DNA damage and health in pregnancy

In healthy pregnancy reactive oxygen species and antioxidants remain in balance and DNA damage is repaired effectively. However, pregnancy is an inflammatory state exhibiting increased susceptibility to oxidative stress such that this balance can be easily disrupted. Increased DNA damage has been sh...

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Vydané v:	Journal of reproductive immunology Ročník 89; číslo 2; s. 153 - 162
Hlavní autori:	Furness, D.L.F., Dekker, G.A., Roberts, C.T.
Médium:	Journal Article Konferenčný príspevok..
Jazyk:	English
Vydavateľské údaje:	Kidlington Elsevier Ireland Ltd 01.05.2011 Elsevier
Predmet:	Animals Biological and medical sciences DNA Damage Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Humans Inflammation Maternal Exposure - adverse effects Micronucleus Obstetrics and Gynecology Oxidative damage Oxidative Stress Placenta Pregnancy Pregnancy Complications - genetics Pregnancy Complications - metabolism Pregnancy Inflammation Placenta Oxidative damage DNA damage Micronucleus Vertebrata Mammalia Fetal membrane Health DNA
ISSN:	0165-0378, 1872-7603, 1872-7603
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Popis
Shrnutí:	In healthy pregnancy reactive oxygen species and antioxidants remain in balance and DNA damage is repaired effectively. However, pregnancy is an inflammatory state exhibiting increased susceptibility to oxidative stress such that this balance can be easily disrupted. Increased DNA damage has been shown to be involved in many pathological states including pregnancy complications. Modern lifestyles including exposure to pollutants, poor diet, and lack of exercise cause excess inflammation, oxidative stress, and ultimately DNA damage. There is a growing body of literature providing evidence that these lifestyle changes are increasing our risk of infertility, miscarriage, and late-gestation pregnancy complications. Moreover, baseline DNA damage rises with age and couples in developed societies are delaying childbirth, placing them at further risk. In order to understand the effect of lifestyle and DNA damage on pregnancy health we require large prospective studies, with the collection of samples prior to conception and endpoints of time-to-pregnancy, early pregnancy loss, and late-gestation maternal and fetal health.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0165-0378 1872-7603 1872-7603
DOI:	10.1016/j.jri.2011.02.004