Intra-Articular Injection of Adipose-Derived Stromal Vascular Fraction in Osteoarthritic Temporomandibular Joints: Study Design of a Randomized Controlled Clinical Trial

Introduction: Temporomandibular joint (TMJ) osteoarthritis is a degenerative disease of the TMJ. It is characterized by progressive degradation of the extracellular matrix components of articular cartilage, with secondary inflammatory components leading to pain in the temporomandibular region and re...

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Veröffentlicht in:	Bioengineering (Basel) Jg. 11; H. 2; S. 171
Hauptverfasser:	Schipper, Jan Aart M., Tuin, Aartje Jorien, van Dongen, Joris A., van Bakelen, Nico B., Harmsen, Martin Conrad, Spijkervet, Fred K. L.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 01.02.2024
Schlagworte:	adipose derived stromal cells adipose tissue Adipose tissues Analysis Arthritis Body fat Care and treatment Cartilage Cartilage (articular) Cartilage diseases Case studies Cell therapy Clinical trials Cytokines Effectiveness Enzymes Extracellular matrix Histochemistry Inflammation Injection intra-articular injection Joint diseases Knee Liposuction Mandible Maxillofacial surgery Mouth Oral hygiene Osteoarthritis Pain Questionnaires Signs and symptoms Surgeons Temporomandibular joint Temporomandibular joint disorders temporomandibular joint osteoarthritis tissue stromal vascular fraction Netherlands temporomandibular joint osteoarthritis adipose tissue tissue stromal vascular fraction intra-articular injection adipose derived stromal cells
ISSN:	2306-5354, 2306-5354
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Abstract	Introduction: Temporomandibular joint (TMJ) osteoarthritis is a degenerative disease of the TMJ. It is characterized by progressive degradation of the extracellular matrix components of articular cartilage, with secondary inflammatory components leading to pain in the temporomandibular region and reduced mouth opening. Current treatments do not halt disease progression, hence the need for new therapies to reduce inflammation and, consequently, improve symptoms. The aim of our randomized controlled clinical trial protocol is to investigate the efficacy of adjuvant intra-articular injections of autologous tissue-like stromal vascular fraction (tSVF), compared to arthrocentesis alone, in reducing pain and improving mouth opening in TMJ osteoarthritis patients. Materials and Methods: The primary endpoint analysis will consist of the visual analogue scale (VAS) for pain. The secondary endpoint analyses will include maximal interincisal mouth opening measurements; assessment of oral health and mandibular function based on the oral health impact profile (OHIP) questionnaire and mandibular functional impairment questionnaire (MFIQ); complications during the follow up; synovial cytokine analysis at baseline and after 26 weeks; and nucleated cells and tSVF (immuno)histochemistry analyses of the intervention group. Discussion: Our randomized clinical trial protocol will be applied to evaluate the efficacy of a new promising tSVF injection therapy for TMJ osteoarthritis. The safety of intra-articular injections of tSVF has been proven for knee osteoarthritis. However, since a tSVF injection is considered a heterologous application of cell therapy, the regulatory requirements are strict, which makes medical ethical approval challenging.
AbstractList	Temporomandibular joint (TMJ) osteoarthritis is a degenerative disease of the TMJ. It is characterized by progressive degradation of the extracellular matrix components of articular cartilage, with secondary inflammatory components leading to pain in the temporomandibular region and reduced mouth opening. Current treatments do not halt disease progression, hence the need for new therapies to reduce inflammation and, consequently, improve symptoms. The aim of our randomized controlled clinical trial protocol is to investigate the efficacy of adjuvant intra-articular injections of autologous tissue-like stromal vascular fraction (tSVF), compared to arthrocentesis alone, in reducing pain and improving mouth opening in TMJ osteoarthritis patients.INTRODUCTIONTemporomandibular joint (TMJ) osteoarthritis is a degenerative disease of the TMJ. It is characterized by progressive degradation of the extracellular matrix components of articular cartilage, with secondary inflammatory components leading to pain in the temporomandibular region and reduced mouth opening. Current treatments do not halt disease progression, hence the need for new therapies to reduce inflammation and, consequently, improve symptoms. The aim of our randomized controlled clinical trial protocol is to investigate the efficacy of adjuvant intra-articular injections of autologous tissue-like stromal vascular fraction (tSVF), compared to arthrocentesis alone, in reducing pain and improving mouth opening in TMJ osteoarthritis patients.The primary endpoint analysis will consist of the visual analogue scale (VAS) for pain. The secondary endpoint analyses will include maximal interincisal mouth opening measurements; assessment of oral health and mandibular function based on the oral health impact profile (OHIP) questionnaire and mandibular functional impairment questionnaire (MFIQ); complications during the follow up; synovial cytokine analysis at baseline and after 26 weeks; and nucleated cells and tSVF (immuno)histochemistry analyses of the intervention group.MATERIALS AND METHODSThe primary endpoint analysis will consist of the visual analogue scale (VAS) for pain. The secondary endpoint analyses will include maximal interincisal mouth opening measurements; assessment of oral health and mandibular function based on the oral health impact profile (OHIP) questionnaire and mandibular functional impairment questionnaire (MFIQ); complications during the follow up; synovial cytokine analysis at baseline and after 26 weeks; and nucleated cells and tSVF (immuno)histochemistry analyses of the intervention group.Our randomized clinical trial protocol will be applied to evaluate the efficacy of a new promising tSVF injection therapy for TMJ osteoarthritis. The safety of intra-articular injections of tSVF has been proven for knee osteoarthritis. However, since a tSVF injection is considered a heterologous application of cell therapy, the regulatory requirements are strict, which makes medical ethical approval challenging.DISCUSSIONOur randomized clinical trial protocol will be applied to evaluate the efficacy of a new promising tSVF injection therapy for TMJ osteoarthritis. The safety of intra-articular injections of tSVF has been proven for knee osteoarthritis. However, since a tSVF injection is considered a heterologous application of cell therapy, the regulatory requirements are strict, which makes medical ethical approval challenging. Introduction: Temporomandibular joint (TMJ) osteoarthritis is a degenerative disease of the TMJ. It is characterized by progressive degradation of the extracellular matrix components of articular cartilage, with secondary inflammatory components leading to pain in the temporomandibular region and reduced mouth opening. Current treatments do not halt disease progression, hence the need for new therapies to reduce inflammation and, consequently, improve symptoms. The aim of our randomized controlled clinical trial protocol is to investigate the efficacy of adjuvant intra-articular injections of autologous tissue-like stromal vascular fraction (tSVF), compared to arthrocentesis alone, in reducing pain and improving mouth opening in TMJ osteoarthritis patients. Materials and Methods: The primary endpoint analysis will consist of the visual analogue scale (VAS) for pain. The secondary endpoint analyses will include maximal interincisal mouth opening measurements; assessment of oral health and mandibular function based on the oral health impact profile (OHIP) questionnaire and mandibular functional impairment questionnaire (MFIQ); complications during the follow up; synovial cytokine analysis at baseline and after 26 weeks; and nucleated cells and tSVF (immuno)histochemistry analyses of the intervention group. Discussion: Our randomized clinical trial protocol will be applied to evaluate the efficacy of a new promising tSVF injection therapy for TMJ osteoarthritis. The safety of intra-articular injections of tSVF has been proven for knee osteoarthritis. However, since a tSVF injection is considered a heterologous application of cell therapy, the regulatory requirements are strict, which makes medical ethical approval challenging. Temporomandibular joint (TMJ) osteoarthritis is a degenerative disease of the TMJ. It is characterized by progressive degradation of the extracellular matrix components of articular cartilage, with secondary inflammatory components leading to pain in the temporomandibular region and reduced mouth opening. Current treatments do not halt disease progression, hence the need for new therapies to reduce inflammation and, consequently, improve symptoms. The aim of our randomized controlled clinical trial protocol is to investigate the efficacy of adjuvant intra-articular injections of autologous tissue-like stromal vascular fraction (tSVF), compared to arthrocentesis alone, in reducing pain and improving mouth opening in TMJ osteoarthritis patients. The primary endpoint analysis will consist of the visual analogue scale (VAS) for pain. The secondary endpoint analyses will include maximal interincisal mouth opening measurements; assessment of oral health and mandibular function based on the oral health impact profile (OHIP) questionnaire and mandibular functional impairment questionnaire (MFIQ); complications during the follow up; synovial cytokine analysis at baseline and after 26 weeks; and nucleated cells and tSVF (immuno)histochemistry analyses of the intervention group. Our randomized clinical trial protocol will be applied to evaluate the efficacy of a new promising tSVF injection therapy for TMJ osteoarthritis. The safety of intra-articular injections of tSVF has been proven for knee osteoarthritis. However, since a tSVF injection is considered a heterologous application of cell therapy, the regulatory requirements are strict, which makes medical ethical approval challenging.
Audience	Academic
Author	van Bakelen, Nico B. Tuin, Aartje Jorien Harmsen, Martin Conrad Schipper, Jan Aart M. van Dongen, Joris A. Spijkervet, Fred K. L.
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Cites_doi	10.1097/SCS.0000000000004884 10.1016/j.ymeth.2008.09.001 10.1111/wrr.12482 10.1016/j.archoralbio.2008.04.004 10.1016/0030-4220(86)90028-9 10.3390/ijms22010443 10.5125/jkaoms.2018.44.5.232 10.4103/0975-5950.102177 10.3727/096368912X657855 10.1186/1749-8090-6-43 10.1016/j.joca.2014.06.014 10.1002/stem.629 10.1097/SCS.0000000000004938 10.1007/978-3-0348-8992-6 10.14740/jocmr3187w 10.1007/s10266-005-0056-7 10.1016/j.jcms.2010.04.010 10.1016/j.joms.2009.07.060 10.11607/jop.1151 10.1097/AJP.0b013e31802f0950 10.1007/s40778-016-0053-5 10.1007/s11427-021-2090-3 10.3390/bioengineering9080345 10.1186/1755-7682-1-23 10.1016/j.joms.2013.08.022 10.1177/1759720X221117879 10.1002/art.24258 10.1097/PRS.0000000000002014 10.5966/sctm.2016-0023 10.1097/PRS.0b013e31829fe1b0 10.11607/jop.1007 10.1016/j.ijom.2022.08.018 10.1002/term.2843 10.1007/s00264-020-04926-x 10.1186/s13075-023-03134-3 10.1016/j.jcms.2013.07.010 10.1155/2020/2863624 10.1016/j.jcot.2022.101773 10.1186/s13018-020-01664-z 10.1007/s13770-020-00268-2 10.1155/2016/5762916 10.1111/j.1600-0528.1997.tb00941.x 10.3390/bioengineering10101175 10.1002/art.30137 10.1016/j.jcms.2018.11.025 10.1177/10454411970080030401 10.1248/bpb.34.1170 10.1016/j.joms.2021.01.038 10.1017/CBO9781139342834 10.1093/asj/sjz223 10.11607/jomi.te20
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References	Karina (ref_48) 2020; 2020 Li (ref_20) 2009; 60 Premaratne (ref_41) 2011; 6 ref_56 Bianchi (ref_31) 2013; 22 Shanmugasundaram (ref_49) 2021; 45 Yang (ref_53) 2023; 25 Tonnard (ref_29) 2013; 132 Milam (ref_8) 2005; 93 Stevens (ref_50) 2016; 24 Jerjes (ref_1) 2008; 1 Liu (ref_55) 2022; 65 Aletto (ref_54) 2022; 25 Lapuente (ref_21) 2020; 15 Westesson (ref_40) 1986; 62 Machon (ref_10) 2011; 39 Gostelie (ref_34) 2020; 40 Stegenga (ref_6) 2001; 15 Carboni (ref_27) 2019; 30 ref_24 ref_22 Nasser (ref_9) 2012; 2012 Murphy (ref_2) 2013; 28 Schiffman (ref_32) 2014; 28 Derogatis (ref_38) 1973; 9 LeResche (ref_4) 1997; 8 Avellanet (ref_15) 2022; 14 Kawabata (ref_19) 2011; 34 Cicione (ref_30) 2016; 137 Mountziaris (ref_3) 2009; 47 Comella (ref_47) 2017; 9 Tjakkes (ref_33) 2007; 23 Slade (ref_37) 1997; 25 Vos (ref_12) 2014; 42 Siennicka (ref_57) 2016; 2016 Nguyen (ref_23) 2017; 6 Sembronio (ref_28) 2021; 79 Vaira (ref_45) 2019; 47 Vos (ref_18) 2014; 72 Shinohara (ref_35) 2012; 3 Vernal (ref_16) 2008; 53 Getova (ref_51) 2019; 13 Vos (ref_11) 2013; 27 ref_46 Cai (ref_39) 2010; 68 Tremolada (ref_52) 2016; 2 ref_44 ref_43 Tang (ref_13) 2023; 52 Mahmmood (ref_26) 2019; 30 Gimble (ref_42) 2011; 29 Scanzello (ref_14) 2011; 63 Stegenga (ref_36) 1993; 7 ref_7 Farzin (ref_5) 2018; 44 Cevidanes (ref_17) 2014; 22 Kim (ref_25) 2020; 17
References_xml	– volume: 30 start-page: 793 year: 2019 ident: ref_27 article-title: Temporomandibular Disorders Clinical and Anatomical Outcomes After Fat-Derived Stem Cells Injection publication-title: J. Craniofac. Surg. doi: 10.1097/SCS.0000000000004884 – volume: 47 start-page: 134 year: 2009 ident: ref_3 article-title: Emerging Intra-Articular Drug Delivery Systems for the Temporomandibular Joint publication-title: Methods doi: 10.1016/j.ymeth.2008.09.001 – volume: 24 start-page: 994 year: 2016 ident: ref_50 article-title: The Fractionation of Adipose Tissue Procedure to Obtain Stromal Vascular Fractions for Regenerative Purposes publication-title: Wound Repair Regen. doi: 10.1111/wrr.12482 – volume: 53 start-page: 910 year: 2008 ident: ref_16 article-title: Expression of Proinflammatory Cytokines in Osteoarthritis of the Temporomandibular Joint publication-title: Arch. Oral Biol. doi: 10.1016/j.archoralbio.2008.04.004 – volume: 62 start-page: 124 year: 1986 ident: ref_40 article-title: The Risk of Damage to Facial Nerve, Superficial Temporal Vessels, Disk, and Articular Surfaces during Arthroscopic Examination of the Temporomandibular Joint publication-title: Oral Surg. Oral Med. Oral Pathol. doi: 10.1016/0030-4220(86)90028-9 – ident: ref_56 doi: 10.3390/ijms22010443 – volume: 44 start-page: 232 year: 2018 ident: ref_5 article-title: Comparison of Temporomandibular Disorders between Menopausal and Non-Menopausal Women publication-title: J. Korean Assoc. Oral Maxillofac. Surg. doi: 10.5125/jkaoms.2018.44.5.232 – volume: 3 start-page: 96 year: 2012 ident: ref_35 article-title: Single Puncture for TMJ Arthrocentesis: An Effective Technique for Hydraulic Distention of the Superior Joint Space publication-title: Natl. J. Maxillofac. Surg. doi: 10.4103/0975-5950.102177 – volume: 22 start-page: 2063 year: 2013 ident: ref_31 article-title: A New Nonenzymatic Method and Device to Obtain a Fat Tissue Derivative Highly Enriched in Pericyte-like Elements by Mild Mechanical Forces from Human Lipoaspirates publication-title: Cell Transplant. doi: 10.3727/096368912X657855 – volume: 6 start-page: 43 year: 2011 ident: ref_41 article-title: Stromal Vascular Fraction Transplantation as an Alternative Therapy for Ischemic Heart Failure: Anti-Inflammatory Role publication-title: J. Cardiothorac. Surg. doi: 10.1186/1749-8090-6-43 – volume: 22 start-page: 1657 year: 2014 ident: ref_17 article-title: 3D Osteoarthritic Changes in TMJ Condylar Morphology Correlates with Specific Systemic and Local Biomarkers of Disease publication-title: Osteoarthr. Cartil. doi: 10.1016/j.joca.2014.06.014 – volume: 29 start-page: 749 year: 2011 ident: ref_42 article-title: Concise Review: Adipose-Derived Stromal Vascular Fraction Cells and Stem Cells: Let’s Not Get Lost in Translation publication-title: Stem Cells doi: 10.1002/stem.629 – volume: 30 start-page: 659 year: 2019 ident: ref_26 article-title: Assessment of Therapeutic Effect of Intra-Articular Nanofat Injection for Temporomandibular Disorders publication-title: J. Craniofac. Surg. doi: 10.1097/SCS.0000000000004938 – ident: ref_7 doi: 10.1007/978-3-0348-8992-6 – volume: 9 start-page: 935 year: 2017 ident: ref_47 article-title: Safety Analysis of Autologous Stem Cell Therapy in a Variety of Degenerative Diseases and Injuries Using the Stromal Vascular Fraction publication-title: J. Clin. Med. Res. doi: 10.14740/jocmr3187w – volume: 93 start-page: 7 year: 2005 ident: ref_8 article-title: Pathogenesis of Degenerative Temporomandibular Joint Arthritides publication-title: Odontology doi: 10.1007/s10266-005-0056-7 – volume: 39 start-page: 127 year: 2011 ident: ref_10 article-title: Therapy of the Osteoarthritis of the Temporomandibular Joint publication-title: J. Cranio-Maxillofac. Surg. doi: 10.1016/j.jcms.2010.04.010 – volume: 68 start-page: 731 year: 2010 ident: ref_39 article-title: Septic Arthritis of the Temporomandibular Joint: A Retrospective Review of 40 Cases publication-title: J. Oral Maxillofac. Surg. doi: 10.1016/j.joms.2009.07.060 – volume: 28 start-page: 6 year: 2014 ident: ref_32 article-title: Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications: Recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Group publication-title: J. Oral Facial Pain Headache doi: 10.11607/jop.1151 – volume: 23 start-page: 233 year: 2007 ident: ref_33 article-title: The Effect of Intra-Articular Injection of Ultracain in the Temporomandibular Joint in Patients with Preauricular Pain: A Randomized Prospective Double-Blind Placebo-Controlled Crossover Study publication-title: Clin. J. Pain doi: 10.1097/AJP.0b013e31802f0950 – volume: 2 start-page: 304 year: 2016 ident: ref_52 article-title: Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems® Technology Development publication-title: Curr. Stem Cell Rep. doi: 10.1007/s40778-016-0053-5 – volume: 65 start-page: 1959 year: 2022 ident: ref_55 article-title: Intra-Articular Injection of Stromal Vascular Fraction for Knee Degenerative Joint Disease: A Concise Review of Preclinical and Clinical Evidence publication-title: Sci. China. Life Sci. doi: 10.1007/s11427-021-2090-3 – ident: ref_24 doi: 10.3390/bioengineering9080345 – volume: 1 start-page: 23 year: 2008 ident: ref_1 article-title: Muscle Disorders and Dentition-Related Aspects in Temporomandibular Disorders: Controversies in the Most Commonly Used Treatment Modalities publication-title: Int. Arch. Med. doi: 10.1186/1755-7682-1-23 – volume: 72 start-page: 35 year: 2014 ident: ref_18 article-title: Inflammation Is More Distinct in Temporomandibular Joint Osteoarthritis Compared to the Knee Joint publication-title: J. Oral Maxillofac. Surg. doi: 10.1016/j.joms.2013.08.022 – volume: 14 start-page: 1759720X221117879 year: 2022 ident: ref_15 article-title: Stromal Vascular Fraction Therapy for Knee Osteoarthritis: A Systematic Review publication-title: Ther. Adv. Musculoskelet. Dis. doi: 10.1177/1759720X221117879 – volume: 60 start-page: 513 year: 2009 ident: ref_20 article-title: Prostaglandin E2 and Its Cognate EP Receptors Control Human Adult Articular Cartilage Homeostasis and Are Linked to the Pathophysiology of Osteoarthritis publication-title: Arthritis Rheum. doi: 10.1002/art.24258 – volume: 137 start-page: 1157 year: 2016 ident: ref_30 article-title: In Vitro Validation of a Closed Device Enabling the Purification of the Fluid Portion of Liposuction Aspirates publication-title: Plast. Reconstr. Surg. doi: 10.1097/PRS.0000000000002014 – volume: 6 start-page: 187 year: 2017 ident: ref_23 article-title: Comparative Clinical Observation of Arthroscopic Microfracture in the Presence and Absence of a Stromal Vascular Fraction Injection for Osteoarthritis publication-title: Stem Cells Transl. Med. doi: 10.5966/sctm.2016-0023 – volume: 132 start-page: 1017 year: 2013 ident: ref_29 article-title: Nanofat Grafting: Basic Research and Clinical Applications publication-title: Plast. Reconstr. Surg. doi: 10.1097/PRS.0b013e31829fe1b0 – volume: 27 start-page: 171 year: 2013 ident: ref_11 article-title: Lavage Therapy versus Nonsurgical Therapy for the Treatment of Arthralgia of the Temporomandibular Joint: A Systematic Review of Randomized Controlled Trials publication-title: J. Orofac. Pain doi: 10.11607/jop.1007 – volume: 52 start-page: 595 year: 2023 ident: ref_13 article-title: Arthrocentesis versus Non-Surgical Intervention as Initial Treatment for Temporomandibular Joint Arthralgia: A Randomized Controlled Trial with Long-Term Follow-Up publication-title: Int. J. Oral Maxillofac. Surg. doi: 10.1016/j.ijom.2022.08.018 – volume: 13 start-page: 973 year: 2019 ident: ref_51 article-title: Adipose Tissue-Derived Extracellular Matrix Hydrogels as a Release Platform for Secreted Paracrine Factors publication-title: J. Tissue Eng. Regen. Med. doi: 10.1002/term.2843 – volume: 2012 start-page: CD007261 year: 2012 ident: ref_9 article-title: Interventions for the Management of Temporomandibular Joint Osteoarthritis publication-title: Cochrane Database Syst. Rev. – volume: 45 start-page: 615 year: 2021 ident: ref_49 article-title: Assessment of Safety and Efficacy of Intra-Articular Injection of Stromal Vascular Fraction for the Treatment of Knee Osteoarthritis—A Systematic Review publication-title: Int. Orthop. doi: 10.1007/s00264-020-04926-x – volume: 25 start-page: 147 year: 2023 ident: ref_53 article-title: Effect of Intra-Knee Injection of Autologous Adipose Stem Cells or Mesenchymal Vascular Components on Short-Term Outcomes in Patients with Knee Osteoarthritis: An Updated Meta-Analysis of Randomized Controlled Trials publication-title: Arthritis Res. Ther. doi: 10.1186/s13075-023-03134-3 – volume: 42 start-page: e134 year: 2014 ident: ref_12 article-title: Arthrocentesis as Initial Treatment for Temporomandibular Joint Arthropathy: A Randomized Controlled Trial publication-title: J. Cranio-Maxillofac. Surg. doi: 10.1016/j.jcms.2013.07.010 – volume: 9 start-page: 13 year: 1973 ident: ref_38 article-title: SCL-90: An Outpatient Psychiatric Rating Scale—Preliminary Report publication-title: Psychopharmacol. Bull. – volume: 2020 start-page: 2863624 year: 2020 ident: ref_48 article-title: Safety of Technique and Procedure of Stromal Vascular Fraction Therapy: From Liposuction to Cell Administration publication-title: Scientifica doi: 10.1155/2020/2863624 – volume: 25 start-page: 101773 year: 2022 ident: ref_54 article-title: Knee Intra-Articular Administration of Stromal Vascular Fraction Obtained from Adipose Tissue: A Systematic Review publication-title: J. Clin. Orthop. Trauma doi: 10.1016/j.jcot.2022.101773 – volume: 15 start-page: 137 year: 2020 ident: ref_21 article-title: Intra-Articular Infiltration of Adipose-Derived Stromal Vascular Fraction Cells Slows the Clinical Progression of Moderate-Severe Knee Osteoarthritis: Hypothesis on the Regulatory Role of Intra-Articular Adipose Tissue publication-title: J. Orthop. Surg. Res. doi: 10.1186/s13018-020-01664-z – volume: 17 start-page: 351 year: 2020 ident: ref_25 article-title: Anti-Inflammatory Effect of Adipose-Derived Stromal Vascular Fraction on Osteoarthritic Temporomandibular Joint Synoviocytes publication-title: Tissue Eng. Regen. Med. doi: 10.1007/s13770-020-00268-2 – volume: 2016 start-page: 5762916 year: 2016 ident: ref_57 article-title: Adipose-Derived Cells (Stromal Vascular Fraction) Transplanted for Orthopedical or Neurological Purposes: Are They Safe Enough? publication-title: Stem Cells Int. doi: 10.1155/2016/5762916 – volume: 25 start-page: 284 year: 1997 ident: ref_37 article-title: Derivation and Validation of a Short-Form Oral Health Impact Profile publication-title: Community Dent. Oral Epidemiol. doi: 10.1111/j.1600-0528.1997.tb00941.x – volume: 7 start-page: 183 year: 1993 ident: ref_36 article-title: Assessment of Mandibular Function Impairment Associated with Temporomandibular Joint Osteoarthrosis and Internal Derangement publication-title: J. Orofac. Pain – ident: ref_46 – volume: 15 start-page: 193 year: 2001 ident: ref_6 article-title: Osteoarthritis of the Temporomandibular Joint Organ and Its Relationship to Disc Displacement publication-title: J. Orofac. Pain – ident: ref_22 doi: 10.3390/bioengineering10101175 – volume: 63 start-page: 391 year: 2011 ident: ref_14 article-title: Synovial Inflammation in Patients Undergoing Arthroscopic Meniscectomy: Molecular Characterization and Relationship to Symptoms publication-title: Arthritis Rheum. doi: 10.1002/art.30137 – volume: 47 start-page: 1728 year: 2019 ident: ref_45 article-title: Bone Marrow Nucleated Cell Concentrate Autograft in Temporomandibular Joint Degenerative Disorders: 1-Year Results of a Randomized Clinical Trial publication-title: J. Cranio-Maxillofac. Surg. doi: 10.1016/j.jcms.2018.11.025 – volume: 8 start-page: 291 year: 1997 ident: ref_4 article-title: Epidemiology of Temporomandibular Disorders: Implications for the Investigation of Etiologic Factors publication-title: Crit. Rev. Oral Biol. Med. Off. Publ. Am. Assoc. Oral Biol. doi: 10.1177/10454411970080030401 – volume: 34 start-page: 1170 year: 2011 ident: ref_19 article-title: Prostaglandin E2 and Pain—An Update publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.34.1170 – ident: ref_43 – volume: 79 start-page: 1447 year: 2021 ident: ref_28 article-title: Temporomandibular Joint Arthrocentesis and Microfragmented Adipose Tissue Injection for the Treatment of Internal Derangement and Osteoarthritis: A Randomized Clinical Trial publication-title: J. Oral Maxillofac. Surg. doi: 10.1016/j.joms.2021.01.038 – ident: ref_44 doi: 10.1017/CBO9781139342834 – volume: 40 start-page: NP194 year: 2020 ident: ref_34 article-title: Fractionation of Adipose Tissue Procedure with a Disposable One-Hole Fractionator publication-title: Aesthetic Surg. J. doi: 10.1093/asj/sjz223 – volume: 28 start-page: e393 year: 2013 ident: ref_2 article-title: Temporomandibular Disorders: A Review of Etiology, Clinical Management, and Tissue Engineering Strategies publication-title: Int. J. Oral Maxillofac. Implant. doi: 10.11607/jomi.te20
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Snippet	Introduction: Temporomandibular joint (TMJ) osteoarthritis is a degenerative disease of the TMJ. It is characterized by progressive degradation of the... Temporomandibular joint (TMJ) osteoarthritis is a degenerative disease of the TMJ. It is characterized by progressive degradation of the extracellular matrix...
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SubjectTerms	adipose derived stromal cells adipose tissue Adipose tissues Analysis Arthritis Body fat Care and treatment Cartilage Cartilage (articular) Cartilage diseases Case studies Cell therapy Clinical trials Cytokines Effectiveness Enzymes Extracellular matrix Histochemistry Inflammation Injection intra-articular injection Joint diseases Knee Liposuction Mandible Maxillofacial surgery Mouth Oral hygiene Osteoarthritis Pain Questionnaires Signs and symptoms Surgeons Temporomandibular joint Temporomandibular joint disorders temporomandibular joint osteoarthritis tissue stromal vascular fraction
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Title	Intra-Articular Injection of Adipose-Derived Stromal Vascular Fraction in Osteoarthritic Temporomandibular Joints: Study Design of a Randomized Controlled Clinical Trial
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