Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

The development of a nanoparticle RNA vaccine is reported that preferentially targets dendritic cells after systemic administration, and is shown to provide durable interferon-α-dependent antigen-specific immunity in mouse tumour models; initial results in advanced melanoma patients indicate potenti...

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Bibliographic Details
Published in:	Nature (London) Vol. 534; no. 7607; pp. 396 - 401
Main Authors:	Kranz, Lena M., Diken, Mustafa, Haas, Heinrich, Kreiter, Sebastian, Loquai, Carmen, Reuter, Kerstin C., Meng, Martin, Fritz, Daniel, Vascotto, Fulvia, Hefesha, Hossam, Grunwitz, Christian, Vormehr, Mathias, Hüsemann, Yves, Selmi, Abderraouf, Kuhn, Andreas N., Buck, Janina, Derhovanessian, Evelyna, Rae, Richard, Attig, Sebastian, Diekmann, Jan, Jabulowsky, Robert A., Heesch, Sandra, Hassel, Jessica, Langguth, Peter, Grabbe, Stephan, Huber, Christoph, Türeci, Özlem, Sahin, Ugur
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 16.06.2016 Nature Publishing Group
Subjects:	13/109 13/21 13/31 14/1 14/19 14/28 14/5 631/250/251/1567 631/250/590 631/250/590/2293 631/67/1059/2325 639/925/352/152 64/110 64/60 Administration, Intravenous Animals Antigen Presentation - immunology Antigens Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Antigens, Viral - genetics Antigens, Viral - immunology Autoantigens - genetics Autoantigens - immunology Cancer Cancer therapies Cancer Vaccines - administration & dosage Cancer Vaccines - genetics Care and treatment Clinical Trials, Phase I as Topic Dendritic cells Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism Disease Models, Animal Drug Carriers - administration & dosage Drug delivery systems Drugs Female Gene expression Genetic aspects Health aspects Humanities and Social Sciences Humans Immunotherapy Immunotherapy - methods Innovations Interferon Type I - immunology Interferon Type I - secretion letter Lipids Lungs Lymphatic system Lymphocyte Activation - immunology Lymphoid Tissue - cytology Lymphoid Tissue - immunology Macrophages - immunology Macrophages - metabolism Male Melanoma Melanoma - immunology Melanoma - therapy Membrane Glycoproteins - immunology Methods Mice Mice, Inbred C57BL Mode of action Molecular targeted therapy multidisciplinary Nanoparticles - administration & dosage Ribonucleic acid RNA RNA - administration & dosage RNA - genetics Science Spleen Static Electricity T-Lymphocytes - cytology T-Lymphocytes - immunology Toll-Like Receptor 7 - immunology Vaccines Vehicles
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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