Sedative load and anticholinergic burden among older adults in Slovenia over a decade: Potential for optimization of pharmacotherapy

This study investigates the 10-year trend in the sedative and anticholinergic burden among older adults in Slovenia, with the aim of identifying opportunities to optimize pharmacotherapy in this population. A retrospective drug utilization analysis was conducted based on a national anonymized databa...

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Vydáno v:Acta Pharmaceutica Ročník 74; číslo 2; s. 329 - 341
Hlavní autoři: Jazbar, Janja, Locatelli, Igor, Kos, Mitja
Médium: Journal Article Paper
Jazyk:angličtina
Vydáno: Poland Sciendo 01.06.2024
De Gruyter Brill Sp. z o.o., Paradigm Publishing Services
Hrvatsko farmaceutsko društvo
Témata:
Age
Age Factors
Age groups
Aged
Aged, 80 and over
anticholinergic burden
Anticholinergics
Cholinergic Antagonists
Clinical significance
Databases, Factual
Drug therapy
Drug Utilization - statistics & numerical data
Drug Utilization - trends
drug utilization study
Female
Humans
Hypnotics and Sedatives
Male
older adults
Older people
pharmaco-therapy optimization
pharmacoepidemiology study
Prevalence
Retrospective Studies
sedative load
sedative load, anticholinergic burden, older adults, pharmacotherapy optimization, drug utilization study, pharmacoepidemiology study
Slovenia
Slovenia
older adults
drug utilization study
pharmaco-therapy optimization
sedative load
pharmacoepidemiology study
anticholinergic burden
ISSN:1846-9558, 1330-0075, 1846-9558
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Abstract This study investigates the 10-year trend in the sedative and anticholinergic burden among older adults in Slovenia, with the aim of identifying opportunities to optimize pharmacotherapy in this population. A retrospective drug utilization analysis was conducted based on a national anonymized database of dispensed prescriptions from 2009 to 2019. The study employed the sedative load model and the anticholinergic cognitive burden scale to assess the sedative and anti cholinergic burden, respectively. The findings indicate that in 2019, 45.6 % and 40.8 % of older adults (≥ 65 years) used sedative and anticholinergic medications, respectively. A high sedative load and a clinically significant anticholinergic burden were observed in a considerable proportion of older adults (13.2 % and 11.2 %, respectively, in 2019). The age-standardized prevalence of sedative load and anti-cholinergic burden significantly decreased over the 10-year study period by 5.6 % and 1.7 %, respectively (absolute difference), while the prevalence of clinically significant anticholinergic burden remained stable. Notably, the age groups 85–89 years and above 90 years had an increase in the proportion of individuals with a clinically significant anticholinergic burden over the years. These results emphasize the need for targeted interventions, particularly in the oldest age groups, to promote safe and effective medication use among older adults.
AbstractList This study investigates the 10-year trend in the sedative and anticholinergic burden among older adults in Slovenia, with the aim of identifying opportunities to optimize pharmacotherapy in this population. A retrospective drug utilization analysis was conducted based on a national anonymized database of dispensed prescriptions from 2009 to 2019. The study employed the sedative load model and the anticholinergic cognitive burden scale to assess the sedative and anti cholinergic burden, respectively. The findings indicate that in 2019, 45.6 % and 40.8 % of older adults (≥ 65 years) used sedative and anticholinergic medications, respectively. A high sedative load and a clinically significant anticholinergic burden were observed in a considerable proportion of older adults (13.2 % and 11.2 %, respectively, in 2019). The age-standardized prevalence of sedative load and anti-cholinergic burden significantly decreased over the 10-year study period by 5.6 % and 1.7 %, respectively (absolute difference), while the prevalence of clinically significant anticholinergic burden remained stable. Notably, the age groups 85–89 years and above 90 years had an increase in the proportion of individuals with a clinically significant anticholinergic burden over the years. These results emphasize the need for targeted interventions, particularly in the oldest age groups, to promote safe and effective medication use among older adults.
This study investigates the 10-year trend in the sedative and anticholinergic burden among older adults in Slovenia, with the aim of identifying opportunities to optimize pharmacotherapy in this population. A retrospective drug utilization analysis was conducted based on a national anonymized database of dispensed prescriptions from 2009 to 2019. The study employed the sedative load model and the anticholinergic cognitive burden scale to assess the sedative and anticholinergic burden, respectively. The findings indicate that in 2019, 45.6 % and 40.8 % of older adults (≥ 65 years) used sedative and anticholinergic medications, respectively. A high sedative load and a clinically significant anticholinergic burden were observed in a considerable proportion of older adults (13.2 % and 11.2 %, respectively, in 2019). The age-standardized prevalence of sedative load and anticholinergic burden significantly decreased over the 10-year study period by 5.6 % and 1.7 %, respectively (absolute difference), while the prevalence of clinically significant anticholinergic burden remained stable. Notably, the age groups 85–89 years and above 90 years had an increase in the proportion of individuals with a clinically significant anticholinergic burden over the years. These results emphasize the need for targeted interventions, particularly in the oldest age groups, to promote safe and effective medication use among older adults.
This study investigates the 10-year trend in the sedative and anticholinergic burden among older adults in Slovenia, with the aim of identifying opportunities to optimize pharmacotherapy in this population. A retrospective drug utilization analysis was conducted based on a national anonymized database of dispensed prescriptions from 2009 to 2019. The study employed the sedative load model and the anticholinergic cognitive burden scale to assess the sedative and anti cholinergic burden, respectively. The findings indicate that in 2019, 45.6 % and 40.8 % of older adults (≥ 65 years) used sedative and anticholinergic medications, respectively. A high sedative load and a clinically significant anticholinergic burden were observed in a considerable proportion of older adults (13.2 % and 11.2 %, respectively, in 2019). The age-standardized prevalence of sedative load and anti-cholinergic burden significantly decreased over the 10-year study period by 5.6 % and 1.7 %, respectively (absolute difference), while the prevalence of clinically significant anticholinergic burden remained stable. Notably, the age groups 85-89 years and above 90 years had an increase in the proportion of individuals with a clinically significant anticholinergic burden over the years. These results emphasize the need for targeted interventions, particularly in the oldest age groups, to promote safe and effective medication use among older adults.This study investigates the 10-year trend in the sedative and anticholinergic burden among older adults in Slovenia, with the aim of identifying opportunities to optimize pharmacotherapy in this population. A retrospective drug utilization analysis was conducted based on a national anonymized database of dispensed prescriptions from 2009 to 2019. The study employed the sedative load model and the anticholinergic cognitive burden scale to assess the sedative and anti cholinergic burden, respectively. The findings indicate that in 2019, 45.6 % and 40.8 % of older adults (≥ 65 years) used sedative and anticholinergic medications, respectively. A high sedative load and a clinically significant anticholinergic burden were observed in a considerable proportion of older adults (13.2 % and 11.2 %, respectively, in 2019). The age-standardized prevalence of sedative load and anti-cholinergic burden significantly decreased over the 10-year study period by 5.6 % and 1.7 %, respectively (absolute difference), while the prevalence of clinically significant anticholinergic burden remained stable. Notably, the age groups 85-89 years and above 90 years had an increase in the proportion of individuals with a clinically significant anticholinergic burden over the years. These results emphasize the need for targeted interventions, particularly in the oldest age groups, to promote safe and effective medication use among older adults.
Author Jazbar, Janja
Locatelli, Igor
Kos, Mitja
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CitedBy_id crossref_primary_10_1016_j_archger_2024_105693
Cites_doi 10.1111/jgs.2013.61.issue-s1
10.4088/JCP.16m10713
10.1016/j.sapharm.2017.07.004
10.1016/j.jamda.2018.12.022
10.1111/bcp.15045
10.1007/s10198-017-0903-9
10.1002/gps.846
10.1002/9780470017975.ch1
10.1111/fcp.12450
10.1186/1471-2318-11-56
10.1016/j.neubiorev.2021.04.031
10.1007/s40266-019-00720-6
10.1007/s40266-016-0380-3
10.2147/CIA.S66660
10.1007/s00228-013-1499-3
10.1002/pds.5383
10.1186/s12877-015-0029-9
10.1016/j.jamda.2014.10.010
10.1186/1471-2458-13-115
10.2217/1745509X.4.3.311
10.1002/pds.3951
10.1007/s40266-022-00968-5
10.1002/phar.1843
10.1016/j.jamda.2015.06.009
10.1097/JCP.0b013e3182485802
10.18773/austprescr.2022.031
10.2165/11597800-000000000-00000
10.1186/s12888-022-03964-6
10.1007/s40266-021-00895-x
10.1111/j.1532-5415.2011.03491.x
10.1111/bcp.12293
10.1016/j.jamda.2019.10.022
10.1331/JAPhA.2013.12138
10.1016/j.jamda.2019.06.001
10.1177/1060028016652997
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Copyright 2024 Janja Jazbar Igor et al., published by Sciendo.
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Issue 2
Keywords older adults
drug utilization study
pharmaco-therapy optimization
sedative load
pharmacoepidemiology study
anticholinergic burden
Language English
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References 2025012419092752637_j_acph-2024-0017_ref_030
2025012419092752637_j_acph-2024-0017_ref_031
2025012419092752637_j_acph-2024-0017_ref_010
2025012419092752637_j_acph-2024-0017_ref_032
2025012419092752637_j_acph-2024-0017_ref_011
2025012419092752637_j_acph-2024-0017_ref_033
2025012419092752637_j_acph-2024-0017_ref_012
2025012419092752637_j_acph-2024-0017_ref_034
2025012419092752637_j_acph-2024-0017_ref_013
2025012419092752637_j_acph-2024-0017_ref_035
2025012419092752637_j_acph-2024-0017_ref_036
2025012419092752637_j_acph-2024-0017_ref_015
2025012419092752637_j_acph-2024-0017_ref_037
cr-split#-2025012419092752637_j_acph-2024-0017_ref_014.3
2025012419092752637_j_acph-2024-0017_ref_016
2025012419092752637_j_acph-2024-0017_ref_038
cr-split#-2025012419092752637_j_acph-2024-0017_ref_014.2
2025012419092752637_j_acph-2024-0017_ref_017
2025012419092752637_j_acph-2024-0017_ref_039
cr-split#-2025012419092752637_j_acph-2024-0017_ref_014.1
2025012419092752637_j_acph-2024-0017_ref_018
2025012419092752637_j_acph-2024-0017_ref_019
2025012419092752637_j_acph-2024-0017_ref_040
2025012419092752637_j_acph-2024-0017_ref_020
2025012419092752637_j_acph-2024-0017_ref_021
2025012419092752637_j_acph-2024-0017_ref_022
2025012419092752637_j_acph-2024-0017_ref_001
2025012419092752637_j_acph-2024-0017_ref_023
2025012419092752637_j_acph-2024-0017_ref_002
2025012419092752637_j_acph-2024-0017_ref_003
2025012419092752637_j_acph-2024-0017_ref_025
2025012419092752637_j_acph-2024-0017_ref_004
2025012419092752637_j_acph-2024-0017_ref_026
2025012419092752637_j_acph-2024-0017_ref_005
2025012419092752637_j_acph-2024-0017_ref_027
2025012419092752637_j_acph-2024-0017_ref_006
2025012419092752637_j_acph-2024-0017_ref_028
2025012419092752637_j_acph-2024-0017_ref_007
2025012419092752637_j_acph-2024-0017_ref_029
2025012419092752637_j_acph-2024-0017_ref_008
2025012419092752637_j_acph-2024-0017_ref_009
cr-split#-2025012419092752637_j_acph-2024-0017_ref_024.1
cr-split#-2025012419092752637_j_acph-2024-0017_ref_024.2
cr-split#-2025012419092752637_j_acph-2024-0017_ref_024.3
References_xml – ident: #cr-split#-2025012419092752637_j_acph-2024-0017_ref_014.3
  doi: 10.1111/jgs.2013.61.issue-s1
– ident: 2025012419092752637_j_acph-2024-0017_ref_029
  doi: 10.4088/JCP.16m10713
– ident: 2025012419092752637_j_acph-2024-0017_ref_036
  doi: 10.1016/j.sapharm.2017.07.004
– ident: 2025012419092752637_j_acph-2024-0017_ref_027
  doi: 10.1016/j.jamda.2018.12.022
– ident: #cr-split#-2025012419092752637_j_acph-2024-0017_ref_024.3
  doi: 10.1111/bcp.15045
– ident: 2025012419092752637_j_acph-2024-0017_ref_037
  doi: 10.1007/s10198-017-0903-9
– ident: 2025012419092752637_j_acph-2024-0017_ref_038
– ident: 2025012419092752637_j_acph-2024-0017_ref_012
  doi: 10.1002/gps.846
– ident: 2025012419092752637_j_acph-2024-0017_ref_003
  doi: 10.1002/9780470017975.ch1
– ident: 2025012419092752637_j_acph-2024-0017_ref_034
  doi: 10.1111/fcp.12450
– ident: 2025012419092752637_j_acph-2024-0017_ref_039
  doi: 10.1186/1471-2318-11-56
– ident: #cr-split#-2025012419092752637_j_acph-2024-0017_ref_014.2
– ident: 2025012419092752637_j_acph-2024-0017_ref_020
  doi: 10.1016/j.neubiorev.2021.04.031
– ident: 2025012419092752637_j_acph-2024-0017_ref_025
  doi: 10.1007/s40266-019-00720-6
– ident: 2025012419092752637_j_acph-2024-0017_ref_026
  doi: 10.1007/s40266-016-0380-3
– ident: #cr-split#-2025012419092752637_j_acph-2024-0017_ref_024.2
  doi: 10.1111/bcp.15045
– ident: 2025012419092752637_j_acph-2024-0017_ref_006
  doi: 10.2147/CIA.S66660
– ident: 2025012419092752637_j_acph-2024-0017_ref_001
– ident: 2025012419092752637_j_acph-2024-0017_ref_011
  doi: 10.1007/s00228-013-1499-3
– ident: 2025012419092752637_j_acph-2024-0017_ref_031
  doi: 10.1002/pds.5383
– ident: 2025012419092752637_j_acph-2024-0017_ref_040
  doi: 10.1186/s12877-015-0029-9
– ident: 2025012419092752637_j_acph-2024-0017_ref_007
  doi: 10.1016/j.jamda.2014.10.010
– ident: 2025012419092752637_j_acph-2024-0017_ref_010
  doi: 10.1186/1471-2458-13-115
– ident: 2025012419092752637_j_acph-2024-0017_ref_013
  doi: 10.2217/1745509X.4.3.311
– ident: 2025012419092752637_j_acph-2024-0017_ref_035
– ident: #cr-split#-2025012419092752637_j_acph-2024-0017_ref_024.1
  doi: 10.1111/bcp.15045
– ident: 2025012419092752637_j_acph-2024-0017_ref_030
  doi: 10.1002/pds.3951
– ident: 2025012419092752637_j_acph-2024-0017_ref_032
  doi: 10.1007/s40266-022-00968-5
– ident: 2025012419092752637_j_acph-2024-0017_ref_019
  doi: 10.1002/phar.1843
– ident: 2025012419092752637_j_acph-2024-0017_ref_033
  doi: 10.1016/j.jamda.2015.06.009
– ident: #cr-split#-2025012419092752637_j_acph-2024-0017_ref_014.1
– ident: 2025012419092752637_j_acph-2024-0017_ref_015
  doi: 10.1097/JCP.0b013e3182485802
– ident: 2025012419092752637_j_acph-2024-0017_ref_022
  doi: 10.18773/austprescr.2022.031
– ident: 2025012419092752637_j_acph-2024-0017_ref_008
  doi: 10.2165/11597800-000000000-00000
– ident: 2025012419092752637_j_acph-2024-0017_ref_028
  doi: 10.1186/s12888-022-03964-6
– ident: 2025012419092752637_j_acph-2024-0017_ref_017
  doi: 10.1007/s40266-021-00895-x
– ident: 2025012419092752637_j_acph-2024-0017_ref_018
  doi: 10.1111/j.1532-5415.2011.03491.x
– ident: 2025012419092752637_j_acph-2024-0017_ref_004
  doi: 10.1111/bcp.12293
– ident: 2025012419092752637_j_acph-2024-0017_ref_005
  doi: 10.1016/j.jamda.2019.10.022
– ident: 2025012419092752637_j_acph-2024-0017_ref_009
  doi: 10.1331/JAPhA.2013.12138
– ident: 2025012419092752637_j_acph-2024-0017_ref_021
  doi: 10.1016/j.jamda.2019.06.001
– ident: 2025012419092752637_j_acph-2024-0017_ref_002
– ident: 2025012419092752637_j_acph-2024-0017_ref_023
– ident: 2025012419092752637_j_acph-2024-0017_ref_016
  doi: 10.1177/1060028016652997
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Snippet This study investigates the 10-year trend in the sedative and anticholinergic burden among older adults in Slovenia, with the aim of identifying opportunities...
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StartPage 329
SubjectTerms Age
Age Factors
Age groups
Aged
Aged, 80 and over
anticholinergic burden
Anticholinergics
Cholinergic Antagonists
Clinical significance
Databases, Factual
Drug therapy
Drug Utilization - statistics & numerical data
Drug Utilization - trends
drug utilization study
Female
Humans
Hypnotics and Sedatives
Male
older adults
Older people
pharmaco-therapy optimization
pharmacoepidemiology study
Prevalence
Retrospective Studies
sedative load
sedative load, anticholinergic burden, older adults, pharmacotherapy optimization, drug utilization study, pharmacoepidemiology study
Slovenia
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Title Sedative load and anticholinergic burden among older adults in Slovenia over a decade: Potential for optimization of pharmacotherapy
URI https://reference-global.com/article/10.2478/acph-2024-0017
https://www.ncbi.nlm.nih.gov/pubmed/38815203
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