Organophosphate-induced brain damage: Mechanisms, neuropsychiatric and neurological consequences, and potential therapeutic strategies

Organophosphate (OP)-induced brain damage is defined as progressive damage to the brain, resulting from the cholinergic neuronal excitotoxicity and dysfunction induced by OP-induced irreversible AChE inhibition. This delayed secondary neuronal damage that occurs mainly in the cholinergic regions of...

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Bibliographic Details
Published in:	Neurotoxicology (Park Forest South) Vol. 33; no. 3; pp. 391 - 400
Main Author:	Chen, Yun
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01.06.2012 Elsevier
Subjects:	Acetylcholinesterase Acetylcholinesterase - metabolism Animals Antidotes - therapeutic use Biological and medical sciences Brain - drug effects Brain - enzymology Brain - pathology Brain - physiopathology Cholinergic neuronal excitotoxicity Cholinesterase Inhibitors - poisoning Excitatory Amino Acid Antagonists - therapeutic use Humans Medical sciences Nerve agents Neurological impairments Neuroprotective Agents - therapeutic use Neuroprotective strategies Neuropsychiatric disorders Neurotoxicity Syndromes - diagnosis Neurotoxicity Syndromes - enzymology Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - physiopathology Neurotoxicity Syndromes - psychology Neurotoxicity Syndromes - therapy Organophosphate Poisoning Organophosphates Secondary neuronal damage Toxicology Treatment Outcome Neuroprotective strategies Neuropsychiatric disorders Secondary neuronal damage Acetylcholinesterase Nerve agents Cholinergic neuronal excitotoxicity Neurological impairments Organophosphates Neuroprotection Toxicity Nervous system Esterases Mechanism of action Nervous system diseases Secondary Enzyme Neuroprotective agent Carboxylic ester hydrolases Cerebral disorder Toxin Neuron Treatment Central nervous system disease Neurotoxin Mental disorder Hydrolases Organophosphorus compounds Lesion
ISSN:	0161-813X, 1872-9711, 1872-9711
Online Access:	Get full text
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