Early Stage Diagnosis of Oral Cancer Using 1H NMR–Based Metabolomics
Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is better than 90% at 5 years, whereas late stage disease survival is only 30%. Therefore, there is an obvious clinical utility for novel metab...
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| Published in: | Neoplasia (New York, N.Y.) Vol. 11; no. 3; pp. 269,IN7 - 276,IN10 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Elsevier Inc
01.03.2009
Neoplasia Press Inc Elsevier |
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| ISSN: | 1476-5586, 1522-8002, 1476-5586, 1522-8002 |
| Online Access: | Get full text |
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| Abstract | Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is better than 90% at 5 years, whereas late stage disease survival is only 30%. Therefore, there is an obvious clinical utility for novel metabolic markers that help to diagnose oral cancer at an early stage and to monitor treatment response. In the current study, blood samples of oral cancer patients were analyzed using nuclear magnetic resonance spectroscopy to derive a metabolic signature for oral cancer. Using multivariate chemometric analysis, we obtained an excellent discrimination between serum samples from cancer patients and from a control group and could also discriminate between different stages of disease. The metabolic profile obtained for oral cancer is significant, even for early stage disease and relatively small tumors. This suggests a systemic metabolic response to cancer, which bears great potential for early diagnosis. |
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| AbstractList | Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is better than 90% at 5 years, whereas late stage disease survival is only 30%. Therefore, there is an obvious clinical utility for novel metabolic markers that help to diagnose oral cancer at an early stage and to monitor treatment response. In the current study, blood samples of oral cancer patients were analyzed using nuclear magnetic resonance spectroscopy to derive a metabolic signature for oral cancer. Using multivariate chemometric analysis, we obtained an excellent discrimination between serum samples from cancer patients and from a control group and could also discriminate between different stages of disease. The metabolic profile obtained for oral cancer is significant, even for early stage disease and relatively small tumors. This suggests a systemic metabolic response to cancer, which bears great potential for early diagnosis.Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is better than 90% at 5 years, whereas late stage disease survival is only 30%. Therefore, there is an obvious clinical utility for novel metabolic markers that help to diagnose oral cancer at an early stage and to monitor treatment response. In the current study, blood samples of oral cancer patients were analyzed using nuclear magnetic resonance spectroscopy to derive a metabolic signature for oral cancer. Using multivariate chemometric analysis, we obtained an excellent discrimination between serum samples from cancer patients and from a control group and could also discriminate between different stages of disease. The metabolic profile obtained for oral cancer is significant, even for early stage disease and relatively small tumors. This suggests a systemic metabolic response to cancer, which bears great potential for early diagnosis. Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is better than 90% at 5 years, whereas late stage disease survival is only 30%. Therefore, there is an obvious clinical utility for novel metabolic markers that help to diagnose oral cancer at an early stage and to monitor treatment response. In the current study, blood samples of oral cancer patients were analyzed using nuclear magnetic resonance spectroscopy to derive a metabolic signature for oral cancer. Using multivariate chemometric analysis, we obtained an excellent discrimination between serum samples from cancer patients and from a control group and could also discriminate between different stages of disease. The metabolic profile obtained for oral cancer is significant, even for early stage disease and relatively small tumors. This suggests a systemic metabolic response to cancer, which bears great potential for early diagnosis. |
| Author | Lopes, Victor Günther, Ulrich L. Tiziani, Stefano |
| AuthorAffiliation | CR UK Institute for Cancer Studies, University of Birmingham, Henry Wellcome Building for Biomolecular NMR Spectroscopy (HWB-NMR), Vincent Drive Edgbaston, Birmingham, B15 2TT United Kingdom Edinburgh Cancer Centre, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU United Kingdom |
| AuthorAffiliation_xml | – name: CR UK Institute for Cancer Studies, University of Birmingham, Henry Wellcome Building for Biomolecular NMR Spectroscopy (HWB-NMR), Vincent Drive Edgbaston, Birmingham, B15 2TT United Kingdom – name: Edinburgh Cancer Centre, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU United Kingdom |
| Author_xml | – sequence: 1 givenname: Stefano surname: Tiziani fullname: Tiziani, Stefano organization: CR UK Institute for Cancer Studies, University of Birmingham, Henry Wellcome Building for Biomolecular NMR Spectroscopy (HWB-NMR), Vincent Drive Edgbaston Birmingham B15 2TT United Kingdom – sequence: 2 givenname: Victor surname: Lopes fullname: Lopes, Victor organization: Edinburgh Cancer Centre, Western General Hospital, Crewe Road South Edinburgh EH4 2XU United Kingdom – sequence: 3 givenname: Ulrich L. surname: Günther fullname: Günther, Ulrich L. email: u.l.gunther@bham.ac.uk organization: CR UK Institute for Cancer Studies, University of Birmingham, Henry Wellcome Building for Biomolecular NMR Spectroscopy (HWB-NMR), Vincent Drive Edgbaston Birmingham B15 2TT United Kingdom |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19242608$$D View this record in MEDLINE/PubMed |
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| Copyright | 2009 Neoplasia Press Inc. Copyright © 2009 Neoplasia Press, Inc. All rights reserved 2009 |
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| Snippet | Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is... |
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| SubjectTerms | Aged Biomarkers, Tumor - blood Early Detection of Cancer Female Humans Magnetic Resonance Spectroscopy Male Metabolome Metabolomics - methods Middle Aged Mouth Neoplasms - blood Mouth Neoplasms - diagnosis Neoplasm Staging Neoplasms, Squamous Cell - blood Neoplasms, Squamous Cell - diagnosis |
| Title | Early Stage Diagnosis of Oral Cancer Using 1H NMR–Based Metabolomics |
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