The effect of the menstrual cycle on human cerebral blood flow: studies using Doppler ultrasound

Objective Previous studies have demonstrated hemodynamic changes at different phases in the menstrual cycle, but the cerebral circulation has not been investigated. Our aim was to study carotid and cerebral blood flow during the menstrual cycle using Doppler ultrasound. Two different techniques of D...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Ultrasound in obstetrics & gynecology Ročník 14; číslo 1; s. 52 - 57
Hlavní autoři: Brackley, K. J., Ramsay, M. M., Broughton Pipkin, F., Rubin, P. C.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Oxford, UK Blackwell Science Ltd 01.07.1999
Wiley
Témata:
Adult
Biological and medical sciences
Blood Flow Velocity
Carotid Arteries - diagnostic imaging
Cerebral Arteries - diagnostic imaging
Cerebral blood flow
Cerebrovascular Circulation
Doppler ultrasound
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Menstrual Cycle
Nervous system
Pregnancy
Prospective Studies
Ultrasonic investigative techniques
Ultrasonography, Doppler, Transcranial
Sonography
Human
Hormonodependence
Menstrual cycle
Medical imagery
Female
Biological effect
Hemodynamics
Duplex ultrasonography
Blood flow
Brain (vertebrata)
ISSN:0960-7692, 1469-0705
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Objective Previous studies have demonstrated hemodynamic changes at different phases in the menstrual cycle, but the cerebral circulation has not been investigated. Our aim was to study carotid and cerebral blood flow during the menstrual cycle using Doppler ultrasound. Two different techniques of Doppler waveform analysis were used: standard Doppler indices and Laplace transform analysis (LTA), which may provide additional hemodynamic information. Design This was a prospective study of healthy volunteers who were providing pre‐conception data for a subsequent longitudinal study set in the Department of Obstetrics and Gynaecology, Nottingham University Hospital. Nineteen women were studied in the mid‐follicular and mid‐luteal phases of 27 ovulatory menstrual cycles. Doppler recordings were obtained from the internal and external carotid and middle cerebral arteries. The standard Doppler indices (systolic/diastolic ratio, pulsatility index and resistance index) and LTA parameters were calculated. Results The standard Doppler indices were all significantly higher in the luteal compared to the follicular phase in the right middle cerebral artery (p < 0.05). However, no changes were seen in the standard indices in the carotid arteries or in any of the LTA parameters in any artery. Using the LTA, vessel wall stiffness was greater and absolute velocity of flow lower in the middle cerebral compared to the carotid arteries. Conclusions Increased ventilation and a subsequent lowering of alveolar CO2 pressure secondary to a raised progesterone level in the mid‐luteal phase could account for the observed changes within the middle cerebral artery. Under the conditions of this study the LTA appears less sensitive at detecting alterations in downstream resistance compared to the standard Doppler indices. Copyright © 1999 International Society of Ultrasound in Obstetrics and Gynecology
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0960-7692
1469-0705
DOI:10.1046/j.1469-0705.1999.14010052.x