Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways
Wnt-signal transduction is critical for development and tissue homeostasis in a wide range of animal species and is frequently deregulated in human cancers. Members of the Frat/GBP family of glycogen synthase kinase 3β (Gsk3b)-binding oncoproteins are recognized as potent activators of the Wnt/β-cat...
Gespeichert in:
| Veröffentlicht in: | Oncogene Jg. 29; H. 1; S. 93 - 104 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
London
Nature Publishing Group UK
07.01.2010
Nature Publishing Group |
| Schlagworte: | |
| ISSN: | 0950-9232, 1476-5594, 1476-5594 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Wnt-signal transduction is critical for development and tissue homeostasis in a wide range of animal species and is frequently deregulated in human cancers. Members of the Frat/GBP family of glycogen synthase kinase 3β (Gsk3b)-binding oncoproteins are recognized as potent activators of the Wnt/β-catenin pathway in vertebrates. Here, we reveal a novel, Gsk3b-independent function of Frat converging on the activation of JNK and AP-1. Both these have been used as readouts for the noncanonical Frizzled/PCP pathway, which controls polarized cell movements and the establishment of tissue polarity. We find that Frat synergizes with Diversin, the mammalian homolog of the Drosophila PCP protein
diego
, in the activation of JNK/AP-1 signaling. Importantly, Frat mutants deficient for binding to Gsk3b retain oncogenic activity
in vivo
, suggesting that Wnt/β-catenin-independent events contribute to Frat-induced malignant transformation. The observed activities of Frat are reminiscent of the dual function of Dishevelled in the Wnt/β-catenin and Frizzled/PCP pathways and suggest that Frat may also function to bridge canonical and noncanonical Wnt pathways. |
|---|---|
| AbstractList | Wnt-signal transduction is critical for development and tissue homeostasis in a wide range of animal species and is frequently deregulated in human cancers. Members of the Frat/GBP family of glycogen synthase kinase 3β (Gsk3b)-binding oncoproteins are recognized as potent activators of the Wnt/β-catenin pathway in vertebrates. Here, we reveal a novel, Gsk3b-independent function of Frat converging on the activation of JNK and AP-1. Both these have been used as readouts for the noncanonical Frizzled/PCP pathway, which controls polarized cell movements and the establishment of tissue polarity. We find that Frat synergizes with Diversin, the mammalian homolog of the Drosophila PCP protein
diego
, in the activation of JNK/AP-1 signaling. Importantly, Frat mutants deficient for binding to Gsk3b retain oncogenic activity
in vivo
, suggesting that Wnt/β-catenin-independent events contribute to Frat-induced malignant transformation. The observed activities of Frat are reminiscent of the dual function of Dishevelled in the Wnt/β-catenin and Frizzled/PCP pathways and suggest that Frat may also function to bridge canonical and noncanonical Wnt pathways. Wnt-signal transduction is critical for development and tissue homeostasis in a wide range of animal species and is frequently deregulated in human cancers. Members of the Frat/GBP family of glycogen synthase kinase 3beta (Gsk3b)-binding oncoproteins are recognized as potent activators of the Wnt/beta-catenin pathway in vertebrates. Here, we reveal a novel, Gsk3b-independent function of Frat converging on the activation of JNK and AP-1. Both these have been used as readouts for the noncanonical Frizzled/PCP pathway, which controls polarized cell movements and the establishment of tissue polarity. We find that Frat synergizes with Diversin, the mammalian homolog of the Drosophila PCP protein diego, in the activation of JNK/AP-1 signaling. Importantly, Frat mutants deficient for binding to Gsk3b retain oncogenic activity in vivo, suggesting that Wnt/beta-catenin-independent events contribute to Frat-induced malignant transformation. The observed activities of Frat are reminiscent of the dual function of Dishevelled in the Wnt/beta-catenin and Frizzled/PCP pathways and suggest that Frat may also function to bridge canonical and noncanonical Wnt pathways. [PUBLICATION ABSTRACT] Wnt-signal transduction is critical for development and tissue homeostasis in a wide range of animal species and is frequently deregulated in human cancers. Members of the Frat/GBP family of glycogen synthase kinase 3b (Gsk3b)-binding oncoproteins are recognized as potent activators of the Wnt/b-catenin pathway in vertebrates. Here, we reveal a novel, Gsk3b-independent function of Frat converging on the activation of JNK and AP-1. Both these have been used as readouts for the noncanonical Frizzled/PCP pathway, which controls polarized cell movements and the establishment of tissue polarity. We find that Frat synergizes with Diversin, the mammalian homolog of the Drosophila PCP protein diego, in the activation of JNK/AP-1 signaling. Importantly, Frat mutants deficient for binding to Gsk3b retain oncogenic activity in vivo, suggesting that Wnt/b-catenin-independent events contribute to Frat-induced malignant transformation. The observed activities of Frat are reminiscent of the dual function of Dishevelled in the Wnt/b-catenin and Frizzled/PCP pathways and suggest that Frat may also function to bridge canonical and noncanonical Wnt pathways. Wnt-signal transduction is critical for development and tissue homeostasis in a wide range of animal species and is frequently deregulated in human cancers. Members of the Frat/GBP family of glycogen synthase kinase 3beta (Gsk3b)-binding oncoproteins are recognized as potent activators of the Wnt/beta-catenin pathway in vertebrates. Here, we reveal a novel, Gsk3b-independent function of Frat converging on the activation of JNK and AP-1. Both these have been used as readouts for the noncanonical Frizzled/PCP pathway, which controls polarized cell movements and the establishment of tissue polarity. We find that Frat synergizes with Diversin, the mammalian homolog of the Drosophila PCP protein diego, in the activation of JNK/AP-1 signaling. Importantly, Frat mutants deficient for binding to Gsk3b retain oncogenic activity in vivo, suggesting that Wnt/beta-catenin-independent events contribute to Frat-induced malignant transformation. The observed activities of Frat are reminiscent of the dual function of Dishevelled in the Wnt/beta-catenin and Frizzled/PCP pathways and suggest that Frat may also function to bridge canonical and noncanonical Wnt pathways. Wnt-signal transduction is critical for development and tissue homeostasis in a wide range of animal species and is frequently deregulated in human cancers. Members of the Frat/GBP family of glycogen synthase kinase 3beta (Gsk3b)-binding oncoproteins are recognized as potent activators of the Wnt/beta-catenin pathway in vertebrates. Here, we reveal a novel, Gsk3b-independent function of Frat converging on the activation of JNK and AP-1. Both these have been used as readouts for the noncanonical Frizzled/PCP pathway, which controls polarized cell movements and the establishment of tissue polarity. We find that Frat synergizes with Diversin, the mammalian homolog of the Drosophila PCP protein diego, in the activation of JNK/AP-1 signaling. Importantly, Frat mutants deficient for binding to Gsk3b retain oncogenic activity in vivo, suggesting that Wnt/beta-catenin-independent events contribute to Frat-induced malignant transformation. The observed activities of Frat are reminiscent of the dual function of Dishevelled in the Wnt/beta-catenin and Frizzled/PCP pathways and suggest that Frat may also function to bridge canonical and noncanonical Wnt pathways.Wnt-signal transduction is critical for development and tissue homeostasis in a wide range of animal species and is frequently deregulated in human cancers. Members of the Frat/GBP family of glycogen synthase kinase 3beta (Gsk3b)-binding oncoproteins are recognized as potent activators of the Wnt/beta-catenin pathway in vertebrates. Here, we reveal a novel, Gsk3b-independent function of Frat converging on the activation of JNK and AP-1. Both these have been used as readouts for the noncanonical Frizzled/PCP pathway, which controls polarized cell movements and the establishment of tissue polarity. We find that Frat synergizes with Diversin, the mammalian homolog of the Drosophila PCP protein diego, in the activation of JNK/AP-1 signaling. Importantly, Frat mutants deficient for binding to Gsk3b retain oncogenic activity in vivo, suggesting that Wnt/beta-catenin-independent events contribute to Frat-induced malignant transformation. The observed activities of Frat are reminiscent of the dual function of Dishevelled in the Wnt/beta-catenin and Frizzled/PCP pathways and suggest that Frat may also function to bridge canonical and noncanonical Wnt pathways. |
| Author | Nawijn, M C van Amerongen, R Lambooij, J -P Jonkers, J Proost, N Berns, A |
| Author_xml | – sequence: 1 givenname: R surname: van Amerongen fullname: van Amerongen, R organization: Division of Molecular Genetics, Netherlands Cancer Institute, Centre of Biomedical Genetics, 5Current address: Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA – sequence: 2 givenname: M C surname: Nawijn fullname: Nawijn, M C organization: Division of Molecular Genetics, Netherlands Cancer Institute, Centre of Biomedical Genetics, 6Current address: Laboratory Allergology and Pulmonary Diseases, Section Pathology and Medical Biology, Groningen University Medical Centre, 9713 GZ, Groningen, The Netherlands – sequence: 3 givenname: J -P surname: Lambooij fullname: Lambooij, J -P organization: Division of Molecular Genetics, Netherlands Cancer Institute, Centre of Biomedical Genetics – sequence: 4 givenname: N surname: Proost fullname: Proost, N organization: Division of Molecular Genetics, Netherlands Cancer Institute, Centre of Biomedical Genetics – sequence: 5 givenname: J surname: Jonkers fullname: Jonkers, J organization: Division of Molecular Biology – sequence: 6 givenname: A surname: Berns fullname: Berns, A email: a.berns@nki.nl organization: Division of Molecular Genetics, Netherlands Cancer Institute, Centre of Biomedical Genetics, Academic Medical Center |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22323253$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19802005$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kcFrFDEUxoO02G315lkGwXrprMnLZGZylGJroeBF8eBheJtJtimzyZpkKf3vfcuuLhTrKY_H7_vC-75TdhRisIy9EXwuuOw_xmDmwLmeS8FfsJlourZWSjdHbMa14rUGCSfsNOd7znmnObxkJ0L3nDRqxn5eJSwVecR1isX6kCs0paJdubOVSTHnFHGsoqsM0s_e4FRhGCuaD4sfodTZLwNOPiyrNZa7B3zMr9ixwynb1_v3jH2_-vzt8kt9-_X65vLTbW0U8FJDw0XntG67tjcIzmhYyHbROHCjsyB5J5sFYtc4q0dsFcpetUaLEYXiACjP2IedL53wa2NzGVY-GztNGGzc5IH0AKBVT-T5f0kQkqtGawLfPQHv4ybRfcQA-fVNv4Xe7qHNYmXHYZ38CtPj8CddAt7vAcwUk0sYjM9_OaBmJChJ3MWO2-Vt3cGKD9uSBwp72JY8UMmEwxPc-ILFx1AS-uk5Ub0TZfIOS5sOF_2T_w3pUrgD |
| CODEN | ONCNES |
| CitedBy_id | crossref_primary_10_1038_leu_2013_78 crossref_primary_10_1002_stem_516 crossref_primary_10_1016_j_cellsig_2018_03_004 crossref_primary_10_1128_MCB_05372_11 crossref_primary_10_1007_s12094_014_1254_y crossref_primary_10_1182_blood_2012_05_432534 crossref_primary_10_1007_s00109_018_1639_4 crossref_primary_10_3390_cancers16091652 crossref_primary_10_1371_journal_pntd_0007932 crossref_primary_10_1371_journal_pone_0227435 crossref_primary_10_1186_s13018_024_04578_2 crossref_primary_10_1007_s13277_012_0394_3 crossref_primary_10_1158_0008_5472_CAN_21_0649 crossref_primary_10_1016_j_aquaculture_2025_743088 crossref_primary_10_1186_s12863_016_0372_7 crossref_primary_10_1371_journal_pone_0024351 crossref_primary_10_1371_journal_pone_0113105 crossref_primary_10_1038_s41388_022_02451_2 crossref_primary_10_1016_j_canlet_2013_10_033 crossref_primary_10_1158_1078_0432_CCR_10_3021 crossref_primary_10_1002_anie_202004883 crossref_primary_10_26508_lsa_202101250 crossref_primary_10_1007_s11064_015_1766_z crossref_primary_10_1007_s13277_015_3752_0 crossref_primary_10_1007_s00428_011_1135_5 crossref_primary_10_1002_wdev_29 crossref_primary_10_1016_j_jocn_2013_02_003 crossref_primary_10_1016_j_semcdb_2021_10_004 crossref_primary_10_1016_j_ydbio_2014_08_029 crossref_primary_10_1002_ange_202004883 |
| Cites_doi | 10.1016/j.cub.2006.06.030 10.1073/pnas.0434590100 10.1038/35011077 10.1073/pnas.071041898 10.1242/dev.02347 10.1242/dev.02772 10.1002/bies.20526 10.1242/dev.013540 10.1038/ng950 10.1128/MCB.23.17.6027-6036.2003 10.1016/j.cub.2006.04.041 10.1093/emboj/16.3.441 10.1242/jcs.00973 10.1074/jbc.M112363200 10.1074/jbc.M109462200 10.2144/000112257 10.1016/S0014-5793(99)01161-8 10.1074/jbc.M400439200 10.1016/S0092-8674(00)81208-8 10.1186/gb-2006-7-10-r100 10.1101/gad.230402 10.1038/sj.onc.1202995 10.1073/pnas.0603808103 10.1093/emboj/cdg286 10.1146/annurev.cellbio.21.012704.132806 10.1074/jbc.274.1.129 10.1016/j.ydbio.2007.03.011 10.1101/gad.326705 10.1074/jbc.M213265200 10.1523/JNEUROSCI.4698-05.2005 10.1038/sj.bjc.6602988 10.1016/S0969-2126(01)00679-7 10.1016/S0925-4773(99)00187-2 10.1242/dev.00164 10.1371/journal.pgen.1000259 10.1126/science.1137065 10.1101/gad.1022203 10.1128/MCB.24.5.2000-2011.2004 10.1038/ng1552 10.1002/j.1460-2075.1995.tb07251.x 10.1016/S0092-8674(00)81226-X 10.1093/emboj/18.15.4233 10.1002/ijc.23600 10.1242/dev.120.2.347 |
| ContentType | Journal Article |
| Copyright | Macmillan Publishers Limited 2010 2015 INIST-CNRS Copyright Nature Publishing Group Jan 7, 2010 |
| Copyright_xml | – notice: Macmillan Publishers Limited 2010 – notice: 2015 INIST-CNRS – notice: Copyright Nature Publishing Group Jan 7, 2010 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 3V. 7TM 7TO 7U9 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0S M1P M2O M7P MBDVC P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U RC3 7X8 |
| DOI | 10.1038/onc.2009.310 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection ProQuest Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Research Library ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Research Library Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China ProQuest One Applied & Life Sciences Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Public Health ProQuest Central Basic ProQuest SciTech Collection ProQuest Medical Library ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Research Library Prep AIDS and Cancer Research Abstracts MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Biology |
| EISSN | 1476-5594 |
| EndPage | 104 |
| ExternalDocumentID | 1934583451 19802005 22323253 10_1038_onc_2009_310 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- -Q- 0R~ 123 29N 2WC 36B 39C 3O- 3V. 4.4 406 53G 5RE 70F 7X7 88A 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 AANZL AAYZH AAZLF ABAKF ABAWZ ABDBF ABJNI ABLJU ABUWG ABZZP ACAOD ACGFO ACGFS ACKTT ACMJI ACPRK ACRQY ACUHS ACZOJ ADBBV ADFRT ADHDB AEJRE AEMSY AENEX AEVLU AEXYK AFBBN AFKRA AFSHS AGHAI AGQEE AHMBA AHSBF AILAN AJRNO ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMYLF ASPBG AVWKF AXYYD AZFZN AZQEC B0M BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CAG CCPQU COF CS3 DIK DNIVK DPUIP DU5 DWQXO E3Z EAD EAP EBC EBD EBLON EBS EE. EIOEI EJD EMB EMK EMOBN EPL ESX F5P FDQFY FEDTE FERAY FIZPM FRP FSGXE FYUFA GNUQQ GUQSH HCIFZ HMCUK HVGLF HZ~ IAO IHR INH INR ITC IWAJR JSO JZLTJ KQ8 L7B LK8 M0L M1P M2O M7P N9A NAO NQJWS NXXTH O9- OK1 OVD P2P PQQKQ PROAC PSQYO Q2X RNT RNTTT ROL SNX SNYQT SOHCF SOJ SRMVM SV3 SWTZT TAOOD TBHMF TDRGL TEORI TSG TUS UKHRP W2D WH7 ~8M AASML AATNV AAYXX ABBRH ABDBE ABFSG ABRTQ ACSTC AEFQL AEZWR AFDZB AFFHD AFHIU AHWEU AIGIU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT PJZUB PPXIY PQGLB .55 .GJ AACDK ABEFU AFFNX BAWUL FIGPU IQODW LGEZI LOTEE NADUK RNS TR2 UDS X7M ZXP CGR CUY CVF ECM EIF NPM 7TM 7TO 7U9 7XB 8FD 8FK FR3 H94 K9. MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 PUEGO 7X8 |
| ID | FETCH-LOGICAL-c520t-24017f996768ca2fc92b36b4f2fdfe230734baa74fe9da65a3856c91da15022a3 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 36 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000273373500009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0950-9232 1476-5594 |
| IngestDate | Sun Sep 28 07:50:22 EDT 2025 Thu Oct 02 09:55:57 EDT 2025 Fri Oct 31 03:41:50 EDT 2025 Mon Jul 21 06:06:44 EDT 2025 Mon Jul 21 09:13:14 EDT 2025 Sat Nov 29 03:40:47 EST 2025 Tue Nov 18 22:15:23 EST 2025 Fri Feb 21 02:39:37 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Wnt-signal transduction Gsk3-binding protein lymphomagenesis Diversin planar cell polarity Frat Malignant hemopathy Carcinogenesis Lymphoma Cell signaling lymphoma-genesis Binding protein Signal transduction Lymphoproliferative syndrome C-Onc gene Cellular polarity Onc gene Cancer |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c520t-24017f996768ca2fc92b36b4f2fdfe230734baa74fe9da65a3856c91da15022a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | https://www.nature.com/articles/onc2009310.pdf |
| PMID | 19802005 |
| PQID | 227348489 |
| PQPubID | 36330 |
| PageCount | 12 |
| ParticipantIDs | proquest_miscellaneous_734222958 proquest_miscellaneous_21305499 proquest_journals_227348489 pubmed_primary_19802005 pascalfrancis_primary_22323253 crossref_primary_10_1038_onc_2009_310 crossref_citationtrail_10_1038_onc_2009_310 springer_journals_10_1038_onc_2009_310 |
| PublicationCentury | 2000 |
| PublicationDate | 2010-01-07 |
| PublicationDateYYYYMMDD | 2010-01-07 |
| PublicationDate_xml | – month: 01 year: 2010 text: 2010-01-07 day: 07 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: Basingstoke – name: England – name: New York |
| PublicationTitle | Oncogene |
| PublicationTitleAbbrev | Oncogene |
| PublicationTitleAlternate | Oncogene |
| PublicationYear | 2010 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | Carpenter, Jones, Lamprecht, Clarke, Kang, Friman (CR4) 2006; 7 Habas, Dawid, He (CR10) 2003; 17 Ferkey, Kimelman (CR8) 2002; 277 Li, Yuan, Xie, Mao, Caruso, McMahon (CR23) 1999; 274 Cong, Schweizer, Varmus (CR5) 2004; 24 Fanto, McNeill (CR7) 2004; 117 Qian, Jones, Rzadzinska, Mark, Zhang, Steel (CR27) 2007; 306 Wang, Hamblet, Mark, Dickinson, Brinkman, Segil (CR40) 2006; 133 Hocevar, Mou, Rennolds, Morris, Cooper, Howe (CR13) 2003; 22 van Amerongen, Nawijn, Franca-Koh, Zevenhoven, van der Gulden, Jonkers (CR36) 2005; 19 Bax, Carter, Lewis, Guy, Bridges, Tanner (CR1) 2001; 9 Jones, Chen (CR15) 2007; 29 Yan, Wallingford, Sun, Nelson, Sakanaka, Reinhard (CR45) 2001; 98 Klein, Mlodzik (CR20) 2005; 21 van der Lugt, Domen, Verhoeven, Linders, van der Gulden, Allen (CR38) 1995; 14 Hino, Michiue, Asashima, Kikuchi (CR12) 2003; 278 Hamblet, Lijam, Ruiz-Lozano, Wang, Yang, Luo (CR11) 2002; 129 Theisen, Purcell, Bennett, Kansagara, Syed, Marsh (CR33) 1994; 120 Moeller, Jenny, Schaeffer, Schwarz-Romond, Mlodzik, Hammerschmidt (CR26) 2006; 103 Saitoh, Katoh (CR28) 2001; 19 Boutros, Paricio, Strutt, Mlodzik (CR3) 1998; 94 Strutt, Price, Strutt (CR32) 2006; 16 van Amerongen, Berns (CR35) 2005; 4 Thomas, Frame, Goedert, Nathke, Polakis, Cohen (CR34) 1999; 458 Fraser, Young, Dajani, Franca-Koh, Ryves, Williams (CR9) 2002; 277 Jonkers, van Amerongen, van der Valk, Robanus-Maandag, Molenaar, Destree (CR17) 1999; 88 Wang, Guo, Nathans (CR41) 2006; 26 Simons, Gloy, Ganner, Bullerkotte, Bashkurov, Kronig (CR31) 2005; 37 Wang, Hewitt, Liu, Zhou, Zhu, Zhou (CR42) 2006; 94 Maretto, Cordenonsi, Dupont, Braghetta, Broccoli, Hassan (CR24) 2003; 100 Sakanaka, Sun, Williams (CR29) 2000; 55 Schwarz-Romond, Asbrand, Bakkers, Kuhl, Schaeffer, Huelsken (CR30) 2002; 16 van Amerongen, van der Gulden, Bleeker, Jonkers, Berns (CR37) 2004; 279 Wang, Nathans (CR44) 2007; 134 Wallingford, Rowning, Vogeli, Rothbacher, Fraser, Harland (CR39) 2000; 405 Lamprecht, Sabatini, Carpenter (CR21) 2007; 42 Zeng, Huang, Tamai, Zhang, Harada, Yokota (CR47) 2008; 135 Jonkers, Korswagen, Acton, Breuer, Berns (CR16) 1997; 16 Yost, Farr, Pierce, Ferkey, Chen, Kimelman (CR46) 1998; 93 Etheridge, Ray, Li, Hamblet, Lijam, Tsang (CR6) 2008; 4 Jonkers, Weening, van der Valk, Bobeldijk, Berns (CR18) 1999; 18 Li, Yuan, Weaver, Mao, Farr, Sussman (CR22) 1999; 18 Hongisto, Smeds, Brecht, Herdegen, Courtney, Coffey (CR14) 2003; 23 Bilic, Huang, Davidson, Zimmermann, Cruciat, Bienz (CR2) 2007; 316 Klein, Jenny, Djiane, Mlodzik (CR19) 2006; 16 Mikkers, Allen, Knipscheer, Romeijn, Hart, Vink (CR25) 2002; 32 Wang, Liu, Zhu, Zhang, Zhang, Zhou (CR43) 2008; 123 Y Wang (BFonc2009310_CR41) 2006; 26 R van Amerongen (BFonc2009310_CR37) 2004; 279 D Yan (BFonc2009310_CR45) 2001; 98 M Boutros (BFonc2009310_CR3) 1998; 94 AE Carpenter (BFonc2009310_CR4) 2006; 7 J Jonkers (BFonc2009310_CR17) 1999; 88 Y Wang (BFonc2009310_CR44) 2007; 134 V Hongisto (BFonc2009310_CR14) 2003; 23 L Li (BFonc2009310_CR23) 1999; 274 J Wang (BFonc2009310_CR40) 2006; 133 L Li (BFonc2009310_CR22) 1999; 18 E Fraser (BFonc2009310_CR9) 2002; 277 H Theisen (BFonc2009310_CR33) 1994; 120 MR Lamprecht (BFonc2009310_CR21) 2007; 42 T Schwarz-Romond (BFonc2009310_CR30) 2002; 16 M Fanto (BFonc2009310_CR7) 2004; 117 R van Amerongen (BFonc2009310_CR35) 2005; 4 NM van der Lugt (BFonc2009310_CR38) 1995; 14 BA Hocevar (BFonc2009310_CR13) 2003; 22 Y Wang (BFonc2009310_CR42) 2006; 94 C Yost (BFonc2009310_CR46) 1998; 93 J Jonkers (BFonc2009310_CR16) 1997; 16 B Bax (BFonc2009310_CR1) 2001; 9 DM Ferkey (BFonc2009310_CR8) 2002; 277 TJ Klein (BFonc2009310_CR19) 2006; 16 GM Thomas (BFonc2009310_CR34) 1999; 458 C Sakanaka (BFonc2009310_CR29) 2000; 55 X Zeng (BFonc2009310_CR47) 2008; 135 D Qian (BFonc2009310_CR27) 2007; 306 S Maretto (BFonc2009310_CR24) 2003; 100 JB Wallingford (BFonc2009310_CR39) 2000; 405 Y Wang (BFonc2009310_CR43) 2008; 123 J Bilic (BFonc2009310_CR2) 2007; 316 R van Amerongen (BFonc2009310_CR36) 2005; 19 S Hino (BFonc2009310_CR12) 2003; 278 R Habas (BFonc2009310_CR10) 2003; 17 H Mikkers (BFonc2009310_CR25) 2002; 32 SL Etheridge (BFonc2009310_CR6) 2008; 4 H Strutt (BFonc2009310_CR32) 2006; 16 T Saitoh (BFonc2009310_CR28) 2001; 19 NS Hamblet (BFonc2009310_CR11) 2002; 129 F Cong (BFonc2009310_CR5) 2004; 24 C Jones (BFonc2009310_CR15) 2007; 29 H Moeller (BFonc2009310_CR26) 2006; 103 TJ Klein (BFonc2009310_CR20) 2005; 21 M Simons (BFonc2009310_CR31) 2005; 37 J Jonkers (BFonc2009310_CR18) 1999; 18 |
| References_xml | – volume: 16 start-page: 1337 year: 2006 end-page: 1343 ident: CR19 article-title: CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila publication-title: Curr Biol doi: 10.1016/j.cub.2006.06.030 – volume: 19 start-page: 311 year: 2001 end-page: 315 ident: CR28 article-title: FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up- regulated in gastric cancer publication-title: Int J Oncol – volume: 100 start-page: 3299 year: 2003 end-page: 3304 ident: CR24 article-title: Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0434590100 – volume: 405 start-page: 81 year: 2000 end-page: 85 ident: CR39 article-title: Dishevelled controls cell polarity during Xenopus gastrulation publication-title: Nature doi: 10.1038/35011077 – volume: 98 start-page: 3802 year: 2001 end-page: 3807 ident: CR45 article-title: Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.071041898 – volume: 133 start-page: 1767 year: 2006 end-page: 1778 ident: CR40 article-title: Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation publication-title: Development doi: 10.1242/dev.02347 – volume: 134 start-page: 647 year: 2007 end-page: 658 ident: CR44 article-title: Tissue/planar cell polarity in vertebrates: new insights and new questions publication-title: Development doi: 10.1242/dev.02772 – volume: 29 start-page: 120 year: 2007 end-page: 132 ident: CR15 article-title: Planar cell polarity signaling in vertebrates publication-title: Bioessays doi: 10.1002/bies.20526 – volume: 135 start-page: 367 year: 2008 end-page: 375 ident: CR47 article-title: Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions publication-title: Development doi: 10.1242/dev.013540 – volume: 32 start-page: 153 year: 2002 end-page: 159 ident: CR25 article-title: High-throughput retroviral tagging to identify components of specific signaling pathways in cancer publication-title: Nat Genet doi: 10.1038/ng950 – volume: 23 start-page: 6027 year: 2003 end-page: 6036 ident: CR14 article-title: Lithium blocks the c-Jun stress response and protects neurons via its action on glycogen synthase kinase 3 publication-title: Mol Cell Biol doi: 10.1128/MCB.23.17.6027-6036.2003 – volume: 16 start-page: 1329 year: 2006 end-page: 1336 ident: CR32 article-title: Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila publication-title: Curr Biol doi: 10.1016/j.cub.2006.04.041 – volume: 16 start-page: 441 year: 1997 end-page: 450 ident: CR16 article-title: Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas publication-title: EMBO J doi: 10.1093/emboj/16.3.441 – volume: 117 start-page: 527 year: 2004 end-page: 533 ident: CR7 article-title: Planar polarity from flies to vertebrates publication-title: J Cell Sci doi: 10.1242/jcs.00973 – volume: 277 start-page: 16147 year: 2002 end-page: 16152 ident: CR8 article-title: Glycogen synthase kinase-3 beta mutagenesis identifies a common binding domain for GBP and Axin publication-title: J Biol Chem doi: 10.1074/jbc.M112363200 – volume: 277 start-page: 2176 year: 2002 end-page: 2185 ident: CR9 article-title: Identification of the Axin and Frat binding region of glycogen synthase kinase-3 publication-title: J Biol Chem doi: 10.1074/jbc.M109462200 – volume: 42 start-page: 71 year: 2007 end-page: 75 ident: CR21 article-title: CellProfiler: free, versatile software for automated biological image analysis publication-title: Biotechniques doi: 10.2144/000112257 – volume: 458 start-page: 247 year: 1999 end-page: 251 ident: CR34 article-title: A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin publication-title: FEBS Lett doi: 10.1016/S0014-5793(99)01161-8 – volume: 279 start-page: 26967 year: 2004 end-page: 26974 ident: CR37 article-title: Characterization and functional analysis of the murine Frat2 gene publication-title: J Biol Chem doi: 10.1074/jbc.M400439200 – volume: 93 start-page: 1031 year: 1998 end-page: 1041 ident: CR46 article-title: GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis publication-title: Cell doi: 10.1016/S0092-8674(00)81208-8 – volume: 7 start-page: R100 year: 2006 ident: CR4 article-title: CellProfiler: image analysis software for identifying and quantifying cell phenotypes publication-title: Genome Biol doi: 10.1186/gb-2006-7-10-r100 – volume: 16 start-page: 2073 year: 2002 end-page: 2084 ident: CR30 article-title: The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling publication-title: Genes Dev doi: 10.1101/gad.230402 – volume: 18 start-page: 5982 year: 1999 end-page: 5990 ident: CR18 article-title: Overexpression of Frat1 in transgenic mice leads to glomerulosclerosis and nephrotic syndrome, and provides direct evidence for the involvement of Frat1 in lymphoma progression publication-title: Oncogene doi: 10.1038/sj.onc.1202995 – volume: 103 start-page: 15900 year: 2006 end-page: 15905 ident: CR26 article-title: Diversin regulates heart formation and gastrulation movements in development publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0603808103 – volume: 22 start-page: 3084 year: 2003 end-page: 3094 ident: CR13 article-title: Regulation of the Wnt signaling pathway by disabled-2 (Dab2) publication-title: EMBO J doi: 10.1093/emboj/cdg286 – volume: 21 start-page: 155 year: 2005 end-page: 176 ident: CR20 article-title: Planar cell polarization: an emerging model points in the right direction publication-title: Annu Rev Cell Dev Biol doi: 10.1146/annurev.cellbio.21.012704.132806 – volume: 55 start-page: 225 year: 2000 end-page: 236 ident: CR29 article-title: New steps in the Wnt/beta-catenin signal transduction pathway publication-title: Recent Prog Horm Res – volume: 274 start-page: 129 year: 1999 end-page: 134 ident: CR23 article-title: Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells publication-title: J Biol Chem doi: 10.1074/jbc.274.1.129 – volume: 306 start-page: 121 year: 2007 end-page: 133 ident: CR27 article-title: Wnt5a functions in planar cell polarity regulation in mice publication-title: Dev Biol doi: 10.1016/j.ydbio.2007.03.011 – volume: 19 start-page: 425 year: 2005 end-page: 430 ident: CR36 article-title: Frat is dispensable for canonical Wnt signaling in mammals publication-title: Genes Dev doi: 10.1101/gad.326705 – volume: 278 start-page: 14066 year: 2003 end-page: 14073 ident: CR12 article-title: Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin publication-title: J Biol Chem doi: 10.1074/jbc.M213265200 – volume: 26 start-page: 2147 year: 2006 end-page: 2156 ident: CR41 article-title: The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells publication-title: J Neurosci doi: 10.1523/JNEUROSCI.4698-05.2005 – volume: 94 start-page: 686 year: 2006 end-page: 691 ident: CR42 article-title: Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours publication-title: Br J Cancer doi: 10.1038/sj.bjc.6602988 – volume: 9 start-page: 1143 year: 2001 end-page: 1152 ident: CR1 article-title: The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation publication-title: Structure (Camb) doi: 10.1016/S0969-2126(01)00679-7 – volume: 88 start-page: 183 year: 1999 end-page: 194 ident: CR17 article-title: analysis of Frat1 deficiency suggests compensatory activity of Frat3 publication-title: Mech Dev doi: 10.1016/S0925-4773(99)00187-2 – volume: 129 start-page: 5827 year: 2002 end-page: 5838 ident: CR11 article-title: Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure publication-title: Development doi: 10.1242/dev.00164 – volume: 4 start-page: e1000259 year: 2008 ident: CR6 article-title: Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development publication-title: PLoS Genet doi: 10.1371/journal.pgen.1000259 – volume: 316 start-page: 1619 year: 2007 end-page: 1622 ident: CR2 article-title: Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation publication-title: Science doi: 10.1126/science.1137065 – volume: 17 start-page: 295 year: 2003 end-page: 309 ident: CR10 article-title: Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation publication-title: Genes Dev doi: 10.1101/gad.1022203 – volume: 24 start-page: 2000 year: 2004 end-page: 2011 ident: CR5 article-title: Casein kinase Iepsilon modulates the signaling specificities of dishevelled publication-title: Mol Cell Biol doi: 10.1128/MCB.24.5.2000-2011.2004 – volume: 4 start-page: 1065 year: 2005 end-page: 1072 ident: CR35 article-title: Re-evaluating the role of Frat in Wnt-signal transduction publication-title: Cell Cycle – volume: 37 start-page: 537 year: 2005 end-page: 543 ident: CR31 article-title: Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways publication-title: Nat Genet doi: 10.1038/ng1552 – volume: 120 start-page: 347 year: 1994 end-page: 360 ident: CR33 article-title: Dishevelled is required during wingless signaling to establish both cell polarity and cell identity publication-title: Development – volume: 14 start-page: 2536 year: 1995 end-page: 2544 ident: CR38 article-title: Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2 publication-title: EMBO J doi: 10.1002/j.1460-2075.1995.tb07251.x – volume: 94 start-page: 109 year: 1998 end-page: 118 ident: CR3 article-title: Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling publication-title: Cell doi: 10.1016/S0092-8674(00)81226-X – volume: 18 start-page: 4233 year: 1999 end-page: 4240 ident: CR22 article-title: Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt- mediated regulation of LEF-1 publication-title: EMBO J doi: 10.1093/emboj/18.15.4233 – volume: 123 start-page: 561 year: 2008 end-page: 568 ident: CR43 article-title: FRAT1 overexpression leads to aberrant activation of beta-catenin/TCF pathway in esophageal squamous cell carcinoma publication-title: Int J Cancer doi: 10.1002/ijc.23600 – volume: 94 start-page: 109 year: 1998 ident: BFonc2009310_CR3 publication-title: Cell doi: 10.1016/S0092-8674(00)81226-X – volume: 22 start-page: 3084 year: 2003 ident: BFonc2009310_CR13 publication-title: EMBO J doi: 10.1093/emboj/cdg286 – volume: 19 start-page: 311 year: 2001 ident: BFonc2009310_CR28 publication-title: Int J Oncol – volume: 133 start-page: 1767 year: 2006 ident: BFonc2009310_CR40 publication-title: Development doi: 10.1242/dev.02347 – volume: 7 start-page: R100 year: 2006 ident: BFonc2009310_CR4 publication-title: Genome Biol doi: 10.1186/gb-2006-7-10-r100 – volume: 4 start-page: 1065 year: 2005 ident: BFonc2009310_CR35 publication-title: Cell Cycle – volume: 279 start-page: 26967 year: 2004 ident: BFonc2009310_CR37 publication-title: J Biol Chem doi: 10.1074/jbc.M400439200 – volume: 9 start-page: 1143 year: 2001 ident: BFonc2009310_CR1 publication-title: Structure (Camb) doi: 10.1016/S0969-2126(01)00679-7 – volume: 129 start-page: 5827 year: 2002 ident: BFonc2009310_CR11 publication-title: Development doi: 10.1242/dev.00164 – volume: 16 start-page: 1337 year: 2006 ident: BFonc2009310_CR19 publication-title: Curr Biol doi: 10.1016/j.cub.2006.06.030 – volume: 135 start-page: 367 year: 2008 ident: BFonc2009310_CR47 publication-title: Development doi: 10.1242/dev.013540 – volume: 19 start-page: 425 year: 2005 ident: BFonc2009310_CR36 publication-title: Genes Dev doi: 10.1101/gad.326705 – volume: 26 start-page: 2147 year: 2006 ident: BFonc2009310_CR41 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.4698-05.2005 – volume: 316 start-page: 1619 year: 2007 ident: BFonc2009310_CR2 publication-title: Science doi: 10.1126/science.1137065 – volume: 42 start-page: 71 year: 2007 ident: BFonc2009310_CR21 publication-title: Biotechniques doi: 10.2144/000112257 – volume: 17 start-page: 295 year: 2003 ident: BFonc2009310_CR10 publication-title: Genes Dev doi: 10.1101/gad.1022203 – volume: 55 start-page: 225 year: 2000 ident: BFonc2009310_CR29 publication-title: Recent Prog Horm Res – volume: 100 start-page: 3299 year: 2003 ident: BFonc2009310_CR24 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0434590100 – volume: 103 start-page: 15900 year: 2006 ident: BFonc2009310_CR26 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0603808103 – volume: 32 start-page: 153 year: 2002 ident: BFonc2009310_CR25 publication-title: Nat Genet doi: 10.1038/ng950 – volume: 274 start-page: 129 year: 1999 ident: BFonc2009310_CR23 publication-title: J Biol Chem doi: 10.1074/jbc.274.1.129 – volume: 278 start-page: 14066 year: 2003 ident: BFonc2009310_CR12 publication-title: J Biol Chem doi: 10.1074/jbc.M213265200 – volume: 16 start-page: 441 year: 1997 ident: BFonc2009310_CR16 publication-title: EMBO J doi: 10.1093/emboj/16.3.441 – volume: 24 start-page: 2000 year: 2004 ident: BFonc2009310_CR5 publication-title: Mol Cell Biol doi: 10.1128/MCB.24.5.2000-2011.2004 – volume: 277 start-page: 16147 year: 2002 ident: BFonc2009310_CR8 publication-title: J Biol Chem doi: 10.1074/jbc.M112363200 – volume: 117 start-page: 527 year: 2004 ident: BFonc2009310_CR7 publication-title: J Cell Sci doi: 10.1242/jcs.00973 – volume: 458 start-page: 247 year: 1999 ident: BFonc2009310_CR34 publication-title: FEBS Lett doi: 10.1016/S0014-5793(99)01161-8 – volume: 29 start-page: 120 year: 2007 ident: BFonc2009310_CR15 publication-title: Bioessays doi: 10.1002/bies.20526 – volume: 306 start-page: 121 year: 2007 ident: BFonc2009310_CR27 publication-title: Dev Biol doi: 10.1016/j.ydbio.2007.03.011 – volume: 21 start-page: 155 year: 2005 ident: BFonc2009310_CR20 publication-title: Annu Rev Cell Dev Biol doi: 10.1146/annurev.cellbio.21.012704.132806 – volume: 16 start-page: 2073 year: 2002 ident: BFonc2009310_CR30 publication-title: Genes Dev doi: 10.1101/gad.230402 – volume: 405 start-page: 81 year: 2000 ident: BFonc2009310_CR39 publication-title: Nature doi: 10.1038/35011077 – volume: 23 start-page: 6027 year: 2003 ident: BFonc2009310_CR14 publication-title: Mol Cell Biol doi: 10.1128/MCB.23.17.6027-6036.2003 – volume: 277 start-page: 2176 year: 2002 ident: BFonc2009310_CR9 publication-title: J Biol Chem doi: 10.1074/jbc.M109462200 – volume: 18 start-page: 4233 year: 1999 ident: BFonc2009310_CR22 publication-title: EMBO J doi: 10.1093/emboj/18.15.4233 – volume: 16 start-page: 1329 year: 2006 ident: BFonc2009310_CR32 publication-title: Curr Biol doi: 10.1016/j.cub.2006.04.041 – volume: 123 start-page: 561 year: 2008 ident: BFonc2009310_CR43 publication-title: Int J Cancer doi: 10.1002/ijc.23600 – volume: 4 start-page: e1000259 year: 2008 ident: BFonc2009310_CR6 publication-title: PLoS Genet doi: 10.1371/journal.pgen.1000259 – volume: 88 start-page: 183 year: 1999 ident: BFonc2009310_CR17 publication-title: Mech Dev doi: 10.1016/S0925-4773(99)00187-2 – volume: 14 start-page: 2536 year: 1995 ident: BFonc2009310_CR38 publication-title: EMBO J doi: 10.1002/j.1460-2075.1995.tb07251.x – volume: 18 start-page: 5982 year: 1999 ident: BFonc2009310_CR18 publication-title: Oncogene doi: 10.1038/sj.onc.1202995 – volume: 120 start-page: 347 year: 1994 ident: BFonc2009310_CR33 publication-title: Development doi: 10.1242/dev.120.2.347 – volume: 98 start-page: 3802 year: 2001 ident: BFonc2009310_CR45 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.071041898 – volume: 37 start-page: 537 year: 2005 ident: BFonc2009310_CR31 publication-title: Nat Genet doi: 10.1038/ng1552 – volume: 134 start-page: 647 year: 2007 ident: BFonc2009310_CR44 publication-title: Development doi: 10.1242/dev.02772 – volume: 93 start-page: 1031 year: 1998 ident: BFonc2009310_CR46 publication-title: Cell doi: 10.1016/S0092-8674(00)81208-8 – volume: 94 start-page: 686 year: 2006 ident: BFonc2009310_CR42 publication-title: Br J Cancer doi: 10.1038/sj.bjc.6602988 |
| SSID | ssj0007902 |
| Score | 2.1456616 |
| Snippet | Wnt-signal transduction is critical for development and tissue homeostasis in a wide range of animal species and is frequently deregulated in human cancers.... |
| SourceID | proquest pubmed pascalfrancis crossref springer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 93 |
| SubjectTerms | Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis beta Catenin - genetics beta Catenin - metabolism Binding sites Biological and medical sciences Blotting, Western Carrier Proteins - genetics Carrier Proteins - metabolism Cell Biology Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular biology Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Dishevelled Proteins Drosophila Drosophila Proteins Female Fundamental and applied biological sciences. Psychology Genetics Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Hematologic and hematopoietic diseases Human Genetics Humans Internal Medicine Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism JNK Mitogen-Activated Protein Kinases - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, T-Cell - genetics Lymphoma, T-Cell - metabolism Lymphoma, T-Cell - pathology Male Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Knockout Molecular and cellular biology Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Oncology original-article Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation Proteins Signal Transduction Survival Analysis TCF Transcription Factors - genetics TCF Transcription Factors - metabolism Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism Transfection Wnt Proteins - genetics Wnt Proteins - metabolism |
| Title | Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways |
| URI | https://link.springer.com/article/10.1038/onc.2009.310 https://www.ncbi.nlm.nih.gov/pubmed/19802005 https://www.proquest.com/docview/227348489 https://www.proquest.com/docview/21305499 https://www.proquest.com/docview/734222958 |
| Volume | 29 |
| WOSCitedRecordID | wos000273373500009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1476-5594 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0007902 issn: 0950-9232 databaseCode: M7P dateStart: 19970101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1476-5594 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0007902 issn: 0950-9232 databaseCode: 7X7 dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1476-5594 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0007902 issn: 0950-9232 databaseCode: BENPR dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Research Library customDbUrl: eissn: 1476-5594 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0007902 issn: 0950-9232 databaseCode: M2O dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1476-5594 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0007902 issn: 0950-9232 databaseCode: 8C1 dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7RlgISAroUCIXFB-gFWU3sPOwTglUrDnRZVUWsxCFyHFuqhJJtk4L67xk7jwXRckGRojxGSSbj2N9kxvMBvC4kOv9latEt0ZLGlnNasNhQjdA6siVjpvCsJZ-y-Vwsl3LR5-Y0fVrl0Cf6jrqstftHfsB8HZZYyHerc-pIo1xwtWfQ2IAtVySB-8y9xdgRZ13KIYKIkCKOYX3ee8jFQV3prlYld1NnfxuR7q9Ugy_HdqwW18HOv0KmfiQ6evifOjyCBz0EJe-7NrMDt0w1ge2OlPJqAndnAwfcBO4c96H3x_ANIW5LUKPal3Y4qxqidEvwGEJI0qlWq5LUlqC1aj_dkqiqJLi9PvC1aqlLGVFuFjxxdMg_1VWzC1-ODk9nH2nPzEB1wsLWhWSizKKrhM6KVsxqyQqeFrFltrTG5ZbzuFAqi62RpUoTxUWSahmVCvEnY4o_gU28sXkGxGYKQYY0oU5ZnIVCKheqM2mqeJHYKAzg7WCdXPdlyx17xvfch8-5yFELR6Ypc-6k34zSq65cxw1y0z8MPQojWsIl4QHsDSbM-6-6yUf7BfBqPIsWcTEWVZn6EkUQEziXOwBygwRewnOoiwCedi1q_aRShO4vXwD7QxNb3_w6NZ7_8yn34F6X6xDRMHsBm-3FpXkJt_WP9qy5mMJGtsz8WuBazKIpbH04nC9OcO-YfZ76b-kXHNcggw |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1LT9wwEB5R2gJS1cf2ldKCD4VLFZHYefmAqooWgVhWHKiKxCE4ji0hoWRLQtH-qP7Hju0k26rQG4cqlygZJX5MnM-ez_MBvC84Tv7LROO0RHI_0oz5BY2ULxFah7qkVBVWtWScTibZyQk_WoCf_V4YQ6vsx0Q7UJe1NGvkW9TmYYky_nH63TeiUSa42itoOK84ULNrnLE12_ufsXs3KN39cryz53eiAr6MadCaaEKYakT5iLOloFpyWrCkiDTVpVaGFs2iQog00oqXIokFy-JE8rAUCJ0oFQyfew_uI4qgmWUKHg0Df-oojghaAh9xE-149gHLtupKutyYzGzV_e0P-GgqGuwM7VQ0boK5f4Vo7Z9v98l_1mZP4XEHsckn9008gwVVjeChE92cjWB5p9e4G8HSYUcteA6nCOFbgi1Y29QV51VDhGwJXkOITFxT1qIktSbojbXdTkpEVRI8n1_4VrW-ocQIs8ufGLnnazFrXsDXO6nwS1jEF6vXQHQqEERxFciERmmQcWFCkSpJBCtiHQYefOi9IZddWnajDnKRW3oAy3KshREL5Tkz1huD9dSlI7nFbu0PxxqMEQ3iETMPVnuXybtRq8kHf_FgfbiLPWJiSKJS9RWaIOYxSwoekFss8BFWIz7z4JXz4HlJeRaYVUwPNnuXnr_8pmq8-Wcp12F57_hwnI_3JwersOJ4HaEfpG9hsb28Uu_ggfzRnjeXa_Y7JXB2107-C3GAd-k |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3LbtQwFL0qBQoS4jG8QqH1grJB1iR2Xl4ghKaMqFpGXYCo1EVwHFuqhJKhSanm0_g7ru1kBkTLrgs0m1FylcT2iXPs-zgAL0uBi_8qNbgsUYLGhnNaslhThdQ6MhVjunSqJQfZbJYfHYnDNfg55MLYsMphTnQTddUou0c-Zq4OS5yLsemjIg53p2_n36kVkLKO1kFNwyNkXy_OcfXWvtnbxaHeYWz6_tPkA-0FBqhKWNhZz0KUGWT8yLmVZEYJVvK0jA0zldE2RJrHpZRZbLSoZJpIniepElElkUYxJjle9xpczziC2CapT1bRJZkPd0QCE1LkUKyPuQ95Pm5q5etkcpu2-9vX8M5ctjgwxitqXER5_3LXuq_g9N5_3H_34W5Pvck7_648gDVdj-CmF-NcjODWZNC-G8HGxz7k4CEcI7XvCPZm40panNQtkaojeAypM_Hd2siKNIYgShuXZkpkXRH8vzrwpe6oDZWRNvufWBnoc7loH8HnK2nwY1jHG-unQEwmkVwJHaqUxVmYC2ldlDpNJS8TE4UBvB6QUai-XLtVDflWuLABnhfYCisiKgpurXeW1nNfpuQSu60_QLY0RpaIv4QHsDnAp-hns7ZYYieA7eVZHBHrW5K1bs7QBLmQ3WoIgFxigZdw2vF5AE88mldPKvLQ7m4G8GqA9-rmFzXj2T-fchs2ENvFwd5sfxNu-3CPiIbZc1jvTs_0C7ihfnQn7emWe2UJfL1qjP8C1aqAXw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Frat+oncoproteins+act+at+the+crossroad+of+canonical+and+noncanonical+Wnt-signaling+pathways&rft.jtitle=Oncogene&rft.au=van+Amerongen%2C+R&rft.au=Nawijn%2C+M+C&rft.au=Lambooij%2C+J+-P&rft.au=Proost%2C+N&rft.date=2010-01-07&rft.pub=Nature+Publishing+Group+UK&rft.issn=0950-9232&rft.eissn=1476-5594&rft.volume=29&rft.issue=1&rft.spage=93&rft.epage=104&rft_id=info:doi/10.1038%2Fonc.2009.310&rft.externalDocID=10_1038_onc_2009_310 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0950-9232&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0950-9232&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0950-9232&client=summon |