Sequence-specific peptide synthesis by an artificial small-molecule machine

The ribosome builds proteins by joining together amino acids in an order determined by messenger RNA. Here, we report on the design, synthesis, and operation of an artificial small-molecule machine that travels along a molecular strand, picking up amino acids that block its path, to synthesize a pep...

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Bibliographic Details

Published in:	Science (American Association for the Advancement of Science) Vol. 339; no. 6116; p. 189
Main Authors:	Lewandowski, Bartosz, De Bo, Guillaume, Ward, John W, Papmeyer, Marcus, Kuschel, Sonja, Aldegunde, María J, Gramlich, Philipp M E, Heckmann, Dominik, Goldup, Stephen M, D'Souza, Daniel M, Fernandes, Antony E, Leigh, David A
Format:	Journal Article
Language:	English
Published:	United States 11.01.2013
Subjects:	Amino Acid Sequence Chemical Phenomena Chemistry Techniques, Synthetic Molecular Structure Nuclear Magnetic Resonance, Biomolecular Peptides - chemical synthesis Peptides - chemistry Rotaxanes - chemistry Tandem Mass Spectrometry
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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