Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth

Background Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of dysregulated Akt/mTORC1 signaling to cancer has been investigated extensively and altere...

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Veröffentlicht in:	Cancer & metabolism Jg. 1; H. 1; S. 3
Hauptverfasser:	Griffiths, Beatrice, Lewis, Caroline A, Bensaad, Karim, Ros, Susana, Zhang, Qifeng, Ferber, Emma C, Konisti, Sofia, Peck, Barrie, Miess, Heike, East, Philip, Wakelam, Michael, Harris, Adrian L, Schulze, Almut
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 23.01.2013 BioMed Central Ltd
Schlagworte:	Ablation (Surgery) Analysis Binding proteins Biomedical and Life Sciences Biomedicine Cancer cells Cancer Research Cell Biology Cell death Fatty acids Genetic engineering Growth Imaging Lipids Metabolic Diseases Metabolomics Nutrition and metabolism in health and disease Oncology Physiological aspects Protein binding Protein biosynthesis Radiology Steroids Synthesis Tumors Unsaturated fatty acids United States United Kingdom SREBP Akt ER-stress Fatty acids Cancer
ISSN:	2049-3002, 2049-3002
Online-Zugang:	Volltext
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