A first-in-human study of 11C-MTP38, a novel PET ligand for phosphodiesterase 7

Purpose Phosphodiesterase 7 (PDE7) is an enzyme that selectively hydrolyses cyclic adenosine monophosphate, and its dysfunction is implicated in neuropsychiatric diseases. However, in vivo visualization of PDE7 in human brains has hitherto not been possible. Using the novel PET ligand 11 C-MTP38, wh...

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Veröffentlicht in:	European Journal of Nuclear Medicine and Molecular Imaging Jg. 48; H. 9; S. 2846 - 2855
Hauptverfasser:	Kubota, Manabu, Seki, Chie, Kimura, Yasuyuki, Takahata, Keisuke, Shimada, Hitoshi, Takado, Yuhei, Matsuoka, Kiwamu, Tagai, Kenji, Sano, Yasunori, Yamamoto, Yasuharu, Okada, Maki, Kikuchi, Tatsuya, Ichise, Masanori, Kawamura, Kazunori, Zhang, Ming-Rong, Higuchi, Makoto
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Berlin/Heidelberg Springer Science and Business Media LLC 01.08.2021 Springer Berlin Heidelberg Springer Nature B.V
Schlagworte:	Adenosine monophosphate Binding Blood C-MTP38 Cardiology Cerebellum Cyclic AMP Globus pallidus Imaging Ligands Medical imaging Medicine Medicine & Public Health Mental disorders Metabolites Neostriatum Neurology Nuclear Medicine Oncology Original Original Article Orthopedics PDE7 Phosphodiesterase Positron emission Positron emission tomography Quantification Radiology Sampling Thalamus Tomography Visualization PDE7 C-MTP38 Quantification Positron emission tomography
ISSN:	1619-7070, 1619-7089, 1619-7089
Online-Zugang:	Volltext
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