Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein

In patients with poorly controlled type 2 diabetes mellitus (T2DM), hepatic insulin resistance and increased gluconeogenesis contribute to fasting and postprandial hyperglycemia. Since cAMP response element-binding protein (CREB) is a key regulator of gluconeogenic gene expression, we hypothesized t...

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Veröffentlicht in:	Cell metabolism Jg. 10; H. 6; S. 499
Hauptverfasser:	Erion, Derek M, Ignatova, Irena D, Yonemitsu, Shin, Nagai, Yoshio, Chatterjee, Paula, Weismann, Dirk, Hsiao, Jennifer J, Zhang, Dongyan, Iwasaki, Takanori, Stark, Romana, Flannery, Clare, Kahn, Mario, Carmean, Christopher M, Yu, Xing Xian, Murray, Susan F, Bhanot, Sanjay, Monia, Brett P, Cline, Gary W, Samuel, Varman T, Shulman, Gerald I
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.12.2009
Schlagworte:	Animals Cholesterol - metabolism Cyclic AMP Response Element-Binding Protein - antagonists & inhibitors Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Diabetes Mellitus, Type 2 - therapy Disease Models, Animal Dyslipidemias - therapy Fatty Liver - genetics Fatty Liver - physiopathology Fatty Liver - therapy Glucose - metabolism Insulin Resistance - genetics Lipogenesis - physiology Liver - metabolism Liver - physiopathology Male Mice Oligonucleotides, Antisense Rats Triglycerides - metabolism
ISSN:	1932-7420, 1932-7420
Online-Zugang:	Weitere Angaben
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