The history, current state and perspectives of aerosol therapy

Nebulization is a very effective method of drug administration. This technique has been popular since ancient times when inhalation of plants rich in tropane alkaloids with spasmolytic and analgesic effects was widely used. Undoubtedly, the invention of anasthesia in the 19th century had an influenc...

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Veröffentlicht in:Acta pharmaceutica (Zagreb, Croatia) Jg. 72; H. 2; S. 225 - 243
Hauptverfasser: ROSPOND, BARTŁOMIEJ, KRAKOWSKA, AGATA, MUSZYŃSKA, BOŻENA, OPOKA, WŁODZIMIERZ
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Poland Sciendo 01.06.2022
De Gruyter Brill Sp. z o.o., Paradigm Publishing Services
Hrvatsko farmaceutsko društvo
Schlagworte:
Administration, Inhalation
Aerosols
Analgesics
Anticholinergics
Corticosteroids
Drug dosages
Dry Powder Inhalers
Inhalation
Inhalers
Intravenous administration
Metered Dose Inhalers
metered-dose inhalers and dry-powder inhalers
nebulization
Nebulizers and Vaporizers
plant raw materials
Respiratory diseases
Tropane alkaloids
inhalation
plant raw materials
metered-dose inhalers and dry-powder inhalers
nebulization
ISSN:1846-9558, 1330-0075, 1846-9558
Online-Zugang:Volltext
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Zusammenfassung:Nebulization is a very effective method of drug administration. This technique has been popular since ancient times when inhalation of plants rich in tropane alkaloids with spasmolytic and analgesic effects was widely used. Undoubtedly, the invention of anasthesia in the 19th century had an influence on the development of this technique. It resulted in the search for devices that facilitated anasthesia such as pulveriser or hydronium. From the second half of the 21st century, when the first DPI and MDI inhalers were launched, the constant development of aerosol therapy has been noticed. This is due to the fact that nebulization, compared with other means of medicinal substance application (such as oral and intravenous routes of administration), is safer and it exhibits a positive dose/efficacy ratio connected to the reduction of the dose. It enables drugs administration through the lung and possesses very fast onset action. Therefore, various drugs prescribed in respiratory diseases (such as corticosteroids, β-agonists, anticholinergics) are present on the market in a form of an aerosol.
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ISSN:1846-9558
1330-0075
1846-9558
DOI:10.2478/acph-2022-0017