SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

Protein function is regulated by diverse posttranslational modifications. The mitochondrial sirtuin SIRT5 removes malonyl and succinyl moieties from target lysines. The spectrum of protein substrates subject to these modifications is unknown. We report systematic profiling of the mammalian succinylo...

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Veröffentlicht in:	Molecular cell Jg. 50; H. 6; S. 919
Hauptverfasser:	Park, Jeongsoon, Chen, Yue, Tishkoff, Daniel X, Peng, Chao, Tan, Minjia, Dai, Lunzhai, Xie, Zhongyu, Zhang, Yi, Zwaans, Bernadette M M, Skinner, Mary E, Lombard, David B, Zhao, Yingming
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 27.06.2013
Schlagworte:	Acetylation Amino Acid Sequence Animals Cell Respiration Cells, Cultured Consensus Sequence Glycosylation Kinetics Lysine - metabolism Metabolic Networks and Pathways Mice Mice, Knockout Mitochondria - enzymology Molecular Sequence Annotation Protein Interaction Maps Protein Processing, Post-Translational Protein Transport Proteome - metabolism Pyruvate Dehydrogenase Complex - metabolism Sirtuins - genetics Sirtuins - metabolism Succinate Dehydrogenase - metabolism
ISSN:	1097-4164, 1097-4164
Online-Zugang:	Weitere Angaben
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