Inhibition of MT1-MMP proteolytic function and ERK1/2 signalling influences cell migration and invasion through changes in MMP-2 and MMP-9 levels

Membrane type-1 matrix metalloproteinase (MT1-MMP, MMP-14) is a unique protease that cleaves extracellular proteins, activates proMMPs, and initiates intracellular signalling. MCF-7 cells are non-invasive and deficient in MT1-MMP, MMP-2, and MMP-9 expression. We created an MCF-7 cell line (C2) that...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cell communication and signaling Jg. 11; H. 2; S. 167 - 179
Hauptverfasser:	Cepeda, Mario A., Evered, Caitlin L., Pelling, Jacob J. H ., Damjanovski, Sashko
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Dordrecht Springer Netherlands 01.06.2017 John Wiley & Sons, Inc
Schlagworte:	3D culture Biomedical and Life Sciences Biomedicine Breast cancer Cell adhesion & migration Cell Biology Cell culture Cell migration ERK signalling Extracellular signal-regulated kinase Furin Gelatinase A Gelatinase B Intracellular signalling Kinases Life Sciences MAP kinase Matrix metalloproteinase Metalloproteinase MMP inhibition MMP‐2 MT1‐MMP Phosphorylation Proteinase Proteolysis Research Article MMP inhibition ERK signalling MT1-MMP 3D culture MMP-2 Cell migration
ISSN:	1873-9601, 1873-961X
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!