DNA damage and health in pregnancy

In healthy pregnancy reactive oxygen species and antioxidants remain in balance and DNA damage is repaired effectively. However, pregnancy is an inflammatory state exhibiting increased susceptibility to oxidative stress such that this balance can be easily disrupted. Increased DNA damage has been sh...

Full description

Saved in:
Bibliographic Details
Published in:Journal of reproductive immunology Vol. 89; no. 2; pp. 153 - 162
Main Authors: Furness, D.L.F., Dekker, G.A., Roberts, C.T.
Format: Journal Article Conference Proceeding
Language:English
Published: Kidlington Elsevier Ireland Ltd 01.05.2011
Elsevier
Subjects:
Animals
Biological and medical sciences
DNA Damage
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Humans
Inflammation
Maternal Exposure - adverse effects
Micronucleus
Obstetrics and Gynecology
Oxidative damage
Oxidative Stress
Placenta
Pregnancy
Pregnancy Complications - genetics
Pregnancy Complications - metabolism
Pregnancy
Inflammation
Placenta
Oxidative damage
DNA damage
Micronucleus
Vertebrata
Mammalia
Fetal membrane
Health
DNA
ISSN:0165-0378, 1872-7603, 1872-7603
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In healthy pregnancy reactive oxygen species and antioxidants remain in balance and DNA damage is repaired effectively. However, pregnancy is an inflammatory state exhibiting increased susceptibility to oxidative stress such that this balance can be easily disrupted. Increased DNA damage has been shown to be involved in many pathological states including pregnancy complications. Modern lifestyles including exposure to pollutants, poor diet, and lack of exercise cause excess inflammation, oxidative stress, and ultimately DNA damage. There is a growing body of literature providing evidence that these lifestyle changes are increasing our risk of infertility, miscarriage, and late-gestation pregnancy complications. Moreover, baseline DNA damage rises with age and couples in developed societies are delaying childbirth, placing them at further risk. In order to understand the effect of lifestyle and DNA damage on pregnancy health we require large prospective studies, with the collection of samples prior to conception and endpoints of time-to-pregnancy, early pregnancy loss, and late-gestation maternal and fetal health.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
ISSN:0165-0378
1872-7603
1872-7603
DOI:10.1016/j.jri.2011.02.004