Long non-coding RNA GAS5 in human cancer

Long non-coding RNAs (lncRNAs) constitute a group of >200-nucleotide ncRNA molecules. lncRNAs regulate several cell functions, such as proliferation, apoptosis, invasion and metastasis. Meanwhile, lncRNAs are abnormally expressed in human malignancies, where they suppress or promote tumor growth....

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Vydáno v:Oncology letters Ročník 20; číslo 3; s. 2587 - 2594
Hlavní autoři: Yang, Xiaoyan, Xie, Zhizhong, Lei, Xiaoyong, Gan, Runliang
Médium: Journal Article
Jazyk:angličtina
Vydáno: Athens D.A. Spandidos 01.09.2020
Spandidos Publications
Spandidos Publications UK Ltd
Témata:
Androgens
Apoptosis
Bladder cancer
Bone cancer
Breast cancer
Cancer metastasis
Cancer research
Cancer therapies
Cell cycle
Cell division
Cell growth
Cervical cancer
Colorectal cancer
diagnostic biomarker
Digestive system cancer
Disease
Endometrial cancer
Esophageal cancer
GAS5
Gastric cancer
Genes
Glioma
Gliomas
Kidney cancer
Lapatinib
Liver cancer
long non-coding RNA
Lung cancer
Lymphatic system
Medical diagnosis
Medical prognosis
Melanoma
Metastasis
Mortality
Oncology
Ovarian cancer
Pancreatic cancer
Prostate cancer
Review
RNA
Sarcoma
Skin cancer
Squamous cell carcinoma
Stomach cancer
therapeutic targe
Thyroid cancer
Thyroid diseases
tumor suppressor gene
Tumors
ISSN:1792-1074, 1792-1082
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Popis
Shrnutí:Long non-coding RNAs (lncRNAs) constitute a group of >200-nucleotide ncRNA molecules. lncRNAs regulate several cell functions, such as proliferation, apoptosis, invasion and metastasis. Meanwhile, lncRNAs are abnormally expressed in human malignancies, where they suppress or promote tumor growth. The present study focused on growth arrest-specific transcript 5 (GAS5), a well-known lncRNA that acts as a tumor suppressor but is suppressed in multiple types of cancer, including mammary carcinoma, prostate cancer, colorectal cancer, gastric cancer, melanoma, esophageal squamous cell carcinoma, lung cancer, ovarian cancer, cervical cancer, gliomas, osteosarcoma, pancreatic cancer, bladder cancer, kidney cancer, papillary thyroid carcinoma, neuroblastoma, endometrial cancer and liver cancer. Notably, GAS5 is overexpressed in liver cancer, potentially functioning as an oncogene. In the present study, the diagnostic and therapeutic roles of GAS5 in different tumors were reviewed, with a summary of the potential clinical application of the lncRNA, which may help identify novel study directions for GAS5.
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ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2020.11809