spectroscopy
Male
Metabolome
Metabolomics - methods
Middle Aged
Mouth Neoplasms - blood
Mouth Neoplasms - diagnosis
Neoplasm Staging
Neoplasms, Squamous Cell - blood
Neoplasms, Squamous Cell - diagnosis
ISSN:1476-5586, 1522-8002, 1476-5586, 1522-8002
Online Access:Get full text
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Summary:Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is better than 90% at 5 years, whereas late stage disease survival is only 30%. Therefore, there is an obvious clinical utility for novel metabolic markers that help to diagnose oral cancer at an early stage and to monitor treatment response. In the current study, blood samples of oral cancer patients were analyzed using nuclear magnetic resonance spectroscopy to derive a metabolic signature for oral cancer. Using multivariate chemometric analysis, we obtained an excellent discrimination between serum samples from cancer patients and from a control group and could also discriminate between different stages of disease. The metabolic profile obtained for oral cancer is significant, even for early stage disease and relatively small tumors. This suggests a systemic metabolic response to cancer, which bears great potential for early diagnosis.
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These authors made equal contributions.
ISSN:1476-5586
1522-8002
1476-5586
1522-8002
DOI:10.1593/neo.81396