Tisagenlecleucel in adult relapsed or refractory follicular lymphoma: the phase 2 ELARA trial

Tisagenlecleucel is an autologous anti-CD19 chimeric antigen receptor-T cell therapy with clinically meaningful outcomes demonstrated in patients with relapsed/refractory (r/r) B-cell lymphoma. In a previous pilot study of tisagenlecleucel in r/r follicular lymphoma (FL), 71% of patients achieved a...

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Veröffentlicht in:	Nature Medicine Jg. 28; H. 2; S. 325 - 332
Hauptverfasser:	Fowler, Nathan Hale, Dickinson, Michael, Dreyling, Martin, Martinez-Lopez, Joaquin, Kolstad, Arne, Butler, Jason, Ghosh, Monalisa, Popplewell, Leslie, Chavez, Julio C., Bachy, Emmanuel, Kato, Koji, Harigae, Hideo, Kersten, Marie José, Andreadis, Charalambos, Riedell, Peter A., Ho, P. Joy, Pérez-Simón, José Antonio, Chen, Andy I., Nastoupil, Loretta J., von Tresckow, Bastian, Ferreri, Andrés José María, Teshima, Takanori, Patten, Piers E. M., McGuirk, Joseph P., Petzer, Andreas L., Offner, Fritz, Viardot, Andreas, Zinzani, Pier Luigi, Malladi, Ram, Zia, Aiesha, Awasthi, Rakesh, Masood, Aisha, Anak, Oezlem, Schuster, Stephen J., Thieblemont, Catherine
Format:	Journal Article Magazine Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.02.2022 Nature Publishing Group
Schlagworte:	631/67/1990/291/1621/1915 692/308/2779/109/1941 692/699/1541/1990/291/1621/1915 692/699/67/1059/2325 Adult Adults Antigens Antigens, CD19 Autografts B-cell lymphoma Biomedical and Life Sciences Biomedicine Cancer Research CD19 antigen Cell therapy Chimeric antigen receptors Confidence intervals Cytokines Elara Humans Immune response Immunotherapy, Adoptive - adverse effects Infectious Diseases Life Sciences Lymphocytes Lymphocytes B Lymphocytes T Lymphoma Lymphoma, Follicular - drug therapy Metabolic Diseases Molecular Medicine Neurosciences Neurotoxicity Patients Pharmacokinetics Pilot Projects Receptors, Antigen, T-Cell - therapeutic use Risk groups Safety Safety management Stem cell transplantation Stem cells Survival
ISSN:	1078-8956, 1546-170X, 1546-170X, 1744-7933
Online-Zugang:	Volltext
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