NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry

Arenaviruses cause fatal hemorrhagic disease in humans. Old World arenavirus glycoproteins (GPs) mainly engage α-dystroglycan as a cell-surface receptor, while New World arenaviruses hijack transferrin receptor. However, the Lujo virus (LUJV) GP does not cluster with New or Old World arenaviruses. U...

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Veröffentlicht in:	Cell host & microbe Jg. 22; H. 5; S. 688
Hauptverfasser:	Raaben, Matthijs, Jae, Lucas T, Herbert, Andrew S, Kuehne, Ana I, Stubbs, Sarah H, Chou, Yi-Ying, Blomen, Vincent A, Kirchhausen, Tomas, Dye, John M, Brummelkamp, Thijn R, Whelan, Sean P
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 08.11.2017
Schlagworte:	Carrier Proteins Cell Line Host-Pathogen Interactions - physiology Human Umbilical Vein Endothelial Cells Humans Lujo virus - genetics Lujo virus - pathogenicity Lujo virus - physiology Neuropilin-2 - metabolism Protein Interaction Domains and Motifs Receptors, Cell Surface - metabolism Receptors, Transferrin Tetraspanin 30 - metabolism Viral Fusion Proteins - genetics Viral Fusion Proteins - metabolism Viral Proteins - genetics Viral Proteins - metabolism Virus Internalization CD63 arenavirus NRP2 Lujo virus LUJV haploid genetics entry receptor
ISSN:	1934-6069, 1934-6069
Online-Zugang:	Weitere Angaben
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