Evolution and Spread of Ebola Virus in Liberia, 2014-2015

The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia...

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Vydáno v:Cell host & microbe Ročník 18; číslo 6; s. 659
Hlavní autoři: Ladner, Jason T, Wiley, Michael R, Mate, Suzanne, Dudas, Gytis, Prieto, Karla, Lovett, Sean, Nagle, Elyse R, Beitzel, Brett, Gilbert, Merle L, Fakoli, Lawrence, Diclaro, 2nd, Joseph W, Schoepp, Randal J, Fair, Joseph, Kuhn, Jens H, Hensley, Lisa E, Park, Daniel J, Sabeti, Pardis C, Rambaut, Andrew, Sanchez-Lockhart, Mariano, Bolay, Fatorma K, Kugelman, Jeffrey R, Palacios, Gustavo
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 09.12.2015
Témata:
Cluster Analysis
Ebolavirus - classification
Ebolavirus - genetics
Ebolavirus - isolation & purification
Genetic Variation
Genome, Viral
Genotype
Hemorrhagic Fever, Ebola - epidemiology
Hemorrhagic Fever, Ebola - transmission
Hemorrhagic Fever, Ebola - virology
Humans
Liberia - epidemiology
Molecular Epidemiology
Molecular Sequence Data
Phylogeography
Sequence Analysis, DNA
Sequence Homology
ISSN:1934-6069, 1934-6069
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Shrnutí:The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1934-6069
1934-6069
DOI:10.1016/j.chom.2015.11.008