Plasma granulysin levels and cellular interferon-γ production correlate with curative host responses in tuberculosis, while plasma interferon-γ levels correlate with tuberculosis disease activity in adults

Granulysin is a recently identified cytolytic protein which is expressed by human cytotoxic T-lymphocytes and natural killer (NK)-cells, and has broad antimicrobial and tumoricidal activity. Circulating granulysin levels are associated with T- and NK-cell activity, and may thus reflect protection-as...

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Bibliographic Details
Published in:	Tuberculosis (Edinburgh, Scotland) Vol. 87; no. 4; pp. 312 - 321
Main Authors:	Sahiratmadja, E., Alisjahbana, B., Buccheri, S., Di Liberto, D., de Boer, T., Adnan, I., van Crevel, R., Klein, M.R., van Meijgaarden, K.E., Nelwan, R.H.H., van de Vosse, E., Dieli, F., Ottenhoff, T.H.M.
Format:	Journal Article
Language:	English
Published:	Scotland Elsevier Ltd 01.07.2007
Subjects:	Adolescent Adult Aged Antigens, Differentiation, T-Lymphocyte - blood Case-Control Studies Cellular granulysin Cellular IFN-γ Disease severity Enzyme-Linked Immunosorbent Assay Female Humans Immunity, Cellular - physiology Infectious Disease Interferon-gamma - blood Interferon-gamma - metabolism Male Middle Aged Mycobacterium Plasma granulysin Plasma IFN-γ Pulmonary/Respiratory Severity of Illness Index Tuberculosis Tuberculosis, Pulmonary - blood Disease severity Cellular IFN-γ Tuberculosis Cellular granulysin Plasma granulysin Plasma IFN-γ Plasma IFN- γ Cellular IFN- γ
ISSN:	1472-9792
Online Access:	Get full text
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