Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding

Dual antiplatelet therapy with aspirin and a P2Y12 receptor blocker is a key strategy to reduce platelet reactivity and to prevent thrombotic events in patients treated with percutaneous coronary intervention. In an earlier consensus document, we proposed cutoff values for high on-treatment platelet...

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Veröffentlicht in:	Journal of the American College of Cardiology Jg. 62; H. 24; S. 2261
Hauptverfasser:	Tantry, Udaya S, Bonello, Laurent, Aradi, Daniel, Price, Matthew J, Jeong, Young-Hoon, Angiolillo, Dominick J, Stone, Gregg W, Curzen, Nick, Geisler, Tobias, Ten Berg, Jurrien, Kirtane, Ajay, Siller-Matula, Jolanta, Mahla, Elisabeth, Becker, Richard C, Bhatt, Deepak L, Waksman, Ron, Rao, Sunil V, Alexopoulos, Dimitrios, Marcucci, Rossella, Reny, Jean-Luc, Trenk, Dietmar, Sibbing, Dirk, Gurbel, Paul A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.12.2013
Schlagworte:	Acute Coronary Syndrome - therapy Adenosine Diphosphate - therapeutic use Angioplasty, Balloon, Coronary Blood Platelets - drug effects Coronary Artery Disease - therapy Coronary Thrombosis - etiology Coronary Thrombosis - prevention & control Hemorrhage - etiology Humans Myocardial Ischemia - etiology Platelet Aggregation Inhibitors - therapeutic use Platelet Function Tests Purinergic P2Y Receptor Antagonists - therapeutic use Receptors, Purinergic P2Y12 - drug effects Risk Assessment Risk Factors Stents - adverse effects coronary artery disease low platelet reactivity to adenosine diphosphate PR bleeding high platelet reactivity to adenosine diphosphate P2Y reaction units PRI myocardial infarction platelet reactivity HR HPR Thrombolysis In Myocardial Infarction odds ratio ADP platelet function testing/test LPR platelet reactivity index PRU percutaneous coronary intervention receiver-operating characteristic adenosine diphosphate stent thrombosis MI acute coronary syndrome(s) PFT ST OR CI CAD ROC coronary artery bypass graft vasodilator-stimulated phosphoprotein-phosphorylation ischemia VASP-P consensus ACS TIMI PCI hazard ratio confidence interval CABG
ISSN:	1558-3597, 1558-3597
Online-Zugang:	Weitere Angaben
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