Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis

The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus) has emerged as a significant threat to public health with startling drawbacks in all sectors globally. This study investigates the practicality of some medicinal plants for SARS-CoV-2 therapy using a systematic review and meta-anal...

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Bibliographic Details
Published in:Acta pharmaceutica (Zagreb, Croatia) Vol. 72; no. 2; pp. 199 - 224
Main Authors: EBENEZER, OLUWAKEMI, BODEDE, OLUSOLA, AWOLADE, PAUL, JORDAAN, MARYAM A., OGUNSAKIN, ROPO E., SHAPI, MICHAEL
Format: Journal Article
Language:English
Published: Poland Sciendo 01.06.2022
De Gruyter Brill Sp. z o.o., Paradigm Publishing Services
Hrvatsko farmaceutsko društvo
Subjects:
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Coronaviruses
COVID-19
COVID-19 main protease
Cryptotanshinone
Drug Repositioning
Herbal medicine
Humans
inhibition
Medicinal plants
Meta-analysis
Papain
Peptide Hydrolases
Plants, Medicinal
Protease Inhibitors
Proteinase
Proteinase inhibitors
Public health
Reviews
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Systematic review
COVID-19 main protease
meta-analysis
inhibition
medicinal plants
systematic review
ISSN:1846-9558, 1330-0075, 1846-9558
Online Access:Get full text
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Summary:The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus) has emerged as a significant threat to public health with startling drawbacks in all sectors globally. This study investigates the practicality of some medicinal plants for SARS-CoV-2 therapy using a systematic review and meta-analysis of their reported SARS-CoV-1 inhibitory potencies. Relevant data were systematically gathered from three databases, , Web of Science, PubMed and Scopus. The information obtained included botanical information, extraction method and extracts concentrations, as well as the proposed mechanisms. Fourteen articles describing 30 different plants met our eligibility criteria. Random effects model and subgroup analysis were applied to investigate heterogeneity. According to subgroup analysis, the substantial heterogeneity of the estimated mean based on the values reporting the most potent anti-SARS-CoV 3C--like protease (3CLpro) inhibitors (10.07 %, < 0.0001), was significantly higher compared to the most active anti-SARS-CoV papain-like protease (PLpro) inhibitors (6.12 %, < 0.0001). More importantly, the literature analysis revealed that fruit extracts of L. and the compound cryptotanshinone isolated from the root of ( = 0.8 ± 0.2 μmol L ) were excellent candidates for anti--SARS-CoV targeting PLpro. Meanwhile, iguesterin ( = 2.6 ± 0.6 μmol L ) isolated from the bark of emerged as the most excellent candidate for anti-SARS--CoV targeting 3CLpro. The present systematic review and meta-analysis provide valuable and comprehensive information about potential medicinal plants for SARS-CoV-2 inhibition. The chemotypes identified herein can be adopted as a starting point for developing new drugs to contain the novel virus.
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262296
ISSN:1846-9558
1330-0075
1846-9558
DOI:10.2478/acph-2022-0021