Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism
Many nonhuman primate cells are unable to support the replication of HIV-1, whereas others are nonpermissive for infection by simian immunodeficiency virus from macaques (SIVmac). Here, we show that restricted HIV-1 and SIVmac infection of primate cell lines shares some salient features with Fv1 and...
Uloženo v:
| Vydáno v: | Proceedings of the National Academy of Sciences - PNAS Ročník 99; číslo 18; s. 11914 |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
03.09.2002
|
| Témata: | |
| ISSN: | 0027-8424 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Many nonhuman primate cells are unable to support the replication of HIV-1, whereas others are nonpermissive for infection by simian immunodeficiency virus from macaques (SIVmac). Here, we show that restricted HIV-1 and SIVmac infection of primate cell lines shares some salient features with Fv1 and Ref1-mediated restriction of murine retrovirus infection. In particular, the nonpermissive phenotype is most evident at low multiplicities of infection, results in reduced accumulation of reverse transcription products, and is dominant in heterokaryons generated by fusion of permissive and nonpermissive target cells. Moreover, in nonpermissive primate cells, HIV-1 and SIVmac infection is cooperative, and enveloped HIV-1 virus-like particles, minimally containing Gag and protease, abrogate restriction. In African green monkey cells, HIV-1 virus-like particles ablate restrictions to HIV-1 and SIVmac, suggesting that both are restricted by the same factor. Finally, a virus that contains an HIV-1 capsid-p2 domain in an SIVmac background exhibits a tropism for primate cells that is HIV-1-like rather than SIVmac-like. These data indicate the existence of one or more saturable inhibitors that are polymorphic in primates and prevent HIV and SIV infection by targeting the capsid of the incoming lentivirus particle. |
|---|---|
| AbstractList | Many nonhuman primate cells are unable to support the replication of HIV-1, whereas others are nonpermissive for infection by simian immunodeficiency virus from macaques (SIVmac). Here, we show that restricted HIV-1 and SIVmac infection of primate cell lines shares some salient features with Fv1 and Ref1-mediated restriction of murine retrovirus infection. In particular, the nonpermissive phenotype is most evident at low multiplicities of infection, results in reduced accumulation of reverse transcription products, and is dominant in heterokaryons generated by fusion of permissive and nonpermissive target cells. Moreover, in nonpermissive primate cells, HIV-1 and SIVmac infection is cooperative, and enveloped HIV-1 virus-like particles, minimally containing Gag and protease, abrogate restriction. In African green monkey cells, HIV-1 virus-like particles ablate restrictions to HIV-1 and SIVmac, suggesting that both are restricted by the same factor. Finally, a virus that contains an HIV-1 capsid-p2 domain in an SIVmac background exhibits a tropism for primate cells that is HIV-1-like rather than SIVmac-like. These data indicate the existence of one or more saturable inhibitors that are polymorphic in primates and prevent HIV and SIV infection by targeting the capsid of the incoming lentivirus particle. Many nonhuman primate cells are unable to support the replication of HIV-1, whereas others are nonpermissive for infection by simian immunodeficiency virus from macaques (SIVmac). Here, we show that restricted HIV-1 and SIVmac infection of primate cell lines shares some salient features with Fv1 and Ref1-mediated restriction of murine retrovirus infection. In particular, the nonpermissive phenotype is most evident at low multiplicities of infection, results in reduced accumulation of reverse transcription products, and is dominant in heterokaryons generated by fusion of permissive and nonpermissive target cells. Moreover, in nonpermissive primate cells, HIV-1 and SIVmac infection is cooperative, and enveloped HIV-1 virus-like particles, minimally containing Gag and protease, abrogate restriction. In African green monkey cells, HIV-1 virus-like particles ablate restrictions to HIV-1 and SIVmac, suggesting that both are restricted by the same factor. Finally, a virus that contains an HIV-1 capsid-p2 domain in an SIVmac background exhibits a tropism for primate cells that is HIV-1-like rather than SIVmac-like. These data indicate the existence of one or more saturable inhibitors that are polymorphic in primates and prevent HIV and SIV infection by targeting the capsid of the incoming lentivirus particle.Many nonhuman primate cells are unable to support the replication of HIV-1, whereas others are nonpermissive for infection by simian immunodeficiency virus from macaques (SIVmac). Here, we show that restricted HIV-1 and SIVmac infection of primate cell lines shares some salient features with Fv1 and Ref1-mediated restriction of murine retrovirus infection. In particular, the nonpermissive phenotype is most evident at low multiplicities of infection, results in reduced accumulation of reverse transcription products, and is dominant in heterokaryons generated by fusion of permissive and nonpermissive target cells. Moreover, in nonpermissive primate cells, HIV-1 and SIVmac infection is cooperative, and enveloped HIV-1 virus-like particles, minimally containing Gag and protease, abrogate restriction. In African green monkey cells, HIV-1 virus-like particles ablate restrictions to HIV-1 and SIVmac, suggesting that both are restricted by the same factor. Finally, a virus that contains an HIV-1 capsid-p2 domain in an SIVmac background exhibits a tropism for primate cells that is HIV-1-like rather than SIVmac-like. These data indicate the existence of one or more saturable inhibitors that are polymorphic in primates and prevent HIV and SIV infection by targeting the capsid of the incoming lentivirus particle. |
| Author | Muesing, Mark A Gottlinger, Heinrich G Hatziioannou, Theodora Cunningham, Tshaka Bieniasz, Paul D Cowan, Simone |
| Author_xml | – sequence: 1 givenname: Simone surname: Cowan fullname: Cowan, Simone organization: Aaron Diamond AIDS Research Center, Rockefeller University, 455 First Avenue, New York, NY 10016, USA – sequence: 2 givenname: Theodora surname: Hatziioannou fullname: Hatziioannou, Theodora – sequence: 3 givenname: Tshaka surname: Cunningham fullname: Cunningham, Tshaka – sequence: 4 givenname: Mark A surname: Muesing fullname: Muesing, Mark A – sequence: 5 givenname: Heinrich G surname: Gottlinger fullname: Gottlinger, Heinrich G – sequence: 6 givenname: Paul D surname: Bieniasz fullname: Bieniasz, Paul D |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12154227$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1kD1PwzAYhD0U0Q9YGZEntoD91onjEVUUkCqxwBzZjq2-kDjFdor674lEme6GR6e7W5JZGIIj5Iaze87k-uEQdLrnFYBSQqkZWTAGsqgFiDlZpvTJGFNlzS7JnAMvBYBcELtxXTd2OlIMezSYh5joD-Y93R550eGXo9pmPGI-0ehSjmgz3Y-9DlSHlibscbLY92MYWufRogv2RI8Yx0RzHA6Y-ity4XWX3PVZV-Rj-_S-eSl2b8-vm8ddYUvguRC-Fto57kFJD5ZJb8CAgrK1bcW5VEzqsnS6AmdaI7hZAytbJVsjvfdVBSty95d7iMP3OJVtekx22qeDG8bUyImvRQkTeHsGR9O7tjlE7HU8Nf-3wC_hNmcN |
| CitedBy_id | crossref_primary_10_1128_JVI_79_22_14446_14450_2005 crossref_primary_10_1128_JVI_80_1_342_352_2006 crossref_primary_10_1186_s12977_015_0208_y crossref_primary_10_1016_j_virol_2005_06_005 crossref_primary_10_1089_0889222041524652 crossref_primary_10_1007_s11904_006_0004_3 crossref_primary_10_1074_jbc_M117_793661 crossref_primary_10_1128_JVI_79_10_6111_6121_2005 crossref_primary_10_1016_j_virol_2004_08_006 crossref_primary_10_1128_JVI_02254_16 crossref_primary_10_1128_JVI_80_5_2463_2471_2006 crossref_primary_10_1016_j_mib_2006_06_011 crossref_primary_10_2217_17460794_1_1_71 crossref_primary_10_1074_jbc_M109_040618 crossref_primary_10_1097_00002030_200216004_00003 crossref_primary_10_1128_JVI_01134_14 crossref_primary_10_1111_j_1348_0421_2008_00040_x crossref_primary_10_1016_j_ymthe_2005_07_291 crossref_primary_10_1128_JVI_79_18_11580_11587_2005 crossref_primary_10_1128_JVI_01880_07 crossref_primary_10_1128_JVI_78_21_11816_11822_2004 crossref_primary_10_1128_JVI_78_18_9592_9598_2004 crossref_primary_10_1089_hum_2015_059 crossref_primary_10_1016_j_virol_2006_05_035 crossref_primary_10_1128_JVI_00713_13 crossref_primary_10_1186_1742_4690_2_25 crossref_primary_10_1128_JVI_79_3_1470_1479_2005 crossref_primary_10_1073_pnas_0509996103 crossref_primary_10_1089_hum_2008_186 crossref_primary_10_1016_j_virol_2010_09_019 crossref_primary_10_1111_j_1600_0684_2006_00172_x crossref_primary_10_1128_JVI_00410_08 crossref_primary_10_1038_ni1125 crossref_primary_10_1128_JVI_00984_20 crossref_primary_10_1007_s00726_009_0393_x crossref_primary_10_1007_s10495_009_0408_9 crossref_primary_10_1128_JVI_79_5_3139_3145_2005 crossref_primary_10_1186_1742_4690_6_70 crossref_primary_10_1128_JVI_78_4_2006_2016_2004 crossref_primary_10_1146_annurev_genet_42_110807_091704 crossref_primary_10_1038_s41579_019_0225_2 crossref_primary_10_1016_j_virol_2007_02_002 crossref_primary_10_1186_1472_6807_4_1 crossref_primary_10_1371_journal_ppat_1002019 crossref_primary_10_1083_jcb_200706154 crossref_primary_10_1007_s12026_010_8164_z crossref_primary_10_1016_j_virusres_2013_01_013 crossref_primary_10_1371_journal_ppat_1000074 crossref_primary_10_1016_j_virol_2014_02_004 crossref_primary_10_1038_nm0703_887 crossref_primary_10_1089_hum_2005_16_ft_113 crossref_primary_10_1016_j_cub_2004_12_042 crossref_primary_10_1002_jgm_1554 crossref_primary_10_1146_annurev_genet_112414_054823 crossref_primary_10_1128_JVI_79_2_869_875_2005 crossref_primary_10_1186_1742_4690_4_68 crossref_primary_10_1016_j_tim_2008_08_013 crossref_primary_10_3390_biology1020134 crossref_primary_10_1128_jvi_00308_24 crossref_primary_10_1089_cell_2012_0041 crossref_primary_10_1128_JVI_78_2_1006_1011_2004 crossref_primary_10_1186_1742_4690_9_112 crossref_primary_10_1371_journal_ppat_1003214 crossref_primary_10_1038_sj_mt_6300244 crossref_primary_10_1128_JVI_80_4_2051_2054_2006 crossref_primary_10_1128_JVI_80_8_4061_4067_2006 crossref_primary_10_1128_JVI_01519_06 crossref_primary_10_1016_j_virol_2006_10_035 crossref_primary_10_1186_s12977_015_0137_9 crossref_primary_10_1073_pnas_1111573109 crossref_primary_10_1099_jgv_0_001790 crossref_primary_10_1128_JVI_00432_08 crossref_primary_10_1128_JVI_02663_07 crossref_primary_10_1073_pnas_0337541100 crossref_primary_10_1073_pnas_0404640101 crossref_primary_10_1016_j_vetimm_2011_06_014 crossref_primary_10_1002_rmv_417 crossref_primary_10_1128_JVI_00821_17 crossref_primary_10_1128_JVI_78_11_6005_6012_2004 crossref_primary_10_1371_journal_ppat_1005050 crossref_primary_10_1128_JVI_77_5_3167_3180_2003 crossref_primary_10_1128_JVI_02727_06 crossref_primary_10_1016_j_imlet_2004_11_026 crossref_primary_10_2217_17460794_2_1_65 crossref_primary_10_1186_s12977_016_0253_1 crossref_primary_10_1099_vir_0_058180_0 crossref_primary_10_1371_journal_ppat_1005727 crossref_primary_10_1371_journal_ppat_1001255 crossref_primary_10_1073_pnas_0709258105 crossref_primary_10_1016_j_virol_2006_09_048 crossref_primary_10_1128_JVI_77_17_9295_9304_2003 crossref_primary_10_1128_JVI_78_22_12537_12547_2004 crossref_primary_10_1038_nm910 crossref_primary_10_1128_JVI_78_10_5423_5437_2004 crossref_primary_10_7554_eLife_54311 crossref_primary_10_1128_AAC_05722_11 crossref_primary_10_1290_1543_706X_2004_40_57_IAOTCF_2_0_CO_2 crossref_primary_10_1016_j_tim_2005_08_004 crossref_primary_10_1016_j_virol_2006_04_021 crossref_primary_10_1182_blood_2008_04_151761 crossref_primary_10_1038_sj_gt_3302591 crossref_primary_10_1016_j_molcel_2004_12_001 crossref_primary_10_1371_journal_ppat_1003667 crossref_primary_10_1186_1742_4690_6_21 crossref_primary_10_1016_S0929_6646_11_60053_3 crossref_primary_10_1128_AAC_00775_09 crossref_primary_10_1186_s12977_017_0358_1 crossref_primary_10_1128_JVI_01052_06 crossref_primary_10_1038_nm1562 crossref_primary_10_1016_j_bbrc_2008_02_025 crossref_primary_10_1182_blood_2003_07_2414 crossref_primary_10_1073_pnas_0510483103 crossref_primary_10_1128_JVI_00620_07 crossref_primary_10_1038_gt_2008_50 crossref_primary_10_1073_pnas_192449399 crossref_primary_10_1074_jbc_M111_248021 crossref_primary_10_1128_JVI_06607_11 crossref_primary_10_1128_JVI_77_24_13403_13406_2003 crossref_primary_10_1038_nature02777 crossref_primary_10_1073_pnas_0404066101 crossref_primary_10_1097_01_COH_0000221591_11294_c1 crossref_primary_10_1128_JVI_02548_12 crossref_primary_10_1073_pnas_0403364101 crossref_primary_10_1186_1742_4690_9_30 crossref_primary_10_1038_mt_sj_6300091 crossref_primary_10_1053_j_seminhematol_2004_07_004 crossref_primary_10_1128_JVI_00283_06 crossref_primary_10_1002_rmv_576 crossref_primary_10_1128_JVI_78_12_6209_6221_2004 crossref_primary_10_1073_pnas_0600771103 crossref_primary_10_1016_S1773_035X_10_70558_X crossref_primary_10_1111_j_1600_0854_2006_00449_x crossref_primary_10_1073_pnas_0402876101 crossref_primary_10_1155_2012_426840 crossref_primary_10_1074_jbc_M606066200 crossref_primary_10_1016_j_antiviral_2009_09_009 crossref_primary_10_1128_JVI_79_24_15175_15188_2005 crossref_primary_10_1182_blood_2004_01_0045 crossref_primary_10_1097_QAD_0b013e3282effa87 crossref_primary_10_1128_JVI_01022_12 crossref_primary_10_1016_j_virol_2006_03_013 crossref_primary_10_1128_JVI_79_10_6560_6564_2005 crossref_primary_10_1128_JVI_79_24_15567_15572_2005 crossref_primary_10_1159_000346963 crossref_primary_10_1016_j_virol_2007_04_005 crossref_primary_10_1517_14728222_12_2_131 crossref_primary_10_1128_JVI_01228_16 crossref_primary_10_1089_hum_2005_16_1125 crossref_primary_10_1128_JVI_00854_10 crossref_primary_10_1074_jbc_M502145200 crossref_primary_10_1128_JVI_01338_20 crossref_primary_10_1016_j_virol_2006_03_023 crossref_primary_10_1128_JVI_78_21_11739_11750_2004 crossref_primary_10_1073_pnas_0402361101 crossref_primary_10_1073_pnas_0402474101 crossref_primary_10_3390_v6010243 crossref_primary_10_1128_JVI_80_6_2855_2862_2006 crossref_primary_10_1016_j_virol_2004_04_038 crossref_primary_10_1111_j_1600_0854_2012_01381_x crossref_primary_10_1038_nature02343 crossref_primary_10_1371_journal_pone_0002796 crossref_primary_10_1128_JVI_01118_19 crossref_primary_10_3390_ijms20122984 crossref_primary_10_1089_jir_2009_0077 crossref_primary_10_1038_sj_mt_6300091 crossref_primary_10_1016_j_vaccine_2009_08_060 crossref_primary_10_1073_pnas_1203536109 crossref_primary_10_1186_1742_4690_10_25 crossref_primary_10_1091_mbc_e06_12_1075 crossref_primary_10_1182_blood_2010_12_327106 crossref_primary_10_1016_j_virol_2008_05_008 crossref_primary_10_1128_JVI_00269_08 crossref_primary_10_1128_JVI_02318_06 crossref_primary_10_1128_JVI_02427_05 crossref_primary_10_1038_nrmicro1248 crossref_primary_10_1073_pnas_0505659102 crossref_primary_10_1182_blood_2007_09_115022 crossref_primary_10_1038_nrmicro772 crossref_primary_10_1128_JVI_01468_07 crossref_primary_10_1038_gt_2010_40 crossref_primary_10_1016_S0168_9525_03_00172_0 crossref_primary_10_1128_JVI_00341_11 crossref_primary_10_1186_1742_4690_1_9 crossref_primary_10_1186_1742_4690_10_37 crossref_primary_10_1371_journal_pone_0084022 crossref_primary_10_1128_JVI_77_1_726_731_2003 crossref_primary_10_1128_JVI_79_14_8969_8978_2005 crossref_primary_10_1002_jcp_21914 crossref_primary_10_1038_nm0903_1112 crossref_primary_10_1128_JVI_00500_10 crossref_primary_10_1186_1742_4690_2_40 crossref_primary_10_3390_v3020132 crossref_primary_10_1128_JVI_03598_14 crossref_primary_10_1128_JVI_02462_07 crossref_primary_10_1016_j_virol_2007_08_032 crossref_primary_10_1038_sj_gt_3302852 crossref_primary_10_1128_JVI_02714_06 crossref_primary_10_1038_srep37489 crossref_primary_10_1128_JVI_00688_06 crossref_primary_10_1097_00002030_200307040_00002 crossref_primary_10_1038_427791a crossref_primary_10_3389_fmicb_2021_652486 crossref_primary_10_1016_S0966_842X_03_00123_9 crossref_primary_10_4103_ijmm_IJMM_20_109 crossref_primary_10_1517_14712598_6_11_1135 crossref_primary_10_1128_JVI_00270_06 crossref_primary_10_1371_journal_pone_0114299 crossref_primary_10_1128_JVI_06035_11 crossref_primary_10_1128_JVI_00516_06 crossref_primary_10_1128_JVI_79_1_176_183_2005 crossref_primary_10_1128_JVI_79_7_3930_3937_2005 crossref_primary_10_1146_annurev_genet_38_072902_094136 crossref_primary_10_1186_1742_4690_7_72 crossref_primary_10_3390_v16101618 crossref_primary_10_1128_JVI_02665_08 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1073/pnas.162299499 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Sciences (General) |
| ExternalDocumentID | 12154227 |
| Genre | Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S Journal Article |
| GrantInformation_xml | – fundername: NIAID NIH HHS grantid: R01AI50111 – fundername: NIAID NIH HHS grantid: R01 AI047054 – fundername: NIAID NIH HHS grantid: R01 AI050111 – fundername: NIAID NIH HHS grantid: R01AI47054 |
| GroupedDBID | --- -DZ -~X .55 .GJ 0R~ 123 29P 2AX 2FS 2WC 3O- 4.4 53G 5RE 5VS 85S AACGO AAFWJ AANCE AAYJJ ABBHK ABOCM ABPLY ABPPZ ABTLG ABXSQ ABZEH ACGOD ACHIC ACIWK ACNCT ACPRK ADULT AENEX AEUPB AEXZC AFFNX AFOSN AFRAH ALMA_UNASSIGNED_HOLDINGS AQVQM AS~ BKOMP CGR CS3 CUY CVF D0L DCCCD DIK DOOOF DU5 E3Z EBS ECM EIF EJD F5P FRP GX1 H13 HGD HH5 HQ3 HTVGU HYE IPSME JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JSODD JST KQ8 L7B LU7 MVM N9A NEJ NPM N~3 O9- OK1 P-O PNE PQQKQ R.V RHF RHI RNA RNS RPM RXW SA0 SJN TAE TN5 UKR VOH VQA VXZ W8F WH7 WHG WOQ WOW X7M XSW Y6R YBH YIF YIN YKV YSK ZCA ZCG ~02 ~KM 7X8 ADQXQ ADXHL |
| ID | FETCH-LOGICAL-c521t-4f84aee1f297f2c07fb2b2925dcd6117907a55ea62ebdb41b3205d97db7fff662 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 248 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000177843100068&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0027-8424 |
| IngestDate | Sun Aug 24 04:01:17 EDT 2025 Wed Feb 19 02:02:46 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 18 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c521t-4f84aee1f297f2c07fb2b2925dcd6117907a55ea62ebdb41b3205d97db7fff662 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | http://doi.org/10.1073/pnas.162299499 |
| PMID | 12154227 |
| PQID | 72058452 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_72058452 pubmed_primary_12154227 |
| PublicationCentury | 2000 |
| PublicationDate | 2002-09-03 |
| PublicationDateYYYYMMDD | 2002-09-03 |
| PublicationDate_xml | – month: 09 year: 2002 text: 2002-09-03 day: 03 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Proceedings of the National Academy of Sciences - PNAS |
| PublicationTitleAlternate | Proc Natl Acad Sci U S A |
| PublicationYear | 2002 |
| References | 12195025 - Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11549-51. doi: 10.1073/pnas.192449399 |
| References_xml | – reference: 12195025 - Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11549-51. doi: 10.1073/pnas.192449399 |
| SSID | ssj0009580 |
| Score | 2.219803 |
| Snippet | Many nonhuman primate cells are unable to support the replication of HIV-1, whereas others are nonpermissive for infection by simian immunodeficiency virus... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 11914 |
| SubjectTerms | Animals Antiviral Agents Cell Line HIV-1 - physiology Humans Proteins - physiology Simian Immunodeficiency Virus - physiology Transcription, Genetic Tropism Virus Replication |
| Title | Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/12154227 https://www.proquest.com/docview/72058452 |
| Volume | 99 |
| WOSCitedRecordID | wos000177843100068&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV09T8MwELUKZWABymf59MAAQyB2HLuRkBCqqFioOoDUrbJjW1i0SWja_n58aSIxwcCSLVJin5_vfH7vIXQdKplCnurLEukLFMF5IJnmgVYyMoTJKAx1ZTYhhsPeeJyMWuih4cLAtcoGEyug1nkKZ-T3goZ-r4zpY_EVgGcU9FZrA40N1I58IgMxLca9H5K7vTUBhXocZpQ1ko0iui8yWd4RTj0Ws-SX5LLaZAa7__u8PbRTJ5f4aR0NHdQy2T7q1Mu3xDe1xvTtAUr7ZjqFG6jYZR9OOfDcwXAmiwcrEkzdp8HAeABjCQzuHR4tF7jy88My07h0Mx9W2AG5JNcGVCiAwolXbr4s8WKeF66cHaL3wfNb_yWo_RaCFGwNAmZ7TBpDLE2EpWkorKKKJjTWqeYgHRcKGcdGcmqUVoyoyP-0ToRWwlrLOT1Cm1memROESWIV4VKxyPgCVCo_FzYmKlaGSkJt2EVXzTBOfDxDk0JmJl-Wk2Ygu-h4PROTYi27MQEdDEapOP3z3TO0XZm2QN8nOkdt61eyuUBb6WrhyvllFSb-ORy9fgM8zsoi |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cellular+inhibitors+with+Fv1-like+activity+restrict+human+and+simian+immunodeficiency+virus+tropism&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+-+PNAS&rft.au=Cowan%2C+Simone&rft.au=Hatziioannou%2C+Theodora&rft.au=Cunningham%2C+Tshaka&rft.au=Muesing%2C+Mark+A&rft.date=2002-09-03&rft.issn=0027-8424&rft.volume=99&rft.issue=18&rft.spage=11914&rft_id=info:doi/10.1073%2Fpnas.162299499&rft_id=info%3Apmid%2F12154227&rft_id=info%3Apmid%2F12154227&rft.externalDocID=12154227 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0027-8424&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0027-8424&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0027-8424&client=summon |