Computational modelling identifies primary mediators of crosstalk between DNA damage and oxidative stress responses

Cells exposed to toxicants, such as drugs, activate a wide variety of stress pathways, often simultaneously. Two important pathways that can influence cell fate and consequently adverse reactions are the oxidative stress response (OSR) and the DNA damage response (DDR). Previous studies have present...

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Bibliographic Details
Published in:	PLoS computational biology Vol. 21; no. 3; p. e1012844
Main Authors:	Burgers, Elsje J., Sharma, Raju P., Eugenio, Carl Joshua S., Heldring, Muriel M., Wijaya, Lukas S., van de Water, Bob, Beltman, Joost B.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.03.2025 Public Library of Science (PLoS)
Subjects:	BTG2 protein Cell culture Cell fate Cell research Cellular signal transduction Cellular stress response Complications and side effects Computational Biology Computer applications Computer Simulation Computer-generated environments Crosstalk Cyclin-dependent kinase inhibitor p21 Damage Deoxyribonucleic acid Diethyl maleate DNA DNA damage DNA Damage - physiology DNA repair Drug dosages Etoposide Etoposide - pharmacology Hep G2 Cells Hepatocytes Humans Kinases Liver Maleates - pharmacology Mathematical models MDM2 protein Methods Models, Biological Ordinary differential equations Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology p53 Protein Pharmaceutical industry Proteins Signal Transduction - drug effects Signal Transduction - physiology Toxicants Toxicity Tumor proteins Netherlands Timor-Leste
ISSN:	1553-7358, 1553-734X, 1553-7358
Online Access:	Get full text
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