Sensitive Troponin I Assay in Early Diagnosis of Acute Myocardial Infarction

A highly sensitive assay for troponin I was found to improve on standard serum markers for the diagnosis of acute myocardial infarction. The measurement of troponin I even within 3 hours after the onset of chest pain provided useful diagnostic information. A highly sensitive assay for troponin I was...

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Vydáno v:The New England journal of medicine Ročník 361; číslo 9; s. 868 - 877
Hlavní autoři: Keller, Till, Zeller, Tanja, Peetz, Dirk, Tzikas, Stergios, Roth, Alexander, Czyz, Ewa, Bickel, Christoph, Baldus, Stephan, Warnholtz, Ascan, Fröhlich, Meike, Sinning, Christoph R, Eleftheriadis, Medea S, Wild, Philipp S, Schnabel, Renate B, Lubos, Edith, Jachmann, Nicole, Genth-Zotz, Sabine, Post, Felix, Nicaud, Viviane, Tiret, Laurence, Lackner, Karl J, Münzel, Thomas F, Blankenberg, Stefan
Médium: Journal Article
Jazyk:angličtina
Vydáno: Waltham, MA Massachusetts Medical Society 27.08.2009
Témata:
Aged
Angina pectoris
Angina, Unstable - blood
Angina, Unstable - diagnosis
Area Under Curve
Armed forces
Biological and medical sciences
Biomarkers - blood
Cardiology. Vascular system
Cardiovascular disease
Chest Pain - etiology
Comorbidity
Coronary heart disease
Early Diagnosis
Electrocardiography
Female
General aspects
Heart
Heart attacks
Hospitals
Humans
Male
Medical imaging
Medical sciences
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Myocarditis. Cardiomyopathies
Predictive Value of Tests
ROC Curve
Sensitivity and Specificity
Troponin I - blood
Troponin T - blood
Assay
Myocardial infarction
Medicine
Troponin I
Acute
Cardiovascular disease
Early stage
Diagnosis
Coronary heart disease
Myocardial disease
ISSN:0028-4793, 1533-4406, 1533-4406
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Shrnutí:A highly sensitive assay for troponin I was found to improve on standard serum markers for the diagnosis of acute myocardial infarction. The measurement of troponin I even within 3 hours after the onset of chest pain provided useful diagnostic information. A highly sensitive assay for troponin I was found to improve on standard serum markers for the diagnosis of acute myocardial infarction. The measurement of troponin I even within 3 hours after the onset of chest pain provided useful diagnostic information. An early diagnosis of myocardial infarction facilitates rapid decision making and treatment and therefore improves the outcome in patients presenting with symptoms of chest pain. 1 , 2 The introduction of the testing of necrosis markers in the emergency setting constituted a milestone in the care of patients with chest pain. 3 – 6 Guidelines recommend the measurement of cardiac troponin levels for the diagnosis of myocardial infarction, with a level above the 99th percentile in a reference population as the discriminatory value, including the detection of a rise or fall in the troponin levels. 7 – 9 Although conventional necrosis markers have a high diagnostic . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa0903515