ATF2, a paradigm of the multifaceted regulation of transcription factors in biology and disease

[Display omitted] Stringent transcriptional regulation is crucial for normal cellular biology and organismal development. Perturbations in the proper regulation of transcription factors can result in numerous pathologies, including cancer. Thus, understanding how transcription factors are regulated...

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Published in:Pharmacological research Vol. 119; pp. 347 - 357
Main Authors: Watson, Gregory, Ronai, Ze’ev A., Lau, Eric
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01.05.2017
Subjects:
Activating Transcription Factor 2 (ATF2)
Activating Transcription Factor 2 - analysis
Activating Transcription Factor 2 - genetics
Activating Transcription Factor 2 - metabolism
Activator Protein 1 (AP1)
Animals
Cancer
Drug Discovery
Humans
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - metabolism
Protein Processing, Post-Translational
Signal transduction
Transcription factor
Transcriptional Activation
Signal transduction
Activating Transcription Factor 2 (ATF2)
Activator Protein 1 (AP1)
Transcription factor
Cancer
ISSN:1043-6618, 1096-1186
Online Access:Get full text
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Summary:[Display omitted] Stringent transcriptional regulation is crucial for normal cellular biology and organismal development. Perturbations in the proper regulation of transcription factors can result in numerous pathologies, including cancer. Thus, understanding how transcription factors are regulated and how they are dysregulated in disease states is key to the therapeutic targeting of these factors and/or the pathways that they regulate. Activating transcription factor 2 (ATF2) has been studied in a number of developmental and pathological conditions. Recent findings have shed light on the transcriptional, post-transcriptional, and post-translational regulatory mechanisms that influence ATF2 function, and thus, the transcriptional programs coordinated by ATF2. Given our current knowledge of its multiple levels of regulation and function, ATF2 represents a paradigm for the mechanistic complexity that can regulate transcription factor function. Thus, increasing our understanding of the regulation and function of ATF2 will provide insights into fundamental regulatory mechanisms that influence how cells integrate extracellular and intracellular signals into a genomic response through transcription factors. Characterization of ATF2 dysfunction in the context of pathological conditions, particularly in cancer biology and response to therapy, will be important in understanding how pathways controlled by ATF2 or other transcription factors might be therapeutically exploited. In this review, we provide an overview of the currently known upstream regulators and downstream targets of ATF2.
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ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2017.02.004