Composition, structure and function of the corneal stroma

No other tissue in the body depends more on the composition and organization of the extracellular matrix (ECM) for normal structure and function than the corneal stroma. The precise arrangement and orientation of collagen fibrils, lamellae and keratocytes that occurs during development and is needed...

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Bibliographic Details
Published in:Experimental eye research Vol. 198; p. 108137
Main Authors: Espana, Edgar M., Birk, David E.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.09.2020
Subjects:
Animals
Collagen - metabolism
Collagen fibril
Collagens
Composition
Cornea
Corneal Stroma - cytology
Corneal Stroma - metabolism
Extracellular Matrix - metabolism
Extracellular Matrix Proteins - metabolism
Humans
Proteoglycans
Stroma
Structure
Cornea
Composition
Proteoglycans
Collagens
Stroma
Collagen fibril
Structure
ISSN:0014-4835, 1096-0007, 1096-0007
Online Access:Get full text
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Abstract No other tissue in the body depends more on the composition and organization of the extracellular matrix (ECM) for normal structure and function than the corneal stroma. The precise arrangement and orientation of collagen fibrils, lamellae and keratocytes that occurs during development and is needed in adults to maintain stromal function is dependent on the regulated interaction of multiple ECM components that contribute to attain the unique properties of the cornea: transparency, shape, mechanical strength, and avascularity. This review summarizes the contribution of different ECM components, their structure, regulation and function in modulating the properties of the corneal stroma. Fibril forming collagens (I, III, V), fibril associated collagens with interrupted triple helices (XII and XIV), network forming collagens (IV, VI and VIII) as well as small leucine-rich proteoglycans (SLRP) expressed in the stroma: decorin, biglycan, lumican, keratocan, and fibromodulin are some of the ECM components reviewed in this manuscript. There are spatial and temporal differences in the expression of these ECM components, as well as interactions among them that contribute to stromal function. Unique regions within the stroma like Bowman's layer and Descemet's layer are discussed. To define the complexity of corneal stroma composition and structure as well as the relationship to function is a daunting task. Our knowledge is expanding, and we expect that this review provides a comprehensive overview of current knowledge, definition of gaps and suggests future research directions. •The unique corneal stromal structure and function is regulated by different extracellular matrix components.•The stroma proper as well as Bowman’ and Descemet’slayers have unique ECM compositions and functions.•Regulated collagen fibril formation is critical for stromal structure and function.•ECM molecules including SLRPs regulate stromal fibrillogenesis, hydration, and the availability of growth factors.•Regulation of ECM components play a major role in wound healing.
AbstractList No other tissue in the body depends more on the composition and organization of the extracellular matrix (ECM) for normal structure and function than the corneal stroma. The precise arrangement and orientation of collagen fibrils, lamellae and keratocytes that occurs during development and is needed in adults to maintain stromal function is dependent on the regulated interaction of multiple ECM components that contribute to attain the unique properties of the cornea: transparency, shape, mechanical strength, and avascularity. This review summarizes the contribution of different ECM components, their structure, regulation and function in modulating the properties of the corneal stroma. Fibril forming collagens (I, III, V), fibril associated collagens with interrupted triple helices (XII and XIV), network forming collagens (IV, VI and VIII) as well as small leucine-rich proteoglycans (SLRP) expressed in the stroma: decorin, biglycan, lumican, keratocan, and fibromodulin are some of the ECM components reviewed in this manuscript. There are spatial and temporal differences in the expression of these ECM components, as well as interactions among them that contribute to stromal function. Unique regions within the stroma like Bowman's layer and Descemet's layer are discussed. To define the complexity of corneal stroma composition and structure as well as the relationship to function is a daunting task. Our knowledge is expanding, and we expect that this review provides a comprehensive overview of current knowledge, definition of gaps and suggests future research directions. •The unique corneal stromal structure and function is regulated by different extracellular matrix components.•The stroma proper as well as Bowman’ and Descemet’slayers have unique ECM compositions and functions.•Regulated collagen fibril formation is critical for stromal structure and function.•ECM molecules including SLRPs regulate stromal fibrillogenesis, hydration, and the availability of growth factors.•Regulation of ECM components play a major role in wound healing.
No other tissue in the body depends more on the composition and organization of the extracellular matrix (ECM) for normal structure and function than the corneal stroma. The precise arrangement and orientation of collagen fibrils, lamellae and keratocytes that occurs during development and is needed in adults to maintain stromal function is dependent on the regulated interaction of multiple ECM components that contribute to attain the unique properties of the cornea: transparency, shape, mechanical strength, and avascularity. This review summarizes the contribution of different ECM components, their structure, regulation and function in modulating the properties of the corneal stroma. Fibril forming collagens (I, III, V), fibril associated collagens with interrupted triple helices (XII and XIV), network forming collagens (IV, VI and VIII) as well as small leucine-rich proteoglycans (SLRP) expressed in the stroma: decorin, biglycan, lumican, keratocan, and fibromodulin are some of the ECM components reviewed in this manuscript. There are spatial and temporal differences in the expression of these ECM components, as well as interactions among them that contribute to stromal function. Unique regions within the stroma like Bowman's layer and Descemet's layer are discussed. To define the complexity of corneal stroma composition and structure as well as the relationship to function is a daunting task. Our knowledge is expanding, and we expect that this review provides a comprehensive overview of current knowledge, definition of gaps and suggests future research directions.No other tissue in the body depends more on the composition and organization of the extracellular matrix (ECM) for normal structure and function than the corneal stroma. The precise arrangement and orientation of collagen fibrils, lamellae and keratocytes that occurs during development and is needed in adults to maintain stromal function is dependent on the regulated interaction of multiple ECM components that contribute to attain the unique properties of the cornea: transparency, shape, mechanical strength, and avascularity. This review summarizes the contribution of different ECM components, their structure, regulation and function in modulating the properties of the corneal stroma. Fibril forming collagens (I, III, V), fibril associated collagens with interrupted triple helices (XII and XIV), network forming collagens (IV, VI and VIII) as well as small leucine-rich proteoglycans (SLRP) expressed in the stroma: decorin, biglycan, lumican, keratocan, and fibromodulin are some of the ECM components reviewed in this manuscript. There are spatial and temporal differences in the expression of these ECM components, as well as interactions among them that contribute to stromal function. Unique regions within the stroma like Bowman's layer and Descemet's layer are discussed. To define the complexity of corneal stroma composition and structure as well as the relationship to function is a daunting task. Our knowledge is expanding, and we expect that this review provides a comprehensive overview of current knowledge, definition of gaps and suggests future research directions.
No other tissue in the body depends more on the composition and organization of the extracellular matrix (ECM) for normal structure and function than the corneal stroma. The precise arrangement and orientation of collagen fibrils, lamellae and keratocytes that occurs during development and is needed in adults to maintain stromal function is dependent on the regulated interaction of multiple ECM components that contribute to attain the unique properties of the cornea: transparency, shape, mechanical strength, and avascularity. This review summarizes the contribution of different ECM components, their structure, regulation and function in modulating the properties of the corneal stroma. Fibril forming collagens (I, III, V), fibril associated collagens with interrupted triple helices (XII and XIV), network forming collagens (IV, VI and VIII) as well as small leucine-rich proteoglycans (SLRP) expressed in the stroma: decorin, biglycan, lumican, keratocan, and fibromodulin are some of the ECM components reviewed in this manuscript. There are spatial and temporal differences in the expression of these ECM components, as well as interactions among them that contribute to stromal function. Unique regions within the stroma like Bowman’s layer and Descemet’s layer are discussed. To define the complexity of corneal stroma composition and structure as well as the relationship to function is a daunting task. Our knowledge is expanding, and we expect that this review provides a comprehensive overview of current knowledge, definition of gaps and suggests future research directions.
ArticleNumber 108137
Author Birk, David E.
Espana, Edgar M.
AuthorAffiliation 2 Cornea, External Disease and Refractive Surgery, Department of Ophthalmology, University of South Florida, Morsani College of Medicine, Tampa, Florida
1 Department of Molecular Pharmacology and Physiology, University of South Florida, Morsani College of Medicine, Tampa, Florida
AuthorAffiliation_xml – name: 2 Cornea, External Disease and Refractive Surgery, Department of Ophthalmology, University of South Florida, Morsani College of Medicine, Tampa, Florida
– name: 1 Department of Molecular Pharmacology and Physiology, University of South Florida, Morsani College of Medicine, Tampa, Florida
Author_xml – sequence: 1
  givenname: Edgar M.
  orcidid: 0000-0001-8377-5212
  surname: Espana
  fullname: Espana, Edgar M.
  organization: Department of Molecular Pharmacology and Physiology, USA
– sequence: 2
  givenname: David E.
  orcidid: 0000-0002-4865-9088
  surname: Birk
  fullname: Birk, David E.
  email: dbirk@usf.edu
  organization: Department of Molecular Pharmacology and Physiology, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32663498$$D View this record in MEDLINE/PubMed
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Keywords Cornea
Composition
Proteoglycans
Collagens
Stroma
Collagen fibril
Structure
Language English
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Snippet No other tissue in the body depends more on the composition and organization of the extracellular matrix (ECM) for normal structure and function than the...
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StartPage 108137
SubjectTerms Animals
Collagen - metabolism
Collagen fibril
Collagens
Composition
Cornea
Corneal Stroma - cytology
Corneal Stroma - metabolism
Extracellular Matrix - metabolism
Extracellular Matrix Proteins - metabolism
Humans
Proteoglycans
Stroma
Structure
Title Composition, structure and function of the corneal stroma
URI https://dx.doi.org/10.1016/j.exer.2020.108137
https://www.ncbi.nlm.nih.gov/pubmed/32663498
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