Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Activation of energy expenditure in thermogenic fat is a promising strategy to improve metabolic health, yet the dynamic processes that evoke this response are poorly understood. Here we show that synthesis of the mitochondrial phospholipid cardiolipin is indispensable for stimulating and sustaining...

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Vydáno v:	Cell metabolism Ročník 28; číslo 1; s. 159
Hlavní autoři:	Sustarsic, Elahu G, Ma, Tao, Lynes, Matthew D, Larsen, Michael, Karavaeva, Iuliia, Havelund, Jesper F, Nielsen, Carsten H, Jedrychowski, Mark P, Moreno-Torres, Marta, Lundh, Morten, Plucinska, Kaja, Jespersen, Naja Z, Grevengoed, Trisha J, Kramar, Barbara, Peics, Julia, Hansen, Jakob B, Shamsi, Farnaz, Forss, Isabel, Neess, Ditte, Keipert, Susanne, Wang, Jianing, Stohlmann, Katharina, Brandslund, Ivan, Christensen, Cramer, Jørgensen, Marit E, Linneberg, Allan, Pedersen, Oluf, Kiebish, Michael A, Qvortrup, Klaus, Han, Xianlin, Pedersen, Bente Klarlund, Jastroch, Martin, Mandrup, Susanne, Kjær, Andreas, Gygi, Steven P, Hansen, Torben, Gillum, Matthew P, Grarup, Niels, Emanuelli, Brice, Nielsen, Søren, Scheele, Camilla, Tseng, Yu-Hua, Færgeman, Nils J, Gerhart-Hines, Zachary
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 03.07.2018
Témata:	Adipocytes - metabolism Adipose Tissue, Beige - metabolism Adipose Tissue, Brown - metabolism Animals Cardiolipins - biosynthesis Cells, Cultured Energy Metabolism Humans Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mitochondria - metabolism Thermogenesis Transferases (Other Substituted Phosphate Groups) - genetics Transferases (Other Substituted Phosphate Groups) - metabolism beige adipose thermogenesis brown adipose mitochondria lipid metabolism CHOP-10 phospholipids CRLS1 cardiolipin insulin resistance
ISSN:	1932-7420, 1932-7420
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Shrnutí:	Activation of energy expenditure in thermogenic fat is a promising strategy to improve metabolic health, yet the dynamic processes that evoke this response are poorly understood. Here we show that synthesis of the mitochondrial phospholipid cardiolipin is indispensable for stimulating and sustaining thermogenic fat function. Cardiolipin biosynthesis is robustly induced in brown and beige adipose upon cold exposure. Mimicking this response through overexpression of cardiolipin synthase (Crls1) enhances energy consumption in mouse and human adipocytes. Crls1 deficiency in thermogenic adipocytes diminishes inducible mitochondrial uncoupling and elicits a nuclear transcriptional response through endoplasmic reticulum stress-mediated retrograde communication. Cardiolipin depletion in brown and beige fat abolishes adipose thermogenesis and glucose uptake, which renders animals insulin resistant. We further identify a rare human CRLS1 variant associated with insulin resistance and show that adipose CRLS1 levels positively correlate with insulin sensitivity. Thus, adipose cardiolipin has a powerful impact on organismal energy homeostasis through thermogenic fat bioenergetics.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1932-7420 1932-7420
DOI:	10.1016/j.cmet.2018.05.003