Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

Caloric restriction (CR) extends the life span and health span of a variety of species and slows the progression of age-related hearing loss (AHL), a common age-related disorder associated with oxidative stress. Here, we report that CR reduces oxidative DNA damage in multiple tissues and prevents AH...

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Vydané v:	Cell Ročník 143; číslo 5; s. 802
Hlavní autori:	Someya, Shinichi, Yu, Wei, Hallows, William C, Xu, Jinze, Vann, James M, Leeuwenburgh, Christiaan, Tanokura, Masaru, Denu, John M, Prolla, Tomas A
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 24.11.2010
Predmet:	Aging - metabolism Animals Antioxidants - metabolism Caloric Restriction DNA Damage Female Glutathione - metabolism Hearing Loss - prevention & control Isocitrate Dehydrogenase - metabolism Male Mice Mice, Inbred C57BL Mitochondria - metabolism Oxidative Stress Sirtuin 3 - genetics Sirtuin 3 - metabolism
ISSN:	1097-4172, 1097-4172
On-line prístup:	Zistit podrobnosti o prístupe
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