The Genetic Links to Anxiety and Depression (GLAD) Study: Online recruitment into the largest recontactable study of depression and anxiety

Anxiety and depression are common, debilitating and costly. These disorders are influenced by multiple risk factors, from genes to psychological vulnerabilities and environmental stressors, but research is hampered by a lack of sufficiently large comprehensive studies. We are recruiting 40,000 indiv...

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Veröffentlicht in:	Behaviour research and therapy Jg. 123; S. 103503
Hauptverfasser:	Davies, Molly R., Kalsi, Gursharan, Armour, Chérie, Jones, Ian R., McIntosh, Andrew M., Smith, Daniel J., Walters, James T.R., Bradley, John R., Kingston, Nathalie, Ashford, Sofie, Beange, Ioana, Brailean, Anamaria, Cleare, Anthony J., Coleman, Jonathan R.I., Curtis, Charles J., Curzons, Susannah C.B., Davis, Katrina A.S., Dowey, Le Roy C., Gault, Victor A., Goldsmith, Kimberley A., Bennett, Megan Hammond, Hirose, Yoriko, Hotopf, Matthew, Hübel, Christopher, Kanz, Carola, Leng, Jennifer, Lyall, Donald M., Mason, Bethany D., McAtarsney-Kovacs, Monika, Monssen, Dina, Moulton, Alexei, Ovington, Nigel, Palaiologou, Elisavet, Pariante, Carmine M., Parikh, Shivani, Peel, Alicia J., Price, Ruth K., Rimes, Katharine A., Rogers, Henry C., Sambrook, Jennifer, Skelton, Megan, Spaul, Anna, Suarez, Eddy L.A., Sykes, Bronte L., Thomas, Keith G., Young, Allan H., Vassos, Evangelos, Veale, David, White, Katie M., Wingrove, Janet, Eley, Thalia C., Breen, Gerome
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.12.2019 Elsevier Science Ltd Elsevier Science
Schlagworte:	Adolescent Adult Adults Age of Onset Aged Aged, 80 and over Anxiety Anxiety - genetics Behavior genetics Bias Campaigns Comorbidity Consent Data Data sharing Depression Depression - genetics Disorders Female Genes Genetics Genotype Humans Internet Life events Male Medical records Mental depression Mental disorders Mental health Middle Aged Patient Selection Phenotype Phobic Disorders - genetics Program Development - methods Psychiatric genetics Questionnaires Recruitment Recruits Recurrent Risk assessment Risk factors Stress Young Adult Young adults NIHR PR GWAS SLaM Data sharing CCG Depression GLAD GP GAD MDD FAST-R SURE Behavior genetics Life events SNP NHS SOPs Anxiety Psychiatric genetics IAPT CRN
ISSN:	0005-7967, 1873-622X, 1873-622X
Online-Zugang:	Volltext
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Zusammenfassung:	Anxiety and depression are common, debilitating and costly. These disorders are influenced by multiple risk factors, from genes to psychological vulnerabilities and environmental stressors, but research is hampered by a lack of sufficiently large comprehensive studies. We are recruiting 40,000 individuals with lifetime depression or anxiety and broad assessment of risks to facilitate future research. The Genetic Links to Anxiety and Depression (GLAD) Study (www.gladstudy.org.uk) recruits individuals with depression or anxiety into the NIHR Mental Health BioResource. Participants invited to join the study (via media campaigns) provide demographic, environmental and genetic data, and consent for medical record linkage and recontact. Online recruitment was effective; 42,531 participants consented and 27,776 completed the questionnaire by end of July 2019. Participants’ questionnaire data identified very high rates of recurrent depression, severe anxiety, and comorbidity. Participants reported high rates of treatment receipt. The age profile of the sample is biased toward young adults, with higher recruitment of females and the more educated, especially at younger ages. This paper describes the study methodology and descriptive data for GLAD, which represents a large, recontactable resource that will enable future research into risks, outcomes, and treatment for anxiety and depression. •Online recruitment of 40,000 individuals with lifetime depression or anxiety.•Detailed online phenotyping combined with genetic and clinical data.•The study sample is severe, highly comorbid, with chronic psychopathology.•The study protocol enables recall of participants for future research and trials.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Joint senior authors.
ISSN:	0005-7967 1873-622X 1873-622X
DOI:	10.1016/j.brat.2019.103503