Multiscale and multimodal signatures of structure-function coupling variability across the human neocortex

•Previous research failed to show a clear hierarchical structure in the time-domain variability of the brain's structure-function coupling.•We show that the time-domain variability of structure-function coupling is higher in transmodal than unimodal cortices.•Time-domain variability of coupling...

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Jg. 302; S. 120902
Hauptverfasser: Facca, Massimiliano, Del Felice, Alessandra, Bertoldo, Alessandra
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Elsevier Inc 15.11.2024
Elsevier Limited
Elsevier
Schlagworte:
Brain mapping
Brain research
Connectivity
Connectome
Functional anatomy
Hierarchy
Hypotheses
Multimodal neuroimaging
Neocortex
Network
Neural networks
Regions
Structure-function
Structure-function relationships
Synaptic density
System theory
Hierarchy
Connectivity
Connectome
Multimodal neuroimaging
Network
Structure-function
ISSN:1053-8119, 1095-9572, 1095-9572
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Zusammenfassung:•Previous research failed to show a clear hierarchical structure in the time-domain variability of the brain's structure-function coupling.•We show that the time-domain variability of structure-function coupling is higher in transmodal than unimodal cortices.•Time-domain variability of coupling shows diverging relationships with myelination and synaptic density.•Long-range vs. short-range fiber tracts explain coupling patterns across the cortex.•A lower and more variable alignment between structure and function favors the emergence of unique functional dynamics. The relationship between the brain's structural wiring and its dynamic activity is thought to vary regionally, implying that the mechanisms underlying structure-function coupling may differ depending on a region's position within the brain's hierarchy. To better bridge the gap between structure and function, it is crucial to identify the factors shaping this regionality, not only in terms of how static functional connectivity aligns with structure, but also regarding the time-domain variability of this interplay. Here we map structure - function coupling and its time-domain variability and relate them to the heterogeneity of the cortex. We show that these two properties split the cortical landscape into two districts anchored to the opposite ends of the brain's hierarchy. By looking at statistical relationships with layer-specific gene transcription, T1w/T2 w ratio, and synaptic density, we show that macro-scale structure-function coupling may be rooted in the brain's microstructure and meso‑scale laminar specialization. Finally, we demonstrate that a lower and more variable alignment of function and structure may bestow the emergence of unique functional dynamics.
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ISSN:1053-8119
1095-9572
1095-9572
DOI:10.1016/j.neuroimage.2024.120902