Effect of Probiotics in Stress-Associated Constipation Model in Zebrafish (Danio rerio) Larvae

The pathophysiology of functional bowel disorders is complex, involving disruptions in gut motility, visceral hypersensitivity, gut–brain–microbiota interactions, and psychosocial factors. Light pollution, as an environmental stressor, has been associated with disruptions in circadian rhythms and th...

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Vydané v:	International Journal of Molecular Sciences Ročník 25; číslo 7; s. 3669
Hlavní autori:	Lee, Ayoung, Kim, Seung Young, Kang, Seyoung, Kang, Seong Hee, Kim, Dong Woo, Choe, Jung Wan, Hyun, Jong Jin, Jung, Sung Woo, Jung, Young Kul, Koo, Ja Seol, Yim, Hyung Joon, Kim, Suhyun
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland MDPI AG 01.04.2024
Predmet:	Animals Aquaporins Bifidobacterium longum Constipation Constipation - etiology Constipation - therapy Corticosteroids Gut-brain axis Hormones Hydrocortisone Hypothalamus Inflammation Irritable bowel syndrome Larva Light Microbiota Microbiota (Symbiotic organisms) Motility Neurophysiology Physiology Probiotics Probiotics - pharmacology Probiotics - therapeutic use Scientific equipment and supplies industry Stress Stress (Psychology) Vasoactive intestinal peptides Zebrafish United States South Korea constipation stress zebrafish B. longum light
ISSN:	1422-0067, 1661-6596, 1422-0067
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Abstract	The pathophysiology of functional bowel disorders is complex, involving disruptions in gut motility, visceral hypersensitivity, gut–brain–microbiota interactions, and psychosocial factors. Light pollution, as an environmental stressor, has been associated with disruptions in circadian rhythms and the aggravation of stress-related conditions. In this study, we investigated the effects of environmental stress, particularly continuous light exposure, on intestinal motility and inflammation using zebrafish larvae as a model system. We also evaluated the efficacy of probiotics, specifically Bifidobacterium longum (B. longum), at alleviating stress-induced constipation. Our results showed that continuous light exposure in zebrafish larvae increased the cortisol levels and reduced the intestinal motility, establishing a stress-induced-constipation model. We observed increased inflammatory markers and decreased intestinal neural activity in response to stress. Furthermore, the expressions of aquaporins and vasoactive intestinal peptide, crucial for regulating water transport and intestinal motility, were altered in the light-induced constipation model. Administration of probiotics, specifically B. longum, ameliorated the stress-induced constipation by reducing the cortisol levels, modulating the intestinal inflammation, and restoring the intestinal motility and neural activity. These findings highlight the potential of probiotics to modulate the gut–brain axis and alleviate stress-induced constipation. Therefore, this study provides a valuable understanding of the complex interplay among environmental stressors, gut function, and potential therapeutic strategies.
AbstractList	The pathophysiology of functional bowel disorders is complex, involving disruptions in gut motility, visceral hypersensitivity, gut–brain–microbiota interactions, and psychosocial factors. Light pollution, as an environmental stressor, has been associated with disruptions in circadian rhythms and the aggravation of stress-related conditions. In this study, we investigated the effects of environmental stress, particularly continuous light exposure, on intestinal motility and inflammation using zebrafish larvae as a model system. We also evaluated the efficacy of probiotics, specifically Bifidobacterium longum (B. longum), at alleviating stress-induced constipation. Our results showed that continuous light exposure in zebrafish larvae increased the cortisol levels and reduced the intestinal motility, establishing a stress-induced-constipation model. We observed increased inflammatory markers and decreased intestinal neural activity in response to stress. Furthermore, the expressions of aquaporins and vasoactive intestinal peptide, crucial for regulating water transport and intestinal motility, were altered in the light-induced constipation model. Administration of probiotics, specifically B. longum, ameliorated the stress-induced constipation by reducing the cortisol levels, modulating the intestinal inflammation, and restoring the intestinal motility and neural activity. These findings highlight the potential of probiotics to modulate the gut–brain axis and alleviate stress-induced constipation. Therefore, this study provides a valuable understanding of the complex interplay among environmental stressors, gut function, and potential therapeutic strategies. The pathophysiology of functional bowel disorders is complex, involving disruptions in gut motility, visceral hypersensitivity, gut-brain-microbiota interactions, and psychosocial factors. Light pollution, as an environmental stressor, has been associated with disruptions in circadian rhythms and the aggravation of stress-related conditions. In this study, we investigated the effects of environmental stress, particularly continuous light exposure, on intestinal motility and inflammation using zebrafish larvae as a model system. We also evaluated the efficacy of probiotics, specifically ( ), at alleviating stress-induced constipation. Our results showed that continuous light exposure in zebrafish larvae increased the cortisol levels and reduced the intestinal motility, establishing a stress-induced-constipation model. We observed increased inflammatory markers and decreased intestinal neural activity in response to stress. Furthermore, the expressions of and , crucial for regulating water transport and intestinal motility, were altered in the light-induced constipation model. Administration of probiotics, specifically , ameliorated the stress-induced constipation by reducing the cortisol levels, modulating the intestinal inflammation, and restoring the intestinal motility and neural activity. These findings highlight the potential of probiotics to modulate the gut-brain axis and alleviate stress-induced constipation. Therefore, this study provides a valuable understanding of the complex interplay among environmental stressors, gut function, and potential therapeutic strategies. The pathophysiology of functional bowel disorders is complex, involving disruptions in gut motility, visceral hypersensitivity, gut-brain-microbiota interactions, and psychosocial factors. Light pollution, as an environmental stressor, has been associated with disruptions in circadian rhythms and the aggravation of stress-related conditions. In this study, we investigated the effects of environmental stress, particularly continuous light exposure, on intestinal motility and inflammation using zebrafish larvae as a model system. We also evaluated the efficacy of probiotics, specifically Bifidobacterium longum (B. longum), at alleviating stress-induced constipation. Our results showed that continuous light exposure in zebrafish larvae increased the cortisol levels and reduced the intestinal motility, establishing a stress-induced-constipation model. We observed increased inflammatory markers and decreased intestinal neural activity in response to stress. Furthermore, the expressions of aquaporins and vasoactive intestinal peptide, crucial for regulating water transport and intestinal motility, were altered in the light-induced constipation model. Administration of probiotics, specifically B. longum, ameliorated the stress-induced constipation by reducing the cortisol levels, modulating the intestinal inflammation, and restoring the intestinal motility and neural activity. These findings highlight the potential of probiotics to modulate the gut-brain axis and alleviate stress-induced constipation. Therefore, this study provides a valuable understanding of the complex interplay among environmental stressors, gut function, and potential therapeutic strategies.The pathophysiology of functional bowel disorders is complex, involving disruptions in gut motility, visceral hypersensitivity, gut-brain-microbiota interactions, and psychosocial factors. Light pollution, as an environmental stressor, has been associated with disruptions in circadian rhythms and the aggravation of stress-related conditions. In this study, we investigated the effects of environmental stress, particularly continuous light exposure, on intestinal motility and inflammation using zebrafish larvae as a model system. We also evaluated the efficacy of probiotics, specifically Bifidobacterium longum (B. longum), at alleviating stress-induced constipation. Our results showed that continuous light exposure in zebrafish larvae increased the cortisol levels and reduced the intestinal motility, establishing a stress-induced-constipation model. We observed increased inflammatory markers and decreased intestinal neural activity in response to stress. Furthermore, the expressions of aquaporins and vasoactive intestinal peptide, crucial for regulating water transport and intestinal motility, were altered in the light-induced constipation model. Administration of probiotics, specifically B. longum, ameliorated the stress-induced constipation by reducing the cortisol levels, modulating the intestinal inflammation, and restoring the intestinal motility and neural activity. These findings highlight the potential of probiotics to modulate the gut-brain axis and alleviate stress-induced constipation. Therefore, this study provides a valuable understanding of the complex interplay among environmental stressors, gut function, and potential therapeutic strategies.
Audience	Academic
Author	Seung Young Kim Dong Woo Kim Hyung Joon Yim Sung Woo Jung Young Kul Jung Seong Hee Kang Jong Jin Hyun Jung Wan Choe Ayoung Lee Ja Seol Koo Suhyun Kim Seyoung Kang
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Cites_doi	10.1111/j.1572-0241.2000.02184.x 10.1111/nmo.13762 10.1016/j.vascn.2013.03.006 10.1172/JCI200519229 10.3389/fimmu.2021.739591 10.1016/j.clnu.2022.10.015 10.1053/j.gastro.2023.03.214 10.1002/ar.22403 10.1002/cne.22481 10.3390/ijms17091399 10.1155/2011/169319 10.2174/1876386300902010011 10.1182/blood-2010-10-314120 10.1038/s41398-020-0694-0 10.1053/j.gastro.2016.02.031 10.1016/j.brainres.2004.02.073 10.1080/21505594.2020.1750123 10.1186/s12866-022-02491-4 10.1080/19768354.2021.1991472 10.1016/j.dci.2016.02.020 10.3390/nu14122482 10.1371/journal.pone.0199041 10.3390/ijms24076585 10.1097/MIB.0000000000000667 10.1111/j.1365-2036.2006.03238.x 10.1016/j.jcmgh.2021.08.021 10.1371/journal.pone.0255201 10.1371/journal.pone.0262942 10.1089/zeb.2020.1877 10.1111/nmo.14195 10.1210/er.2013-1051 10.1111/j.1365-2982.2008.01234.x 10.3748/wjg.v20.i34.12144 10.1292/jvms.22-0073 10.1038/16040 10.1016/j.vascn.2004.02.008 10.3390/ijms17071172 10.1016/j.bbi.2017.01.016 10.1152/ajpregu.00671.2007 10.1016/j.devcel.2009.11.015 10.4291/wjgp.v2.i5.72 10.1038/nrn3346 10.3168/jds.2019-17836
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References	Nehra (ref_17) 2000; 95 Mearin (ref_1) 2016; 150 Konturek (ref_7) 2011; 62 Ji (ref_34) 1999; 2 ref_14 ref_36 Gao (ref_35) 2009; 2 Chang (ref_23) 2023; 164 Johanson (ref_25) 2007; 25 ref_31 Kim (ref_15) 2021; 25 ref_39 Field (ref_11) 2009; 21 Chapman (ref_18) 2012; 295 ref_37 Marks (ref_9) 2013; 68 Rieder (ref_3) 2017; 66 Smythies (ref_22) 2005; 115 Yang (ref_43) 2021; 12 Clarke (ref_20) 2011; 15 Yip (ref_21) 2021; 12 Serra (ref_24) 2019; 32 Hu (ref_38) 2020; 103 Grupp (ref_46) 2010; 518 Mueller (ref_12) 2004; 1011 Alsop (ref_13) 2008; 294 Andrews (ref_32) 2011; 25 Fonken (ref_5) 2014; 35 Walker (ref_6) 2020; 10 Hendrix (ref_2) 2021; 34 Yang (ref_44) 2020; 11 ref_45 Helander (ref_26) 2022; 41 Wang (ref_29) 2020; 17 ref_42 Turco (ref_33) 2016; 22 Brugman (ref_8) 2016; 64 Harrison (ref_10) 2004; 49 ref_28 Soares (ref_4) 2014; 20 ref_27 Ono (ref_19) 2022; 84 Cryan (ref_30) 2012; 13 Yoo (ref_41) 2010; 18 Akiho (ref_16) 2011; 2 Cassar (ref_47) 2018; 23 Ellett (ref_40) 2011; 117
References_xml	– volume: 95 start-page: 1755 year: 2000 ident: ref_17 article-title: Psychological disorders in patients with evacuation dis-orders and constipation in a tertiary practice publication-title: Am. J. Gastroenterol. doi: 10.1111/j.1572-0241.2000.02184.x – volume: 32 start-page: e13762 year: 2019 ident: ref_24 article-title: European society of neurogastroenterology and motility guidelines on functional constipation in adults publication-title: Neurogastroenterol. Motil. doi: 10.1111/nmo.13762 – volume: 68 start-page: 123 year: 2013 ident: ref_9 article-title: An evaluation of the non-invasive faecal pellet assessment method as an early drug discovery screen for gastrointestinal liability publication-title: J. Pharmacol. Toxicol. Methods doi: 10.1016/j.vascn.2013.03.006 – volume: 115 start-page: 66 year: 2005 ident: ref_22 article-title: Human intestinal macrophages display profound in-flammatory anergy despite avid phagocytic and bacteriocidal activity publication-title: J. Clin. Investig. doi: 10.1172/JCI200519229 – volume: 12 start-page: 739591 year: 2021 ident: ref_43 article-title: Activation of the TCA Cycle to Provide Immune Protection in Zebrafish Immunized by High Magnesium-Prepared Vibrio alginolyticus Vaccine publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.739591 – volume: 41 start-page: 2759 year: 2022 ident: ref_26 article-title: Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials publication-title: Clin. Nutr. doi: 10.1016/j.clnu.2022.10.015 – volume: 164 start-page: 1086 year: 2023 ident: ref_23 article-title: American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation publication-title: Gastroenterology doi: 10.1053/j.gastro.2023.03.214 – volume: 295 start-page: 515 year: 2012 ident: ref_18 article-title: The Effects of Rearing Light Level and Duration Differences on the Optic Nerve, Brain, and Associated Structures in Developing Zebrafish Larvae: A Light and Transmission Electron Microscope Study publication-title: Anat. Rec. doi: 10.1002/ar.22403 – volume: 518 start-page: 4277 year: 2010 ident: ref_46 article-title: Astroglial structures in the zebrafish brain publication-title: J. Comp. Neurol. doi: 10.1002/cne.22481 – ident: ref_36 doi: 10.3390/ijms17091399 – volume: 25 start-page: 16b year: 2011 ident: ref_32 article-title: The pathophysiology of chronic constipation publication-title: Can. J. Gastroenterol. doi: 10.1155/2011/169319 – volume: 2 start-page: 11 year: 2009 ident: ref_35 article-title: c-Fos and pERK, which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury? publication-title: Open Pain J. doi: 10.2174/1876386300902010011 – volume: 117 start-page: e49 year: 2011 ident: ref_40 article-title: mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish publication-title: Blood doi: 10.1182/blood-2010-10-314120 – volume: 10 start-page: 28 year: 2020 ident: ref_6 article-title: Circadian rhythm disruption and mental health publication-title: Transl. Psychiatry doi: 10.1038/s41398-020-0694-0 – volume: 150 start-page: 1393 year: 2016 ident: ref_1 article-title: Bowel Disorders publication-title: Gastroenterology doi: 10.1053/j.gastro.2016.02.031 – volume: 1011 start-page: 156 year: 2004 ident: ref_12 article-title: The adult central nervous cholinergic system of a neurogenetic model animal, the zebrafish Danio rerio publication-title: Brain Res. doi: 10.1016/j.brainres.2004.02.073 – ident: ref_14 – volume: 11 start-page: 349 year: 2020 ident: ref_44 article-title: Malate enhances survival of zebrafish against Vibrio alginolyticus infection in the same manner as taurine publication-title: Virulence doi: 10.1080/21505594.2020.1750123 – ident: ref_42 doi: 10.1186/s12866-022-02491-4 – volume: 25 start-page: 264 year: 2021 ident: ref_15 article-title: Prokinetic effects of diatrizoate meglumine (Gastrografin®) in a zebrafish for opioid-induced constipation model publication-title: Anim. Cells Syst. doi: 10.1080/19768354.2021.1991472 – volume: 23 start-page: 58497 year: 2018 ident: ref_47 article-title: High-throughput Measurement of Gut Transit Time Using Larval Zebrafish publication-title: J. Vis. Exp. – volume: 64 start-page: 82 year: 2016 ident: ref_8 article-title: The zebrafish as a model to study intestinal inflammation publication-title: Dev. Comp. Immunol. doi: 10.1016/j.dci.2016.02.020 – ident: ref_27 doi: 10.3390/nu14122482 – ident: ref_31 doi: 10.1371/journal.pone.0199041 – volume: 62 start-page: 591 year: 2011 ident: ref_7 article-title: Stress and the gut: Pathophysiology, clinical consequences, diagnostic approach and treatment options publication-title: J. Physiol. Pharmacol. – ident: ref_39 doi: 10.3390/ijms24076585 – volume: 22 start-page: 433 year: 2016 ident: ref_33 article-title: Enteric Glial Cells: A New Frontier in Neurogastroen-terology and Clinical Target for Inflammatory Bowel Diseases publication-title: Inflamm. Bowel Dis. doi: 10.1097/MIB.0000000000000667 – volume: 25 start-page: 599 year: 2007 ident: ref_25 article-title: Chronic constipation: A survey of the patient perspective publication-title: Aliment. Pharmacol. Ther. doi: 10.1111/j.1365-2036.2006.03238.x – volume: 12 start-page: 1701 year: 2021 ident: ref_21 article-title: The Role of Intestinal Macrophages in Gastrointestinal Homeostasis: Heterogeneity and Implications in Disease publication-title: Cell. Mol. Gastroenterol. Hepatol. doi: 10.1016/j.jcmgh.2021.08.021 – ident: ref_45 doi: 10.1371/journal.pone.0255201 – ident: ref_28 doi: 10.1371/journal.pone.0262942 – volume: 15 start-page: 218 year: 2011 ident: ref_20 article-title: Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent publication-title: Stress – volume: 17 start-page: 382 year: 2020 ident: ref_29 article-title: Probiotics Modulate Intestinal Motility and Inflammation in Zebrafish Models publication-title: Zebrafish doi: 10.1089/zeb.2020.1877 – volume: 34 start-page: e14195 year: 2021 ident: ref_2 article-title: Early adverse life events and post-traumatic stress disorder in patients with constipation and suspected disordered defecation publication-title: Neurogastroenterol. Motil. doi: 10.1111/nmo.14195 – volume: 35 start-page: 648 year: 2014 ident: ref_5 article-title: The effects of light at night on circadian clocks and metabolism publication-title: Endocr. Rev. doi: 10.1210/er.2013-1051 – volume: 21 start-page: 304 year: 2009 ident: ref_11 article-title: Analysis of gastrointestinal physiology using a novel intestinal transit assay in zebrafish publication-title: Neurogastroenterol. Motil. doi: 10.1111/j.1365-2982.2008.01234.x – volume: 20 start-page: 12144 year: 2014 ident: ref_4 article-title: Irritable bowel syndrome: A clinical review publication-title: World J. Gastroenterol. doi: 10.3748/wjg.v20.i34.12144 – volume: 84 start-page: 1061 year: 2022 ident: ref_19 article-title: Stress decreases contraction of the colon, and the effects of stress are different among the regions of the colon publication-title: J. Vet. Med. Sci. doi: 10.1292/jvms.22-0073 – volume: 2 start-page: 1114 year: 1999 ident: ref_34 article-title: Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity publication-title: Nat. Neurosci. doi: 10.1038/16040 – volume: 49 start-page: 187 year: 2004 ident: ref_10 article-title: Gastrointestinal-tract models and techniques for use in safety pharmacology publication-title: J. Pharmacol. Toxicol. Methods doi: 10.1016/j.vascn.2004.02.008 – ident: ref_37 doi: 10.3390/ijms17071172 – volume: 66 start-page: 9 year: 2017 ident: ref_3 article-title: Microbes and mental health: A review publication-title: Brain Behav. Immun. doi: 10.1016/j.bbi.2017.01.016 – volume: 294 start-page: R711 year: 2008 ident: ref_13 article-title: Development of the corticosteroid stress axis and receptor expression in zebrafish publication-title: Am. J. Physiol. Integr. Comp. Physiol. doi: 10.1152/ajpregu.00671.2007 – volume: 18 start-page: 226 year: 2010 ident: ref_41 article-title: Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish publication-title: Dev. Cell doi: 10.1016/j.devcel.2009.11.015 – volume: 2 start-page: 72 year: 2011 ident: ref_16 article-title: Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders publication-title: World J. Gastrointest. Pathophysiol. doi: 10.4291/wjgp.v2.i5.72 – volume: 13 start-page: 701 year: 2012 ident: ref_30 article-title: Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3346 – volume: 103 start-page: 5003 year: 2020 ident: ref_38 article-title: Lactobacillus rhamnosus FLRH93 protects against intestinal damage in mice induced by 5-fluorouracil publication-title: J. Dairy Sci. doi: 10.3168/jds.2019-17836
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Snippet	The pathophysiology of functional bowel disorders is complex, involving disruptions in gut motility, visceral hypersensitivity, gut–brain–microbiota... The pathophysiology of functional bowel disorders is complex, involving disruptions in gut motility, visceral hypersensitivity, gut-brain-microbiota...
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SubjectTerms	Animals Aquaporins Bifidobacterium longum Constipation Constipation - etiology Constipation - therapy Corticosteroids Gut-brain axis Hormones Hydrocortisone Hypothalamus Inflammation Irritable bowel syndrome Larva Light Microbiota Microbiota (Symbiotic organisms) Motility Neurophysiology Physiology Probiotics Probiotics - pharmacology Probiotics - therapeutic use Scientific equipment and supplies industry Stress Stress (Psychology) Vasoactive intestinal peptides Zebrafish
Title	Effect of Probiotics in Stress-Associated Constipation Model in Zebrafish (Danio rerio) Larvae
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