Inhibition of MT1-MMP proteolytic function and ERK1/2 signalling influences cell migration and invasion through changes in MMP-2 and MMP-9 levels

Membrane type-1 matrix metalloproteinase (MT1-MMP, MMP-14) is a unique protease that cleaves extracellular proteins, activates proMMPs, and initiates intracellular signalling. MCF-7 cells are non-invasive and deficient in MT1-MMP, MMP-2, and MMP-9 expression. We created an MCF-7 cell line (C2) that...

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Bibliographic Details
Published in:	Journal of cell communication and signaling Vol. 11; no. 2; pp. 167 - 179
Main Authors:	Cepeda, Mario A., Evered, Caitlin L., Pelling, Jacob J. H ., Damjanovski, Sashko
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01.06.2017 John Wiley & Sons, Inc
Subjects:	3D culture Biomedical and Life Sciences Biomedicine Breast cancer Cell adhesion & migration Cell Biology Cell culture Cell migration ERK signalling Extracellular signal-regulated kinase Furin Gelatinase A Gelatinase B Intracellular signalling Kinases Life Sciences MAP kinase Matrix metalloproteinase Metalloproteinase MMP inhibition MMP‐2 MT1‐MMP Phosphorylation Proteinase Proteolysis Research Article MMP inhibition ERK signalling MT1-MMP 3D culture MMP-2 Cell migration
ISSN:	1873-9601, 1873-961X
Online Access:	Get full text
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