Loss of Mismatched HLA in Leukemia after Stem-Cell Transplantation
Five patients with acute myelogenous leukemia received hematopoietic stem-cell transplants from a haploidentical donor. They also received T cells from the donor. All five patients had a relapse, and at the time of relapse, genomic HLA typing of leukemic blasts could not detect the recipient's...
Uloženo v:
| Vydáno v: | The New England journal of medicine Ročník 361; číslo 5; s. 478 - 488 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Waltham, MA
Massachusetts Medical Society
30.07.2009
|
| Témata: | |
| ISSN: | 0028-4793, 1533-4406, 1533-4406 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Five patients with acute myelogenous leukemia received hematopoietic stem-cell transplants from a haploidentical donor. They also received T cells from the donor. All five patients had a relapse, and at the time of relapse, genomic HLA typing of leukemic blasts could not detect the recipient's HLA haplotype that differed from the donor's. The loss of the haplotype was due to uniparental disomy. In vitro, the donor's T cells reacted against leukemic blasts obtained at the time of diagnosis, not against blasts obtained at relapse. The results indicate the presence of a mutation that allowed the leukemic cells to escape the immunosurveillance of the donor's T cells.
Five patients with acute myelogenous leukemia received hematopoietic stem-cell transplants from a haploidentical donor. They also received T cells from the donor. All five patients had a relapse, and at the time of relapse, genomic HLA typing of leukemic blasts could not detect the recipient's HLA haplotype that differed from the donor's.
Transplantation of hematopoietic stem cells from a haploidentical family donor who shares only one HLA haplotype with the recipient is a potentially curative option for patients with high-risk hematologic cancers who lack an HLA-matched donor.
1
–
3
The major limitation of this strategy is the risk of severe graft-versus-host disease (GVHD), which can result from alloreactions mediated by donor T cells against the recipient's unshared HLA haplotype. Since the publication of studies on extensively T-cell–depleted grafts,
1
,
2
a variety of strategies have been developed to prevent or control GVHD after transfer of haploidentical T cells.
4
,
5
The feasibility and efficacy of . . . |
|---|---|
| AbstractList | Five patients with acute myelogenous leukemia received hematopoietic stem-cell transplants from a haploidentical donor. They also received T cells from the donor. All five patients had a relapse, and at the time of relapse, genomic HLA typing of leukemic blasts could not detect the recipient's HLA haplotype that differed from the donor's. The loss of the haplotype was due to uniparental disomy. In vitro, the donor's T cells reacted against leukemic blasts obtained at the time of diagnosis, not against blasts obtained at relapse. The results indicate the presence of a mutation that allowed the leukemic cells to escape the immunosurveillance of the donor's T cells.
Five patients with acute myelogenous leukemia received hematopoietic stem-cell transplants from a haploidentical donor. They also received T cells from the donor. All five patients had a relapse, and at the time of relapse, genomic HLA typing of leukemic blasts could not detect the recipient's HLA haplotype that differed from the donor's.
Transplantation of hematopoietic stem cells from a haploidentical family donor who shares only one HLA haplotype with the recipient is a potentially curative option for patients with high-risk hematologic cancers who lack an HLA-matched donor.
1
–
3
The major limitation of this strategy is the risk of severe graft-versus-host disease (GVHD), which can result from alloreactions mediated by donor T cells against the recipient's unshared HLA haplotype. Since the publication of studies on extensively T-cell–depleted grafts,
1
,
2
a variety of strategies have been developed to prevent or control GVHD after transfer of haploidentical T cells.
4
,
5
The feasibility and efficacy of . . . Transplantation of hematopoietic stem cells from partially matched family donors is a promising therapy for patients who have a hematologic cancer and are at high risk for relapse. The donor T-cell infusions associated with such transplantation can promote post-transplantation immune reconstitution and control residual disease.BACKGROUNDTransplantation of hematopoietic stem cells from partially matched family donors is a promising therapy for patients who have a hematologic cancer and are at high risk for relapse. The donor T-cell infusions associated with such transplantation can promote post-transplantation immune reconstitution and control residual disease.We identified 43 patients who underwent haploidentical transplantation and infusion of donor T cells for acute myeloid leukemia or myelodysplastic syndrome and conducted post-transplantation studies that included morphologic examination of bone marrow, assessment of hematopoietic chimerism with the use of short-tandem-repeat amplification, and HLA typing. The genomic rearrangements in mutant variants of leukemia were studied with the use of genomic HLA typing, microsatellite mapping, and single-nucleotide-polymorphism arrays. The post-transplantation immune responses against the original cells and the mutated leukemic cells were analyzed with the use of mixed lymphocyte cultures.METHODSWe identified 43 patients who underwent haploidentical transplantation and infusion of donor T cells for acute myeloid leukemia or myelodysplastic syndrome and conducted post-transplantation studies that included morphologic examination of bone marrow, assessment of hematopoietic chimerism with the use of short-tandem-repeat amplification, and HLA typing. The genomic rearrangements in mutant variants of leukemia were studied with the use of genomic HLA typing, microsatellite mapping, and single-nucleotide-polymorphism arrays. The post-transplantation immune responses against the original cells and the mutated leukemic cells were analyzed with the use of mixed lymphocyte cultures.In 5 of 17 patients with leukemia relapse after haploidentical transplantation and infusion of donor T cells, we identified mutant variants of the original leukemic cells. In the mutant leukemic cells, the HLA haplotype that differed from the donor's haplotype had been lost because of acquired uniparental disomy of chromosome 6p. T cells from the donor and the patient after transplantation did not recognize the mutant leukemic cells, whereas the original leukemic cells taken at the time of diagnosis were efficiently recognized and killed.RESULTSIn 5 of 17 patients with leukemia relapse after haploidentical transplantation and infusion of donor T cells, we identified mutant variants of the original leukemic cells. In the mutant leukemic cells, the HLA haplotype that differed from the donor's haplotype had been lost because of acquired uniparental disomy of chromosome 6p. T cells from the donor and the patient after transplantation did not recognize the mutant leukemic cells, whereas the original leukemic cells taken at the time of diagnosis were efficiently recognized and killed.After transplantation of haploidentical hematopoietic stem cells and infusion of donor T cells, leukemic cells can escape from the donor's antileukemic T cells through the loss of the mismatched HLA haplotype. This event leads to relapse.CONCLUSIONSAfter transplantation of haploidentical hematopoietic stem cells and infusion of donor T cells, leukemic cells can escape from the donor's antileukemic T cells through the loss of the mismatched HLA haplotype. This event leads to relapse. Background Transplantation of hematopoietic stem cells from partially matched family donors is a promising therapy for patients who have a hematologic cancer and are at high risk for relapse. The donor T-cell infusions associated with such transplantation can promote post-transplantation immune reconstitution and control residual disease. Methods We identified 43 patients who underwent haploidentical transplantation and infusion of donor T cells for acute myeloid leukemia or myelodysplastic syndrome and conducted post-transplantation studies that included morphologic examination of bone marrow, assessment of hematopoietic chimerism with the use of short-tandem-repeat amplification, and HLA typing. The genomic rearrangements in mutant variants of leukemia were studied with the use of genomic HLA typing, microsatellite mapping, and single-nucleotide-polymorphism arrays. The post-transplantation immune responses against the original cells and the mutated leukemic cells were analyzed with the use of mixed lymphocyte cultures. Results In 5 of 17 patients with leukemia relapse after haploidentical transplantation and infusion of donor T cells, we identified mutant variants of the original leukemic cells. In the mutant leukemic cells, the HLA haplotype that differed from the donor's haplotype had been lost because of acquired uniparental disomy of chromosome 6p. T cells from the donor and the patient after transplantation did not recognize the mutant leukemic cells, whereas the original leukemic cells taken at the time of diagnosis were efficiently recognized and killed. Conclusions After transplantation of haploidentical hematopoietic stem cells and infusion of donor T cells, leukemic cells can escape from the donor's antileukemic T cells through the loss of the mismatched HLA haplotype. This event leads to relapse. Transplantation of hematopoietic stem cells from partially matched family donors is a promising therapy for patients who have a hematologic cancer and are at high risk for relapse. The donor T-cell infusions associated with such transplantation can promote post-transplantation immune reconstitution and control residual disease. We identified 43 patients who underwent haploidentical transplantation and infusion of donor T cells for acute myeloid leukemia or myelodysplastic syndrome and conducted post-transplantation studies that included morphologic examination of bone marrow, assessment of hematopoietic chimerism with the use of short-tandem-repeat amplification, and HLA typing. The genomic rearrangements in mutant variants of leukemia were studied with the use of genomic HLA typing, microsatellite mapping, and single-nucleotide-polymorphism arrays. The post-transplantation immune responses against the original cells and the mutated leukemic cells were analyzed with the use of mixed lymphocyte cultures. In 5 of 17 patients with leukemia relapse after haploidentical transplantation and infusion of donor T cells, we identified mutant variants of the original leukemic cells. In the mutant leukemic cells, the HLA haplotype that differed from the donor's haplotype had been lost because of acquired uniparental disomy of chromosome 6p. T cells from the donor and the patient after transplantation did not recognize the mutant leukemic cells, whereas the original leukemic cells taken at the time of diagnosis were efficiently recognized and killed. After transplantation of haploidentical hematopoietic stem cells and infusion of donor T cells, leukemic cells can escape from the donor's antileukemic T cells through the loss of the mismatched HLA haplotype. This event leads to relapse. |
| Author | Cosentino, Cristian Casucci, Monica Bordignon, Claudio Ciceri, Fabio Perrelli, Nicola Flavio Bernardi, Massimo Forno, Barbara Peccatori, Jacopo Stanghellini, Maria Teresa Lupo Vago, Luca Angius, Andrea Zanussi, Monica Mazzi, Benedetta Roncarolo, Maria Grazia Rossini, Silvano Bonini, Chiara Perna, Serena Kimi Bondanza, Attilio Barlassina, Cristina Torri, Federica Corti, Consuelo Ferrari, Maurizio Fleischhauer, Katharina |
| Author_xml | – sequence: 1 givenname: Luca surname: Vago fullname: Vago, Luca – sequence: 2 givenname: Serena Kimi surname: Perna fullname: Perna, Serena Kimi – sequence: 3 givenname: Monica surname: Zanussi fullname: Zanussi, Monica – sequence: 4 givenname: Benedetta surname: Mazzi fullname: Mazzi, Benedetta – sequence: 5 givenname: Cristina surname: Barlassina fullname: Barlassina, Cristina – sequence: 6 givenname: Maria Teresa Lupo surname: Stanghellini fullname: Stanghellini, Maria Teresa Lupo – sequence: 7 givenname: Nicola Flavio surname: Perrelli fullname: Perrelli, Nicola Flavio – sequence: 8 givenname: Cristian surname: Cosentino fullname: Cosentino, Cristian – sequence: 9 givenname: Federica surname: Torri fullname: Torri, Federica – sequence: 10 givenname: Andrea surname: Angius fullname: Angius, Andrea – sequence: 11 givenname: Barbara surname: Forno fullname: Forno, Barbara – sequence: 12 givenname: Monica surname: Casucci fullname: Casucci, Monica – sequence: 13 givenname: Massimo surname: Bernardi fullname: Bernardi, Massimo – sequence: 14 givenname: Jacopo surname: Peccatori fullname: Peccatori, Jacopo – sequence: 15 givenname: Consuelo surname: Corti fullname: Corti, Consuelo – sequence: 16 givenname: Attilio surname: Bondanza fullname: Bondanza, Attilio – sequence: 17 givenname: Maurizio surname: Ferrari fullname: Ferrari, Maurizio – sequence: 18 givenname: Silvano surname: Rossini fullname: Rossini, Silvano – sequence: 19 givenname: Maria Grazia surname: Roncarolo fullname: Roncarolo, Maria Grazia – sequence: 20 givenname: Claudio surname: Bordignon fullname: Bordignon, Claudio – sequence: 21 givenname: Chiara surname: Bonini fullname: Bonini, Chiara – sequence: 22 givenname: Fabio surname: Ciceri fullname: Ciceri, Fabio – sequence: 23 givenname: Katharina surname: Fleischhauer fullname: Fleischhauer, Katharina |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21804290$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19641204$$D View this record in MEDLINE/PubMed |
| BookMark | eNp10U1P3DAQBmALUcFCe-RaRZXKLe34M8kRVhSoQnsoPUcTx1a9jZ2tnRz493W1C6hI2AdfHo_emTkhh2EKhpAzCp8oSPX529XXuwmhphS4OiArKjkvhQB1SFYArC5F1fBjcpLSBvKhojkix7RRgjIQK3LZTikVky3uXPI4619mKG7ai8KFojXLb-MdFmhnE4sfs_Hl2oxjcR8xpO2IYcbZTeEteWNxTObd_j0lP79c3a9vyvb79e36oi21ZDCXOcYgWU-hlkO-UlnKBEhRGdn3stdKa0RrZUWFwgGRM1tVolJGGlNr4PyUnO_qbuP0ZzFp7rxLOgfCYKYldaqSXAKlGX54ATfTEkPO1jHGG8pU02T0fo-W3puh20bnMT50j6PJ4OMeYNI42ty0dunJMVqDYA1kV-6cjnmU0djnUtD9W1H334qy5y-8drtBzhHd-OqvfRrvUxfMxr_i_gLunpx_ |
| CODEN | NEJMAG |
| CitedBy_id | crossref_primary_10_1517_14712590903431022 crossref_primary_10_1111_ejh_12017 crossref_primary_10_1097_MPH_0000000000001443 crossref_primary_10_3389_fimmu_2020_01854 crossref_primary_10_1016_j_cellimm_2012_03_011 crossref_primary_10_3390_diseases10020033 crossref_primary_10_1038_s41409_021_01211_2 crossref_primary_10_1182_blood_2022019106 crossref_primary_10_1016_j_blre_2015_11_002 crossref_primary_10_1080_10428194_2020_1789630 crossref_primary_10_1002_cnr2_1519 crossref_primary_10_1002_JLB_5AB0820_542RR crossref_primary_10_1182_blood_2012_04_427039 crossref_primary_10_1684_bdc_2014_1944 crossref_primary_10_1182_blood_2016_11_752378 crossref_primary_10_1007_s00262_009_0805_5 crossref_primary_10_1038_leu_2014_131 crossref_primary_10_1182_blood_2013_04_493361 crossref_primary_10_1155_2014_541345 crossref_primary_10_1016_j_coi_2014_01_010 crossref_primary_10_1158_2159_8290_CD_17_0343 crossref_primary_10_1097_MPH_0000000000000454 crossref_primary_10_1007_s11899_012_0145_y crossref_primary_10_1186_s13073_018_0598_2 crossref_primary_10_1517_14712598_2011_573476 crossref_primary_10_3390_cancers13215319 crossref_primary_10_3389_fimmu_2024_1459175 crossref_primary_10_1093_jnci_djv439 crossref_primary_10_1007_s00277_020_04080_9 crossref_primary_10_1053_j_seminhematol_2022_08_004 crossref_primary_10_1038_s41409_022_01635_4 crossref_primary_10_3390_cancers15164137 crossref_primary_10_1016_j_bbmt_2017_10_023 crossref_primary_10_1016_j_exphem_2016_12_004 crossref_primary_10_1182_blood_2016_11_751065 crossref_primary_10_1158_2159_8290_CD_21_0980 crossref_primary_10_1038_s41409_017_0078_0 crossref_primary_10_1038_nrclinonc_2015_128 crossref_primary_10_1038_onc_2013_269 crossref_primary_10_1158_1078_0432_CCR_17_3016 crossref_primary_10_3389_fimmu_2021_642087 crossref_primary_10_3390_ph8020230 crossref_primary_10_3389_fimmu_2018_03136 crossref_primary_10_1111_ajt_17174 crossref_primary_10_1038_s41409_018_0244_z crossref_primary_10_1038_s41568_025_00857_0 crossref_primary_10_3389_fimmu_2022_944872 crossref_primary_10_1182_bloodadvances_2017006429 crossref_primary_10_1007_s12185_021_03273_w crossref_primary_10_1016_j_beha_2024_101561 crossref_primary_10_1097_MPH_0000000000000672 crossref_primary_10_1002_ajh_25750 crossref_primary_10_1182_blood_2010_11_314393 crossref_primary_10_1038_s41375_022_01619_9 crossref_primary_10_1182_bloodadvances_2024014460 crossref_primary_10_1080_10428194_2021_1984453 crossref_primary_10_1038_onc_2011_138 crossref_primary_10_1111_cas_16102 crossref_primary_10_1038_s41392_025_02269_w crossref_primary_10_1111_tan_12830 crossref_primary_10_1016_j_pcl_2009_12_002 crossref_primary_10_1016_S2352_3026_24_00098_X crossref_primary_10_1111_eva_12017 crossref_primary_10_1038_s41408_024_01060_4 crossref_primary_10_1016_j_trim_2012_09_002 crossref_primary_10_3389_fimmu_2022_1066748 crossref_primary_10_3389_fimmu_2024_1347492 crossref_primary_10_1038_s41409_022_01777_5 crossref_primary_10_1158_2159_8290_CD_22_0329 crossref_primary_10_1038_leu_2014_327 crossref_primary_10_1111_ejh_12322 crossref_primary_10_1007_s12185_024_03778_0 crossref_primary_10_1038_leu_2012_68 crossref_primary_10_1016_j_bbmt_2015_04_025 crossref_primary_10_1182_blood_2021014532 crossref_primary_10_1038_bmt_2016_324 crossref_primary_10_2147_CMAR_S261721 crossref_primary_10_3390_jcm12020646 crossref_primary_10_1016_j_exphem_2022_03_003 crossref_primary_10_1016_j_blre_2021_100829 crossref_primary_10_3389_fped_2023_1232281 crossref_primary_10_1182_bloodadvances_2017015230 crossref_primary_10_1097_TP_0b013e3182481113 crossref_primary_10_3389_fimmu_2024_1328858 crossref_primary_10_1002_jgm_2637 crossref_primary_10_1038_s41409_025_02622_1 crossref_primary_10_1016_j_molmed_2011_12_003 crossref_primary_10_1182_blood_2012_01_405670 crossref_primary_10_1038_s41408_019_0251_3 crossref_primary_10_1007_s00277_018_3482_7 crossref_primary_10_1080_17474086_2018_1459184 crossref_primary_10_1586_ehm_12_28 crossref_primary_10_1016_j_leukres_2010_09_016 crossref_primary_10_1177_20406207211043748 crossref_primary_10_1038_s41571_020_0356_4 crossref_primary_10_1016_j_bbmt_2012_09_020 crossref_primary_10_1016_j_bbmt_2017_07_014 crossref_primary_10_1177_2040620715616544 crossref_primary_10_1016_j_bbmt_2011_07_012 crossref_primary_10_1053_j_seminhematol_2016_01_010 crossref_primary_10_1111_tan_14372 crossref_primary_10_1016_j_beha_2010_06_002 crossref_primary_10_1038_s41586_023_06496_5 crossref_primary_10_1002_pbc_24962 crossref_primary_10_1016_j_jtct_2021_05_023 crossref_primary_10_1182_bloodadvances_2016002188 crossref_primary_10_1111_tan_70093 crossref_primary_10_1016_j_drup_2025_101286 crossref_primary_10_1158_2643_3230_BCD_25_0017 crossref_primary_10_1007_s00262_009_0809_1 crossref_primary_10_12998_wjcc_v11_i2_268 crossref_primary_10_1016_j_bbmt_2012_09_012 crossref_primary_10_1038_bmt_2014_116 crossref_primary_10_3389_fcell_2019_00207 crossref_primary_10_1016_j_humimm_2010_10_009 crossref_primary_10_1056_NEJMe0903177 crossref_primary_10_1016_j_ccell_2020_06_002 crossref_primary_10_1186_s12943_023_01889_6 crossref_primary_10_1182_blood_2024025705 crossref_primary_10_1016_j_ymthe_2017_06_029 crossref_primary_10_1586_ehm_10_32 crossref_primary_10_1097_PPO_0000000000000378 crossref_primary_10_1111_tan_12090 crossref_primary_10_3390_cancers16233974 crossref_primary_10_1111_trf_17189 crossref_primary_10_1097_TP_0b013e3182481154 crossref_primary_10_1056_NEJMoa1601202 crossref_primary_10_1016_j_hemonc_2021_03_001 crossref_primary_10_3389_fimmu_2024_1359113 crossref_primary_10_1056_NEJMoa1808777 crossref_primary_10_1097_MOH_0000000000000412 crossref_primary_10_1038_leu_2016_57 crossref_primary_10_1038_s41409_020_01081_0 crossref_primary_10_1016_j_humimm_2022_04_008 crossref_primary_10_1038_s41409_023_01985_7 crossref_primary_10_1111_tan_15472 crossref_primary_10_1097_MOH_0b013e32835822f5 crossref_primary_10_3389_fonc_2020_00697 crossref_primary_10_1093_emph_eoy011 crossref_primary_10_1038_bmt_2017_193 crossref_primary_10_1089_hum_2010_014 crossref_primary_10_1038_bmt_2015_91 crossref_primary_10_1182_blood_2021012411 crossref_primary_10_1182_blood_2021012895 crossref_primary_10_1038_bmt_2016_62 crossref_primary_10_1080_17474086_2020_1796621 crossref_primary_10_1016_j_clim_2010_11_015 crossref_primary_10_4049_jimmunol_2300111 crossref_primary_10_3390_ijms20092057 crossref_primary_10_1038_icb_2010_124 crossref_primary_10_1038_s41375_024_02268_w crossref_primary_10_1158_2326_6066_CIR_15_0001 crossref_primary_10_1016_j_exphem_2020_09_189 crossref_primary_10_1146_annurev_med_051914_021702 crossref_primary_10_1097_PPO_0b013e3182341fde crossref_primary_10_3389_fimmu_2015_00479 crossref_primary_10_1073_pnas_0904658106 crossref_primary_10_1038_bmt_2015_99 crossref_primary_10_1053_j_seminoncol_2012_09_009 crossref_primary_10_3109_14653241003786155 crossref_primary_10_1053_j_seminoncol_2012_09_006 crossref_primary_10_1016_j_coi_2017_11_003 crossref_primary_10_1053_j_seminoncol_2012_09_005 crossref_primary_10_1111_imr_12130 crossref_primary_10_1182_blood_2019000823 crossref_primary_10_1111_j_1399_0039_2012_01868_x crossref_primary_10_3389_fphar_2014_00254 crossref_primary_10_1182_blood_2011_07_365189 crossref_primary_10_1111_tan_14167 crossref_primary_10_3390_jcm9010039 crossref_primary_10_1038_leu_2014_180 crossref_primary_10_1016_j_apsb_2020_06_012 crossref_primary_10_1016_j_bbmt_2017_09_009 crossref_primary_10_1016_j_leukres_2023_107038 crossref_primary_10_1111_bjh_19007 crossref_primary_10_3389_fimmu_2020_00147 crossref_primary_10_3389_fimmu_2022_999163 crossref_primary_10_1038_bmt_2016_167 crossref_primary_10_1038_s41409_021_01508_2 crossref_primary_10_1097_PPO_0000000000000575 crossref_primary_10_1038_bmt_2016_283 crossref_primary_10_3390_cancers16152615 crossref_primary_10_1002_cai2_72 crossref_primary_10_1007_s00277_020_04131_1 crossref_primary_10_1038_nature10738 crossref_primary_10_1182_blood_2022016082 crossref_primary_10_1182_bloodadvances_2016000943 crossref_primary_10_46989_001c_117961 crossref_primary_10_1038_s41591_019_0400_z crossref_primary_10_3390_cancers12010069 crossref_primary_10_1111_ejh_13030 crossref_primary_10_1182_bloodadvances_2021004335 crossref_primary_10_1111_bjh_20215 crossref_primary_10_1038_pr_2011_60 crossref_primary_10_1111_bjh_19463 crossref_primary_10_1038_s41375_022_01723_w crossref_primary_10_3389_fimmu_2022_1085978 crossref_primary_10_1080_10428194_2017_1306646 crossref_primary_10_1016_j_exphem_2024_104256 crossref_primary_10_1016_j_it_2017_04_004 crossref_primary_10_3390_cancers13153767 crossref_primary_10_1016_j_humimm_2019_02_009 crossref_primary_10_1038_s41409_017_0071_7 crossref_primary_10_1186_s40425_017_0211_z crossref_primary_10_1111_j_1365_2249_2010_04197_x crossref_primary_10_1515_sagmb_2020_0075 crossref_primary_10_1182_blood_2018_10_846824 crossref_primary_10_4049_jimmunol_1103710 crossref_primary_10_1016_S1773_035X_23_00085_0 crossref_primary_10_1080_14712598_2018_1384463 crossref_primary_10_1002_pbc_26839 crossref_primary_10_1016_j_humimm_2021_07_013 crossref_primary_10_1080_10428194_2020_1779255 crossref_primary_10_1084_jem_20092450 crossref_primary_10_3389_fimmu_2023_1290059 crossref_primary_10_3390_ijms241915019 crossref_primary_10_1038_s41416_020_0955_y crossref_primary_10_1155_2011_303487 crossref_primary_10_1172_JCI129204 crossref_primary_10_1186_2051_1426_1_13 crossref_primary_10_3389_fimmu_2020_00191 crossref_primary_10_1016_j_bbmt_2011_02_013 crossref_primary_10_1182_bloodadvances_2019000445 crossref_primary_10_1016_j_bbmt_2015_02_003 crossref_primary_10_1016_j_blre_2018_12_001 crossref_primary_10_1172_JCI87366 crossref_primary_10_1136_jitc_2020_000734 crossref_primary_10_1200_JCO_2010_30_5813 crossref_primary_10_3389_fonc_2021_812207 crossref_primary_10_1016_j_bbmt_2018_01_031 crossref_primary_10_1016_j_clml_2025_08_013 crossref_primary_10_2217_imt_13_152 crossref_primary_10_1111_bjh_19304 crossref_primary_10_1182_bloodadvances_2020002945 crossref_primary_10_1182_blood_2011_07_365338 crossref_primary_10_1186_s13045_020_00882_6 crossref_primary_10_2217_imt_09_84 crossref_primary_10_1182_blood_2009_11_254284 crossref_primary_10_1158_2159_8290_CD_15_0439 crossref_primary_10_1093_labmed_lmac132 crossref_primary_10_1016_j_bulcan_2023_03_013 crossref_primary_10_1172_JCI177460 crossref_primary_10_1182_blood_2015_12_629089 crossref_primary_10_1016_S2352_3026_19_30158_9 crossref_primary_10_1111_tan_13005 crossref_primary_10_1136_jitc_2021_003392 crossref_primary_10_1056_NEJMe1612215 crossref_primary_10_1111_iji_12393 crossref_primary_10_3389_fimmu_2018_01819 crossref_primary_10_1053_j_seminoncol_2011_11_005 crossref_primary_10_2217_imt_2019_0215 crossref_primary_10_1182_bloodadvances_2022009493 crossref_primary_10_1016_j_humimm_2011_03_003 crossref_primary_10_1016_j_bbcan_2015_12_001 crossref_primary_10_1016_j_exphem_2017_11_001 crossref_primary_10_1111_bjh_18561 crossref_primary_10_1038_s41409_018_0171_z crossref_primary_10_1016_j_jtct_2022_02_007 crossref_primary_10_3109_14653249_2010_530649 crossref_primary_10_1182_blood_2017_05_784306 crossref_primary_10_26508_lsa_201800079 crossref_primary_10_1016_j_jtct_2025_07_004 crossref_primary_10_1002_ajh_27471 crossref_primary_10_3390_life11020102 crossref_primary_10_1038_bmt_2014_285 crossref_primary_10_1080_16078454_2024_2347673 crossref_primary_10_1182_blood_2010_01_043737 crossref_primary_10_1038_s41409_020_0980_8 crossref_primary_10_1158_0008_5472_CAN_21_0301 crossref_primary_10_1038_mt_2012_227 crossref_primary_10_1016_j_clml_2013_05_006 crossref_primary_10_3389_fonc_2020_00262 crossref_primary_10_1016_j_cytogfr_2017_06_007 crossref_primary_10_1182_blood_2009_12_234096 crossref_primary_10_1016_j_bbmt_2019_01_016 crossref_primary_10_1158_2643_3230_BCD_24_0063 crossref_primary_10_1016_j_humimm_2022_03_001 crossref_primary_10_1038_s41467_019_08871_1 crossref_primary_10_1053_j_seminhematol_2015_04_002 crossref_primary_10_1016_j_bbmt_2010_08_001 crossref_primary_10_3389_fimmu_2021_695051 crossref_primary_10_1002_pbc_25819 crossref_primary_10_1111_petr_12267 crossref_primary_10_1038_leu_2010_133 crossref_primary_10_1080_14712598_2023_2174015 crossref_primary_10_3389_fonc_2022_787108 crossref_primary_10_1136_jitc_2020_000810 crossref_primary_10_3389_fped_2021_743294 crossref_primary_10_1038_s41409_021_01493_6 crossref_primary_10_1002_ijc_34243 crossref_primary_10_1007_s00262_022_03217_1 crossref_primary_10_1111_tan_13490 crossref_primary_10_1007_s11912_010_0113_4 crossref_primary_10_1053_j_seminhematol_2024_01_002 crossref_primary_10_1158_2159_8290_CD_20_1378 crossref_primary_10_1182_blood_2009_10_201848 crossref_primary_10_3390_cells12192392 crossref_primary_10_1038_s41375_021_01202_8 crossref_primary_10_1016_j_heliyon_2024_e39731 crossref_primary_10_1002_ajh_27175 crossref_primary_10_1111_bjh_16356 crossref_primary_10_1016_j_jmoldx_2017_01_005 crossref_primary_10_1038_leu_2010_189 crossref_primary_10_1111_bjh_16355 crossref_primary_10_1038_gt_2013_87 crossref_primary_10_1016_j_annonc_2021_08_2153 crossref_primary_10_1186_1752_1947_7_18 crossref_primary_10_3390_biomedicines12050975 crossref_primary_10_1002_acg2_77 crossref_primary_10_1182_blood_2025028617 crossref_primary_10_1053_j_seminhematol_2018_08_008 crossref_primary_10_1016_j_blre_2018_11_001 crossref_primary_10_1111_bjh_18529 crossref_primary_10_1016_j_beha_2011_04_002 crossref_primary_10_3389_fonc_2022_802648 crossref_primary_10_3390_cells11142249 crossref_primary_10_1038_s41598_024_51942_7 crossref_primary_10_1182_blood_2019001323 crossref_primary_10_1182_blood_2023019962 crossref_primary_10_1016_j_mrrev_2022_108445 crossref_primary_10_3389_fonc_2022_1066285 crossref_primary_10_1002_ajh_21628 crossref_primary_10_1038_s41409_019_0604_3 crossref_primary_10_3390_cancers13215390 crossref_primary_10_1038_s41467_020_17991_y crossref_primary_10_1016_j_humimm_2012_10_003 crossref_primary_10_1016_j_ccell_2023_08_014 crossref_primary_10_1111_tan_12898 crossref_primary_10_3389_fimmu_2023_1237782 crossref_primary_10_1007_s00262_020_02749_8 crossref_primary_10_1038_s41409_022_01579_9 crossref_primary_10_3389_fimmu_2023_1269012 crossref_primary_10_1182_blood_2011_04_350868 crossref_primary_10_1111_tan_12770 crossref_primary_10_1016_j_omtn_2024_102225 crossref_primary_10_1038_leu_2014_314 crossref_primary_10_3390_cancers13133170 crossref_primary_10_3390_jcm11010253 crossref_primary_10_1111_bjh_18863 crossref_primary_10_1038_bmt_2012_267 crossref_primary_10_1182_blood_2010_04_283119 crossref_primary_10_3390_diseases13010019 crossref_primary_10_1038_leu_2016_144 crossref_primary_10_3389_fimmu_2021_659595 crossref_primary_10_1038_s41467_023_38113_4 crossref_primary_10_3389_fonc_2019_01217 crossref_primary_10_1002_stem_1140 crossref_primary_10_3389_fgene_2023_1063227 crossref_primary_10_1056_NEJMoa2030391 crossref_primary_10_1126_scitranslmed_aap9630 crossref_primary_10_3389_fimmu_2025_1603188 crossref_primary_10_1111_bjh_12197 crossref_primary_10_1182_bloodadvances_2024012798 crossref_primary_10_1016_j_advenzreg_2009_10_030 crossref_primary_10_1016_j_exphem_2016_05_013 crossref_primary_10_1007_s12032_022_01911_9 crossref_primary_10_1111_tan_12313 crossref_primary_10_1007_s12185_016_2168_y crossref_primary_10_1111_tan_13640 crossref_primary_10_1186_s13287_021_02420_8 crossref_primary_10_1016_j_jmoldx_2014_04_003 crossref_primary_10_1080_14737140_2019_1589374 crossref_primary_10_1007_s11899_016_0330_5 crossref_primary_10_1016_j_blre_2023_101093 crossref_primary_10_1002_ijc_27661 crossref_primary_10_1186_s40364_025_00817_8 crossref_primary_10_1016_j_trim_2022_101602 crossref_primary_10_1111_j_1399_0039_2011_01799_x crossref_primary_10_3390_ijms21218000 crossref_primary_10_1016_j_bbmt_2010_02_018 crossref_primary_10_1182_blood_2016_01_636381 crossref_primary_10_1097_MPH_0000000000000937 crossref_primary_10_1182_blood_2017_07_795062 crossref_primary_10_3390_medsci1010037 crossref_primary_10_1038_s41598_025_05602_z crossref_primary_10_1182_bloodadvances_2025015938 crossref_primary_10_1182_blood_2019003566 crossref_primary_10_1053_j_seminhematol_2016_10_002 crossref_primary_10_1002_pd_4097 crossref_primary_10_1016_j_bbmt_2012_05_010 crossref_primary_10_3390_ijms20010228 crossref_primary_10_24287_1726_1708_2023_22_2_44_53 crossref_primary_10_1182_blood_2012_02_411686 crossref_primary_10_3109_10428194_2016_1167204 crossref_primary_10_1084_jem_20140410 crossref_primary_10_1177_09636897221102902 |
| Cites_doi | 10.1007/s10875-007-9166-z 10.1093/jnci/88.2.100 10.1002/1097-0215(20010101)91:1<109::AID-IJC1017>3.0.CO;2-E 10.1038/nri2200 10.1097/MOH.0b013e3282ef615a 10.1182/blood-2006-02-001909 10.1016/j.bbmt.2008.08.014 10.1038/ni1102-999 10.1016/S0065-230X(01)83005-0 10.1016/j.bcmd.2004.08.012 10.1158/0008-5472.CAN-08-2754 10.1200/JCO.2005.09.117 10.1007/s00281-008-0136-1 10.1111/j.1349-7006.2006.00356.x 10.1002/ijc.11241 10.1002/gcc.20234 10.1182/blood-2007-07-103325 10.1126/science.1068440 10.1016/j.humimm.2006.03.012 10.1053/j.seminhematol.2005.01.008 10.1182/blood-2008-02-140095 10.1016/j.bbmt.2007.08.003 10.1182/blood-2008-03-077974 10.1016/S0167-5699(00)01692-3 10.1016/S1470-2045(09)70074-9 10.1038/nri999 10.1158/0008-5472.375.65.2 10.1038/leu.2008.98 10.1056/NEJM199810223391702 10.1016/j.it.2008.02.005 |
| ContentType | Journal Article |
| Copyright | Copyright © 2009 Massachusetts Medical Society. All rights reserved. 2009 INIST-CNRS 2009 Massachusetts Medical Society |
| Copyright_xml | – notice: Copyright © 2009 Massachusetts Medical Society. All rights reserved. – notice: 2009 INIST-CNRS – notice: 2009 Massachusetts Medical Society |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7RV 7X7 7XB 8AO 8C1 8FE 8FH 8FI ABUWG AFKRA AN0 AZQEC BBNVY BEC BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH HCIFZ K0Y LK8 M0R M0T M1P M2M M2O M2P M7P MBDVC NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 |
| DOI | 10.1056/NEJMoa0811036 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Nursing & Allied Health Database Health & Medical Collection ProQuest Central (purchase pre-March 2016) ProQuest Pharma Collection Public Health Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection ProQuest Central (Alumni Edition) ProQuest Central UK/Ireland British Nursing Database ProQuest Central Essentials Biological Science Collection eLibrary ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep SciTech Premium Collection New England Journal of Medicine ProQuest Biological Science Collection Consumer Health Database Healthcare Administration Database Medical Database Psychology Database Research Library Science Database Biological Science Database Research Library (Corporate) Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology Research Library Prep ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials elibrary ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing New England Journal of Medicine ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Research Library ProQuest Central (New) ProQuest Public Health ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest Family Health ProQuest One Academic Eastern Edition British Nursing Index with Full Text ProQuest Health Management ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic ProQuest One Psychology MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7RV name: Nursing & Allied Health Database url: https://search.proquest.com/nahs sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1533-4406 |
| EndPage | 488 |
| ExternalDocumentID | 1811092041 19641204 21804290 10_1056_NEJMoa0811036 NJ200907303610509 |
| Genre | Original Article Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Telethon grantid: GGP08201 |
| GroupedDBID | - 0R 0WA 123 186 1AW 1KJ 1VV 29N 2KS 2WC 34G 39C 3O- 3V. 4 4.4 53G 55 5D0 5RE 68V 7FN 7RV 7X7 85S 8AO 8C1 8FE 8FH 8FI 8RP AACLI AAEJM AAIKC AALRV AAPBV AAQQT AARDX AASXA AAWTL ABACO ABEFU ABEHJ ABFLS ABIVO ABOCM ABPPZ ABPTK ABQES ABQIJ ABUFD ABUWG ABWJO ACDCL ACGFS ACGOD ACJLH ACNCT ACPRK ACRZS ACVYA ADBBV ADCBC AENEX AETEA AFDAS AFFNX AFKRA AFMIJ AGNAY AHMBA AHVBC AIKQT AJJEV AJUXI AJYGW ALMA_UNASSIGNED_HOLDINGS AN0 AQUVI AZQEC BBAFP BBNVY BCR BCU BENPR BES BHPHI BKEYQ BKNYI BLC BNQBC BPHCQ BVXVI C45 CJ0 CO CS3 DCD DU5 DWQXO DZ EBS EJD ET EX3 F20 F5P FD8 FM. FYUFA G8K GJ GNUQQ GUQSH H13 HCIFZ HZ IH2 J5H K-O K78 KM KOO L7B LK8 M0R M0T M1P M2M M2O M2P M7P MBDVC MVM N9A NEJ O0- O9- OHM OHT OK1 OMK OVD P-O P2P PADUT PCD PEA PQEST PQQKQ PQUKI PRINS PROAC PSQYO QJJ RHI RWL RXW S10 S6N SJFOW SJN TAE TAF TN5 TWZ U1N UCV UKR UMD UQL VQA W2G WH7 WOQ WOW X X7M XJT XYN XZL YCJ YNT YZZ ZA5 ZGI ZHY ZKB ZR0 ZXP --- -DZ -ET -~X .-4 .55 .CO .GJ 0R~ 36B 6TJ AAMNW AAYXX ABBLC ABCQX ABDPE ABDQB ABJNI ACKOT ACPFK ADRHT ADUKH ADXHL AERZD AFFHD AGHSJ BYPQX CCPQU CITATION HF~ HMCUK HZ~ N4W NAPCQ PHGZM PHGZT PJZUB PPXIY PQGLB PSYQQ TEORI TUQ UKHRP YFH YR2 YR5 YYP ZCA ZVN ~KM 1CY 41~ 8WZ 9M8 A6W AAQOH AAUTI ACPVT ACTDY AFFDN AFHKK AFOSN ALIPV D0S FA8 IQODW LPU MQT NHB QZG SKT UBX WHG XOL YHZ YQI YQJ YRY YYQ CGR CUY CVF ECM EIF NPM 7XB BEC K0Y PKEHL Q9U 7X8 |
| ID | FETCH-LOGICAL-c520t-793d52b1085d5d556f1240547e5bb5bc6ccaaff57146adaa32f77476e5ee8c033 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 428 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000268443900008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0028-4793 1533-4406 |
| IngestDate | Sun Nov 09 09:53:16 EST 2025 Mon Oct 06 17:59:22 EDT 2025 Mon Jul 21 06:03:57 EDT 2025 Mon Jul 21 09:14:18 EDT 2025 Tue Nov 18 22:36:06 EST 2025 Sat Nov 29 06:18:03 EST 2025 Wed Nov 11 00:33:08 EST 2020 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | Incompatibility Medicine HLA-System Stem cell Major histocompatibility system Loss Hematopoietic cell Stem cell transplantation Class I histocompatibility antigen Tumor cell |
| Language | English |
| License | CC BY 4.0 2009 Massachusetts Medical Society |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c520t-793d52b1085d5d556f1240547e5bb5bc6ccaaff57146adaa32f77476e5ee8c033 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-General Information-1 content type line 14 ObjectType-Feature-3 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://zenodo.org/record/3444067 |
| PMID | 19641204 |
| PQID | 223912699 |
| PQPubID | 40644 |
| PageCount | 11 |
| ParticipantIDs | proquest_miscellaneous_67535011 proquest_journals_223912699 pubmed_primary_19641204 pascalfrancis_primary_21804290 crossref_primary_10_1056_NEJMoa0811036 crossref_citationtrail_10_1056_NEJMoa0811036 mms_nejm_10_1056_NEJMoa0811036 |
| ProviderPackageCode | DCD 7FN |
| PublicationCentury | 2000 |
| PublicationDate | 2009-07-30 |
| PublicationDateYYYYMMDD | 2009-07-30 |
| PublicationDate_xml | – month: 07 year: 2009 text: 2009-07-30 day: 30 |
| PublicationDecade | 2000 |
| PublicationPlace | Waltham, MA |
| PublicationPlace_xml | – name: Waltham, MA – name: United States – name: Boston |
| PublicationTitle | The New England journal of medicine |
| PublicationTitleAlternate | N Engl J Med |
| PublicationYear | 2009 |
| Publisher | Massachusetts Medical Society |
| Publisher_xml | – name: Massachusetts Medical Society |
| References | r020 r021 r022 r001 r017 r018 r019 r013 r015 r016 Raghavan M (r023) 2005; 65 r031 r010 r011 r012 r030 r006 r028 r007 r029 r008 r009 r002 r024 r003 Zheng P (r014) 1999; 59 r025 r004 r026 r005 r027 19641211 - N Engl J Med. 2009 Jul 30;361(5):524-5. doi: 10.1056/NEJMe0903177. |
| References_xml | – ident: r010 doi: 10.1007/s10875-007-9166-z – ident: r017 doi: 10.1093/jnci/88.2.100 – ident: r015 doi: 10.1002/1097-0215(20010101)91:1<109::AID-IJC1017>3.0.CO;2-E – ident: r021 doi: 10.1038/nri2200 – ident: r004 doi: 10.1097/MOH.0b013e3282ef615a – ident: r006 doi: 10.1182/blood-2006-02-001909 – ident: r009 doi: 10.1016/j.bbmt.2008.08.014 – ident: r018 doi: 10.1038/ni1102-999 – ident: r012 doi: 10.1016/S0065-230X(01)83005-0 – ident: r007 doi: 10.1016/j.bcmd.2004.08.012 – ident: r025 doi: 10.1158/0008-5472.CAN-08-2754 – ident: r002 doi: 10.1200/JCO.2005.09.117 – ident: r027 doi: 10.1007/s00281-008-0136-1 – ident: r019 doi: 10.1111/j.1349-7006.2006.00356.x – ident: r016 doi: 10.1002/ijc.11241 – ident: r024 doi: 10.1002/gcc.20234 – ident: r029 doi: 10.1182/blood-2007-07-103325 – ident: r026 doi: 10.1126/science.1068440 – ident: r030 doi: 10.1016/j.humimm.2006.03.012 – volume: 59 start-page: 3461 year: 1999 ident: r014 publication-title: Cancer Res – ident: r031 doi: 10.1053/j.seminhematol.2005.01.008 – ident: r003 doi: 10.1182/blood-2008-02-140095 – ident: r005 doi: 10.1016/j.bbmt.2007.08.003 – ident: r011 doi: 10.1182/blood-2008-03-077974 – ident: r013 doi: 10.1016/S0167-5699(00)01692-3 – ident: r008 doi: 10.1016/S1470-2045(09)70074-9 – ident: r028 doi: 10.1038/nri999 – volume: 65 start-page: 375 year: 2005 ident: r023 publication-title: Cancer Res doi: 10.1158/0008-5472.375.65.2 – ident: r020 doi: 10.1038/leu.2008.98 – ident: r001 doi: 10.1056/NEJM199810223391702 – ident: r022 doi: 10.1016/j.it.2008.02.005 – reference: 19641211 - N Engl J Med. 2009 Jul 30;361(5):524-5. doi: 10.1056/NEJMe0903177. |
| SSID | ssj0000149 |
| Score | 2.50237 |
| Snippet | Five patients with acute myelogenous leukemia received hematopoietic stem-cell transplants from a haploidentical donor. They also received T cells from the... Transplantation of hematopoietic stem cells from partially matched family donors is a promising therapy for patients who have a hematologic cancer and are at... Background Transplantation of hematopoietic stem cells from partially matched family donors is a promising therapy for patients who have a hematologic cancer... |
| SourceID | proquest pubmed pascalfrancis crossref mms |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 478 |
| SubjectTerms | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Cells, Cultured Chromosomes, Human, Pair 6 General aspects Graft vs Leukemia Effect - genetics Graft vs Leukemia Effect - immunology Haplotypes Hematopoietic Stem Cell Transplantation Histocompatibility Testing HLA Antigens - genetics Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - immunology Leukemia, Myeloid, Acute - therapy Lymphocytes Major Histocompatibility Complex Medical sciences Mutation Myelodysplastic Syndromes Recurrence Retrospective Studies Stem cells T-Lymphocytes - immunology Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Chimera Transplants & implants |
| SummonAdditionalLinks | – databaseName: New England Journal of Medicine dbid: DCD link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LT4NAEJ5oNcaL7wdW6x6MJ4m8doFjbW16aBsTNemNLLCboIWa0vr7nQXaWk2j4chCJjOzOx_M7vcB3ISRKx21udW0XV93hO_pHlYCXUaMhTR0GeNRITbhDgbecOg_LUmSfnbwKbtXmvBjjpXLxMV2E7Ywx3yl0dButb_xRFU4t_pVVJFp_np8pfhspmmutkLyHL0hSxmL9TizqDed_X9begB7FaQkzTIHDmFDZEew06-a5sfw0ENbyFiSfpIjPsUoxaTba5IkIz0xexdpwkkhFU6epyLVW2I0IiXn-YiXB5OyE3jtPL60unolnaBH1DKmOvogplaojhbEeFEmsY4jOnMFDTEEEcPAcSmpiwsljzm3LYk40GWCCuFFhm2fQi0bZ-IciMPwq5A7sbCZdGRsccsOhecxRSZnebGjwd3cp0FU8YoreYtRUPS3KQtW_KLB7WL4R0mosW5gAwMUZOItXTtgJXaL1yFqUWXW0KA-D2ZQzcw8QDjkmxbzfQ2uF3dxSqk-Cc_EeJYH-A2l2q2mBmdlBiwN9ZljWoZz8Zdtddgt2064ghuXUJtOZuIKtqPPaZJPGkXyfgGjreIc priority: 102 providerName: Massachusetts Medical Society |
| Title | Loss of Mismatched HLA in Leukemia after Stem-Cell Transplantation |
| URI | http://dx.doi.org/10.1056/NEJMoa0811036 https://www.ncbi.nlm.nih.gov/pubmed/19641204 https://www.proquest.com/docview/223912699 https://www.proquest.com/docview/67535011 |
| Volume | 361 |
| WOSCitedRecordID | wos000268443900008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVBGY databaseName: New England Journal of Medicine Current customDbUrl: eissn: 1533-4406 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: DCD dateStart: 19900101 isFulltext: true titleUrlDefault: https://www.nejm.org/medical-index providerName: Massachusetts Medical Society – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M7P dateStart: 19800103 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Consumer Health Database (subscription) customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M0R dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/familyhealth providerName: ProQuest – providerCode: PRVPQU databaseName: Health Management Database customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M0T dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/healthmanagement providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: 7RV dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: BENPR dateStart: 19800103 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Health & Medical Collection customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: 7X7 dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Psychology Database customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M2M dateStart: 19800103 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Public Health Database customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: 8C1 dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Research Library customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M2O dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database (subscription) customDbUrl: eissn: 1533-4406 dateEnd: 20250909 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M2P dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwED_RDSFe-P4Ig-IHxBPREiexnSe0dZv20JaqDNS3yHFsqdAkY2n5-zk7bsceyguKdFIUy7L8s-938Z3vAD6UipvUBrfGCc_DVOciFMgEoVGMlVnJGZPKFZvg06lYLPKZj83pfFjlVic6RV21yp6RHyON5TFlef75-ldoi0ZZ56qvoDGAQ5skIXGRe7O_skd569cfIPkUm0j5x7bQfCuRDuPIJWe-paRBXXc2QFJ2OEemL26x3_p0LHTx-D_H_wQeefOTnPTr5Snc080zeDDxDvbncDrGEZLWkMmyQ1sWEa3I5fiELBsy1puful5K4sqKk69rXYcjvVqRPj_6SvaXmJoX8O3i_Gp0GfoyC6HKaLQOcWaqjJb2GkKFT8YMcj5aclxnJcKlGIIsjck4KlVZSZlQgzYjZzrTWqgoSV7CQdM2-jWQlOEfpEwrnTCTmopKmpRaCGYTz1FRpQF82s50oXwOclsKY1U4X3jGijvABPBx1_y6T76xr-EQYSsa_aPe2-AOorvu0MKxlBwFcLSFrfC7uCt2mAXwfvcVt5_1qchGt5uuwP8t65qNA3jVr4vbgeYsjWmUvvlnz0fwsPdPoaqP3sLB-maj38F99Xu97G6GMODz71YuuJMCpRjFQzg8PZ_O5vh2NjpDOYnmTl5ZSSdOfnFyNnR74g9YCQNy |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1LT9wwEB5RqAqX0iektOBD21MjEm_iJAeEKC1aRHZVqVuJW3CcsbSwSYDsgvhR_Y8d57GUw_bGocoxVuTH55nPnsl8AB9TFWjPJLe6vSCyPYxCOyRPYGslROqngRBS1WITwXAYnp5GP5bgd_cvjEmr7GxibaizUpk78l1yY5HLRRTtX17ZRjTKBFc7BY0GFSd4d0sntmrv-Bst7yfOj76PDvt2KypgK587U5vwmPk8NUn3GT2-0OThiLcE6KfUOSVoSFJrPyATIjMpe1wTQwoE-oihcsz9J1n8FVNWz2QQDpzRX9WqWrbdXli1JT2JYuwaYftSkvt1nboY9L0LfJLnlUnIlBWtiW7ENBaz3drrHa3_Z_P1Ap639JodNPvhJSxh8QqeDdoEgtfwNaYZYaVmg3FFXJ0Qm7F-fMDGBYtxdoH5WLJaNp39nGJuH-Jkwpr67xPZ_KRVvIFfjzKCt7BclAVuAvMEnZCll2FPaE9nXPJeimEoTGE9HmaeBV-6lU1UW2PdSH1MkjrW74vkARAs-DxvftkUF1nUcJtgkhR4ni9s8ABB888RgzOUw7Fgq4NJ0lqpKpljxIKd-VsyLyZmJAssZ1VC50kTenYt2GhweN_RSHgud7x3__zyDqz2R4M4iY-HJ1uw1sTiyK0572F5ej3DD_BU3UzH1fV2vZcYnD02GP8AeuVVuA |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Nb9QwEB2Vgqpe-KYNhdYH4ES0iZM4yQGhsmXVqttVJUDqLTjOWFq6SUqzC-Kn9d91nDhbelhuPaAcY1n-eJ55tsfzAN7kKtahCW71gzh1Q0wTNyFP4GolRB7lsRBStWIT8WSSnJ2lp2tw1b-FMWGVvU1sDXVRK3NGPiA3lvpcpOlA26iI04PRx4ufrhGQMhetvZpGh5Bj_PObdm_Nh6MDmuq3nI8-fx0eulZgwFUR9-YuYbOIeG4C8Av6IqHJ2xGHiTHKqaFKUPek1lFM5kQWUgZcE1uKBUaIifLMWShZ__txQCA2j9SH_l-ZqyzztodXNr0n0Y2BEbmvJbli32sTQ9-4w3tl2ZjgTNnQ_OhOWGM182094OjRfzx2j-Ghpd1sv1snT2ANq6ewcWIDC57BpzGNDqs1O5k2xOEJyQU7HO-zacXGuDjHcipZK6fOvsyxdIc4m7EuL_xMdo-3qufw7U568ALWq7rCbWChoJ2zDAsMhA51wSUPckwSYRLu8aQIHXjfz3KmbO51IwEyy9oYgEhkt0DhwLtl8Ysu6ciqgrsEmazCH-XKArfQtKyOmJ2hIp4DOz1kMmu9mmyJFwf2ln_J7Ji7JFlhvWgy2meaK2nfga0OkzcNTUXocy98-c-a92CDMJiNjybHO7DZXdGRt_Newfr8coGv4YH6NZ82l7vtsmLw_a6xeA3ThF42 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Loss+of+Mismatched+HLA+in+Leukemia+after+Stem-Cell+Transplantation&rft.jtitle=The+New+England+journal+of+medicine&rft.au=Vago%2C+Luca&rft.au=Perna%2C+Serena+Kimi&rft.au=Zanussi%2C+Monica&rft.au=Mazzi%2C+Benedetta&rft.date=2009-07-30&rft.pub=Massachusetts+Medical+Society&rft.issn=0028-4793&rft.eissn=1533-4406&rft.volume=361&rft.issue=5&rft.spage=478&rft_id=info:doi/10.1056%2FNEJMoa0811036&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=1811092041 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-4793&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-4793&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-4793&client=summon |